Receptor de Androgénio
O receptor de andrógenos (AR) é um receptor hormonal nuclear que é ativado pela ligação a andrógenos, como a testosterona e a diidrotestosterona. Este receptor desempenha um papel crucial no desenvolvimento e na manutenção das características masculinas, bem como na regulação de vários processos fisiológicos, incluindo o crescimento muscular, a libido e a densidade óssea. Inibidores do receptor de andrógenos são amplamente estudados no contexto do câncer de próstata, onde a sinalização do AR é frequentemente aumentada. Na CymitQuimica, oferecemos uma gama de moduladores do receptor de andrógenos de alta qualidade para apoiar sua pesquisa em endocrinologia, biologia do câncer e regulação hormonal.
Foram encontrados 229 produtos de "Receptor de Androgénio"
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BWA-6047
BWA-6047 is a dual AR/AR-V7 and GSPT1 PROTAC-type degrader (AR: DC50= 3.7 nM; AR-V7: DC50= 3.0 nM; GSPT1: DC50= 1.2 nM). It facilitates the ubiquitination and degradation of AR/AR-V7 and, through molecular glue properties, induces a PPI between GSPT1 and CRBN, leading to GSPT1 degradation. BWA-6047 is applicable in prostate cancer research.Fórmula:C42H46ClN5O7Cor e Forma:SolidPeso molecular:767.308582-sec-Butylphenol
CAS:2-sec-Butylphenol is an inhibitor of the androgen receptor and P450 aromatase, and can be used in research and experiments in the field of life sciences.Fórmula:C10H14OCor e Forma:SolidPeso molecular:150.22ARD-266
CAS:ARD-266 is a PROTAC degrader based on the von Hippel-Lindau E3 ligase that induces the degradation of AR proteins and is useful in prostate cancer research.Fórmula:C52H59ClN6O7Pureza:99.89%Cor e Forma:SolidPeso molecular:915.513-Cl-Pyridine-amide-acrylaldehyde-piperazine
3-Cl-Pyridine-amide-acrylaldehyde-piperazine serves as a synthetic intermediate for LO-4-25. LO-4-25 is a ligand for the androgen receptor (AR) DNA binding domain and is linked to a truncated fumaramide handle via a connector. In 22Rv1 cells, LO-4-25 demonstrates potent degradation of both AR and AR-V7.Cor e Forma:Odour SolidARD-69
ARD-69, a potent PROTAC, degrades AR in prostate cancer, with low DC50 values in AR+ cell lines, and suppresses AR gene expression.Fórmula:C62H74ClFN8O7SCor e Forma:SolidPeso molecular:1129.83TD-802
CAS:TD-802, an AR-targeting PROTAC with microsomal stability, shows promise for castration-resistant prostate cancer.Fórmula:C52H61ClN10O6Cor e Forma:SolidPeso molecular:957.56ARD-2051
CAS:ARD-2051 is a potent, orally active proteolysis-targeting chimera degrader of the androgen receptor (AR), exhibiting DC50 values of 0.6 nM in degrading ARFórmula:C43H45ClN8O5Pureza:98%Cor e Forma:SolidPeso molecular:789.32Galloylalbiflorin
CAS:Galloylalbiflorin, an AR antagonist with IC50 53.3μM, is sourced from Paeonia lactiflora roots, exhibiting anti-androgenic properties.Fórmula:C30H32O15Cor e Forma:SolidPeso molecular:632.57RLA-5331
RLA-5331: iron activator with anti-androgen properties; inhibits mCRPC cell proliferation.Fórmula:C40H43F3N6O7SCor e Forma:SolidPeso molecular:808.87PROTAC AR-V7 degrader-1
CAS:Potent, oral AR-V7 degrader (Compound 6); DC50: 0.32µM; targets AR-DBD via VHL E3; EC50: 0.88µM in 22Rv1 cells.Fórmula:C41H52N6O6S2Cor e Forma:SolidPeso molecular:789.02Ludaterone
CAS:Ludaterone is an antiandrogen agent, with potent antiandrogenic activity.Fórmula:C20H25ClO5Cor e Forma:SolidPeso molecular:380.86Tibolone
CAS:Tibolone is an estrogen-like compound used for the treatment of the symptoms associated with menopausal transition (i.e., climacteric symptoms) and also for theFórmula:C21H28O2Pureza:99.70% - 99.71%Cor e Forma:White To Off-White Crystalline PowderPeso molecular:312.45ARCC-4
CAS:ARCC-4: A VHL-recruiting, low-nanomolar (DC50=5nM) AR degrader; outshines enzalutamide; degrades AR mutants resistant to therapy.Fórmula:C53H56F3N7O7S2Pureza:98%Cor e Forma:SolidPeso molecular:1024.18Adrenocorticotropic hormone
CAS:ACTH, a polypeptide, is secreted by the pituitary gland and regulates cortisol and androgen.Cor e Forma:SolidARD-61
CAS:ARD-61: potent PROTAC, degrades AR/PR in AR+ cancers, triggers apoptosis, inhibits tumor growth in mice.Fórmula:C61H71ClN8O7SCor e Forma:SolidPeso molecular:1095.82-Ethylhexyl trans-4-methoxycinnamate
CAS:2-Ethylhexyl trans-4-methoxycinnamate is a sunscreen agent.Fórmula:C18H26O3Pureza:98.92%Cor e Forma:Pale Yellow LiquidPeso molecular:290.4PROTAC AR Degrader-9
PROTAC AR Degrader-9 (Compound c6) is a PROTAC-based degrader specifically targeting the androgen receptor. It effectively degrades the androgen receptor in human dermal papilla cells (HDPC) with a DC50 of 262.38 nM. Additionally, this compound enhances the expression of paracrine factors, such as TGF-β1 and β-catenin, thereby promoting hair regeneration in mouse models. [Pink: ligand for target protein AR ligand-38; Black: linker; Blue: ligand for E3 ligase Cereblon]Fórmula:C43H49ClN6O5Cor e Forma:SolidPeso molecular:765.339Cl-4AS-1
CAS:steroidal androgen receptor agonistFórmula:C26H33ClN2O2Pureza:98%Cor e Forma:SolidPeso molecular:441.01VAL-201
CAS:VAL-201, an androgen receptor antagonist, is used potentially for the treatment of prostate cancer.Fórmula:C55H87N19O11Cor e Forma:SolidPeso molecular:1190.4TLB 150 Benzoate
CAS:TLB 150 Benzoate (RAD150) is a modulator of the androgen receptor with an IC50 value of 0.13 μM.Fórmula:C27H20ClN5O3Cor e Forma:SolidPeso molecular:497.93
