NF-κB
O fator nuclear kappa-light-chain-enhancer de células B ativadas (NF-κB) é um fator de transcrição que regula a expressão de genes envolvidos em respostas imunes, inflamação, sobrevivência celular e proliferação. O NF-κB é ativado em resposta a vários estímulos, incluindo citocinas, patógenos e sinais de estresse. A desregulação da sinalização do NF-κB está associada a doenças inflamatórias crônicas, câncer e distúrbios autoimunes. Na CymitQuimica, oferecemos uma seleção abrangente de moduladores da via NF-κB para apoiar sua pesquisa em inflamação, oncologia e regulação imunológica.
Foram encontrados 445 produtos de "NF-κB"
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Mangiferin
CAS:<p>Mangiferin (Hedysarid) is used for antidiabetes. Extracted from Mangifera indica L.</p>Fórmula:C19H18O11Pureza:99.78% - 99.86%Cor e Forma:Light Yellow PowderPeso molecular:422.34Indacaterol maleate
CAS:<p>Indacaterol maleate (QAB149) is an ultra-long-acting β-adrenoceptor agonist.</p>Fórmula:C28H32N2O7Pureza:99.03% - 99.67%Cor e Forma:SolidPeso molecular:508.56Articaine hydrochloride
CAS:<p>Articaine hydrochloride (Hoe-045) is a thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE.</p>Fórmula:C13H21ClN2O3SPureza:99.76%Cor e Forma:White Crystalline PowderPeso molecular:320.84IRAK4-IN-4
CAS:<p>IRAK4-IN-4 (compound 15) inhibits cyclic GMP-AMP synthase (cGAS) with an IC50 of 2.1 nM.IRAK4-IN-4 is an interleukin-1 receptor–associated kinase 4 (IRAK4)</p>Fórmula:C22H16N2O2Pureza:99.52%Cor e Forma:SolidPeso molecular:340.37GLPG2534
CAS:<p>GLPG2534 is an orally active, selective and potent IRAK4 inhibitor with anti-inflammatory activity. GLPG2534 can be used in psoriasis and atopic dermatitis.</p>Fórmula:C21H24N6O4Pureza:99.51% - 99.61%Cor e Forma:SolidPeso molecular:424.45RIPK1-IN-7
CAS:<p>RIPK1-IN-7: Strong, selective RIPK1 inhibitor (Kd=4 nM, IC50=11 nM) with great antimetastasis effects in B16 melanoma.</p>Fórmula:C25H22F3N5O2Pureza:98.02% - 98.18%Cor e Forma:SolidPeso molecular:481.47GSK3145095
CAS:<p>GSK3145095 is an orally active inhibitor of RIPK1 with IC50 of 5 nM, with potential immunomodulatory activities and antineoplastic.</p>Fórmula:C20H17F2N5O2Pureza:99.50%Cor e Forma:SolidPeso molecular:397.38BAY-985
CAS:<p>BAY-985: potent oral TBK1/IKKε inhibitor; IC50s: TBK1 (2/30 nM), IKKε (2 nM); has antitumor properties.</p>Fórmula:C27H30F3N9OPureza:99.62%Cor e Forma:SolidPeso molecular:553.58Urolithin B
CAS:<p>Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in diverse plant foods, including pomegranates, berries, walnuts, tropical</p>Fórmula:C13H8O3Pureza:99.45%Cor e Forma:SolidPeso molecular:212.25-Aminosalicylic Acid
CAS:<p>5-Aminosalicylic Acid (5-ASA) is a specific PPARγ agonist and also inhibits P21-activated kinase 1 (PAK1) and NF-Κb. High-Quality, Low-Cost!</p>Fórmula:C7H7NO3Pureza:98.88% - 99.49%Cor e Forma:Purplish-Tan Solid PowderPeso molecular:153.14DCZ0415
CAS:<p>DCZ0415: Potent TRIP13 inhibitor; combats myeloma in vitro, in vivo, and in drug-resistant patients; hinders DNA repair and NF-κB activity.</p>Fórmula:C23H20N2O2Pureza:99.34% - 99.95%Cor e Forma:SolidPeso molecular:356.42(E/Z)-BCI
CAS:<p>(E/Z)-BCI (NSC-150117), a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory properties, reduces LPS-induced inflammatory mediators and ROS</p>Fórmula:C22H23NOPureza:99.94%Cor e Forma:SolidPeso molecular:317.42DMAPT
CAS:<p>DMAPT is a water-soluble PTL analogue, orally active NF-κB inhibitor with 1.7 μM LD50 in acute myeloid leukemia cells.</p>Fórmula:C17H27NO3Pureza:99.91%Cor e Forma:SolidPeso molecular:293.4Sulfasalazine
CAS:<p>Sulfasalazine (Azulfidine) is a synthetic salicylic acid derivative. Sulfasalazine induces ferroptosis and inhibits NF-κB. Cost effective and quality assured.</p>Fórmula:C18H14N4O5SPureza:98.00% - 99.28%Cor e Forma:Minute Brownish-Yellow CrystalsPeso molecular:398.39Sodium salicylate
CAS:<p>Sodium salicylate (2-Hydroxybenzoic acid sodium salt), a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.</p>Fórmula:C7H5NaO3Pureza:99.36% - 99.92%Cor e Forma:White Solid AmorphousPeso molecular:160.11Ergolide
CAS:<p>Ergolide, from Inula Britannica, inhibits iNOS and COX-2 by deactivating NF-κB in macrophages.</p>Fórmula:C17H22O5Pureza:99.64%Cor e Forma:SolidPeso molecular:306.35SN50 acetate (213546-53-3 free base)
<p>SN50 acetate is a cell permeable inhibitor of NF-κB translocation.</p>Fórmula:C131H234N36O31SPureza:99.86%Cor e Forma:SolidPeso molecular:2841.55IMD-0560
CAS:<p>IMD-0560 is a novel inhibitor of IκB kinase β.</p>Fórmula:C15H8BrF6NO2Pureza:99.51%Cor e Forma:SolidPeso molecular:428.12Metaxalone
CAS:<p>Metaxalone, sold as Skelaxin by King Pharmaceuticals, is a muscle relaxant for pain from strains and sprains.</p>Fórmula:C12H15NO3Pureza:98.84% - 99.94%Cor e Forma:White To Almost White Crystalline Powder SolidPeso molecular:221.25Mevastatin
CAS:<p>Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum.</p>Fórmula:C23H34O5Pureza:99.12%Cor e Forma:White-Yellowish To Yellow Powder Solid PowderPeso molecular:390.51Oxaprozin
CAS:<p>Oxaprozin (Oxaprozinum) is a Nonsteroidal Anti-inflammatory Drug.</p>Fórmula:C18H15NO3Pureza:98.53%Cor e Forma:SolidPeso molecular:293.32Aspirin
CAS:<p>Aspirin (Acetylsalicylic Acid) is a COX inhibitor. Aspirin has anti-inflammatory, antipyretic and analgesic activities. Cost-effective and quality-assured.</p>Fórmula:C9H8O4Pureza:99.78% - 99.91%Cor e Forma:White Solid CrystallinePeso molecular:180.16NIK SMI1
CAS:<p>NIK SMI1 is an effective and selective NF-κB inducing kinase (NIK) inhibitor. It also inhibits NIK-catalyzed hydrolysis of ATP to ADP (IC50: 0.23±0.17 nM).</p>Fórmula:C20H19N3O4Pureza:99.04% - 99.99%Cor e Forma:SolidPeso molecular:365.38Sulindac
CAS:<p>Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity.</p>Fórmula:C20H17FO3SPureza:99.09% - 99.15%Cor e Forma:Yellow SolidPeso molecular:356.41Asatone
CAS:<p>Asatone from Radix et Rhizoma Asari has anti-inflammatory properties, acting on NF-κB and suppressing p-MAPK pathways (ERK, JNK, p38).</p>Fórmula:C24H32O8Pureza:99.84% - 99.92%Cor e Forma:SolidPeso molecular:448.51Naringin dihydrochalcone
CAS:<p>Naringin dihydrochalcone (Naringin DC) is an inhibitor of CYP enzymes, used as an artificial sweetener.</p>Fórmula:C27H34O14Pureza:99.07% - 99.73%Cor e Forma:Solid PowderPeso molecular:582.55Theophylline monohydrate
CAS:<p>Theophylline monohydrate (Quibron) appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium</p>Fórmula:C7H8N4O2·H2OPureza:99.78%Cor e Forma:SolidPeso molecular:198.184-Hydroxychalcone
CAS:<p>4-Hydroxychalcone (P-Cinnamoylphenol) attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice.</p>Fórmula:C15H12O2Pureza:99.75%Cor e Forma:Yellow PowderPeso molecular:224.25Lidocaine hydrochloride
CAS:<p>Lidocaine HCl: local anesthetic, antiarrhythmic, stronger & longer-lasting than procaine but shorter than bupivacaine/prilocaine.</p>Fórmula:C14H23ClN2OPureza:99.81% - 99.92%Cor e Forma:White Crystal PowderPeso molecular:270.798Dihydroartemisinin
CAS:<p>Dihydroartemisinin (Artenimol) is an antimalarial drug. High-Quality, Low-Cost!</p>Fórmula:C15H24O5Pureza:98% - 99.41%Cor e Forma:White SolidPeso molecular:284.35Sinomenine hydrochloride
CAS:<p>Sinomenine hydrochloride (Kukoline hydrochloride) is extracted from Sinomenium Acutum Rehderett Wilson.</p>Fórmula:C19H24ClNO4Pureza:99.43%Cor e Forma:SolidPeso molecular:365.851Nimbolide
CAS:<p>Nimbolide, from neem, inhibits CDK4/6, NF-κB, Wnt, PI3K-Akt, MAPK, JAK-STAT pathways and induces apoptosis.</p>Fórmula:C27H30O7Pureza:95.84% - 99.4%Cor e Forma:SolidPeso molecular:466.52Lidocaine Hydrochloride hydrate
CAS:<p>Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.</p>Fórmula:C14H22N2O·HCl·H2OPureza:99.95%Cor e Forma:SolidPeso molecular:288.82TBK1/IKKε-IN-2
CAS:<p>TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.</p>Fórmula:C26H27N5O3Pureza:98.89%Cor e Forma:SolidPeso molecular:457.52CDDO-dhTFEA
CAS:<p>CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor.</p>Fórmula:C33H45F3N2O3Pureza:95.61% - 99.59%Cor e Forma:SolidPeso molecular:574.72AZ1495
CAS:<p>AZ1495: oral IRAK4 inhibitor (IC50: 5 nM), IRAK1 (23 nM), treats MYD88L265P DLBCL.</p>Fórmula:C21H31N5O2Pureza:98.81%Cor e Forma:SolidPeso molecular:385.5Baicalin
CAS:<p>Baicalin (Baicalein 7-O-β-D-glucuronide) is a prolyl endopeptidase inhibitor isolated from scutellaria baicalensis, with antioxidant, anti-tumor, anti-HIV</p>Fórmula:C21H18O11Pureza:90.08% - 99.32%Cor e Forma:Yellow PowderPeso molecular:446.36Theophylline
CAS:<p>Theophylline (1,3-Dimethylxanthine) is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central</p>Fórmula:C7H8N4O2Pureza:99.65% - 99.98%Cor e Forma:White Solid PowderPeso molecular:180.16Methylthiouracil
CAS:<p>Methylthiouracil (NSC-193526) is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.</p>Fórmula:C5H6N2OSPureza:99.89% - >99.99%Cor e Forma:Crystals Saturated Aqueous Solution Is Neutral Or Slightly Acidic (Ntp 1992)Peso molecular:142.18DRI-C21045
CAS:<p>Dri-c21045 inhibits NF-kB (IC50=17.1μM) and B cell proliferation (IC50=4.5μM), selectively blocking CD40-CD40L interaction (IC50=0.17μM).</p>Fórmula:C32H24N2O7SPureza:97.20%Cor e Forma:SolidPeso molecular:580.61α-Lipoic Acid
CAS:<p>α-Lipoic Acid, a sulfur-containing octanoic acid derivative, is biosynthesized from linoleic acid and used in dietary supplements.</p>Fórmula:C8H14O2S2Pureza:98.39% - 99.73%Cor e Forma:Forms Yellowish Flakes Light Yellow To Yellow PowderPeso molecular:206.33Lidocaine
CAS:<p>Lidocaine, an amide local anesthetic, reduces pain and inflammation by dampening ICAM-1, cytokines, and neutrophil influx.</p>Fórmula:C14H22N2OPureza:99.95% - >99.99%Cor e Forma:Needles From Benzene Or Alcohol SolidPeso molecular:234.34Guaiacol
CAS:<p>Guaiacol, a flavorant precursor, has medicinal uses and serves as an oxygen indicator turning yellow-brown at 470 nm.</p>Fórmula:C7H8O2Pureza:99.95%Cor e Forma:Colourless To Pale Yellow Solid CrystallinePeso molecular:124.14Erdosteine
CAS:<p>Erdosteine (RV 144), a mucolytic thiol, modulates mucus and aids expectoration, reduces cough, and protects lungs from smoke damage.</p>Fórmula:C8H11NO4S2Pureza:99.43% - 99.94%Cor e Forma:White Or Almost White Crystalline PowderPeso molecular:249.31CAY10512
CAS:<p>CAY10512, a resveratrol analog, is 100x more potent, inhibiting NF-κB with an IC50 of 0.15 μM versus resveratrol's 20 μM.</p>Fórmula:C15H13FOCor e Forma:SolidPeso molecular:228.26612-Oxo phytodienoic acid
CAS:<p>12-oxo PDA boosts alkaloid production in E. californica, enhances B. dioica tendril curls, and blocks JA-induced cell death in A. fru mutants.</p>Fórmula:C18H28O3Pureza:98%Cor e Forma:SolidPeso molecular:292.41MJ210
<p>MJ210 is an orally active and blood-brain barrier-permeable modulator of the NF-κB and MAPK pathways, exhibiting neuroprotective properties. In vitro, 5 μM MJ210 can increase the survival rate of rotenone-treated SH-SY5Y cells to 81.9% and reduce levels of ROS. In vivo, 5 mg/kg MJ210 improves motor dysfunction in rat models of Parkinson's disease. MJ210 is useful for research in neurological disorders, including Parkinson's disease.</p>Cor e Forma:Odour SolidIKKγ NBD Inhibitory Peptide
CAS:<p>A cell-permeable synthetic peptide NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region is shown to block TNF</p>Fórmula:C170H259N49O42S1Pureza:98%Cor e Forma:SolidPeso molecular:3693.3R1-ICR-5
CAS:<p>R1-ICR-5 is a selective PROTAC degrader targeting serine/threonine-protein kinase 1 (RIPK1). Mediated by VHL, R1-ICR-5 promotes the degradation of RIPK1, disrupting the TNFR1 and TLR3/4 signaling hubs, enhancing NF-κB, MAPK, and IFN signal output, and facilitating RIPK3 activation and necroptosis induction. R1-ICR-5 holds potential for research in cancer and inflammatory diseases.</p>Fórmula:C54H70N8O7S2Cor e Forma:SolidPeso molecular:1007.31Cyclo(L-Pro-L-Val)
CAS:<p>Cyclo(L-Pro-L-Val), from Mycobacterium spp., has anti-inflammatory effects, hinders phytopathogens, and suppresses IKKα, NF-κB, iNOS, and COX-2 activation.</p>Fórmula:C10H16N2O2Pureza:98.18%Cor e Forma:SolidPeso molecular:196.25
