NF-κB
O fator nuclear kappa-light-chain-enhancer de células B ativadas (NF-κB) é um fator de transcrição que regula a expressão de genes envolvidos em respostas imunes, inflamação, sobrevivência celular e proliferação. O NF-κB é ativado em resposta a vários estímulos, incluindo citocinas, patógenos e sinais de estresse. A desregulação da sinalização do NF-κB está associada a doenças inflamatórias crônicas, câncer e distúrbios autoimunes. Na CymitQuimica, oferecemos uma seleção abrangente de moduladores da via NF-κB para apoiar sua pesquisa em inflamação, oncologia e regulação imunológica.
Foram encontrados 390 produtos de "NF-κB"
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CAY10512
CAS:CAY10512, a resveratrol analog, is 100x more potent, inhibiting NF-κB with an IC50 of 0.15 μM versus resveratrol's 20 μM.Fórmula:C15H13FOCor e Forma:SolidPeso molecular:228.26612-Oxo phytodienoic acid
CAS:12-oxo PDA boosts alkaloid production in E. californica, enhances B. dioica tendril curls, and blocks JA-induced cell death in A. fru mutants.
Fórmula:C18H28O3Pureza:98%Cor e Forma:SolidPeso molecular:292.41(R)-(-)-Ibuprofen
CAS:(R)-(-)-Ibuprofen ((R)-Ibuprofen) is the R enantiomer of Ibuprofen and inhibits NF-κB activation.Fórmula:C13H18O2Pureza:99.86%Cor e Forma:SolidPeso molecular:206.28Anti-inflammatory agent 51
CAS:Anti-inflammatory agent 51 amide/sulfonamide anti-inflammatory and anti-tumor activity inhibition of NF-κB activation acute lung injury and ulcerative colitis.Fórmula:C22H22N6O6SPureza:99.76%Cor e Forma:SoildPeso molecular:498.51CTP-NBD
CAS:CTP-NBD is a cell-permeable, specific inhibitor of the NFκB peptide, which has been utilized in studies of colitis [1] [2].Fórmula:C121H194N46O32Pureza:98%Cor e Forma:SolidPeso molecular:2805.12Helenalin
CAS:Helenalin: anti-inflammatory sesquiterpene, inhibits NF-κB by alkylating p65 cysteine groups, blocks DNA binding.Fórmula:C15H18O4Pureza:98%Cor e Forma:SolidPeso molecular:262.3Apo A-I mimetic 5A peptide
Apo A-I mimetic 5A peptide is a synthetic peptide molecule designed based on the structure and function of naturally occurring apolipoprotein A-I (Apo A-I). It facilitates the efflux of cholesterol from inside cells, helping to reduce intracellular cholesterol accumulation. Additionally, Apo A-I mimetic 5A peptide exhibits anti-inflammatory properties, lowering inflammatory markers in blood and tissues. This peptide is used in cardiovascular disease research.Fórmula:C197H295N47O56Peso molecular:4215.16808HOIPIN-1
CAS:HOIPIN-1 (JTP0819958) is a selective and potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) (IC50 >2.8 μM).HOIPIN-1 inhibits LUBAC-mediated NF-Fórmula:C17H13NaO4Pureza:98.65%Cor e Forma:SoildPeso molecular:304.27NF-κΒ activator 1
CAS:NF-κΒ activator 1 can activate the nf-kappa Β gene activator, EC50 of 0.9 microns.Fórmula:C16H11FN2O2SPureza:99.58%Cor e Forma:SolidPeso molecular:314.33Ref: TM-T39965
1mg95,00€5mg202,00€10mg329,00€25mg560,00€50mg800,00€100mg1.103,00€500mg2.213,00€1mL*10mM (DMSO)224,00€Transcription Factor-Targeted Compound Library
Well-chosen xnum compounds with unique structures targeting transcription factor;Cor e Forma:Odour SolidRef: TM-L1380
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarMRT67307
CAS:Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy.Fórmula:C26H36N6O2Pureza:99.25% - 99.84%Cor e Forma:SolidPeso molecular:464.6Halleridone
CAS:Halleridone, a natural product, is identified in Teuanchum decipiens and Abeliophyllum distichum.Fórmula:C8H10O3Cor e Forma:SolidPeso molecular:154.165Gliotoxin
CAS:Gliotoxin, a mycotoxin, inhibits Wnt pathway, causing apoptosis in mutated colorectal cancer cells and blocks NF-κB by preserving IκB.Fórmula:C13H14N2O4S2Pureza:98%Cor e Forma:SolidPeso molecular:326.39Anti-inflammatory agent 48
Anti-inflammatory agent 48 functions by inhibiting the NF-κB signaling pathway and activating HO-1 expression, characterizing its role as an anti-inflammatoryFórmula:C24H21Cl2NO3Pureza:98%Cor e Forma:SolidPeso molecular:442.33Antidesmone
CAS:Antidesmone from Ajuga decumbens inhibits acute lung injury by modulating MAPK and NF-κB.Fórmula:C19H29NO3Pureza:98%Cor e Forma:SolidPeso molecular:319.44Aloenin aglycone
CAS:Aloenin aglycone (compound 13), an inhibitor of NF-κB, can be sourced from aloe exudate.Fórmula:C13H12O5Pureza:98%Cor e Forma:SolidPeso molecular:248.23Eupenicisirenin C
CAS:Eupenicisirenin C (compound 1), a sirenin derivative, exhibits strong NF-κB inhibitory activities and suppresses the cGAS-STING pathway. Additionally, Eupenicisirenin C inhibits RANKL-induced osteoclast differentiation in bone marrow macrophage cells [1].Fórmula:C13H18O4Cor e Forma:SolidPeso molecular:238.28R-HP210
R-HP210 blocks LPS-triggered IL-1β, IL-6, COX-2 gene transcription and has a 3.80 μM IC50 for NF-κB inhibition without activating GCs.Fórmula:C22H19N3O2S2Cor e Forma:SolidPeso molecular:421.54MJ210
MJ210 is an orally active and blood-brain barrier-permeable modulator of the NF-κB and MAPK pathways, exhibiting neuroprotective properties. In vitro, 5 μM MJ210 can increase the survival rate of rotenone-treated SH-SY5Y cells to 81.9% and reduce levels of ROS. In vivo, 5 mg/kg MJ210 improves motor dysfunction in rat models of Parkinson's disease. MJ210 is useful for research in neurological disorders, including Parkinson's disease.Cor e Forma:Odour SolidMitogen-activated protein kinase 1
CAS:Mitogen-activated protein kinase 1 (MAPK1) activates the p38/NF-κB pathway and regulates cellular processes in sepsis-associated diseases.Pureza:98%Cor e Forma:SolidSN50 TFA
SN50 TFA is an inhibitor of NF-κB and attenuates alveolar hypercoagulation and fibrinolysis inhibition. SN50 TFA can be used in studies about ARDS.Fórmula:C129H230N36O29S·XCF3COOHCor e Forma:SolidPeso molecular:2781.5 (free base)SU1261
SU1261, an IKK inhibitor, exhibits Ki values of 10 nM for IKKα and 680 nM for IKKβ. It effectively inhibits non-canonical NF-κB signaling in U2OS osteosarcoma cells.Cor e Forma:Odour SolidSiegesbeckialide I
Siegesbeckialide I effectively suppresses LPS-induced NO production in RAW264.7 murine macrophages by directly interacting with IKKα/β.Fórmula:C20H28O6Cor e Forma:SolidPeso molecular:364.43TBK1/IKKε-IN-6
CAS:TBK1/IKKε-IN-6 (example 110) is a potent inhibitor of TBK1 and IKKε, with IC50 values of less than 100 nM for both enzymes.Fórmula:C31H36F2N8O4Cor e Forma:SolidPeso molecular:622.678LY2409881
CAS:LY2409881 is a selective IκB kinase β ( IKK2 ) inhibitor with an IC 50 of 30 nM.Fórmula:C24H29ClN6OSCor e Forma:SolidPeso molecular:485.05Anti-inflammatory agent 7
Anti-inflammatory Agent 7 suppresses proinflammatory cytokines by hindering the NF-κB/MAPK signaling pathway in both LPS-treated RAW 264.7 cells and mice.Fórmula:C36H40N4O9Cor e Forma:SolidPeso molecular:672.72NBD peptide
CAS:NBD peptide inhibits the NF-κB signaling pathway by preventing the binding of the NEMO-IKK complex. It exhibits anti-inflammatory activity by blocking the production of pro-inflammatory cytokines. Additionally, NBD peptide demonstrates immunosuppressive effects through the regulation of immune cells. It enhances transmembrane capacity by conjugating with the cell-penetrating peptide HIV-TAT.Fórmula:C62H88N14O20Cor e Forma:SolidPeso molecular:1349.44SjDX5-271
CAS:SjDX5-271 is a 3 kDa peptide that inhibits the TLR4/MyD88/NF-κB signaling pathway. It induces cell polarization, alleviates liver inflammation, and protects mice from liver ischemia-reperfusion injury.Fórmula:C137H215N47O49SCor e Forma:SolidPeso molecular:3336.52N-Acetyldopamine dimer-2
CAS:Compound 2, an N-acetyldopamine dimer from Periostracum Cicadae, exhibits antioxidant and anti-inflammatory properties.Fórmula:C20H20N2O6Cor e Forma:SolidPeso molecular:384.38Diprovocim-1
CAS:Diprovocim-1: TLR1/2 agonist; triggers TNF-α in THP-1 cells; boosts ovalbumin IgG1 & CTLs against tumors with anti-PD-L1 in mice.Fórmula:C56H56N6O6Cor e Forma:SolidPeso molecular:909.1NLRP3-IN-51
NLRP3-IN-51 (Compound 3q) is an effective activator of the cholinergic anti-inflammatory pathway (CAP). This compound demonstrates potential for treating gouty arthritis as it inhibits the production of IL-1β in THP-1 cells induced by monosodium urate (MSU). Furthermore, NLRP3-IN-51 suppresses the phosphorylation of NF-κBp65 triggered by MSU without impacting the self-cleavage and activation of NLRP3, pro-caspase 1, or the second messenger caspase-1. Therefore, the initial stage of NLRP3 inhibition by NLRP3-IN-51 occurs through the activation of CAP.Cor e Forma:Odour SolidMesalamine impurity P
CAS:Mesalamine impurity P, a 5-Aminosalicylic acid derivative, is a PPARγ agonist, inhibiting PAK1 and NF-κB.Fórmula:C13H11NO6SCor e Forma:SolidPeso molecular:309.30Licoagrochalcone C
CAS:Licoagrochalcone C, a flavonoid, inhibits NF-κB and NO production effectively.Fórmula:C21H22O5Cor e Forma:SolidPeso molecular:354.4PS 1145 dihydrochloride
CAS:IκB kinase (IKK) inhibitorFórmula:C17H13Cl3N4OPureza:98%Cor e Forma:SolidPeso molecular:395.677-O-Methylaloeasinol
CAS:7-O-Methylaloeasinol is a useful organic compound for research related to life sciences. The catalog number is T126468 and the CAS number is 105317-69-9.Fórmula:C20H26O9Cor e Forma:SolidPeso molecular:410.419Nasunin
CAS:Delphanin, also known as Nasunin, is an anthocyanin isolated as purple colored crystals from eggplant peels.Fórmula:C42H47ClO23Cor e Forma:SolidPeso molecular:955.26Pratensein
CAS:Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells.Fórmula:C16H12O6Pureza:99.90%Cor e Forma:SolidPeso molecular:300.26IKK-IN-3
CAS:IKK-IN-3: potent IKK2 inhibitor (IC50=19nM), affects IKK1(IC50=400nM).Fórmula:C17H17N5SCor e Forma:SolidPeso molecular:323.42NF-κB-IN-9
NF-κB-IN-9, a nuclear factor kappa B (NF-κB) targeting sonosensitizer with excitation and emission wavelengths (λex/λem) of 489/628 nm, features dualFórmula:C62H50N4O4SCor e Forma:SolidPeso molecular:947.15CAY10657
CAS:CAY10657 has a wide range of applications in life science related research.
Fórmula:C17H20N4O3SCor e Forma:SolidPeso molecular:360.43PROTAC STING degrader-3
PROTACSTING degrader-3 (Compound ST9) is a STINGPROTAC-type degrader with a DC50 of 0.62 μM. It induces STING degradation via the ubiquitin-proteasome pathway. This compound exerts anti-inflammatory effects by inhibiting the STING/TBK1/NF-κB signaling. Additionally, it offers renal protection and can be used in research on acute kidney injury.Cor e Forma:Odour SolidLemnalol
CAS:Lemnalol, from Lemnalia cervicorni, has anti-inflammatory and analgesic properties.Fórmula:C15H24OPureza:98%Cor e Forma:SolidPeso molecular:220.35Ginger extract
CAS:Ginger extract demonstrates (exhibits) anti-cancer, anti-inflammatory, and chemotherapeutic properties in living organisms (in vivo).
Cor e Forma:SolidCyclo(L-Pro-L-Val)
CAS:Cyclo(L-Pro-L-Val), from Mycobacterium spp., has anti-inflammatory effects, hinders phytopathogens, and suppresses IKKα, NF-κB, iNOS, and COX-2 activation.
Fórmula:C10H16N2O2Pureza:98.18%Cor e Forma:SolidPeso molecular:196.25Murrayafoline A
CAS:Murrayafoline A is a useful organic compound for research related to life sciences. The catalog number is T124835 and the CAS number is 4532-33-6.Fórmula:C14H13NOCor e Forma:SolidPeso molecular:211.2643-(2-Hydroxyethyl) thio withaferin A
3-(2-Hydroxyethyl) thio withaferin A, a steroidal lactone, blocks NF-kB, targets vimentin, and inhibits EPCR shedding.Fórmula:C30H44O7SCor e Forma:SolidPeso molecular:548.73Anti-osteoporosis agent-8
Anti-osteoporosis agent-8 (Compound 4aa) is a RANKL inhibitor, capable of preventing RANKL-induced osteoclastogenesis and osteoclast differentiation, with an IC50 of 2.41 μM. Furthermore, Anti-osteoporosis agent-8 has been shown to mitigate bone loss in an ovariectomized (OVX) mouse model.Fórmula:C18H19F3N2O2SePeso molecular:432.05638SN50M
CAS:SN50M (NF-κB Control) is a synthetic peptide containing a hydrophobic region and mutant nuclear localization sequences that can enter cells.Fórmula:C123H215N33O30SCor e Forma:SolidPeso molecular:2668.29IVMT-Rx-3
IVMT-Rx-3 is a chemical compound that serves as an inhibitor of SDCBP's targeting of the PDZ1 and PDZ2 domains of MDA-9/Syntenin.Fórmula:C69H90F3N13O24Pureza:98%Cor e Forma:SoildPeso molecular:1542.54Sanggenon A
CAS:Sanggenon A (Sanggenone A) exhibits anti-inflammatory properties by modulating the NF-κB and HO-1/Nrf2 signaling pathways in BV2 and RAW264.7 cells, and itFórmula:C25H24O7Pureza:98%Cor e Forma:SolidPeso molecular:436.45
