IκB/IKK
O complexo IκB/IKK é um regulador chave da via de sinalização NF-κB, que controla a expressão de genes envolvidos em respostas imunes, inflamação e sobrevivência celular. As proteínas IκB inibem a atividade do NF-κB sequestrando-o no citoplasma, enquanto as IKKs fosforilam a IκB, levando à sua degradação e à ativação do NF-κB. A desregulação da via IκB/IKK está associada à inflamação crônica, câncer e doenças autoimunes. Na CymitQuimica, oferecemos uma seleção de moduladores IκB/IKK de alta qualidade para apoiar sua pesquisa em transdução de sinal, inflamação e desenvolvimento terapêutico.
Foram encontrados 61 produtos de "IκB/IKK"
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Ac2-26 ammonium
<p>Ac2-26 ammonium is an N-terminal derivative peptide of Annexin-A1 (AnxA1) with anti-inflammatory activity.</p>Fórmula:C141H210N32O44S·xNH3Pureza:95.58%Cor e Forma:SolidPeso molecular:3089.43 (free base)IMD-0560
CAS:<p>IMD-0560 is a novel inhibitor of IκB kinase β.</p>Fórmula:C15H8BrF6NO2Pureza:99.51%Cor e Forma:SolidPeso molecular:428.12Vinpocetine
CAS:<p>Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).</p>Fórmula:C22H26N2O2Pureza:99.85% - 99.98%Cor e Forma:White Crystalline SolidPeso molecular:350.45BAY-985
CAS:<p>BAY-985: potent oral TBK1/IKKε inhibitor; IC50s: TBK1 (2/30 nM), IKKε (2 nM); has antitumor properties.</p>Fórmula:C27H30F3N9OPureza:99.62%Cor e Forma:SolidPeso molecular:553.58TBK1/IKKε-IN-2
CAS:<p>TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.</p>Fórmula:C26H27N5O3Pureza:98.89%Cor e Forma:SolidPeso molecular:457.52Siegesbeckialide I
<p>Siegesbeckialide I effectively suppresses LPS-induced NO production in RAW264.7 murine macrophages by directly interacting with IKKα/β.</p>Fórmula:C20H28O6Cor e Forma:SolidPeso molecular:364.43HOIPIN-1
CAS:<p>HOIPIN-1 (JTP0819958) is a selective and potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) (IC50 >2.8 μM).HOIPIN-1 inhibits LUBAC-mediated NF-</p>Fórmula:C17H13NaO4Pureza:98.83%Cor e Forma:SoildPeso molecular:304.27TBK1/IKKε-IN-6
CAS:<p>TBK1/IKKε-IN-6 (example 110) is a potent inhibitor of TBK1 and IKKε, with IC50 values of less than 100 nM for both enzymes.</p>Fórmula:C31H36F2N8O4Cor e Forma:SolidPeso molecular:622.678PROTAC STING degrader-4
<p>PROTACSTING degrader-4 is a covalent STINGPROTAC degrader free of nitro groups, exhibiting a DC50 of 3.23 μM. It effectively inhibits STING and its downstream signaling pathways, including p-TBK1 and p-NF-κB (p-P65), as well as immune-inflammatory cytokines. Additionally, PROTACSTING degrader-4 mitigates renal and blood inflammation in mouse models of Cisplatin-induced acute kidney injury (AKI).</p>Fórmula:C39H42Cl2N8O9Cor e Forma:SolidPeso molecular:836.24518IKK-IN-3
CAS:<p>IKK-IN-3: potent IKK2 inhibitor (IC50=19nM), affects IKK1(IC50=400nM).</p>Fórmula:C17H17N5SCor e Forma:SolidPeso molecular:323.42PS 1145 dihydrochloride
CAS:<p>IκB kinase (IKK) inhibitor</p>Fórmula:C17H13Cl3N4OPureza:98%Cor e Forma:SolidPeso molecular:395.67MRT67307
CAS:<p>Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy.</p>Fórmula:C26H36N6O2Pureza:99.25% - 99.84%Cor e Forma:SolidPeso molecular:464.6Verproside
CAS:<p>Verproside is a useful organic compound for research related to life sciences. The catalog number is T124745 and the CAS number is 50932-20-2.</p>Fórmula:C22H26O13Cor e Forma:SolidPeso molecular:498.437LY2409881
CAS:<p>LY2409881 is a selective IκB kinase β ( IKK2 ) inhibitor with an IC 50 of 30 nM.</p>Fórmula:C24H29ClN6OSCor e Forma:SolidPeso molecular:485.05SU1261
<p>SU1261, an IKK inhibitor, exhibits Ki values of 10 nM for IKKα and 680 nM for IKKβ. It effectively inhibits non-canonical NF-κB signaling in U2OS osteosarcoma cells.</p>Cor e Forma:Odour SolidIKK 16 hydrochloride
CAS:<p>IKK 16 hydrochloride, a potent IKK1/2 and LRRK2 inhibitor, IC50s: 40-200 nM and 50 nM respectively.</p>Fórmula:C28H30ClN5OSCor e Forma:SolidPeso molecular:520.09ML 120B dihydrochloride
CAS:<p>MLN120B dihydrochloride: oral IKKβ inhibitor with 60 nM IC50, suppresses myeloma growth, used in arthritis research.</p>Fórmula:C19H17Cl3N4O2Cor e Forma:SolidPeso molecular:439.72BMS-345541 hydrochloride
CAS:<p>BMS-345541 hydrochloride is a selective IKK inhibitor (IKK2 and IKK1 with IC50 of 0.3 μM and 4 μM,respectively).</p>Fórmula:C14H18ClN5Pureza:99.13%Cor e Forma:SolidPeso molecular:291.78GSK8612
CAS:<p>GSK8612 is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1, pIC50: 6.8) .</p>Fórmula:C17H17BrF3N7O2SPureza:99.46% - 99.8%Cor e Forma:SolidPeso molecular:520.33SC-514
CAS:<p>SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.</p>Fórmula:C9H8N2OS2Pureza:99.88% - >99.99%Cor e Forma:SolidPeso molecular:224.3MLN120B
CAS:<p>MLN120B is a selective and ATP competitive IKKβ inhibitor (IC50: 60 nM).</p>Fórmula:C19H15ClN4O2Pureza:98.92%Cor e Forma:SolidPeso molecular:366.8AZD3264
CAS:<p>AZD3264 is a new type IKK2 inhibitor.</p>Fórmula:C21H23N5O4SPureza:98.98% - 99.17%Cor e Forma:SolidPeso molecular:441.5IKK 16
CAS:<p>IKK 16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.</p>Fórmula:C28H29N5OSPureza:98.76% - 99.61%Cor e Forma:SolidPeso molecular:483.63MRT67307 HCl (1190378-57-4(free base))
<p>MRT67307 is a kinase inhibitor of TBK1, MARK1-4, IKKε, and NUAK1 (IC50: 19, 27-52, 160, and 230 nM, respectively).</p>Fórmula:C26H37ClN6O2Pureza:98.19%Cor e Forma:SolidPeso molecular:501.07NF-κB-IN-1
CAS:<p>NF-κB-IN-1 (1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-) is a potent NF-κB signaling pathway</p>Fórmula:C31H30O8Pureza:99.03%Cor e Forma:SolidPeso molecular:530.572-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC
CAS:<p>2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC is Inhibitior of IKKβ.</p>Fórmula:C11H10N2OSPureza:99.48%Cor e Forma:SolidPeso molecular:218.27TBK1/IKKε-IN-5
CAS:<p>TBK1/IKKε-IN-5 is a dual TBK1 and IKKε inhibitor(IC50 of 1 nM and 5.6 nM, respectively).</p>Fórmula:C28H31N7O3Pureza:98.77%Cor e Forma:SolidPeso molecular:513.59BMS-345541
CAS:<p>BMS-345541 (IKK Inhibitor III) is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively.</p>Fórmula:C14H17N5Pureza:99.36% - 99.74%Cor e Forma:SolidPeso molecular:255.32JTP 0819958 - HOIPIN-1
<p>JTP-0819958: LUBAC inhibitor, IC50 2.8 μM; blocks NF-kB activation in vitro.</p>Fórmula:C17H13NaO4Pureza:99.95%Cor e Forma:SolidPeso molecular:304.27BOT-64
CAS:<p>BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathiole</p>Fórmula:C15H15NO2SPureza:99.73%Cor e Forma:SolidPeso molecular:273.35BX795
CAS:<p>BX795 selectively inhibits PDK1 (IC50: 6 nM), 140x over PKA, 1600x over PKC, 100x over GSK3β in cell-free assays.</p>Fórmula:C23H26IN7O2SPureza:98% - 99.57%Cor e Forma:SolidPeso molecular:591.47IMD-0354
CAS:<p>IMD-0354 (IKK2 Inhibitor V) is an IKKβ inhibitor and inhibits IκBα phosphorylation in NF-κB pathway.</p>Fórmula:C15H8ClF6NO2Pureza:99.65% - 99.98%Cor e Forma:SolidPeso molecular:383.67GS143
CAS:<p>GS143 inhibits IκBα ubiquitination (IC50=5.2μM), suppresses NF-κB, and has anti-asthma properties without hindering proteasomes.</p>Fórmula:C28H19FN2O4Pureza:97.67%Cor e Forma:SolidPeso molecular:466.46INH14
CAS:<p>INH14 is a novel inhibitor of the IKKα/β-dependent TLR inflammatory response (IC50s: 8.97/3.59 μM for IKKα/IKKβ).</p>Fórmula:C15H16N2OPureza:95.41%Cor e Forma:SolidPeso molecular:240.3Ertiprotafib
CAS:<p>Ertiprotafib (PTP 112), a PTP1B and IKK-β inhibitor, is a novel insulin sensitizer for the study of type 2 diabetes and breast cancer.</p>Fórmula:C31H27BrO3SPureza:98.70%Cor e Forma:SolidPeso molecular:559.51IKKβ-IN-1
CAS:<p>IKKβ-IN-1 is a potent, orally active inhibitor of IkappaB (IKK-β) (IC50: 0.20 μM).</p>Fórmula:C31H30N4O4SCor e Forma:SolidPeso molecular:554.66BAY32-5915
CAS:<p>BAY32-5915 is a selective inhibitor of IKKalpha.</p>Fórmula:C10H7NO3Pureza:96.48% - 97%Cor e Forma:Yellow Crystalline PowderPeso molecular:189.17Bay 65-1942 free base
CAS:<p>Bay 65-1942 free base is an inhibitor of ATP-competitive and selective IKKβ.</p>Fórmula:C22H25N3O4Pureza:98%Cor e Forma:SolidPeso molecular:395.45TBK1/IKKε-IN-4
CAS:<p>TBK1/IKKε-IN-4, a 6-aminopyrazolopyrimidine derivative, serves as a potent, selective inhibitor for TBK1 and IKKε, demonstrating IC50 values of 13 nM and 59 nM</p>Fórmula:C28H35N7O4Cor e Forma:SolidPeso molecular:533.62PHA-408
CAS:<p>PHA-408 is a novel potent, highly selective and ATP-competitive inhibitor of IKB kinase-2.</p>Fórmula:C29H27ClFN7O2Pureza:98%Cor e Forma:SolidPeso molecular:560.02DMX-129
CAS:<p>DMX-129 is a chemical compound acting as an inhibitor for both ΙΚΚε and TBK-1, demonstrating efficacy with IC50 values of below 30 nM for each [1].</p>Fórmula:C19H17FN8Cor e Forma:SolidPeso molecular:376.39IKK2-IN-4
CAS:<p>IKK2-IN-4(IKK2 Inhibitor VI) is a highly potent IKK-2 inhibitor with an IC50 value of 25 nM. IKK2-IN-4 inhibited the production of TNF-α in PBMC induced by LPS.</p>Fórmula:C12H11N3O2SPureza:>99.99%Cor e Forma:SolidPeso molecular:261.31-Dehydro-[10]-gingerdione
CAS:<p>1-Dehydro-[10]-gingerdione blocks IKKβ, curbs IκBα phosphorylation, halts NF-κB activity, and aids inflammation research.</p>Fórmula:C21H30O4Cor e Forma:SolidPeso molecular:346.46HPN-01
CAS:<p>HPN-01 (IKK inhibitor XII) is an IKK inhibitor that inhibits IKK-α and IKK-ε, prolongs the lifespan of mice, and can be used to study immune disorders.</p>Fórmula:C19H16ClN3O3SPureza:98.07% - 98.17%Cor e Forma:SolidPeso molecular:401.87CAY10575
CAS:<p>CAY10575 (IKK2-IN-3) is a potent IKK2 inhibitor with potential anti-inflammatory activity for the study of inflammatory and endocrine diseases.</p>Fórmula:C22H21N3O6S2Cor e Forma:SolidPeso molecular:487.55Bay 65-1942 hydrochloride
CAS:<p>Bay 65-1942 hydrochloride is an inhibitor of ATP-competitive and selective IKKβ.</p>Fórmula:C22H26ClN3O4Cor e Forma:SolidPeso molecular:431.91GSK319347A
CAS:<p>GSK319347A is a dual inhibitor of TBK1 and IKKε that inhibits IKK2 and can be used to study bladder and lung adenocarcinomas.</p>Fórmula:C22H19N3O5S2Pureza:98.42%Cor e Forma:SolidPeso molecular:469.53CGA-JK3
CAS:<p>CGA-JK3 is an IkappaB kinase inhibitor in innate immune process.</p>Fórmula:C15H19NO3Pureza:98%Cor e Forma:SolidPeso molecular:261.32IKK-IN-1
CAS:<p>IKK-IN-1 is an inhibitor of IKK.</p>Fórmula:C22H26ClN3O4Pureza:98%Cor e Forma:SolidPeso molecular:431.91PF 184
CAS:<p>IKKβ inhibitor</p>Fórmula:C32H32ClFN6O4Pureza:98%Cor e Forma:SolidPeso molecular:619.09(Rac)-BAY-985
CAS:<p>(Rac)-BAY-985 is a potent, ATP-competitive and selective inhibitor of TBK1(IC50 of 1.5 nM),with antitumor efficacy.</p>Fórmula:C27H30F3N9OPureza:98%Cor e Forma:SolidPeso molecular:553.58Bay 65-1942 (R form)
CAS:<p>Bay 65-1942 R form is the less active R-form of Bay 65-1942. Bay 65-1942 is a selective and ATP-competitive IKKβ inhibitor.</p>Fórmula:C22H25N3O4Pureza:98%Cor e Forma:SolidPeso molecular:395.45ACHP Hydrochloride
CAS:<p>ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective IKK-β inhibitor with an IC50 of 8.5 nM.</p>Fórmula:C21H25ClN4O2Pureza:99.83%Cor e Forma:SolidPeso molecular:400.9IKK-IN-4
CAS:<p>IKK-IN-4 is a potent and selective inhibitor of IkappaB kinase 2 with IC 50 values of 45 and 650 nM against IKKβ and IKKα, respectively [1].</p>Fórmula:C18H19N5SCor e Forma:SolidPeso molecular:337.44TBK1-IN-1
CAS:<p>TBK1-IN-1 is a TANK-binding kinase 1 inhibitor with anticancer activity.TBK1-IN-1 inhibits the expression of TBK1 downstream target genes, cxcl10 and ifnβ.</p>Fórmula:C27H37N7O2Pureza:>99.99%Cor e Forma:SolidPeso molecular:491.63PF-184
<p>PF-184: potent IKK-2 inhibitor, selective over 30+ kinases; useful for asthma & COPD research. IC50: 37 nM.</p>Fórmula:C32H32ClFN6O4Cor e Forma:SolidPeso molecular:619.09Glabrescone C
CAS:<p>Glabrescone C exhibits strong anti-inflammatory properties through direct binding to IKKα/β.</p>Fórmula:C19H22O7Cor e Forma:SolidPeso molecular:362.37Anti-inflammatory agent 6
<p>Anti-inflammatory agent 6 blocks IKKα/β, IκBα, and NF-κB p65 phosphorylation, key to controlling inflammation.</p>Fórmula:C22H20O12Cor e Forma:SolidPeso molecular:476.39TBK1/IKKε-IN-1
CAS:<p>TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of <100 nM).</p>Fórmula:C28H26N4O5Pureza:98%Cor e Forma:SolidPeso molecular:498.53GTCpFE
CAS:<p>GTCpFE, a compound synthesized from Dimethyl fumarate (DMF) and Aspirin (ASA), inhibits IKKα/β in the NF-κB pathway, exhibiting anti-inflammatory activity by preventing p65 from entering the nucleus. It selectively inhibits cancer stem cell (CSC) activity by reducing the growth of mammospheres and the expression of the CD44+CD24- immune phenotype. Furthermore, GTCpFE targets breast cancer stem cells, crucial in aggressive cancer phenotypes that depend on NFκB and PGE2.</p>Fórmula:C22H20O8Cor e Forma:SolidPeso molecular:412.39BMS-066
CAS:<p>BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor. With IC50s of 9 nM and 72 nM, respectively.</p>Fórmula:C19H21N7O2Pureza:98%Cor e Forma:SolidPeso molecular:379.42
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