IκB/IKK
O complexo IκB/IKK é um regulador chave da via de sinalização NF-κB, que controla a expressão de genes envolvidos em respostas imunes, inflamação e sobrevivência celular. As proteínas IκB inibem a atividade do NF-κB sequestrando-o no citoplasma, enquanto as IKKs fosforilam a IκB, levando à sua degradação e à ativação do NF-κB. A desregulação da via IκB/IKK está associada à inflamação crônica, câncer e doenças autoimunes. Na CymitQuimica, oferecemos uma seleção de moduladores IκB/IKK de alta qualidade para apoiar sua pesquisa em transdução de sinal, inflamação e desenvolvimento terapêutico.
Foram encontrados 58 produtos de "IκB/IKK"
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Ac2-26 ammonium
Ac2-26 ammonium is an N-terminal derivative peptide of Annexin-A1 (AnxA1) with anti-inflammatory activity.Fórmula:C141H210N32O44S·xNH3Pureza:95.58%Cor e Forma:SolidPeso molecular:3089.43 (free base)BAY-985
CAS:BAY-985: potent oral TBK1/IKKε inhibitor; IC50s: TBK1 (2/30 nM), IKKε (2 nM); has antitumor properties.Fórmula:C27H30F3N9OPureza:99.62%Cor e Forma:SolidPeso molecular:553.58Ref: TM-T10477
1mg163,00€5mg334,00€1mL*10mM (DMSO)408,00€10mg502,00€25mg853,00€50mg1.161,00€100mg1.558,00€TBK1/IKKε-IN-2
CAS:TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.Fórmula:C26H27N5O3Pureza:98.89%Cor e Forma:SolidPeso molecular:457.52Ref: TM-T15559
1mg52,00€5mg111,00€1mL*10mM (DMSO)111,00€10mg173,00€25mg278,00€50mg375,00€100mg482,00€IMD-0560
CAS:IMD-0560 is a novel inhibitor of IκB kinase β.Fórmula:C15H8BrF6NO2Pureza:99.51%Cor e Forma:SolidPeso molecular:428.12Vinpocetine
CAS:Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).Fórmula:C22H26N2O2Pureza:99.85% - 99.98%Cor e Forma:White Crystalline SolidPeso molecular:350.45LY2409881
CAS:LY2409881 is a selective IκB kinase β ( IKK2 ) inhibitor with an IC 50 of 30 nM.Fórmula:C24H29ClN6OSCor e Forma:SolidPeso molecular:485.05PS 1145 dihydrochloride
CAS:IκB kinase (IKK) inhibitorFórmula:C17H13Cl3N4OPureza:98%Cor e Forma:SolidPeso molecular:395.67Siegesbeckialide I
Siegesbeckialide I effectively suppresses LPS-induced NO production in RAW264.7 murine macrophages by directly interacting with IKKα/β.Fórmula:C20H28O6Cor e Forma:SolidPeso molecular:364.43SU1261
SU1261, an IKK inhibitor, exhibits Ki values of 10 nM for IKKα and 680 nM for IKKβ. It effectively inhibits non-canonical NF-κB signaling in U2OS osteosarcoma cells.Cor e Forma:Odour SolidIKK-IN-3
CAS:IKK-IN-3: potent IKK2 inhibitor (IC50=19nM), affects IKK1(IC50=400nM).Fórmula:C17H17N5SCor e Forma:SolidPeso molecular:323.42TBK1/IKKε-IN-6
CAS:TBK1/IKKε-IN-6 (example 110) is a potent inhibitor of TBK1 and IKKε, with IC50 values of less than 100 nM for both enzymes.Fórmula:C31H36F2N8O4Cor e Forma:SolidPeso molecular:622.678PROTAC STING degrader-4
PROTACSTING degrader-4 is a covalent STINGPROTAC degrader free of nitro groups, exhibiting a DC50 of 3.23 μM. It effectively inhibits STING and its downstream signaling pathways, including p-TBK1 and p-NF-κB (p-P65), as well as immune-inflammatory cytokines. Additionally, PROTACSTING degrader-4 mitigates renal and blood inflammation in mouse models of Cisplatin-induced acute kidney injury (AKI).Fórmula:C39H42Cl2N8O9Cor e Forma:SolidPeso molecular:836.24518Verproside
CAS:Verproside is a useful organic compound for research related to life sciences. The catalog number is T124745 and the CAS number is 50932-20-2.Fórmula:C22H26O13Cor e Forma:SolidPeso molecular:498.437MRT67307
CAS:Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy.Fórmula:C26H36N6O2Pureza:99.25% - 99.84%Cor e Forma:SolidPeso molecular:464.6HOIPIN-1
CAS:HOIPIN-1 (JTP0819958) is a selective and potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) (IC50 >2.8 μM).HOIPIN-1 inhibits LUBAC-mediated NF-Fórmula:C17H13NaO4Pureza:98.65%Cor e Forma:SoildPeso molecular:304.27IKK 16 hydrochloride
CAS:IKK 16 hydrochloride, a potent IKK1/2 and LRRK2 inhibitor, IC50s: 40-200 nM and 50 nM respectively.Fórmula:C28H30ClN5OSCor e Forma:SolidPeso molecular:520.09ML 120B dihydrochloride
CAS:MLN120B dihydrochloride: oral IKKβ inhibitor with 60 nM IC50, suppresses myeloma growth, used in arthritis research.Fórmula:C19H17Cl3N4O2Cor e Forma:SolidPeso molecular:439.72MLN120B
CAS:MLN120B is a selective and ATP competitive IKKβ inhibitor (IC50: 60 nM).Fórmula:C19H15ClN4O2Pureza:98.92%Cor e Forma:SolidPeso molecular:366.8Ref: TM-TQ0306
1mg50,00€2mg66,00€5mg90,00€1mL*10mM (DMSO)110,00€10mg152,00€25mg313,00€50mg537,00€100mg735,00€AZD3264
CAS:AZD3264 is a new type IKK2 inhibitor.Fórmula:C21H23N5O4SPureza:98.98% - 99.17%Cor e Forma:SolidPeso molecular:441.5Ref: TM-T6771
1mg52,00€2mg70,00€5mg103,00€1mL*10mM (DMSO)114,00€10mg160,00€25mg311,00€50mg502,00€100mg805,00€500mg1.605,00€GSK8612
CAS:GSK8612 is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1, pIC50: 6.8) .Fórmula:C17H17BrF3N7O2SPureza:99.68% - 99.99%Cor e Forma:SolidPeso molecular:520.33SC-514
CAS:SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.
Fórmula:C9H8N2OS2Pureza:99.88% - >99.99%Cor e Forma:SolidPeso molecular:224.3BMS-345541
CAS:BMS-345541 (IKK Inhibitor III) is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively.Fórmula:C14H17N5Pureza:99.36% - 99.74%Cor e Forma:SolidPeso molecular:255.32TBK1/IKKε-IN-5
CAS:TBK1/IKKε-IN-5 is a dual TBK1 and IKKε inhibitor(IC50 of 1 nM and 5.6 nM, respectively).Fórmula:C28H31N7O3Pureza:98.77%Cor e Forma:SolidPeso molecular:513.59Ref: TM-T7951
1mg88,00€5mg182,00€1mL*10mM (DMSO)224,00€10mg269,00€25mg429,00€50mg587,00€100mg837,00€200mg1.125,00€JTP 0819958 - HOIPIN-1
JTP-0819958: LUBAC inhibitor, IC50 2.8 μM; blocks NF-kB activation in vitro.Fórmula:C17H13NaO4Pureza:99.95%Cor e Forma:SolidPeso molecular:304.27Ref: TM-T8951
1mg37,00€2mg50,00€5mg65,00€1mL*10mM (DMSO)77,00€10mg95,00€25mg210,00€50mg339,00€100mg495,00€500mg1.099,00€2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC
CAS:2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC is Inhibitior of IKKβ.
Fórmula:C11H10N2OSPureza:99.48%Cor e Forma:SolidPeso molecular:218.27BMS-345541 hydrochloride
CAS:BMS-345541 hydrochloride is a selective IKK inhibitor (IKK2 and IKK1 with IC50 of 0.3 μM and 4 μM,respectively).Fórmula:C14H18ClN5Pureza:99.13%Cor e Forma:SolidPeso molecular:291.78Ref: TM-T8542
1mg38,00€2mg50,00€1mL*10mM (DMSO)52,00€5mg82,00€10mg119,00€25mg212,00€50mg356,00€100mg533,00€BOT-64
CAS:BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathioleFórmula:C15H15NO2SPureza:99.73%Cor e Forma:SolidPeso molecular:273.35Ref: TM-T8705
1mg50,00€1mL*10mM (DMSO)102,00€5mg110,00€10mg170,00€25mg323,00€50mg494,00€100mg665,00€200mg893,00€IMD-0354
CAS:IMD-0354 (IKK2 Inhibitor V) is an IKKβ inhibitor and inhibits IκBα phosphorylation in NF-κB pathway.Fórmula:C15H8ClF6NO2Pureza:99.65% - 99.98%Cor e Forma:SolidPeso molecular:383.67Ref: TM-T6141
2mg46,00€5mg63,00€1mL*10mM (DMSO)65,00€10mg87,00€25mg155,00€50mg210,00€100mg294,00€500mg713,00€NF-κB-IN-1
CAS:NF-κB-IN-1 (1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-) is a potent NF-κB signaling pathwayFórmula:C31H30O8Pureza:99.03%Cor e Forma:SolidPeso molecular:530.57Ref: TM-T9105
1mg166,00€5mg341,00€1mL*10mM (DMSO)398,00€10mg550,00€25mg898,00€50mg1.216,00€100mg1.644,00€INH14
CAS:INH14 is a novel inhibitor of the IKKα/β-dependent TLR inflammatory response (IC50s: 8.97/3.59 μM for IKKα/IKKβ).Fórmula:C15H16N2OPureza:95.41%Cor e Forma:SolidPeso molecular:240.3GSK319347A
CAS:GSK319347A is a dual inhibitor of TBK1 and IKKε that inhibits IKK2 and can be used to study bladder and lung adenocarcinomas.Fórmula:C22H19N3O5S2Pureza:98.42%Cor e Forma:SolidPeso molecular:469.53BAY32-5915
CAS:BAY32-5915 is a selective inhibitor of IKKalpha.Fórmula:C10H7NO3Pureza:96.48% - 97%Cor e Forma:Yellow Crystalline PowderPeso molecular:189.17Bay 65-1942 free base
CAS:Bay 65-1942 free base is an inhibitor of ATP-competitive and selective IKKβ.Fórmula:C22H25N3O4Pureza:98%Cor e Forma:SolidPeso molecular:395.45Ertiprotafib
CAS:Ertiprotafib (PTP 112), a PTP1B and IKK-β inhibitor, is a novel insulin sensitizer for the study of type 2 diabetes and breast cancer.Fórmula:C31H27BrO3SPureza:98.70%Cor e Forma:SolidPeso molecular:559.51TBK1/IKKε-IN-4
CAS:TBK1/IKKε-IN-4, a 6-aminopyrazolopyrimidine derivative, serves as a potent, selective inhibitor for TBK1 and IKKε, demonstrating IC50 values of 13 nM and 59 nMFórmula:C28H35N7O4Cor e Forma:SolidPeso molecular:533.62PHA-408
CAS:PHA-408 is a novel potent, highly selective and ATP-competitive inhibitor of IKB kinase-2.Fórmula:C29H27ClFN7O2Pureza:98%Cor e Forma:SolidPeso molecular:560.02DMX-129
CAS:DMX-129 is a chemical compound acting as an inhibitor for both ΙΚΚε and TBK-1, demonstrating efficacy with IC50 values of below 30 nM for each [1].Fórmula:C19H17FN8Cor e Forma:SolidPeso molecular:376.39IKK2-IN-4
CAS:IKK2-IN-4(IKK2 Inhibitor VI) is a highly potent IKK-2 inhibitor with an IC50 value of 25 nM. IKK2-IN-4 inhibited the production of TNF-α in PBMC induced by LPS.Fórmula:C12H11N3O2SPureza:99.83%Cor e Forma:SolidPeso molecular:261.3Ref: TM-T36524
500µg82,00€1mg108,00€5mg261,00€10mg401,00€25mg622,00€50mg837,00€100mg1.125,00€200mg1.504,00€1-Dehydro-[10]-gingerdione
CAS:1-Dehydro-[10]-gingerdione blocks IKKβ, curbs IκBα phosphorylation, halts NF-κB activity, and aids inflammation research.Fórmula:C21H30O4Cor e Forma:SolidPeso molecular:346.46CS12192
CAS:CS12192 enhances survival, boosts weight, and shows promise in GVHD research per patent CN112773802A.Fórmula:C25H23ClFN7O2Cor e Forma:SolidPeso molecular:507.95HPN-01
CAS:HPN-01 (IKK inhibitor XII) is an IKK inhibitor that inhibits IKK-α and IKK-ε, prolongs the lifespan of mice, and can be used to study immune disorders.Fórmula:C19H16ClN3O3SPureza:98.07% - 98.17%Cor e Forma:SolidPeso molecular:401.87Ref: TM-T11573
2mg137,00€5mg222,00€1mL*10mM (DMSO)245,00€10mg356,00€25mg708,00€50mg1.063,00€100mg1.603,00€200mg2.187,00€CAY10575
CAS:CAY10575 (IKK2-IN-3) is a potent IKK2 inhibitor with potential anti-inflammatory activity for the study of inflammatory and endocrine diseases.Fórmula:C22H21N3O6S2Cor e Forma:SolidPeso molecular:487.55Bay 65-1942 hydrochloride
CAS:Bay 65-1942 hydrochloride is an inhibitor of ATP-competitive and selective IKKβ.Fórmula:C22H26ClN3O4Cor e Forma:SolidPeso molecular:431.91IKKβ-IN-1
CAS:IKKβ-IN-1 is a potent, orally active inhibitor of IkappaB (IKK-β) (IC50: 0.20 μM).Fórmula:C31H30N4O4SCor e Forma:SolidPeso molecular:554.66CGA-JK3
CAS:CGA-JK3 is an IkappaB kinase inhibitor in innate immune process.Fórmula:C15H19NO3Pureza:98%Cor e Forma:SolidPeso molecular:261.32(Rac)-BAY-985
CAS:(Rac)-BAY-985 is a potent, ATP-competitive and selective inhibitor of TBK1(IC50 of 1.5 nM),with antitumor efficacy.Fórmula:C27H30F3N9OPureza:98%Cor e Forma:SolidPeso molecular:553.58Bay 65-1942 (R form)
CAS:Bay 65-1942 R form is the less active R-form of Bay 65-1942. Bay 65-1942 is a selective and ATP-competitive IKKβ inhibitor.Fórmula:C22H25N3O4Pureza:98%Cor e Forma:SolidPeso molecular:395.45IKK-IN-1
CAS:IKK-IN-1 is an inhibitor of IKK.Fórmula:C22H26ClN3O4Pureza:98%Cor e Forma:SolidPeso molecular:431.91ACHP Hydrochloride
CAS:ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective IKK-β inhibitor with an IC50 of 8.5 nM.Fórmula:C21H25ClN4O2Pureza:99.83%Cor e Forma:SolidPeso molecular:400.9Ref: TM-T10237
1mg66,00€5mg144,00€1mL*10mM (DMSO)159,00€10mg227,00€25mg375,00€50mg540,00€100mg777,00€500mg1.549,00€
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