CCR
Os receptores de quimiocinas C-C (CCRs) são um grupo de GPCRs que respondem às quimiocinas, moléculas de sinalização que orientam a migração de células imunológicas para locais de inflamação ou infecção. Os CCRs desempenham papéis cruciais nas respostas imunológicas, inflamação e no desenvolvimento de várias doenças, incluindo distúrbios autoimunes e câncer. A modulação da atividade dos CCRs está sendo explorada como uma estratégia terapêutica para condições como artrite reumatoide, esclerose múltipla e infecção pelo HIV. Na CymitQuimica, oferecemos uma gama de moduladores de CCR de alta qualidade para apoiar sua pesquisa em imunologia, inflamação e desenvolvimento terapêutico.
Foram encontrados 136 produtos de "CCR"
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IPG7236
CAS:<p>IPG7236, a selective CCR8 antagonist, demonstrates notable tumor suppression in a mouse xenograft model of human breast cancer and is applicable in cancer</p>Fórmula:C23H31N3O3SPureza:98%Cor e Forma:SolidPeso molecular:429.58(1S)-CCR2 antagonist 1
CAS:<p>(1S)-CCR2 antagonist 1, a left-handed chiral form of CCR2 antagonist 1, exhibits high affinity and a long residence time as a CCR2 antagonist, with an inhibition constant (K i) of 2.4 nM [1].</p>Fórmula:C28H32BrF3N2OCor e Forma:SolidPeso molecular:549.47MLN-3897
CAS:<p>MLN-3897 is an oral CCR1 antagonist, Ki 2.3 nM, blocks 125I-MIP-1α binding, and inhibits Akt signaling in MM cells.</p>Fórmula:C30H31ClN2O4Pureza:98.62%Cor e Forma:SolidPeso molecular:519.03AZD2423
CAS:<p>AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator and it has an IC50 of 1.2 nM for</p>Fórmula:C20H29ClFN5O2Pureza:98%Cor e Forma:SolidPeso molecular:425.93SB-649701
CAS:<p>SB-649701 is a potent antagonist of the human CCR8 receptor, exhibiting a pIC50 value of 7.7, and is utilized in asthma research [1].</p>Fórmula:C27H28N4O3Pureza:98%Cor e Forma:SolidPeso molecular:456.54cis-J-113863
CAS:<p>Cis-J-113863 is a competitive antagonist for the chemokine receptor 1 (CCR1), demonstrating inhibitory concentration 50 (IC50) values of 0.9 nM for human CCR1 receptors and 5.8 nM for mouse CCR1 receptors, respectively [1].</p>Fórmula:C30H37Cl2IN2O2Cor e Forma:SolidPeso molecular:655.44PF-04634817
CAS:<p>PF-0463481: safe, well-tolerated, dual CCR2/CCR5 antagonist for diabetic nephropathy; similar human/rodent CCR2 potency, less rodent CCR5 effect.</p>Fórmula:C25H36F3N5O3Pureza:98%Cor e Forma:SolidPeso molecular:511.58(Rac)-PF-4136309(1341224-83-6 Free base)
CAS:<p>PF-4136309 (INCB8761, PF-04136309) is a highly effective and selective oral CCR2 antagonist with good bioavailability, with an IC50 value of 5.2 nM for human</p>Fórmula:C29H31F3N6O3Cor e Forma:SolidPeso molecular:568.59CMPD167
CAS:<p>CMPD167 (MRK-1) is a potent, orally active inhibitor of CCR5 with significant in vitro antiviral efficacy [1].</p>Fórmula:C35H47FN4O2Pureza:98%Cor e Forma:SolidPeso molecular:574.77RP-23618
CAS:<p>RP-23618 is a non-peptidic antagonist of RANTES.</p>Fórmula:C30H35N5O3S2Pureza:98%Cor e Forma:SolidPeso molecular:577.76trans-J-113863
CAS:<p>Trans-J-113863 serves as a potent antagonist of chemokine receptors CCR1 and CCR3, effectively inhibiting MIP-1α-induced chemotaxis in CCR1 transfectants and eotaxin-induced chemotaxis in CCR3 transfectants, with respective half-maximal inhibitory concentrations (IC50) of 9.57 nM and 93.8 nM [1] [2].</p>Fórmula:C30H37Cl2IN2O2Cor e Forma:SolidPeso molecular:655.44BMS-639623
CAS:<p>BMS-639623 is a CCR3 antagonist with a picomolar inhibitory effect on eosinophilic chemotaxis and can be used in the treatment of asthma.</p>Fórmula:C25H32FN7O2Cor e Forma:SolidPeso molecular:481.57LMD-009
CAS:<p>LMD-009 is a non-peptide, selective CCR8 agonist that mediates chemotaxis, inositol phosphate accumulation, and calcium release, with an EC50 of 11–87 nM.</p>Fórmula:C29H33N3O3Pureza:98%Cor e Forma:SolidPeso molecular:471.59K777
CAS:<p>K777: Oral cysteine protease inhibitor, CYP3A4 blocker (IC50=60 nM), CCR4 antagonist, anti-Trypanosoma cruzi, antiviral, halts EBOV/SARS-CoV entry (IC50<1 nM).</p>Fórmula:C32H38N4O4SPureza:98.43% - 99.14%Cor e Forma:SolidPeso molecular:574.73CCR3 antagonist 1
CAS:<p>CCR3 antagonist 1 is a potent CCR3 antagonist, used for the research of inflammatory and immunologic diseases.</p>Fórmula:C19H21Cl2N3O4S2Pureza:98.28%Cor e Forma:SolidPeso molecular:490.42INCB3344
CAS:<p>INCB3344 is an effective, specific and orally bioavailable CCR2 antagonist with IC50 values of 9.5 nM (mCCR2) and 5.1 nM (hCCR2) in binding antagonism and 7.8</p>Fórmula:C29H34F3N3O6Pureza:98% - 98.2%Cor e Forma:SolidPeso molecular:577.59CP-865569
CAS:<p>CP-865569 is a CCR1 antagonist useful in the research of inflammatory and autoimmune diseases, including conditions such as rheumatoid arthritis and multiple sclerosis.</p>Fórmula:C22H26ClFN2O5SCor e Forma:SolidPeso molecular:484.969Aplaviroc
CAS:<p>Aplaviroc (AK 602), a SDP derivative, is a CCR5 antagonist. With IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.</p>Fórmula:C33H43N3O6Pureza:97.98% - 98.26%Cor e Forma:SolidPeso molecular:577.71CCR5 antagonist 1
CAS:<p>CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2. It can inhibit HIV replication.</p>Fórmula:C39H46ClF2N5O3SPureza:98%Cor e Forma:SolidPeso molecular:738.33CXCR2/CCR7 antagonist-1
CAS:<p>CXCR2/CCR7 antagonist-1 (compound 6) is a potent dual antagonist of CXCR2 and CCR7, with IC50 values of 0.0046 μM and 0.0014 μM, respectively. It is valuable for research in tumor metastasis and autoimmune diseases.</p>Fórmula:C23H27N3O5Cor e Forma:SolidPeso molecular:425.48
