CCR
Os receptores de quimiocinas C-C (CCRs) são um grupo de GPCRs que respondem às quimiocinas, moléculas de sinalização que orientam a migração de células imunológicas para locais de inflamação ou infecção. Os CCRs desempenham papéis cruciais nas respostas imunológicas, inflamação e no desenvolvimento de várias doenças, incluindo distúrbios autoimunes e câncer. A modulação da atividade dos CCRs está sendo explorada como uma estratégia terapêutica para condições como artrite reumatoide, esclerose múltipla e infecção pelo HIV. Na CymitQuimica, oferecemos uma gama de moduladores de CCR de alta qualidade para apoiar sua pesquisa em imunologia, inflamação e desenvolvimento terapêutico.
Foram encontrados 140 produtos de "CCR"
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cis-J-113863
CAS:Cis-J-113863 is a competitive antagonist for the chemokine receptor 1 (CCR1), demonstrating inhibitory concentration 50 (IC50) values of 0.9 nM for human CCR1 receptors and 5.8 nM for mouse CCR1 receptors, respectively [1].Fórmula:C30H37Cl2IN2O2Cor e Forma:SolidPeso molecular:655.44CCR2 antagonist 4
CAS:CCR2 antagonist 4 (Teijin compound 1) is a potent and specific antagonist of CCR2(IC50s of 180 nM), and potently inhibits MCP-1-induced chemotaxis(IC50 of 24 nMFórmula:C21H21ClF3N3O2Pureza:99.86%Cor e Forma:SolidPeso molecular:439.86Ref: TM-T13114
1mg52,00€5mg120,00€10mg188,00€25mg329,00€50mg490,00€100mg697,00€1mL*10mM (DMSO)133,00€PF-04634817
CAS:PF-0463481: safe, well-tolerated, dual CCR2/CCR5 antagonist for diabetic nephropathy; similar human/rodent CCR2 potency, less rodent CCR5 effect.Fórmula:C25H36F3N5O3Pureza:98%Cor e Forma:SolidPeso molecular:511.58AZD2423
CAS:AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator and it has an IC50 of 1.2 nM forFórmula:C20H29ClFN5O2Pureza:98%Cor e Forma:SolidPeso molecular:425.93trans-J-113863
CAS:Trans-J-113863 serves as a potent antagonist of chemokine receptors CCR1 and CCR3, effectively inhibiting MIP-1α-induced chemotaxis in CCR1 transfectants and eotaxin-induced chemotaxis in CCR3 transfectants, with respective half-maximal inhibitory concentrations (IC50) of 9.57 nM and 93.8 nM [1] [2].Fórmula:C30H37Cl2IN2O2Cor e Forma:SolidPeso molecular:655.44LMD-009
CAS:LMD-009 is a non-peptide, selective CCR8 agonist that mediates chemotaxis, inositol phosphate accumulation, and calcium release, with an EC50 of 11–87 nM.Fórmula:C29H33N3O3Pureza:98%Cor e Forma:SolidPeso molecular:471.59IPG7236
CAS:IPG7236, a selective CCR8 antagonist, demonstrates notable tumor suppression in a mouse xenograft model of human breast cancer and is applicable in cancerFórmula:C23H31N3O3SPureza:98%Cor e Forma:SolidPeso molecular:429.58SB-649701
CAS:SB-649701 is a potent antagonist of the human CCR8 receptor, exhibiting a pIC50 value of 7.7, and is utilized in asthma research [1].Fórmula:C27H28N4O3Pureza:98%Cor e Forma:SolidPeso molecular:456.54PF-04634817 succinate
CAS:PF-0463481 succinate is a potent and orally active dual antagonist of CCR2/CCR5 with comparable human and rodent CCR2 potency with IC50 of 20.8 nM.Fórmula:C29H42F3N5O7Pureza:98%Cor e Forma:SolidPeso molecular:629.67CMPD167
CAS:CMPD167 (MRK-1) is a potent, orally active inhibitor of CCR5 with significant in vitro antiviral efficacy [1].Fórmula:C35H47FN4O2Pureza:98%Cor e Forma:SolidPeso molecular:574.77BMS-639623
CAS:BMS-639623 is a CCR3 antagonist with a picomolar inhibitory effect on eosinophilic chemotaxis and can be used in the treatment of asthma.Fórmula:C25H32FN7O2Cor e Forma:SolidPeso molecular:481.57(Rac)-PF-4136309(1341224-83-6 Free base)
CAS:PF-4136309 (INCB8761, PF-04136309) is a highly effective and selective oral CCR2 antagonist with good bioavailability, with an IC50 value of 5.2 nM for humanFórmula:C29H31F3N6O3Cor e Forma:SolidPeso molecular:568.59(1S)-CCR2 antagonist 1
CAS:(1S)-CCR2 antagonist 1, a left-handed chiral form of CCR2 antagonist 1, exhibits high affinity and a long residence time as a CCR2 antagonist, with an inhibition constant (K i) of 2.4 nM [1].Fórmula:C28H32BrF3N2OCor e Forma:SolidPeso molecular:549.47VCH-286
CAS:VCH-286 is a C-C chemokine receptor type 5 (CCR5) receptor antagonist.Fórmula:C34H50F2N4O3Pureza:98%Cor e Forma:SolidPeso molecular:600.78RP-23618
CAS:RP-23618 is a non-peptidic antagonist of RANTES.Fórmula:C30H35N5O3S2Pureza:98%Cor e Forma:SolidPeso molecular:577.76CCR3 antagonist 1
CAS:CCR3 antagonist 1 is a potent CCR3 antagonist, used for the research of inflammatory and immunologic diseases.Fórmula:C19H21Cl2N3O4S2Pureza:98.28%Cor e Forma:SolidPeso molecular:490.42Ref: TM-T10156
1mg96,00€5mg178,00€10mg289,00€25mg462,00€50mg622,00€100mg837,00€1mL*10mM (DMSO)212,00€K777
CAS:K777: Oral cysteine protease inhibitor, CYP3A4 blocker (IC50=60 nM), CCR4 antagonist, anti-Trypanosoma cruzi, antiviral, halts EBOV/SARS-CoV entry (IC50<1 nM).Fórmula:C32H38N4O4SPureza:98.43% - 99.14%Cor e Forma:SolidPeso molecular:574.73INCB3344
CAS:INCB3344 is an effective, specific and orally bioavailable CCR2 antagonist with IC50 values of 9.5 nM (mCCR2) and 5.1 nM (hCCR2) in binding antagonism and 7.8Fórmula:C29H34F3N3O6Pureza:98% - 98.2%Cor e Forma:SolidPeso molecular:577.59Ref: TM-TQ0103
1mg66,00€5mg144,00€10mg230,00€25mg358,00€50mg512,00€100mg707,00€200mg973,00€1mL*10mM (DMSO)178,00€BAY-3153
CAS:BAY-3153 is a selective CCR1 ( C-C motif chemokine receptor 1 ) antagonist (human IC 50 =3 nM ; rat IC 50 =11 nM ; mice IC 50 =81 nM) .Fórmula:C25H29Cl2N3O4Pureza:98%Cor e Forma:SolidPeso molecular:506.42MK-0812
CAS:MK-0812 is a dual antagonist of the CCR2 and CCR5 receptors that can alleviate adipose inflammation in ob/ob mice.Fórmula:C24H34F3N3O3Pureza:98%Cor e Forma:SolidPeso molecular:469.54
