CCR
Os receptores de quimiocinas C-C (CCRs) são um grupo de GPCRs que respondem às quimiocinas, moléculas de sinalização que orientam a migração de células imunológicas para locais de inflamação ou infecção. Os CCRs desempenham papéis cruciais nas respostas imunológicas, inflamação e no desenvolvimento de várias doenças, incluindo distúrbios autoimunes e câncer. A modulação da atividade dos CCRs está sendo explorada como uma estratégia terapêutica para condições como artrite reumatoide, esclerose múltipla e infecção pelo HIV. Na CymitQuimica, oferecemos uma gama de moduladores de CCR de alta qualidade para apoiar sua pesquisa em imunologia, inflamação e desenvolvimento terapêutico.
Foram encontrados 147 produtos para "CCR".
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PNU-177864
CAS:PNU-177864 is a selective dopamine D3 receptor antagonist.Fórmula:C18H21F3N2O3SPureza:99.92%Cor e Forma:SolidPeso molecular:402.43TAK-220
CAS:TAK-220: Oral CCR5 antagonist. IC50: 3.5 nM (RANTES), 1.4 nM (MIP-1α).Fórmula:C31H41ClN4O3Pureza:98%Cor e Forma:SolidPeso molecular:553.14ALK4290
CAS:ALK4290 (AKST4290), a potent oral CCR3 inhibitor with a Ki of 3.2 nM, may treat macular degeneration and Parkinsonism.Fórmula:C27H34ClN5O3Cor e Forma:SolidPeso molecular:512.04YM022
CAS:YM022 is a highly effective and selective gastrin/cholecystokinin (CCK)-B receptor antagonist.Fórmula:C32H28N4O3Pureza:98%Cor e Forma:SolidPeso molecular:516.59AF-399/42018025
CAS:AF-399/42018025 is a small-molecule CCR4 antagonist applied to investigate chemokine-mediated immune cell trafficking and inflammatory disease mechanisms.Fórmula:C26H16ClN3O4S3Pureza:99.96%Cor e Forma:Yellow SolidPeso molecular:566.07AZD-1678
CAS:AZD-1678 is a potent CCR4 receptor antagonist.Fórmula:C11H8Cl2FN3O3SCor e Forma:SolidPeso molecular:352.17CCX354
CAS:CCX354 (CCR1 antagonist 1) is a potent small molecule CCR1 antagonist with anti-inflammatory activity for the treatment of rheumatoid arthritis.Fórmula:C22H22ClN7O2Pureza:99.43% - 99.44%Cor e Forma:SolidPeso molecular:451.91C-021 dihydrochloride
CAS:C-021 dihydrochloride is a potent CCR4 antagonist. It potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM.Fórmula:C27H43Cl2N5O2Pureza:98.67%Cor e Forma:White SolidPeso molecular:540.57MLN3126
CAS:MLN3126: Oral CCR9 blocker, hinders CCL25-triggered chemotaxis/thymocyte calcium influx, IC50 of 6.3 nM.Fórmula:C21H19ClN2O5SCor e Forma:SolidPeso molecular:446.9CCR4 antagonist 3-1
CAS:CCR4 antagonist 3-1 is a weak inhibitor of [125I]TARC binding and CEM cell migration, with IC50 values of 1.7 μM and 6.4 μM, respectively.Fórmula:C14H12N2SPureza:99.87%Cor e Forma:SolidPeso molecular:240.32RPT193
CAS:RPT193 is an oral CCR4 inhibitor reducing Th2 cell migration in atopic dermatitis, asthma, and allergies.Fórmula:C27H34Cl3N5O2Cor e Forma:SolidPeso molecular:566.95CCR2 antagonist 3
CAS:CCR2 antagonist 3 (AZD-2927) is an antagonist of CCR2.Fórmula:C17H25FN2O2Pureza:99.87%Cor e Forma:SolidPeso molecular:308.39Ref: TM-T10712
1mg66,00€5mg147,00€1mL*10mM (DMSO)161,00€10mg225,00€25mg398,00€50mg532,00€100mg745,00€200mg982,00€APC-3316 tosylate
CAS:APC-3316 tosylate is a vinyl sulfone cysteine protease inhibitor and selective CCR4 antagonist.Fórmula:C39H46N4O7S2Cor e Forma:SolidPeso molecular:746.94GW 766994
CAS:GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist. It has the potential for asthma and eosinophilic bronchitis treatment.Fórmula:C21H24Cl2N4O3Pureza:98.77%Cor e Forma:White SolidPeso molecular:451.35CCR1 antagonist 9
CAS:CCR1 antagonist 9 (compound 19e) is a selective CCR1 antagonist based on aziridine. CCR1 inhibition in calcium flux assays.Fórmula:C20H16FN5O3SPureza:99.13%Cor e Forma:SolidPeso molecular:425.44Ref: TM-T10710
1mg94,00€5mg222,00€1mL*10mM (DMSO)245,00€10mg371,00€25mg682,00€50mg982,00€100mg1.431,00€BI-6901
CAS:BI-6901 is a CCR10 antagonist. In a mouse model of DNFB exposure hypersensitivity, BI 6901 displays its anti-inflammatory response in a dose-dependent manner.Fórmula:C23H27N5O3SPureza:99.83% - 99.98%Cor e Forma:White SolidPeso molecular:453.56Ref: TM-T36478
1mg117,00€5mg281,00€1mL*10mM (DMSO)310,00€10mg447,00€25mg827,00€50mg1.108,00€100mg1.494,00€Cosalane
CAS:Cosalane (NSC 658586) is an HIV replication inhibitor and an inhibitor of chemokine receptor 7 (CCR7) signalling in humans and mice.Fórmula:C45H60Cl2O6Pureza:99.53% - 99.78%Cor e Forma:White SolidPeso molecular:767.86BMS CCR2 22
CAS:BMS CCR2 22 is a potent and selective antagonist of CCR2 with calcium flux IC50 of 18 nM, chemotaxis IC50 of 1 nM, and binding IC50 of 5.1 nM.Fórmula:C28H34F3N5O4SPureza:99.65%Cor e Forma:SolidPeso molecular:593.66Ref: TM-T14688
1mg55,00€5mg110,00€1mL*10mM (DMSO)147,00€10mg173,00€25mg349,00€50mg532,00€100mg718,00€200mg964,00€Ancriviroc
CAS:Ancriviroc (SCH-351125) is an orally bioavailable small molecule chemokine receptor CCR5 antagonist.Cost-effective and quality-assured.Fórmula:C28H37BrN4O3Pureza:99.76% - 99.82%Cor e Forma:SolidPeso molecular:557.533Tanimilast
CAS:Tanimilast (CHF-6001) is a potent PDE4 inhibitor with IC50 of 0.026 nM, used topically for obstructive lung disease.Fórmula:C30H30Cl2F2N2O8SPureza:99.18%Cor e Forma:SolidPeso molecular:687.54
