CCR
Os receptores de quimiocinas C-C (CCRs) são um grupo de GPCRs que respondem às quimiocinas, moléculas de sinalização que orientam a migração de células imunológicas para locais de inflamação ou infecção. Os CCRs desempenham papéis cruciais nas respostas imunológicas, inflamação e no desenvolvimento de várias doenças, incluindo distúrbios autoimunes e câncer. A modulação da atividade dos CCRs está sendo explorada como uma estratégia terapêutica para condições como artrite reumatoide, esclerose múltipla e infecção pelo HIV. Na CymitQuimica, oferecemos uma gama de moduladores de CCR de alta qualidade para apoiar sua pesquisa em imunologia, inflamação e desenvolvimento terapêutico.
Foram encontrados 140 produtos de "CCR"
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PNU-177864 hydrochloride
CAS:PNU-177864 hydrochloride is a potent, selective and orally active antagonist of dopamine D3 receptor.
Fórmula:C18H22ClF3N2O3SPureza:99.95%Cor e Forma:SolidPeso molecular:438.89PNU-177864
CAS:PNU-177864 is a selective dopamine D3 receptor antagonist.Fórmula:C18H21F3N2O3SPureza:99.92%Cor e Forma:SolidPeso molecular:402.43C-021 dihydrochloride
CAS:C-021 dihydrochloride is a potent CCR4 antagonist. It potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM.Fórmula:C27H43Cl2N5O2Pureza:98.67%Cor e Forma:SolidPeso molecular:540.57CCX354
CAS:CCX354 (CCR1 antagonist 1) is a potent small molecule CCR1 antagonist with anti-inflammatory activity for the treatment of rheumatoid arthritis.Fórmula:C22H22ClN7O2Pureza:99.43% - 99.44%Cor e Forma:SolidPeso molecular:451.91APC-3316 tosylate
CAS:APC-3316 tosylate is a vinyl sulfone cysteine protease inhibitor and selective CCR4 antagonist.Fórmula:C39H46N4O7S2Cor e Forma:SolidPeso molecular:746.94GW 766994
CAS:GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist. It has the potential for asthma and eosinophilic bronchitis treatment.Fórmula:C21H24Cl2N4O3Pureza:98.77%Cor e Forma:SolidPeso molecular:451.35AF-399/42018025
CAS:AF-399/42018025 is a small-molecule CCR4 antagonist applied to investigate chemokine-mediated immune cell trafficking and inflammatory disease mechanisms.Fórmula:C26H16ClN3O4S3Pureza:99.96%Cor e Forma:SolidPeso molecular:566.07BMS-457
CAS:BMS-457 is a potent, CCR1-selective antagonist.Fórmula:C24H35ClN2O4Pureza:98%Cor e Forma:SolidPeso molecular:451JNJ-27141491
CAS:JNJ-27141491 is a potent, noncompetitive antagonist of human CCR2.Fórmula:C17H15F2N3O3SPureza:98%Cor e Forma:SolidPeso molecular:379.38Cosalane
CAS:Cosalane (NSC 658586) is an HIV replication inhibitor and an inhibitor of chemokine receptor 7 (CCR7) signalling in humans and mice.Fórmula:C45H60Cl2O6Pureza:99.53% - 99.78%Cor e Forma:SolidPeso molecular:767.86Ancriviroc
CAS:Ancriviroc (SCH-351125) is an orally bioavailable small molecule chemokine receptor CCR5 antagonist.Cost-effective and quality-assured.Fórmula:C28H37BrN4O3Pureza:99.76% - 99.82%Cor e Forma:SolidPeso molecular:557.533CCR2 antagonist 5
CAS:JNJ-41443532: oral hCCR2 antagonist, IC50=37 nM, anti-chemotaxis, treats inflammation & diabetes.Fórmula:C22H25F3N4O3SPureza:99.98%Cor e Forma:SolidPeso molecular:482.52BMS-817399
CAS:BMS-817399: oral CCR1 antagonist with binding and chemotaxis inhibition IC50s, potential for rheumatoid arthritis research.Fórmula:C23H36ClN3O4Pureza:99.7%Cor e Forma:SolidPeso molecular:454Ref: TM-T26861
1mg152,00€5mg319,00€10mg485,00€25mg770,00€50mg1.035,00€100mg1.395,00€1mL*10mM (DMSO)356,00€SB 328437
CAS:SB 328437 ((S)-methyl 2-(1-naphthamido)-3-(4-nitrophenyl)propanoate) is an effective and selective antagonist of CCR3 (IC50 = 4.5 nM).Fórmula:C21H18N2O5Pureza:99.54%Cor e Forma:SolidPeso molecular:378.38Ref: TM-T23321
1mg39,00€5mg82,00€10mg123,00€25mg250,00€50mg394,00€100mg618,00€200mg874,00€1mL*10mM (DMSO)69,00€BMS CCR2 22
CAS:BMS CCR2 22 is a potent and selective antagonist of CCR2 with calcium flux IC50 of 18 nM, chemotaxis IC50 of 1 nM, and binding IC50 of 5.1 nM.Fórmula:C28H34F3N5O4SPureza:99.65%Cor e Forma:SolidPeso molecular:593.66Ref: TM-T14688
1mg55,00€5mg110,00€10mg173,00€25mg349,00€50mg532,00€100mg718,00€200mg964,00€1mL*10mM (DMSO)147,00€GSK2239633A
CAS:GSK2239633A is an allosteric antagonist of CC-chemokine receptor 4 (CCR4) with a pIC50 of 7.96 for the binding of [125I]-TARC to human CCR4.Fórmula:C24H25ClN4O5S2Pureza:99.82%Cor e Forma:SolidPeso molecular:549.06Ref: TM-T11481
1mg35,00€5mg79,00€10mg118,00€25mg245,00€50mg355,00€100mg515,00€500mgA consultar1mL*10mM (DMSO)87,00€CCR1 antagonist 6
CAS:CCR1 antagonist 6 is a CCR1 antagonist (IC50: 3 nM).
Fórmula:C21H23ClN4O3SPureza:99.02% - 99.15%Cor e Forma:SolidPeso molecular:446.95Tanimilast
CAS:Tanimilast (CHF-6001) is a potent PDE4 inhibitor with IC50 of 0.026 nM, used topically for obstructive lung disease.Fórmula:C30H30Cl2F2N2O8SPureza:99.18%Cor e Forma:SolidPeso molecular:687.54CCR4 antagonist 4
CAS:CCR4 Antagonist 4 (Compound 22) is a potent and selective antagonist of the CC chemokine receptor-4 (CCR4), displaying an IC50 value of 0.02 μM. It also inhibits MDC-mediated chemotaxis and Ca2+ mobilization, with IC50 values of 0.007 μM and 0.003 μM, respectively. This compound is utilized in research on allergic inflammation [1].Fórmula:C24H27Cl2N7OCor e Forma:SolidPeso molecular:500.42MLN-3897
CAS:MLN-3897 is an oral CCR1 antagonist, Ki 2.3 nM, blocks 125I-MIP-1α binding, and inhibits Akt signaling in MM cells.Fórmula:C30H31ClN2O4Pureza:98.62%Cor e Forma:SolidPeso molecular:519.03
