CCR
Os receptores de quimiocinas C-C (CCRs) são um grupo de GPCRs que respondem às quimiocinas, moléculas de sinalização que orientam a migração de células imunológicas para locais de inflamação ou infecção. Os CCRs desempenham papéis cruciais nas respostas imunológicas, inflamação e no desenvolvimento de várias doenças, incluindo distúrbios autoimunes e câncer. A modulação da atividade dos CCRs está sendo explorada como uma estratégia terapêutica para condições como artrite reumatoide, esclerose múltipla e infecção pelo HIV. Na CymitQuimica, oferecemos uma gama de moduladores de CCR de alta qualidade para apoiar sua pesquisa em imunologia, inflamação e desenvolvimento terapêutico.
Foram encontrados 166 produtos para "CCR".
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INCB3344
CAS:INCB3344 is an effective, specific and orally bioavailable CCR2 antagonist with IC50 values of 9.5 nM (mCCR2) and 5.1 nM (hCCR2) in binding antagonism and 7.8Fórmula:C29H34F3N3O6Pureza:98.19% - 99.61%Cor e Forma:SolidPeso molecular:577.592CB-0821
CAS:CB-0821 is a high-affinity CCR5 inhibitor with a Ki of 0.04 nM. It effectively binds to the hydrophobic pocket of the CCR5 protein, hindering the interaction between viral proteins and CCR5, thereby blocking virus entry. CB-0821 holds potential for anti-HIV research.Fórmula:C35H24N8Cor e Forma:SolidPeso molecular:556.62CCL17-IN-2
CAS:CCL17-IN-2 (Compound Ex.128) is a CCL17 secretion inhibitor with an EC50 of 0.3 nM. CCL17-IN-1 is applicable for research into autoimmune diseases, dermatological conditions, and respiratory disorders.Fórmula:C29H38N8O3Peso molecular:546.66CCR1 antagonist 11 hydrochloride
Oral CCR1 antagonist A1B1 targets h/m/rCCR1 (IC50: 0.03/0.58/0.32 μM), potential for treating inflammatory diseases.Cor e Forma:SolidPF-07054894
CAS:PF-07054894: potent CCR6 antagonist, targets GPCR, for inflammatory bowel disease research.Fórmula:C24H30N6O4Cor e Forma:SolidPeso molecular:466.53BMS-741672
CAS:BMS-741672 is a potent, selective CCR2 antagonist for the treatment of neuropathic pain.Fórmula:C25H33F3N6O2Cor e Forma:SolidPeso molecular:506.56Aplaviroc
CAS:Aplaviroc (AK 602), a SDP derivative, is a CCR5 antagonist. With IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.Fórmula:C33H43N3O6Pureza:98.26% - 99.47%Cor e Forma:SolidPeso molecular:577.71CCR5 antagonist 1
CAS:CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2. It can inhibit HIV replication.Fórmula:C39H46ClF2N5O3SPureza:98%Cor e Forma:SolidPeso molecular:738.33BAY-3153
CAS:BAY-3153 is a selective CCR1 ( C-C motif chemokine receptor 1 ) antagonist (human IC 50 =3 nM ; rat IC 50 =11 nM ; mice IC 50 =81 nM) .Fórmula:C25H29Cl2N3O4Pureza:98%Cor e Forma:White SolidPeso molecular:506.42INCB-9471 dihydrochloride
CAS:INCB-9471 HCl: a potent CCR5 antagonist, blocks monocyte migration & HIV-1.Fórmula:C30H42Cl2F3N5O2Pureza:98%Cor e Forma:SolidPeso molecular:632.59CCR7 Ligand 1
CAS:CCR7-Cmp2105 is a thiadiazole-dioxide allosteric antagonist for CCR7 with a Kd of 3 nM and IC50 of 7.3 μM against arrestin binding.Fórmula:C22H29N5O5SCor e Forma:SolidPeso molecular:475.561MK-0812
CAS:MK-0812 is a dual antagonist of the CCR2 and CCR5 receptors that can alleviate adipose inflammation in ob/ob mice.Fórmula:C24H34F3N3O3Pureza:98%Cor e Forma:SolidPeso molecular:469.5403CP-865569
CAS:CP-865569 is a CCR1 antagonist useful in the research of inflammatory and autoimmune diseases, including conditions such as rheumatoid arthritis and multiple sclerosis.Fórmula:C22H26ClFN2O5SCor e Forma:SolidPeso molecular:484.969CXCR2/CCR7 antagonist-1
CAS:CXCR2/CCR7 antagonist-1 (compound 6) is a potent dual antagonist of CXCR2 and CCR7, with IC50 values of 0.0046 μM and 0.0014 μM, respectively. It is valuable for research in tumor metastasis and autoimmune diseases.Fórmula:C23H27N3O5Cor e Forma:SolidPeso molecular:425.48BI 639667
CAS:BI 639667, an azaindazole-class compound, potently inhibits CCR1 (IC50=1.8 nM in calcium flux assays).Fórmula:C22H18FN5O3SPureza:99.86%Cor e Forma:SolidPeso molecular:451.473YM-344031
CAS:YM-344031 is an orally administered antagonist targeting CCR3. It effectively inhibits the binding of Eotaxin-1 and RANTES to CCR3, with IC50 values of 3.0 and 16.3 nM, respectively. YM-344031 also suppresses ligand-induced increases in intracellular Ca [2+] levels and chemotaxis, alters eosinophil morphology induced by eotaxin-1 in macaque blood, and prevents allergic skin reactions in a mouse allergy model.Fórmula:C29H31FN4O3Peso molecular:502.58Nifeviroc
CAS:Nifeviroc (TD-0232) is an orally active CCR5 antagonist, useful in HIV-1 infection research.Fórmula:C33H42N4O6Pureza:98.14%Cor e Forma:SolidPeso molecular:590.7098CCR2 antagonist 6
CAS:CCR2 antagonist6 (Example 98) is a CCR2 antagonist with a Kb value of 0.215 μM for CCR2 and 0.174 μM for hCCR2B. It is utilized in research pertaining to inflammation and autoimmune diseases.Fórmula:C33H36F3N3OPeso molecular:547.65CP-481715
CAS:CP 481715 is an effective selective CCR1 antagonist with potential therapeutic significance for inflammatory diseases.Fórmula:C26H31FN4O4Cor e Forma:SolidPeso molecular:482.55CH-0076989
CAS:CH-0076989 is a chemokine receptor CCR3 agonist.Fórmula:C24H22Br2N2O2Cor e Forma:SolidPeso molecular:530.25
