Nrf2
Nrf2 é um fator de transcrição que regula a expressão de proteínas antioxidantes e enzimas de desintoxicação, desempenhando um papel fundamental na defesa celular contra o estresse oxidativo e a inflamação. A ativação da sinalização Nrf2 oferece proteção contra várias doenças, incluindo câncer, neurodegeneração e distúrbios cardiovasculares. Os moduladores de Nrf2 estão sendo explorados por suas potenciais aplicações terapêuticas na redução de danos oxidativos e inflamação. Na CymitQuimica, oferecemos uma gama de moduladores da via Nrf2 de alta qualidade para apoiar sua pesquisa em estresse oxidativo, inflamação e prevenção de doenças.
Foram encontrados 80 produtos para "Nrf2".
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AT 14 acetate
TAT 14 acetate, a 14-mer peptide, activates Nrf2, has anti-inflammatory effects, and targets Keap1 without altering Nrf2 mRNA.Fórmula:C139H234N48O41Pureza:96.9%Cor e Forma:SolidPeso molecular:3233.64Kinsenoside
CAS:Kinsenoside ((+)-Kinsenoside) shows significant antihepatotoxic, and anti-inflammatory activities.Fórmula:C10H16O8Pureza:99.2% - 99.92%Cor e Forma:SolidPeso molecular:264.23AEM1
CAS:AEM1 is an inhibitor of deregulated NRF2 transcriptional activity in cancer.Fórmula:C20H14FN3O2SPureza:98.37% - 99.88%Cor e Forma:SolidPeso molecular:379.41Artemisitene
CAS:Artemisitene, an oxidized antimalarial derivative of Artemisinin, stems from precursors like Artemisinin B and Artemisinic acid.Fórmula:C15H20O5Pureza:99.58%Cor e Forma:SolidPeso molecular:280.32Ref: TM-T21065
1mg89,00€5mg177,00€1mL*10mM (DMSO)266,00€10mg313,00€25mg530,00€50mg757,00€100mg1.044,00€Brusatol
CAS:Brusatol (NSC-172924) is a natural product isolated from the Brucea javanica plant. It inhibits Nrf2.Fórmula:C26H32O11Pureza:99.35% - 99.95%Cor e Forma:SolidPeso molecular:520.53Ref: TM-TQ0211
1mg37,00€5mg88,00€1mL*10mM (DMSO)102,00€10mg152,00€25mg295,00€50mg477,00€100mg677,00€200mg888,00€Trilobatin
CAS:Trilobatin (P-Phlorizin) has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentiallyFórmula:C21H24O10Pureza:97.16%Cor e Forma:SolidPeso molecular:436.41Ref: TM-T2S0731
1mg50,00€5mg99,00€1mL*10mM (DMSO)109,00€10mg141,00€25mg260,00€50mg385,00€100mg557,00€200mg790,00€Diroximel fumarate
CAS:Diroximel fumarate (Diroximel Fumarete), a prodrug of monomethyl fumarate in a controlled-release formulation, rapidly and potently converts to MMF in the body.Fórmula:C11H13NO6Pureza:99.8% - 99.88%Cor e Forma:SolidPeso molecular:255.22Ref: TM-T4271
2mg35,00€5mg55,00€1mL*10mM (DMSO)55,00€10mg80,00€25mg126,00€50mg187,00€100mg301,00€200mg425,00€CBR-470-1
CAS:CBR-470-1 is a glycolytic phosphoglycerate kinase 1 inhibitor and Nrf2 activator that exhibits neuroprotective activity by activating the Keap1-Nrf2 cascade.Fórmula:C14H20ClNO4S2Pureza:98.87%Cor e Forma:SolidPeso molecular:365.9Nrf2-Activator-12G
CAS:Nrf2-Activator-12G is a potent Nrf-2 activator.Fórmula:C15H13ClO3SPureza:99.92%Cor e Forma:White SolidPeso molecular:308.78AI-3
CAS:Nrf2/Keap1 and Keap1/Cul3 interaction inhibitorFórmula:C11H13ClO3S2Pureza:98%Cor e Forma:SolidPeso molecular:292.8Keap1-Nrf2-IN-14
CAS:Keap1-Nrf2-IN-14, a KEAP1-NRF2 inhibitor (IC50: 75 nM, Kd: 24 nM), boosts NRF2 gene expression, antioxidative and anti-inflammatory response.Fórmula:C30H29NO8SCor e Forma:SolidPeso molecular:563.62Keap1-Nrf2-IN-13
CAS:Keap1-Nrf2-IN-13 is a PPI inhibitor (IC50: 0.15 μM) that binds Keap1 strongly, useful for oxidative stress and inflammation research.Fórmula:C28H32N2O10S2Cor e Forma:SolidPeso molecular:620.69Keap1-Nrf2-IN-12
CAS:eap1-Nrf2-IN-12 is a potent inhibitor of Keap1-Nrf2 (IC50: 2.30 μM). eap1-Nrf2-IN-12 is metabolically stable in human liver microsomes.Fórmula:C26H28N2O10S2Cor e Forma:SolidPeso molecular:592.64NXPZ-2
CAS:NXPZ-2, an oral Keap1-Nrf2 PPI inhibitor (Ki: 95 nM, EC50: 120-170 nM), may improve cognition and neuron health in AD.Fórmula:C27H27N5O7S2Cor e Forma:SolidPeso molecular:597.66MIND4-17
CAS:MIND4-17 activates NRF2 by binding Keap1 C151, blocking Keap1-Nrf2, stabilizes Nrf2, and promotes its nuclear entry, with strong antioxidant effects.Fórmula:C20H15N5O3SCor e Forma:SolidPeso molecular:405.43SPC-180002
CAS:SPC-180002, a dual SIRT1/3 inhibitor, exhibits IC50 values of 1.13 and 5.41 μM for SIRT1 and SIRT3, respectively.Fórmula:C18H23NO4Pureza:98%Cor e Forma:SolidPeso molecular:317.38K67
CAS:K67 competitively inhibits the interaction between Nrf2-ETGE and Keap1 and can be used to study cancer.Fórmula:C29H30N2O7S2Pureza:98.43%Cor e Forma:Yellow SolidPeso molecular:582.69(+)-DHMEQ
CAS:(+)-DHMEQ is an antioxidant transcription factor Nrf2 activator. (+)-DHMEQ is the enantiomer of (-)-DHMEQ.Fórmula:C13H11NO5Cor e Forma:SolidPeso molecular:261.23MSU38225
CAS:MSU38225, an Nrf-2 inhibitor, elevates reactive oxygen species (ROS) levels and suppresses the proliferation of human lung cancer cells.Fórmula:C21H19N3Cor e Forma:SolidPeso molecular:313.4BPK-29
CAS:BPK-29 disrupts NR0B1 binding and modifies C274, inhibiting growth in KEAP1-mutant cancers.Fórmula:C26H32ClN3O3Pureza:98%Cor e Forma:SolidPeso molecular:470
