Nrf2
Nrf2 é um fator de transcrição que regula a expressão de proteínas antioxidantes e enzimas de desintoxicação, desempenhando um papel fundamental na defesa celular contra o estresse oxidativo e a inflamação. A ativação da sinalização Nrf2 oferece proteção contra várias doenças, incluindo câncer, neurodegeneração e distúrbios cardiovasculares. Os moduladores de Nrf2 estão sendo explorados por suas potenciais aplicações terapêuticas na redução de danos oxidativos e inflamação. Na CymitQuimica, oferecemos uma gama de moduladores da via Nrf2 de alta qualidade para apoiar sua pesquisa em estresse oxidativo, inflamação e prevenção de doenças.
Foram encontrados 78 produtos de "Nrf2"
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CAS:<p>Nrf2/Keap1 and Keap1/Cul3 interaction inhibitor</p>Fórmula:C11H13ClO3S2Pureza:98%Cor e Forma:SolidPeso molecular:292.8Nrf2 activator-4
CAS:<p>Nrf2 activator-4 is an Nrf2 activator for the treatment of fatty liver disease associated with metabolic dysfunction in humans.</p>Fórmula:C23H24ClF3N2O3Pureza:98.53%Cor e Forma:SolidPeso molecular:468.9K67
CAS:<p>K67 competitively inhibits the interaction between Nrf2-ETGE and Keap1 and can be used to study cancer.</p>Fórmula:C29H30N2O7S2Pureza:98.43%Cor e Forma:SolidPeso molecular:582.69DDO-7263
CAS:<p>DDO-7263, a 1,2,4-Oxadiazole, boosts Nrf2 by binding Rpn6, blocking 26S proteasome assembly, and has anti-inflammatory effects.</p>Fórmula:C14H9F2N3OPureza:99.85%Cor e Forma:SolidPeso molecular:273.24CDDO-EA
CAS:<p>CDDO-EA (CDDO ethyl amide) is an activator of the Nrf2/antioxidant response element.</p>Fórmula:C33H46N2O3Pureza:99.66%Cor e Forma:SolidPeso molecular:518.73Keap1-Nrf2-IN-15
CAS:<p>Keap1-Nrf2-IN-15 (Compound 24a) is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, displaying IC50 values of 77 nM in a fluorescence</p>Fórmula:C39H35N3O12S2Cor e Forma:SolidPeso molecular:801.84Keap1-Nrf2-IN-16
CAS:<p>Keap1-Nrf2-IN-16 is a biologically active peptide with KEAP1 binding activity.</p>Fórmula:C73H114N16O26Cor e Forma:SolidPeso molecular:1631.78Keap1-Nrf2-IN-6
<p>Keap1-Nrf2-IN-6 is a potent, selective inhibitor of the Keap1-Nrf2 protein−protein interaction (PPI), demonstrating an inhibitory concentration (IC50) of 41 nM</p>Fórmula:C30H34N4O8SCor e Forma:SolidPeso molecular:610.68Nrf2-IN-1
CAS:<p>Nrf2-IN-1 is an nuclear factor-erythroid 2-related factor 2 (Nrf2) inhibitor. Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML).</p>Fórmula:C21H22ClN3O2Pureza:95.00% - 99.68%Cor e Forma:SolidPeso molecular:383.87Nrf2 activator-7
CAS:<p>Nrf2 Activator-7 (Compound 12b) effectively enhances the Nrf2 signaling pathway as a potent Nrf2 activator.</p>Fórmula:C35H32N2O11S2Cor e Forma:SolidPeso molecular:720.77Nrf2-IN-3
CAS:<p>Nrf2-IN-3 is an NRF2 inhibitor that selectively sensitizes xenografts of mouse mKEAP1 cancer cells to cisplatin.</p>Fórmula:C22H26N4O4SPureza:98.07%Cor e Forma:SolidPeso molecular:442.53CPDT
CAS:<p>CPDT is an orally active and potent inducer of phase 2 enzymes as well as an activator of Nrf2. CPDT enhances the activity of critical phase 2 enzymes, such as glutathione S-transferase, NAD(P)H:quinone oxidoreductase 1, and gamma-glutamylcysteine synthetase, and increases glutathione levels both in the bladder of rats and in bladder cells in vitro.</p>Fórmula:C6H6S3Cor e Forma:SolidPeso molecular:174.307Nrf2 activator-2
<p>Compound O15, an Osthole derivative, is a potent Nrf2 agonist with an EC50 of 2.9 μM; it inhibits Keap1-Nrf2 binding and Nrf2 ubiquitination.</p>Fórmula:C20H17BrO3Cor e Forma:SolidPeso molecular:385.25Nrf2 activator-6
CAS:<p>Nrf2 activator-6, a tetrahydroisoquinoline, inhibits Kelch-Nrf2 at 5 nM IC50 (WO2021214470A1).</p>Fórmula:C31H37ClFN5O5Cor e Forma:SolidPeso molecular:614.11Keap1-Nrf2-IN-5
CAS:<p>Keap1-Nrf2-IN-5 is a potent inhibitor of Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) (IC50: 4.1 μM, Kd: 3.7 μM).</p>Fórmula:C23H30N4O6SCor e Forma:SolidPeso molecular:490.57VVD-130037
CAS:<p>VVD-130037 is a KEAP1 activator with potential antitumor activity.VVD-130037 inhibits tumor growth in advanced solid tumors by degrading NRF2.</p>Fórmula:C17H17ClN4O2Pureza:99.01% - 99.92%Cor e Forma:SolidPeso molecular:344.8KI696
CAS:<p>KI696 is a high-affinity probe that potently inhibits the interaction of Keap1 and NRF2.</p>Fórmula:C28H30N4O6SPureza:99.74%Cor e Forma:SolidPeso molecular:550.63NSC23925
CAS:<p>NSC23925 is a selective and effective inhibitor of P-glycoprotein (Pgp).</p>Fórmula:C22H26Cl2N2O2Pureza:98%Cor e Forma:SolidPeso molecular:421.36
