Nrf2
Nrf2 é um fator de transcrição que regula a expressão de proteínas antioxidantes e enzimas de desintoxicação, desempenhando um papel fundamental na defesa celular contra o estresse oxidativo e a inflamação. A ativação da sinalização Nrf2 oferece proteção contra várias doenças, incluindo câncer, neurodegeneração e distúrbios cardiovasculares. Os moduladores de Nrf2 estão sendo explorados por suas potenciais aplicações terapêuticas na redução de danos oxidativos e inflamação. Na CymitQuimica, oferecemos uma gama de moduladores da via Nrf2 de alta qualidade para apoiar sua pesquisa em estresse oxidativo, inflamação e prevenção de doenças.
Foram encontrados 82 produtos para "Nrf2".
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NXPZ-2
CAS:NXPZ-2 is an orally active Keap1-Nrf2 PPI inhibitor (Kᵢ = 95 nM, EC₅₀ = 120–170 nM) that upregulates Nrf2 and alleviates Aβ-induced cognitive impairment.Fórmula:C27H27N5O7S2Cor e Forma:SolidPeso molecular:597.66Ref: TM-T64214
1mgA consultar5mgA consultar10mgA consultar1mL*10mM (DMSO)A consultar25mg835,00€50mg1.341,00€100mg2.187,00€SPC-180002
CAS:SPC-180002, a dual SIRT1/3 inhibitor, exhibits IC50 values of 1.13 and 5.41 μM for SIRT1 and SIRT3, respectively.Fórmula:C18H23NO4Pureza:98%Cor e Forma:SolidPeso molecular:317.38Keap1-Nrf2-IN-14
CAS:Keap1-Nrf2-IN-14, a KEAP1-NRF2 inhibitor (IC50: 75 nM, Kd: 24 nM), boosts NRF2 gene expression, antioxidative and anti-inflammatory response.Fórmula:C30H29NO8SCor e Forma:SolidPeso molecular:563.62CDDO-EA
CAS:CDDO-EA (CDDO ethyl amide) is an activator of the Nrf2/antioxidant response element.Fórmula:C33H46N2O3Pureza:99.66%Cor e Forma:SolidPeso molecular:518.73Ref: TM-T10733
1mg80,00€5mg160,00€1mL*10mM (DMSO)177,00€10mg281,00€25mg485,00€50mg693,00€100mg893,00€200mg1.198,00€DDO-7263
CAS:DDO-7263, a 1,2,4-Oxadiazole, boosts Nrf2 by binding Rpn6, blocking 26S proteasome assembly, and has anti-inflammatory effects.Fórmula:C14H9F2N3OPureza:99.85%Cor e Forma:White SolidPeso molecular:273.24Keap1-Nrf2-IN-15
CAS:Keap1-Nrf2-IN-15 (Compound 24a) is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, displaying IC50 values of 77 nM in a fluorescenceFórmula:C39H35N3O12S2Cor e Forma:SolidPeso molecular:801.84Keap1-IN-1
Keap1-IN-1 (Compound 27) is an inhibitor of Keap1, functioning by covalently modifying the Cys151 residue on the BTB domain of KEAP1, thereby disrupting the interaction between Keap and Nrf. It enhances the mRNA expression of the antioxidant response element (ARE) dependent gene NQO1, with an EC50 of 160 nM, and exhibits cytotoxicity in U2OS cells, with an EC50 of 527 nM.Fórmula:C17H21Cl2N2O5PS3Cor e Forma:SolidPeso molecular:531.434Nrf2-IN-1
CAS:Nrf2-IN-1 is an nuclear factor-erythroid 2-related factor 2 (Nrf2) inhibitor. Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML).Fórmula:C21H22ClN3O2Pureza:95.00% - 99.68%Cor e Forma:SolidPeso molecular:383.87Ref: TM-T12253
1mg71,00€2mg92,00€5mg152,00€1mL*10mM (DMSO)168,00€10mg207,00€25mg344,00€50mg485,00€100mg690,00€200mg888,00€WRR139
CAS:WRR139 is an NGLY1 inhibitor that impairs Nrf1 processing and sensitizes cancer cells to proteasome inhibitors.Fórmula:C25H32N2O4SPureza:99.90%Cor e Forma:White SolidPeso molecular:456.6Ref: TM-T80771
1mg57,00€5mg120,00€1mL*10mM (DMSO)123,00€10mg192,00€25mg416,00€50mg685,00€100mg1.099,00€Keap1-Nrf2-IN-16
CAS:Keap1-Nrf2-IN-16 is a biologically active peptide with KEAP1 binding activity.Fórmula:C73H114N16O26Cor e Forma:SolidPeso molecular:1631.78Nrf2 activator-7
CAS:Nrf2 Activator-7 (Compound 12b) effectively enhances the Nrf2 signaling pathway as a potent Nrf2 activator.Fórmula:C35H32N2O11S2Cor e Forma:SolidPeso molecular:720.77Nrf2-IN-3
CAS:Nrf2-IN-3 is an NRF2 inhibitor that selectively sensitizes xenografts of mouse mKEAP1 cancer cells to cisplatin.Fórmula:C22H26N4O4SPureza:97.75%Cor e Forma:SolidPeso molecular:442.53Ref: TM-T78841
1mg58,00€5mg126,00€1mL*10mM (DMSO)138,00€10mg197,00€25mg371,00€50mg512,00€100mg707,00€200mg1.018,00€Keap1-Nrf2-IN-17
CAS:Keap1-Nrf2-IN-17 (compound 18) is a potent inhibitor of the protein-protein interaction between Keap1 and Nrf2.Fórmula:C30H28N2O11S2Cor e Forma:SolidPeso molecular:656.68LMDP10
CAS:LMDP10 is an orally active 3-aminoquinazoline derivative that activates the Keap1-Nrf2 pathway. It binds to Keap1, inhibiting the Keap1-Nrf2 interaction and subsequently activating the Nrf2 pathway. This leads to increased levels of Nrf2, SOD, and GSH, while reducing MDA and TNF-α levels. As a result, LMDP10 alleviates neurodegeneration and improves memory in Alzheimer's disease (AD) rat models. LMDP10 is applicable for Alzheimer's disease (AD) research.Fórmula:C29H21FN4O3Peso molecular:492.51Keap1-Nrf2-IN-5
CAS:Keap1-Nrf2-IN-5 is a potent inhibitor of Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) (IC50: 4.1 μM, Kd: 3.7 μM).Fórmula:C23H30N4O6SCor e Forma:SolidPeso molecular:490.57Nrf2 activator-2
Compound O15, an Osthole derivative, is a potent Nrf2 agonist with an EC50 of 2.9 μM; it inhibits Keap1-Nrf2 binding and Nrf2 ubiquitination.Fórmula:C20H17BrO3Cor e Forma:SolidPeso molecular:385.25CPDT
CAS:CPDT is an orally active and potent inducer of phase 2 enzymes as well as an activator of Nrf2. CPDT enhances the activity of critical phase 2 enzymes, such as glutathione S-transferase, NAD(P)H:quinone oxidoreductase 1, and gamma-glutamylcysteine synthetase, and increases glutathione levels both in the bladder of rats and in bladder cells in vitro.Fórmula:C6H6S3Cor e Forma:SolidPeso molecular:174.307NFE2L2 activator 3
CAS:NFE2L2 activator 3 (Compound 3) is an activator of NFE2L2/NRF2, specifically enhancing the activity of NAD(P)H:quinone oxidoreductase (NQO1), with an EC50 of less than 1 nM. It is useful for researching respiratory diseases such as chronic obstructive pulmonary disease.Fórmula:C29H33ClN4O5S2Peso molecular:617.18Nrf2 degrader 1
CAS:Nrf2 degrader 1 is a PROTAC degrading Nrf2, inhibiting A549 and LK-2 cells (IC₅₀ = 100 nM and 40 nM).Fórmula:C45H42N6O8SCor e Forma:SolidPeso molecular:826.92Keap1-Nrf2-IN-3
CAS:Keap1-Nrf2-IN-3 is a KEAP1:NRF2 protein protein interaction inhibitor, and with a K d value of 2.5 nM for KEAP1 protein.Fórmula:C31H34N6O3Cor e Forma:SolidPeso molecular:538.652
