Nrf2
Nrf2 é um fator de transcrição que regula a expressão de proteínas antioxidantes e enzimas de desintoxicação, desempenhando um papel fundamental na defesa celular contra o estresse oxidativo e a inflamação. A ativação da sinalização Nrf2 oferece proteção contra várias doenças, incluindo câncer, neurodegeneração e distúrbios cardiovasculares. Os moduladores de Nrf2 estão sendo explorados por suas potenciais aplicações terapêuticas na redução de danos oxidativos e inflamação. Na CymitQuimica, oferecemos uma gama de moduladores da via Nrf2 de alta qualidade para apoiar sua pesquisa em estresse oxidativo, inflamação e prevenção de doenças.
Foram encontrados 80 produtos para "Nrf2".
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Nrf2 activator-4
CAS:Nrf2 activator-4 is an Nrf2 activator for the treatment of fatty liver disease associated with metabolic dysfunction in humans.Fórmula:C23H24ClF3N2O3Pureza:98.53%Cor e Forma:SolidPeso molecular:468.9NXPZ-2
CAS:NXPZ-2, an oral Keap1-Nrf2 PPI inhibitor (Ki: 95 nM, EC50: 120-170 nM), may improve cognition and neuron health in AD.Fórmula:C27H27N5O7S2Cor e Forma:SolidPeso molecular:597.66SPC-180002
CAS:SPC-180002, a dual SIRT1/3 inhibitor, exhibits IC50 values of 1.13 and 5.41 μM for SIRT1 and SIRT3, respectively.Fórmula:C18H23NO4Pureza:98%Cor e Forma:SolidPeso molecular:317.38Keap1-Nrf2-IN-14
CAS:Keap1-Nrf2-IN-14, a KEAP1-NRF2 inhibitor (IC50: 75 nM, Kd: 24 nM), boosts NRF2 gene expression, antioxidative and anti-inflammatory response.Fórmula:C30H29NO8SCor e Forma:SolidPeso molecular:563.62CDDO-EA
CAS:CDDO-EA (CDDO ethyl amide) is an activator of the Nrf2/antioxidant response element.Fórmula:C33H46N2O3Pureza:99.66%Cor e Forma:SolidPeso molecular:518.73Ref: TM-T10733
1mg80,00€5mg160,00€1mL*10mM (DMSO)177,00€10mg281,00€25mg485,00€50mg693,00€100mg893,00€200mg1.198,00€DDO-7263
CAS:DDO-7263, a 1,2,4-Oxadiazole, boosts Nrf2 by binding Rpn6, blocking 26S proteasome assembly, and has anti-inflammatory effects.Fórmula:C14H9F2N3OPureza:99.85%Cor e Forma:White SolidPeso molecular:273.24Keap1-Nrf2-IN-16
CAS:Keap1-Nrf2-IN-16 is a biologically active peptide with KEAP1 binding activity.Fórmula:C73H114N16O26Cor e Forma:SolidPeso molecular:1631.78Keap1-Nrf2-IN-15
CAS:Keap1-Nrf2-IN-15 (Compound 24a) is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, displaying IC50 values of 77 nM in a fluorescenceFórmula:C39H35N3O12S2Cor e Forma:SolidPeso molecular:801.84Nrf2 activator-7
CAS:Nrf2 Activator-7 (Compound 12b) effectively enhances the Nrf2 signaling pathway as a potent Nrf2 activator.Fórmula:C35H32N2O11S2Cor e Forma:SolidPeso molecular:720.77Nrf2-IN-1
CAS:Nrf2-IN-1 is an nuclear factor-erythroid 2-related factor 2 (Nrf2) inhibitor. Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML).Fórmula:C21H22ClN3O2Pureza:95.00% - 99.68%Cor e Forma:SolidPeso molecular:383.87Ref: TM-T12253
1mg71,00€2mg92,00€5mg152,00€1mL*10mM (DMSO)168,00€10mg207,00€25mg344,00€50mg485,00€100mg690,00€200mg888,00€WRR139
CAS:WRR139 is an NGLY1 inhibitor that impairs Nrf1 processing and sensitizes cancer cells to proteasome inhibitors.Fórmula:C25H32N2O4SCor e Forma:White SolidPeso molecular:456.6Nrf2-IN-3
CAS:Nrf2-IN-3 is an NRF2 inhibitor that selectively sensitizes xenografts of mouse mKEAP1 cancer cells to cisplatin.Fórmula:C22H26N4O4SPureza:97.75%Cor e Forma:SolidPeso molecular:442.53Ref: TM-T78841
1mg58,00€5mg126,00€1mL*10mM (DMSO)138,00€10mg197,00€25mg371,00€50mg512,00€100mg707,00€200mg1.018,00€Keap1-Nrf2-IN-3
CAS:Keap1-Nrf2-IN-3 is a KEAP1:NRF2 protein protein interaction inhibitor, and with a K d value of 2.5 nM for KEAP1 protein.Fórmula:C31H34N6O3Cor e Forma:SolidPeso molecular:538.652Nrf2 degrader 1
CAS:Nrf2 degrader 1 (compound 1), a PROTAC Nrf2 degrader, exhibits anticancer properties by inhibiting the growth of cancer cells. It demonstrates IC 50 values of 100 nM for A549 cells and 40 nM for LK-2 cells, indicating potent efficacy [1].Fórmula:C45H42N6O8SCor e Forma:SolidPeso molecular:826.92CPDT
CAS:CPDT is an orally active and potent inducer of phase 2 enzymes as well as an activator of Nrf2. CPDT enhances the activity of critical phase 2 enzymes, such as glutathione S-transferase, NAD(P)H:quinone oxidoreductase 1, and gamma-glutamylcysteine synthetase, and increases glutathione levels both in the bladder of rats and in bladder cells in vitro.Fórmula:C6H6S3Cor e Forma:SolidPeso molecular:174.307Keap1-Nrf2-IN-5
CAS:Keap1-Nrf2-IN-5 is a potent inhibitor of Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) (IC50: 4.1 μM, Kd: 3.7 μM).Fórmula:C23H30N4O6SCor e Forma:SolidPeso molecular:490.57Nrf2 activator-2
Compound O15, an Osthole derivative, is a potent Nrf2 agonist with an EC50 of 2.9 μM; it inhibits Keap1-Nrf2 binding and Nrf2 ubiquitination.Fórmula:C20H17BrO3Cor e Forma:SolidPeso molecular:385.25Keap1-Nrf2-IN-17
CAS:Keap1-Nrf2-IN-17 (compound 18) is a potent inhibitor of the protein-protein interaction between Keap1 and Nrf2.Fórmula:C30H28N2O11S2Cor e Forma:SolidPeso molecular:656.68VVD-130037
CAS:VVD-130037 is a KEAP1 activator with potential antitumor activity.VVD-130037 inhibits tumor growth in advanced solid tumors by degrading NRF2.Fórmula:C17H17ClN4O2Pureza:99.01% - 99.92%Cor e Forma:SolidPeso molecular:344.8KI696
CAS:KI696 is a high-affinity probe that potently inhibits the interaction of Keap1 and NRF2.Fórmula:C28H30N4O6SPureza:99.74%Cor e Forma:SolidPeso molecular:550.63Ref: TM-T11758L
1mg131,00€5mg268,00€1mL*10mM (DMSO)324,00€10mg401,00€25mg672,00€50mg964,00€100mg1.378,00€
