Nrf2
Nrf2 é um fator de transcrição que regula a expressão de proteínas antioxidantes e enzimas de desintoxicação, desempenhando um papel fundamental na defesa celular contra o estresse oxidativo e a inflamação. A ativação da sinalização Nrf2 oferece proteção contra várias doenças, incluindo câncer, neurodegeneração e distúrbios cardiovasculares. Os moduladores de Nrf2 estão sendo explorados por suas potenciais aplicações terapêuticas na redução de danos oxidativos e inflamação. Na CymitQuimica, oferecemos uma gama de moduladores da via Nrf2 de alta qualidade para apoiar sua pesquisa em estresse oxidativo, inflamação e prevenção de doenças.
Foram encontrados 80 produtos para "Nrf2".
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WN1316
CAS:WN1316 is a unique neuroprotectant against oxidative injury, being a highly promising remedy for the treatment of amyotrophic lateral sclerosis (ALS).Fórmula:C20H26Cl3N5OCor e Forma:SolidPeso molecular:458.81Nrf2 activator-4
CAS:Nrf2 activator-4 is an Nrf2 activator for the treatment of fatty liver disease associated with metabolic dysfunction in humans.Fórmula:C23H24ClF3N2O3Pureza:98.53%Cor e Forma:SolidPeso molecular:468.9Dihydrolipoic acid
CAS:Dihydrolipoic acid (USAF XR-12), a dithiol carboxylic acid, is a potent antioxidant active against various reactive oxygen species at 0.01-0.5 mM.Fórmula:C8H16O2S2Pureza:97.51%Cor e Forma:Yellow To Orange LiquidPeso molecular:208.34Nrf2 activator-5
CAS:Nrf2 activator-5 combats oxidative stress and inflammation in microglia, with potent antioxidant effects.Fórmula:C25H30Cl2O6Cor e Forma:SolidPeso molecular:497.41DDO-7263
CAS:DDO-7263, a 1,2,4-Oxadiazole, boosts Nrf2 by binding Rpn6, blocking 26S proteasome assembly, and has anti-inflammatory effects.Fórmula:C14H9F2N3OPureza:99.85%Cor e Forma:White SolidPeso molecular:273.24CDDO-EA
CAS:CDDO-EA (CDDO ethyl amide) is an activator of the Nrf2/antioxidant response element.Fórmula:C33H46N2O3Pureza:99.66%Cor e Forma:SolidPeso molecular:518.73Ref: TM-T10733
1mg80,00€5mg160,00€1mL*10mM (DMSO)177,00€10mg281,00€25mg485,00€50mg693,00€100mg893,00€200mg1.198,00€Keap1-Nrf2-IN-15
CAS:Keap1-Nrf2-IN-15 (Compound 24a) is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, displaying IC50 values of 77 nM in a fluorescenceFórmula:C39H35N3O12S2Cor e Forma:SolidPeso molecular:801.84Keap1-Nrf2-IN-6
Keap1-Nrf2-IN-6 is a potent, selective inhibitor of the Keap1-Nrf2 protein−protein interaction (PPI), demonstrating an inhibitory concentration (IC50) of 41 nMFórmula:C30H34N4O8SCor e Forma:SolidPeso molecular:610.68WRR139
CAS:WRR139 is an NGLY1 inhibitor that impairs Nrf1 processing and sensitizes cancer cells to proteasome inhibitors.Fórmula:C25H32N2O4SCor e Forma:SolidPeso molecular:456.6Nrf2 activator-7
CAS:Nrf2 Activator-7 (Compound 12b) effectively enhances the Nrf2 signaling pathway as a potent Nrf2 activator.Fórmula:C35H32N2O11S2Cor e Forma:SolidPeso molecular:720.77Keap1-Nrf2-IN-16
CAS:Keap1-Nrf2-IN-16 is a biologically active peptide with KEAP1 binding activity.Fórmula:C73H114N16O26Cor e Forma:SolidPeso molecular:1631.78Nrf2-IN-1
CAS:Nrf2-IN-1 is an nuclear factor-erythroid 2-related factor 2 (Nrf2) inhibitor. Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML).Fórmula:C21H22ClN3O2Pureza:95.00% - 99.68%Cor e Forma:SolidPeso molecular:383.87Ref: TM-T12253
1mg71,00€2mg92,00€5mg152,00€10mg207,00€1mL*10mM (DMSO)285,00€25mg344,00€50mg485,00€100mg690,00€200mg888,00€Nrf2-IN-3
CAS:Nrf2-IN-3 is an NRF2 inhibitor that selectively sensitizes xenografts of mouse mKEAP1 cancer cells to cisplatin.Fórmula:C22H26N4O4SPureza:98.07%Cor e Forma:SolidPeso molecular:442.53Ref: TM-T78841
1mg58,00€5mg126,00€1mL*10mM (DMSO)138,00€10mg197,00€25mg371,00€50mg512,00€100mg707,00€200mg1.018,00€Keap1-Nrf2-IN-5
CAS:Keap1-Nrf2-IN-5 is a potent inhibitor of Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) (IC50: 4.1 μM, Kd: 3.7 μM).Fórmula:C23H30N4O6SCor e Forma:SolidPeso molecular:490.57CPDT
CAS:CPDT is an orally active and potent inducer of phase 2 enzymes as well as an activator of Nrf2. CPDT enhances the activity of critical phase 2 enzymes, such as glutathione S-transferase, NAD(P)H:quinone oxidoreductase 1, and gamma-glutamylcysteine synthetase, and increases glutathione levels both in the bladder of rats and in bladder cells in vitro.Fórmula:C6H6S3Cor e Forma:SolidPeso molecular:174.307Nrf2 activator-2
Compound O15, an Osthole derivative, is a potent Nrf2 agonist with an EC50 of 2.9 μM; it inhibits Keap1-Nrf2 binding and Nrf2 ubiquitination.Fórmula:C20H17BrO3Cor e Forma:SolidPeso molecular:385.25Nrf2 activator-6
CAS:Nrf2 activator-6, a tetrahydroisoquinoline, inhibits Kelch-Nrf2 at 5 nM IC50 (WO2021214470A1).Fórmula:C31H37ClFN5O5Cor e Forma:SolidPeso molecular:614.11Keap1-Nrf2-IN-17
CAS:Keap1-Nrf2-IN-17 (compound 18) is a potent inhibitor of the protein-protein interaction between Keap1 and Nrf2.Fórmula:C30H28N2O11S2Cor e Forma:SolidPeso molecular:656.68KI696
CAS:KI696 is a high-affinity probe that potently inhibits the interaction of Keap1 and NRF2.Fórmula:C28H30N4O6SPureza:99.74%Cor e Forma:SolidPeso molecular:550.63Ref: TM-T11758L
1mg131,00€5mg268,00€1mL*10mM (DMSO)324,00€10mg401,00€25mg672,00€50mg964,00€100mg1.378,00€VVD-130037
CAS:VVD-130037 is a KEAP1 activator with potential antitumor activity.VVD-130037 inhibits tumor growth in advanced solid tumors by degrading NRF2.Fórmula:C17H17ClN4O2Pureza:99.01% - 99.92%Cor e Forma:SolidPeso molecular:344.8
