CXCR
Os CXCRs são uma subclasse de GPCRs que se ligam a quimiocinas, pequenas proteínas sinalizadoras que guiam o movimento de células imunológicas em direção a locais de inflamação, infecção ou lesão. Os CXCRs desempenham papéis cruciais nas respostas imunológicas, metástase do câncer e doenças inflamatórias. Moduladores de CXCRs estão sendo investigados por seu potencial no tratamento de doenças autoimunes, câncer e condições inflamatórias crônicas. Na CymitQuimica, oferecemos uma gama de moduladores de CXCRs de alta qualidade para apoiar sua pesquisa em imunologia, oncologia e inflamação.
Foram encontrados 155 produtos de "CXCR"
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HF50731
CAS:HF50731 is a CXCR4 antagonist with high binding affinity (IC50: 19.8 nM) and inhibits calcium mobilization, cell migration, and HIV-1 (IC50: 1.5 nM).Fórmula:C26H46N4Cor e Forma:SolidPeso molecular:414.67SB-332235
CAS:SB-332235 is an effective specific CXCR2 antagonist. And it is effectively inhibited CS-induced neutrophilia in a dose-dependent manner.Fórmula:C13H10Cl3N3O4SCor e Forma:SolidPeso molecular:410.66VUF11211
CAS:VUF11211 is an effective antagonist of CXCR3 that acts by extending from the minor pocket into the major pocket of the transmembrane domains.Fórmula:C26H35Cl2N5OPureza:98%Cor e Forma:SolidPeso molecular:504.49TN-14003
CAS:TN-14003 is a synthetic antagonist 14-mer peptide inhibiting metastasis in an animal model.Fórmula:C90H141N33O18S2Cor e Forma:SolidPeso molecular:2037.42CXCR4 antagonist 8
CAS:CXCR4 antagonist 8 (Compound 3) blocks CXCR4, IC50 of 57 nM; stops CXCL12-induced Ca2+ increase, IC50 of 0.24 nM; hinders cell migration.Fórmula:C21H26N6Cor e Forma:SolidPeso molecular:362.47HF51116
CAS:HF51116 blocks XCR4, hinders SDF-1α cell effects & HIV-1; potential for HIV, stem cells, cancer spread.Fórmula:C29H46N8OCor e Forma:SolidPeso molecular:522.73SX-517
CAS:SX-517 is a non-competitive dual antagonist of CXCR1/2, demonstrating anti-inflammatory effects, inhibits CXCL-1-induced Ca²⁺ flux.Fórmula:C19H16BFN2O3SCor e Forma:SolidPeso molecular:382.22KRH-1636
CAS:KRH-1636: potent, selective CXCR4 antagonist; orally active; inhibits X4 HIV-1 by blocking viral entry and membrane fusion.Fórmula:C32H37N7O2Cor e Forma:SolidPeso molecular:551.68IT1t
CAS:IT1t inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM. is a potent CXCR4 antagonist.Fórmula:C21H34N4S2Pureza:98%Cor e Forma:SolidPeso molecular:406.65VUF5834
CAS:VUF5834 is a full inverse agonist of CXCR3 N3.35A.Fórmula:C31H41N5O2Pureza:98%Cor e Forma:SolidPeso molecular:515.69GSK812397
CAS:GSK812397 inhibits X4-tropic HIV-1 with high potency, targeting CXCR4 receptor noncompetitively and showing broad efficacy and good pharmacokinetics.Fórmula:C24H32N6OCor e Forma:SolidPeso molecular:420.55Burixafor hydrobromide
CAS:<p>Burixafor hydrobromide is an oral CXCR4 blocker with anti-angiogenic properties, potentially treating choroid neovascularization.</p>Fórmula:C27H52BrN8O3PPureza:98%Cor e Forma:SolidPeso molecular:647.644SRT3190
CAS:SRT3190 is an antagonist of CXCR2.Fórmula:C18H23F2N5O4S2Pureza:98%Cor e Forma:SolidPeso molecular:475.53Elubrixin
CAS:<p>Elubrixin (SB-656933) inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM).</p>Fórmula:C17H17Cl2FN4O4SPureza:98.65% - 99.78%Cor e Forma:SolidPeso molecular:463.31IT1t dihydrochloride
CAS:IT1t dihydrochloride inhibits CXCL12/CXCR4 interaction with IC50 of 2.1 nM. IT1t dihydrochloride is an antagonist of CXCR4.Fórmula:C21H36Cl2N4S2Pureza:99.91%Cor e Forma:SolidPeso molecular:479.57NUCC-390
CAS:NUCC-390, a novel small-molecule CXCR4 receptor agonist, selectively induces CXCR4 receptor internalization while acting antagonistically to AMD3100.Fórmula:C23H33N5OPureza:97.08%Cor e Forma:SolidPeso molecular:395.54Mavorixafor
CAS:<p>Mavorixafor (AMD-070) is an effective and selective antagonist of CXCR4, with an IC50 value of 13 nM against CXCR4 125I-SDF binding.</p>Fórmula:C21H27N5Pureza:98.56%Cor e Forma:SolidPeso molecular:349.47AZD8797
CAS:<p>AZD8797 (KAND567) is a CX3CR1 antagonist with potential protective effects against neuronal damage and prevents nociceptive hypersensitivity in rats.</p>Fórmula:C19H25N5OS2Pureza:98.73% - 99.68%Cor e Forma:SolidPeso molecular:403.56AZD8309
CAS:<p>AZD8309 is an oral CXCR2 antagonist, curbing neutrophil movement, lowering MPO in lungs/pancreas, and trypsin/elastase activity.</p>Fórmula:C15H14F2N4O2S2Pureza:98.35% - 99.67%Cor e Forma:SolidPeso molecular:384.42
