CXCR
Os CXCRs são uma subclasse de GPCRs que se ligam a quimiocinas, pequenas proteínas sinalizadoras que guiam o movimento de células imunológicas em direção a locais de inflamação, infecção ou lesão. Os CXCRs desempenham papéis cruciais nas respostas imunológicas, metástase do câncer e doenças inflamatórias. Moduladores de CXCRs estão sendo investigados por seu potencial no tratamento de doenças autoimunes, câncer e condições inflamatórias crônicas. Na CymitQuimica, oferecemos uma gama de moduladores de CXCRs de alta qualidade para apoiar sua pesquisa em imunologia, oncologia e inflamação.
Foram encontrados 159 produtos para "CXCR".
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Elubrixin
CAS:Elubrixin (SB-656933) inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM).Fórmula:C17H17Cl2FN4O4SPureza:98.65% - 99.78%Cor e Forma:SolidPeso molecular:463.31Ref: TM-T11179
1mg109,00€5mg235,00€1mL*10mM (DMSO)253,00€10mg349,00€25mg532,00€50mg745,00€100mg999,00€200mg1.333,00€AZD8309
CAS:AZD8309 is an oral CXCR2 antagonist, curbing neutrophil movement, lowering MPO in lungs/pancreas, and trypsin/elastase activity.Fórmula:C15H14F2N4O2S2Pureza:98.35% - 99.67%Cor e Forma:SolidPeso molecular:384.42Ref: TM-T25131
1mg60,00€5mg130,00€1mL*10mM (DMSO)142,00€10mg197,00€25mg396,00€50mg595,00€100mg893,00€Mavorixafor
CAS:Mavorixafor (AMD-070) is an effective and selective antagonist of CXCR4, with an IC50 value of 13 nM against CXCR4 125I-SDF binding.Fórmula:C21H27N5Pureza:98.56%Cor e Forma:SolidPeso molecular:349.47Ref: TM-TQ0174
1mg39,00€2mg50,00€5mg84,00€1mL*10mM (DMSO)92,00€10mg123,00€25mg215,00€50mg348,00€100mg557,00€IT1t dihydrochloride
CAS:IT1t dihydrochloride inhibits CXCL12/CXCR4 interaction with IC50 of 2.1 nM. IT1t dihydrochloride is an antagonist of CXCR4.Fórmula:C21H36Cl2N4S2Pureza:99.91%Cor e Forma:White SolidPeso molecular:479.57Ref: TM-T11693L
2mg34,00€5mg50,00€1mL*10mM (DMSO)56,00€10mg92,00€25mg166,00€50mg289,00€100mg420,00€200mg583,00€AZD8797
CAS:AZD8797 (KAND567) is a CX3CR1 antagonist with potential protective effects against neuronal damage and prevents nociceptive hypersensitivity in rats.Fórmula:C19H25N5OS2Pureza:98.73% - 99.68%Cor e Forma:SolidPeso molecular:403.56Ref: TM-T14384
1mg80,00€5mg170,00€1mL*10mM (DMSO)178,00€10mg222,00€25mg358,00€50mg512,00€100mg707,00€NUCC-390 dihydrochloride (1060524-97-1 free base)
NUCC-390 dihydrochloride is selective agonist of small-molecule CXCR4 receptor.Fórmula:C23H35Cl2N5OPureza:98%Cor e Forma:SolidPeso molecular:468.46CXCR4 antagonist 7
CAS:Compound PARA-B, a CXCR4 antagonist with IC50 = 9.3 nM, targets HIV, cancer, inflammatory diseases, and WHIM syndrome.Fórmula:C15H17N5O3Cor e Forma:SolidPeso molecular:315.33TIQ-15
CAS:TIQ-15 is an effective and selective CXCR4 antagonist. It has good drug-like properties.Fórmula:C23H32N4Pureza:98%Cor e Forma:SolidPeso molecular:364.53CXCR2 antagonist 3
CAS:Compound 11h, a CXCR2 antagonist, inhibits neutrophil/MDSCs and boosts CD3+ T cells in Pan02 tumors.Fórmula:C17H15FN2O4SCor e Forma:SolidPeso molecular:362.38CXCR4 antagonist 6
CAS:CXCR4 antagonist 6 is a potent small-molecule inhibitor of CXCL12/CXCR4 signaling that suppresses cell migration and metastasis in cancer models.Fórmula:C21H30N6Pureza:100% - 99.72%Cor e Forma:Yellow OilPeso molecular:366.5Ladarixin Sodium
CAS:Ladarixin Sodium, an Chemokine CXCR antagonist, is used potentially for the treatment of type I diabetes.Fórmula:C11H12F3NNaO6S2Cor e Forma:SolidPeso molecular:398.32(±)-AMG 487
AMG 487 is an effective and selective antagonist of chemokine receptor 3.Fórmula:C32H28F3N5O4Pureza:98%Cor e Forma:SolidPeso molecular:603.59E6130
CAS:E6130 may be effective in the treatment of inflammatory bowel disease and is a highly selective CX3CR1 regulator for oral administration.Fórmula:C28H37ClF3N3O3Cor e Forma:SolidPeso molecular:556.06Pentixafor
CAS:Pentixafor is a peptide that selectively targets the CXCR4 receptor and can be labeled with Gallium-68 (68Ga) for visualization using positron emissionFórmula:C60H80N14O14Pureza:98%Cor e Forma:SolidPeso molecular:1221.36AZD0233
CAS:AZD0233, Oral CX3CR1 antagonist, modulates CX3CR1/CX3CL1 axis, improves cardiac function in DCM models.Fórmula:C19H29FN6O4SPureza:98.81%Cor e Forma:SolidPeso molecular:456.54AMD-3329 free base
CAS:AMD-3329 is a potent anti-HIV agent that blocks virus replication by targeting CXCR4, a key receptor for X4 viruses' entry.Fórmula:C34H50N8Cor e Forma:SolidPeso molecular:570.81UNBS5162
CAS:UNBS5162 (UNBS-5162) is a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers.Fórmula:C17H18N4O3Pureza:98.37% - 99.97%Cor e Forma:SolidPeso molecular:326.35Ref: TM-T2477
1mg37,00€5mg77,00€1mL*10mM (DMSO)85,00€10mg110,00€25mg205,00€50mg323,00€100mg512,00€200mg747,00€AMD-3329 hydrobromide
CAS:AMD-3329 hydrobromide: strong, selective anti-HIV agent, blocks virus replication by targeting CXCR4 co-receptor.Fórmula:C34H58Br8N8Cor e Forma:SolidPeso molecular:1218.13CXCR2 antagonist 2
CAS:CXCR2 antagonist 2 is a potent CXCR2 antagonist for cancer immunotherapy with an IC 50 value of 95 nM.Fórmula:C17H17FN2O4SCor e Forma:SolidPeso molecular:364.39(R,R)-CXCR2-IN-2
CAS:'(R,R)-CXCR2-IN-2 is a brain-penetrating diastereoisomer and CXCR2 antagonist with pIC50 of 9 (Tango) and 6.8 (HWB Gro-α/CD11b).'Fórmula:C18H23ClN2O5SCor e Forma:SolidPeso molecular:414.9
