TLR
Os receptores Toll-like (TLRs) são uma classe de proteínas que desempenham um papel crítico no sistema imunológico inato ao reconhecer padrões moleculares associados a patógenos (PAMPs) e iniciar respostas imunes. Os TLRs estão envolvidos na detecção de uma ampla gama de patógenos, incluindo bactérias, vírus e fungos, e são essenciais para a ativação de vias de sinalização inflamatória. A desregulação da sinalização dos TLRs está associada a doenças inflamatórias crônicas, distúrbios autoimunes e câncer. Na CymitQuimica, oferecemos uma variedade de moduladores de TLR de alta qualidade para apoiar sua pesquisa em imunidade inata, inflamação e doenças infecciosas.
Foram encontrados 93 produtos para "TLR".
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TLR7/8 agonist 11
TLR7/8 agonist 11 (compound 30) serves as a powerful agonist for hTLR7 and hTLR8, exhibiting EC50 values of 31.1 nM and 13.1 nM, respectively. This compound is crucial in the functioning of both adaptive and innate immune responses.Fórmula:C28H38N8O2Peso molecular:518.65TLR7 agonist 26
CAS:TLR7 agonist26 (Compound 4) serves as an effective Toll-like receptor7 (TLR7) agonist with an EC50 value of 225.5 nM. It exhibits immunopotentiating effects.Fórmula:C17H19N5O4Peso molecular:357.36TLR7 agonist 20 hydrochloride
TLR7 agonist20 hydrochloride is an imidazoquinoline analog that functions as a potent and specific agonist for TLR7, with an EC50 value of 0.23 μM against hTLR7. It demonstrates strong adjuvant activity in enhancing spike antibody levels and induces a robust T helper cell 1 (Th1) response. Additionally, it increases levels of IgG2b and IgG2c, aside from IgG1.Fórmula:C22H25ClN4OPeso molecular:396.91MTT5
MTT5, a toll-like receptor 7 (TLR7) agonist, can be conjugated with Deruxtecan to exert antitumor activity in HER2-positive solid tumors through tumor cell killing and immune activation.Fórmula:C22H27N7O4Cor e Forma:SolidPeso molecular:453.49Pam3CSK4-Biotin
CAS:Pam3CSK4-Biotin is a biotinylated derivative of Pam3CSK4, functioning as a Toll-like receptor 1/2 (TLR1/2) agonist.Fórmula:C103H192N14O17S2Pureza:98%Cor e Forma:SolidPeso molecular:1962.85Pam2CSK4
CAS:TLR2/6 agonist; boosts TNF-α in human cells & mouse B cell growth/activation.Fórmula:C65H126N10O12SPureza:98%Cor e Forma:SolidPeso molecular:1271.83Pam3CSK4
CAS:Pam3CSK4 is a synthetic triacylated lipopeptide (LP) that mimics the acylated amino terminus of bacterial LPs.Fórmula:C81H156N10O13SPureza:98%Cor e Forma:SolidPeso molecular:1510.23TLR2 antagonist-1
TLR2antagonist-1 is a selective antagonist of Toll-like receptor 2 (TLR2). It effectively inhibits excessive activation of TLR2, with an IC50 value of 11.41 μM, and reduces the production of inflammatory factors. TLR2antagonist-1 exhibits metabolic stability, with a half-life (T1/2) of 16.67 minutes in mouse liver microsomes. This compound is useful for research in inflammation, immunology, and neurological disorders.TLR7/8 agonist 12
TLR7/8 agonist 12 (compound 9) is a human TLR7/8 agonist with EC50 values of 11 nM for hTLR7 and 150 nM for hTLR8, indicating its potential for immune modulation.Fórmula:C29H38N6O3Cor e Forma:SolidPeso molecular:518.65MTvkPABC-P5 TFA
MTvkPABC-P5d TFA, a TLR7 agonist, functions as an immune stimulant. It is applicable in the synthesis of immune-stimulating antibody conjugates (ISAC).Cor e Forma:Odour SolidODN 4084-F
CAS:ODN 4084-F, a class B ('broadly-active') inhibitory ODN, is a potent inhibitor of TLR9-induced B cells and macrophages.Cor e Forma:SolidSARM1-IN-6
CAS:SARM1-IN-6 (Compound 17a) is a brain-penetrant orthosteric inhibitor of SARM1. It exhibits an IC50 of 14 nM against NAM and 74 nM against HEK cells.Fórmula:C20H19F2N3OPeso molecular:355.38Ezeprogind
CAS:Ezeprogind, TLR9 inhibitor for Alzheimer's. Affordable Excellence: Reliable Quality You Can TrustFórmula:C25H44N6Pureza:99.28%Cor e Forma:White SolidPeso molecular:428.66PTD-N5-1
CAS:PTD-N5-1 (N5-1) is an IRF5 inhibitory peptide. It can block the production of IL-12 induced by β-glucan in both wild-type and Clec2d-deficient bone marrow-derived dendritic cells (BMDC) that are activated by IFN-γ. PTD-N5-1 modulates antifungal immunity by inhibiting IRF5-mediated IL-12 production.Fórmula:C148H248N52O30SCor e Forma:SolidPeso molecular:3267.95TLR7 agonist 17
CAS:TLR7 agonist 17 (compound 20) functions as a highly effective TLR7 agonist, exhibiting EC 50 values of 12 nM for hTLR7 and 17 nM for mTLR7. Additionally, this compound has demonstrated anticancer activity [1].Fórmula:C25H37N7O3Cor e Forma:SolidPeso molecular:483.61RKH acetate
RKH acetate offers protective effects against mortality and organ damage caused by sepsis. It can directly bind to Toll-like receptor 4 (TLR4) and inhibit TLR4 signaling in immune cells.Fórmula:C18H33N9O4·xC2H4O2Cor e Forma:SolidPSMα3 TFA
PSMα3 TFA is a peptide utilized in directing dendritic cells (DCs) towards a tolerogenic state, pivotal for DC vaccination approaches.MMG-11
CAS:MMG-11 is a TLR2 antagonist with cellular potency in HEK-Blue hTLR2 assays, enabling research on innate immune and inflammation pathways.Fórmula:C15H14O7Cor e Forma:SolidPeso molecular:306.2675TLR7 agonist 3
CAS:TLR7 agonist 3 is a Toll-like receptor 7 (TLR7) agonist that has anticancer activity and is used in the study of diseases of the immune system.Fórmula:C18H24N4OPureza:99.65%Cor e Forma:SolidPeso molecular:312.4094Polyinosinic-polycytidylic acid potassium
CAS:Polyinosinic-polycytidylic acid potassium can activate TLR3, RIG-I, and MDA5, induces IFN-β expression and apoptosis in melanoma models, and is suitable for innate RNA sensing and tumor immunology research.Fórmula:(C10H13N4O8P)x·(C9H14N3O8P)x·xKCor e Forma:Solid
