TLR
Os receptores Toll-like (TLRs) são uma classe de proteínas que desempenham um papel crítico no sistema imunológico inato ao reconhecer padrões moleculares associados a patógenos (PAMPs) e iniciar respostas imunes. Os TLRs estão envolvidos na detecção de uma ampla gama de patógenos, incluindo bactérias, vírus e fungos, e são essenciais para a ativação de vias de sinalização inflamatória. A desregulação da sinalização dos TLRs está associada a doenças inflamatórias crônicas, distúrbios autoimunes e câncer. Na CymitQuimica, oferecemos uma variedade de moduladores de TLR de alta qualidade para apoiar sua pesquisa em imunidade inata, inflamação e doenças infecciosas.
Foram encontrados 79 produtos para "TLR".
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Motolimod
CAS:Motolimod (VTX-378) (VTX-2337) is an effective and specific Toll-like receptor (TLR) 8 agonist (EC50: 100 nM), > 50-fold selectivity over TLR7.Fórmula:C28H34N4O2Pureza:97.43% - 99.66%Cor e Forma:SolidPeso molecular:458.6TLR7/8 agonist 1 dihydrochloride
CAS:TLR7/8 agonist 1 dihydrochloride (TLR7/8 agonist-5d) is a TLR7/8 agonist which shows prominent immunostimulatory activities.Fórmula:C22H27Cl2N5Pureza:98.33%Cor e Forma:SolidPeso molecular:432.39Robinin
CAS:Robinin: a kaempferol-derived flavone glycoside with antibacterial, diuretic traits; minimal effect on Colo 320 MDR1/LRP resistance; detected in MCF-7 cells.Fórmula:C33H40O19Pureza:98.78% - 99.96%Cor e Forma:White SolidPeso molecular:740.66TLR7 agonist 2
CAS:TLR7 agonist 2 (TLR7-IN-1) is a specific and effective Toll-like Receptor 7 (TLR7) agonist (LEC=0.4 μM).Fórmula:C17H16N6O2Pureza:99.33%Cor e Forma:SolidPeso molecular:336.35TLR3-IN-1
CAS:TLR3-IN-1 (CU CPT 4a) is a selective TLR3 inhibitor. It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit the TNF-α and IL-1β.Fórmula:C18H13ClFNO3SPureza:98.56%Cor e Forma:SolidPeso molecular:377.82Ref: TM-T22698
1mg52,00€5mg103,00€1mL*10mM (DMSO)113,00€10mg168,00€25mg353,00€50mg504,00€100mg708,00€RS09 2TFA (1449566-36-2 free base)
RS09 2TFA is a TLR4 agonist enhancing NF-κB and cytokines in macrophages; it's an adjuvant that boosts X-15 antibodies.Fórmula:C35H51F6N9O13Pureza:99.96%Cor e Forma:SolidPeso molecular:919.82CU-CPT-9a
CAS:CU-CPT-9a is a potent TLR8 inhibitor (IC50 : 0.5 nM), that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells-Fórmula:C17H15NO2Pureza:99.01%Cor e Forma:SolidPeso molecular:265.31Ref: TM-T7317
1mg38,00€2mg50,00€5mg84,00€1mL*10mM (DMSO)93,00€10mg119,00€25mg225,00€50mg409,00€100mg605,00€TLR7/8 agonist 1
CAS:TLR7/8 agonist 1 is a toll-like receptor TLR7/TLR8 agonist with anticancer and antiviral activities and can be used to study immune-related diseases.Fórmula:C22H25N5Pureza:99.4%Cor e Forma:SolidPeso molecular:359.47Telratolimod
CAS:Telratolimod (MEDI9197) is a toll-like receptors 7/8 agonist. It has an antitumor activity.Fórmula:C36H59N5O2Pureza:98.61%Cor e Forma:SolidPeso molecular:593.89Enpatoran
CAS:Enpatoran is an inhibitor of TLR7(IC50 = 11.1 nM) and TLR8(IC50 = 24.1 nM).Fórmula:C16H15F3N4Pureza:97.08% - 99.38%Cor e Forma:SolidPeso molecular:320.31Ref: TM-T9570
1mg113,00€1mL*10mM (DMSO)161,00€5mg222,00€10mg334,00€25mg552,00€50mg782,00€100mg1.054,00€200mg1.414,00€TLR7/8/9-IN-1
CAS:TLR7/8/9-IN-1 is a potent inhibitor of Toll-like receptors 7/8/9 (TLR7/8/9) with an IC50 of 43 nM.Fórmula:C27H37N3O2Pureza:99.56%Cor e Forma:SolidPeso molecular:435.6Ref: TM-T39669
1mg49,00€2mg70,00€5mg111,00€1mL*10mM (DMSO)166,00€10mg178,00€25mg290,00€50mg424,00€100mg577,00€200mg825,00€Bropirimine
CAS:Bropirimine (U-54461) (U-54461) is a biological response modifier that is thought to act through the induction of lymphokines.Fórmula:C10H8BrN3OPureza:99.01%Cor e Forma:White SolidPeso molecular:266.09TLR4-IN-C34
CAS:TLR4-IN-C34 is an inhibitor of TLR4, and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitisFórmula:C17H27NO9Pureza:99.69%Cor e Forma:SolidPeso molecular:389.4CU-CPT-8m
CAS:CU-CPT-8m (TLR8-specific antagonist) is an toll-like receptor 8 (TLR8) antagonist (IC50 : 67 nM)Fórmula:C14H12N4OPureza:99.00%Cor e Forma:SolidPeso molecular:252.27SM-324405
CAS:SM-324405 is an agonist of TLR7.Fórmula:C19H23N5O4Pureza:97.83%Cor e Forma:White SolidPeso molecular:385.42Ref: TM-T7860
2mg34,00€5mg52,00€1mL*10mM (DMSO)57,00€10mg84,00€25mg138,00€50mg215,00€100mg306,00€200mg427,00€CU-CPT9b
CAS:CU-CPT9b (TLR8-specific antagonist 1) is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM).Fórmula:C16H13NO2Pureza:98.1%Cor e Forma:SolidPeso molecular:251.28Ref: TM-T7302
1mg49,00€5mg92,00€1mL*10mM (DMSO)105,00€10mg152,00€25mg245,00€50mg340,00€100mg504,00€200mg717,00€MD2-IN-1
CAS:MD2-IN-1 is a Myeloid differentiation protein 2 (MD2) inhibitor with a KD of 189 μM for the recombinant human MD2 (rhMD2).Fórmula:C20H22O6Pureza:99.87%Cor e Forma:SolidPeso molecular:358.39Paridiprubart
CAS:Paridiprubart (NI-0101) is a humanised monoclonal antibody targeting TLR4, ameliorative effects in COVID-19 patients with ARDS and rheumatoid arthritis.Pureza:95% - 96.9% (SDS-PAGE); 98.5% (SEC-HPLC)Cor e Forma:Transparent LiquidPeso molecular:145.16 kDaAZD8848
CAS:AZD8848 is a selective antedrug agonist of toll-like receptor 7 (TLR7). It is developed for the research of asthma and allergic rhinitis.Fórmula:C29H43N7O5Cor e Forma:SolidPeso molecular:569.7TLR7 agonist 1
CAS:TLR7 agonist 1 is a selective and oral TLR7 agonist (IC50: 90 nM).Fórmula:C21H25N5OPureza:98%Cor e Forma:SolidPeso molecular:363.46
