TLR
Os receptores Toll-like (TLRs) são uma classe de proteínas que desempenham um papel crítico no sistema imunológico inato ao reconhecer padrões moleculares associados a patógenos (PAMPs) e iniciar respostas imunes. Os TLRs estão envolvidos na detecção de uma ampla gama de patógenos, incluindo bactérias, vírus e fungos, e são essenciais para a ativação de vias de sinalização inflamatória. A desregulação da sinalização dos TLRs está associada a doenças inflamatórias crônicas, distúrbios autoimunes e câncer. Na CymitQuimica, oferecemos uma variedade de moduladores de TLR de alta qualidade para apoiar sua pesquisa em imunidade inata, inflamação e doenças infecciosas.
Foram encontrados 66 produtos de "TLR"
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TH1020
CAS:<p>TH1020 is a novel Inhibitor of Toll-Like Receptor 5 (TLR5)/Flagellin Complex with promising activity (IC50 =0.85±0.12 μm) and specificity.</p>Fórmula:C23H15N7S2Pureza:99.23%Cor e Forma:SolidPeso molecular:453.54Motolimod
CAS:<p>Motolimod (VTX-378) (VTX-2337) is an effective and specific Toll-like receptor (TLR) 8 agonist (EC50: 100 nM), > 50-fold selectivity over TLR7.</p>Fórmula:C28H34N4O2Pureza:97.43% - 99.66%Cor e Forma:SolidPeso molecular:458.6TLR7/8 agonist 1 dihydrochloride
CAS:<p>TLR7/8 agonist 1 dihydrochloride (TLR7/8 agonist-5d) is a TLR7/8 agonist which shows prominent immunostimulatory activities.</p>Fórmula:C22H27Cl2N5Pureza:98.33%Cor e Forma:SolidPeso molecular:432.39Robinin
CAS:<p>Robinin: a kaempferol-derived flavone glycoside with antibacterial, diuretic traits; minimal effect on Colo 320 MDR1/LRP resistance; detected in MCF-7 cells.</p>Fórmula:C33H40O19Pureza:98.78% - 99.13%Cor e Forma:SolidPeso molecular:740.66Paridiprubart
CAS:<p>Paridiprubart (NI-0101) is a humanised monoclonal antibody targeting TLR4, ameliorative effects in COVID-19 patients with ARDS and rheumatoid arthritis.</p>Pureza:95% - 95%Cor e Forma:LiquidCL264
CAS:<p>CL264, a selective agonist of TLR7, can be used in studies about innate immune signals.</p>Fórmula:C19H23N7O4Pureza:98.01%Cor e Forma:SolidPeso molecular:413.43AXC-715 trihydrochloride
CAS:<p>AXC-715 trihydrochloride is a TLR7/8 agonist used to make PD-L1 adjuvanted antibody immunocouplings.</p>Fórmula:C18H28Cl3N5Pureza:99.74%Cor e Forma:SolidPeso molecular:420.81TLR7 agonist 1
CAS:<p>TLR7 agonist 1 is a selective and oral TLR7 agonist (IC50: 90 nM).</p>Fórmula:C21H25N5OPureza:98%Cor e Forma:SolidPeso molecular:363.46AZD8848
CAS:<p>AZD8848 is a selective antedrug agonist of toll-like receptor 7 (TLR7). It is developed for the research of asthma and allergic rhinitis.</p>Fórmula:C29H43N7O5Cor e Forma:SolidPeso molecular:569.7TL8-506
CAS:<p>TL8-506 is a selective and potent TLR8 agonist that induces cytokine and chemokine production.TL8-506 alleviates inflammatory and autoimmune diseases.</p>Fórmula:C20H17N3O2Pureza:95% - 99.97%Cor e Forma:SolidPeso molecular:331.37DSR-6434
CAS:<p>DSR-6434 is a selective agonist of TLR7 with antitumor effect. DSR-6434 exhibits EC50s of 7.2 nM and 4.6 nM for human and mouse.</p>Fórmula:C19H28N8O2Pureza:99.78%Cor e Forma:SolidPeso molecular:400.48AT791
CAS:<p>AT791 is an orally available TLR7 and TLR9 inhibitor, suppressing TLR7 and TLR9 signaling, used in autoimmune lupus research.</p>Fórmula:C23H31N3O3Pureza:99.88%Cor e Forma:SolidPeso molecular:397.51Rabeximod
CAS:<p>Rabeximod, an immunomodulator, eases autoimmune diseases, inhibits arthritis, and aids brain recovery post-injury by blocking inflammation.</p>Fórmula:C22H24ClN5OPureza:99.99%Cor e Forma:SolidPeso molecular:409.91BBIQ
CAS:<p>BBIQ is a powerful vaccine adjuvant that enhances innate immune responses and a potent and selectively toll-like receptor 7 (TLR7) agonist with an EC50 of 59.1</p>Fórmula:C21H22N4Pureza:99.71%Cor e Forma:SolidPeso molecular:330.43M62812
CAS:<p>TLR4 inhibitor blocks LPS-induced NF-κB (IC50=2.4μg/mL), cytokines in PBMCs/HUVECs, and extends life in septic shock mice.</p>Fórmula:C13H13Cl2N3OSPureza:99.07%Cor e Forma:SolidPeso molecular:330.23SM360320
CAS:<p>SM360320 (CL-087) is a selective TLR7 agonist that blocks HCV replication in hepatocytes and aids immunology research.</p>Fórmula:C15H17N5O3Pureza:99.13%Cor e Forma:SolidPeso molecular:315.33TLR7/8-IN-1
CAS:<p>TLR7/8-IN-1, a crystalline TLR7/TLR8 inhibitor, is a valuable compound for autoimmune disease research.Cost-effective and quality-assured.</p>Fórmula:C29H40N8O2Pureza:99.83%Cor e Forma:SolidPeso molecular:532.68TLR7 agonist 23
CAS:<p>TLR7 agonist23 (compound 12b) is a potent agonist of Toll-like receptor-7 (TLR7), with an EC50 value of 0.15 uM. It is suitable for research in immune diseases.</p>Fórmula:C21H22N4O2Cor e Forma:SolidPeso molecular:362.42TLR9-IN-1
CAS:<p>TLR9-IN-1: selective, potent human TLR9 inhibitor (IC50: 7 nM), useful for researching immune-related diseases.</p>Fórmula:C23H31N7OCor e Forma:SolidPeso molecular:421.54ABR-238901
CAS:<p>ABR-238901 is an oral, active S100A8/A9 blocker that inhibits the interaction of S100A8/A9 with its receptors RAGE(receptor for advanced glycation end products</p>Fórmula:C11H9BrClN3O4SPureza:98.63% - 98.71%Cor e Forma:SolidPeso molecular:394.63
