Sinalização JAK/STAT
Os inibidores da sinalização JAK/STAT são compostos que interrompem a via da Janus quinase (JAK) e do transdutor e ativador da transcrição (STAT), que está envolvida na sinalização de citocinas, crescimento celular e resposta imunológica. Esses inibidores são ferramentas importantes para estudar a regulação dessa via e seu papel em diversas doenças, incluindo cânceres, distúrbios imunológicos e condições inflamatórias. Os inibidores de JAK/STAT também estão sendo desenvolvidos como terapias direcionadas para essas doenças. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de sinalização JAK/STAT de alta qualidade para apoiar sua pesquisa em biologia molecular, oncologia e imunologia.
Subcategorias de "Sinalização JAK/STAT"
Foram encontrados 360 produtos de "Sinalização JAK/STAT"
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APTSTAT3-9R
APTSTAT3-9R-9R blocks STAT3 (Ki: 231 nmol/L), hindering cancer cell growth and resistance.Fórmula:C223H330N80O51Pureza:98%Cor e Forma:SolidPeso molecular:4947.51CMD178
CMD178 is an important polypeptide that consistently reduces the expression of Foxp3 and STAT5 by inhibiting the IL-2/s IL-2Rα signaling pathway.Fórmula:C46H59N9O7Pureza:98%Cor e Forma:SolidPeso molecular:850.03STAT3 degrader-1
CAS:STAT3 Degrader-1 (Compound 295) is a potent degrader of STAT3, utilized in anticancer research [1].Fórmula:C58H63F5N9O12PSCor e Forma:SolidPeso molecular:1236.2R8-T198wt
CAS:Cell-permeable peptide blocking Pim-1 kinase, halts DU145 cell growth, causes G1 arrest and apoptosis, inert to RPWE-1 cells at 10-20 μM.Fórmula:C111H211N59O26SPureza:98%Cor e Forma:SolidPeso molecular:2820.33SJ988497
CAS:SJ988497: PROTAC JAK2 degrader, inhibits CRLF2r cell growth, degrades GSPT1, combines Ruxolitinib, linker, Pomalidomide; researched for ALL.Fórmula:C36H36N10O5Cor e Forma:SolidPeso molecular:688.74S-Ruxolitinib
CAS:S-Ruxolitinib can be used in related research in the field of life sciences. Its product number is T3066 and CAS number is 1160597-27-2.
Fórmula:C17H18N6Pureza:98%Cor e Forma:SolidPeso molecular:306.37JAK1/TYK2-IN-1
CAS:JAK1/TYK2-IN-1 is a dual inhibitor of TYK2 and JAK1 ( IC 50 = 29 and 41 nM respectively).Fórmula:C18H20F3N7OCor e Forma:SolidPeso molecular:407.401WDR5 ligand 2
CAS:WDR5ligand 2 is a ligand for WDR5 and can be utilized in the synthesis of PROTAC WDR5degrader 1.Fórmula:C29H31F3N4O4Cor e Forma:SolidPeso molecular:556.576JAK1/STAT3-IN-1
JAK1/STAT3-IN-1 (compound 4f) functions as an anti-atopic dermatitis (AD) agent by inhibiting the JAK1/STAT3 signaling pathway. It has an IC50 value of 2.17 μM for inhibiting NO production. Additionally, JAK1/STAT3-IN-1 improves skin conditions in AD-like mice by reducing inflammatory infiltration, suppressing the expression of p-JAK1/JAK1 and p-STAT3/STAT3, and alleviating the hyperimmune response induced by MC903 (Calcipotriol).Fórmula:C30H33FN4O3SCor e Forma:SolidPeso molecular:548.67AK-2292
AK-2292: potent STAT5 PROTAC degrader, DC50 0.10 μM, degrades STAT5A/B, may shrink leukemia tumors in mice.Fórmula:C52H54F2N7O10PS2Cor e Forma:SolidPeso molecular:1070.13STAT4-IN-1
STAT4-IN-1 is a STAT4 inhibitor with a Ki of 0.35 μM. It holds promise for research into autoimmune diseases, including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and diabetes.Cor e Forma:Odour SolidTYD-68
TYD-68 is a potent and selective CRBN-recruiting TYK2 PROTAC degrader, with a DC50 value of 0.42 nM. This compound effectively inhibits IL-12 and IFN-α-induced phosphorylation of STAT4 and STAT1, thereby blocking TYK2-dependent signaling pathways. TYD-68 is applicable in psoriasis research.Cor e Forma:Odour SolidPovorcitinib phosphate
CAS:Povorcitinib phosphate is a selective JAK1 inhibitor and can be used in studies about the treatment of cutaneous lupus erythematosus and Lichen planus.Fórmula:C23H25F5N7O5PPureza:99.57%Cor e Forma:SolidPeso molecular:605.45Ref: TM-T39113L
1mg46,00€5mg96,00€10mg145,00€25mg236,00€50mg339,00€100mg460,00€200mg622,00€1mL*10mM (DMSO)128,00€JAK-IN-15
CAS:JAK-IN-15 is a JAK inhibitor. WO2016119700A1 (Compound 15).Fórmula:C22H23FN4O3SCor e Forma:SolidPeso molecular:442.51Axltide
CAS:Axltide mimics mouse Insulin receptor substrate 1, amino acids 979-989 with sequence KKSRGDYMTMQIG.Fórmula:C63H107N19O20S2Pureza:98%Cor e Forma:SolidPeso molecular:1514.77Fulipiftide
CAS:Fulipiftide is a short peptide derived from pigment epithelium-derived factor (PEDF). It stimulates the amplification of nuclear stem cell factor+TSPC by activating the ERK2 and STAT3 signaling pathways. Fulipiftide also exhibits anti-inflammatory properties and is applicable in research on acute tendon injuries.Fórmula:C144H227N41O47Cor e Forma:SolidPeso molecular:3284.59TYK2 activator-1
TYK2activator-1 (16b) is a TYK2 activator with an EC50 value of 1.78 μM. It inhibits JAK2 and JAK3 with IC50 values of 6.8 μM and 6.3 μM, respectively.Fórmula:C23H21FN4O2Cor e Forma:SolidPeso molecular:404.16485PROTAC STAT3 degrader-2
CAS:PROTAC STAT3 degrader-2 selectively breaks down STAT3 (DC50: 3.54μM, Molm-16) with cancer research potential.Fórmula:C59H60F2N9O13PCor e Forma:SolidPeso molecular:1172.13JAK3-IN-15
JAK3-IN-15 (compound 22) is a JAK3 inhibitor that reduces the secretion of p-JAK3 induced by LPS. It is utilized in research for rheumatoid arthritis.Cor e Forma:Odour SolidJAK-STAT Compound Library
A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;Cor e Forma:Odour SolidRef: TM-L3700
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultar
