Pim
As quinases Pim são uma família de quinases serina/treonina que desempenham um papel fundamental na sobrevivência celular, proliferação e apoptose. Estas quinases são efetores a jusante na via de sinalização JAK/STAT e estão envolvidas em vários processos fisiológicos, incluindo respostas imunológicas e hematopoiese. A superexpressão das quinases Pim tem sido associada ao desenvolvimento de câncer, tornando-as alvos importantes para a intervenção terapêutica. Na CymitQuimica, oferecemos uma variedade de inibidores e moduladores de quinases Pim de alta qualidade para apoiar sua pesquisa em oncologia, biologia celular e transdução de sinal.
Foram encontrados 35 produtos para "Pim".
Filtrar por
Percentagem de pureza
0
100
|
0
|
50
|
90
|
95
|
100
- Preços em ordem crescente
- Preços em ordem decrescente
- Menor grau de pureza
- Maior grau de pureza
- Estimativa de entrega mais rápida
Pim-1 kinase inhibitor 8
CAS:Pim-1 kinase inhibitor 8 is a Pim-1 kinase inhibitor with anticancer activity that inhibits cell migration and can be studied in breast cancer.Fórmula:C14H17N3O3Pureza:99.92%Cor e Forma:SolidPeso molecular:275.3Uzansertib phosphate
CAS:Uzansertib phosphate (INCB053914 phosphate) is an orally active, ATP-competitive inhibitor of pan-PIM kinase, inhibiting PIM1, PIM2 and PIM3.Fórmula:C26H29F3N5O7PPureza:99.75% - 99.79%Cor e Forma:SolidPeso molecular:611.51Pim-1 kinase inhibitor 11
Pim-1 kinase inhibitor 11 (10f) is an inhibitor of PIM-1 with an IC50 value of 0.18 μM. It exhibits anticancer activity by inducing apoptosis and causing cell cycle arrest.Cor e Forma:Odour SolidPim-1 kinase-IN-15
Pim-1 kinase-IN-15 (Compound 15) is a highly potent and selective inhibitor of Pim-1 kinase, with an IC50 value of 0.212 μM. This compound is capable of inducing apoptosis in tumor cells and inhibiting cell migration, making it a promising candidate for oncology research, including breast cancer studies.R8-T198wt
CAS:Cell-permeable peptide blocking Pim-1 kinase, halts DU145 cell growth, causes G1 arrest and apoptosis, inert to RPWE-1 cells at 10-20 μM.Fórmula:C111H211N59O26SPureza:98%Cor e Forma:SolidPeso molecular:2820.33PIM3-IN-1 hydrochloride
PIM3-IN-1 hydrochloride (Compound 19a) is an inhibitor of PIM2/3 kinases, showing the strongest inhibition against PIM3 with an IC50 in the nanomolar range. PIM3-IN-1 hydrochloride is applicable in cancer research.Fórmula:C23H23Cl2N5Peso molecular:439.13305Pim-1/2 kinase inhibitor 1
CAS:Orally active Pim-1/2 inhibitor blocks kinase phosphorylation; used in prostate cancer research.Fórmula:C11H9NO3SPureza:99.78%Cor e Forma:SolidPeso molecular:235.2596-Methyl-1H-Indole-2-Carboxylic Acid
CAS:6-Methyl-1H-Indole-2-Carboxylic Acid is a PIM-1 inhibitor (IC₅₀ = 63.6 µM) and can be used in biochemical research.Fórmula:C10H9NO2Pureza:99.93%Peso molecular:175.184TP-3654
CAS:TP-3654 is a second-generation Pim kinase inhibitor (Ki values against Pim-1/3: 5/42 nM).Fórmula:C22H25F3N4OPureza:99.8% - 99.95%Cor e Forma:SolidPeso molecular:418.4553Pim1/AKK1-IN-1
CAS:Pim1/AKK1-IN-1: LKB1/AAK1 inhibitor with Kd 35/53/75/380 nM for Pim1/AKK1/MST2/LKB1, also targets MPSK1, TNIK.Fórmula:C20H13N5OPureza:97.03% - 98.69%Cor e Forma:White SolidPeso molecular:339.3501SGI-1776
CAS:SGI-1776 (Pim-Kinase Inhibitor IX) has been used in trials studying the treatment of Prostate Cancer, Non-Hodgkins Lymphoma, and Relapsed/Refractory Leukemias.Fórmula:C20H22F3N5OPureza:99.3% - >99.99%Cor e Forma:SolidPeso molecular:405.4168HJ-PI01
CAS:HJ-PI01 (HJ-PI01) is a Pim-2 inhibitor. HJ-PI01 (HJ-PI01) induces apoptosis and autophagic cell death in triple-negative human breast cancer.Fórmula:C14H11NO2Pureza:98.92%Cor e Forma:SolidPeso molecular:225.2426AZD1208
CAS:AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.Fórmula:C21H21N3O2SPureza:97.24% - 99.83%Cor e Forma:Yellow SolidPeso molecular:379.475(Z)-SMI-4a
CAS:(Z)-SMI-4a (TCS PIM-1 4a) is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM.Fórmula:C11H6F3NO2SPureza:97.66% - 99.93%Cor e Forma:White SolidPeso molecular:273.231Quercetagetin
CAS:Quercetagetin, a flavonoid from Citrus unshiu, inhibits pim-1 kinase (IC50: 0.34 μM), cell-permeable.Fórmula:C15H10O8Pureza:99.65% - 99.91%Cor e Forma:SolidPeso molecular:318.2351TCS-PIM-1-4a
CAS:SMI-4a, a Pim inhibitor, activates AMPK, halts mTORC1, and kills various myeloid/lymphoid cells (IC50=0.8-40μM).Fórmula:C11H6F3NO2SPureza:98.82% - 99.89%Cor e Forma:White SolidPeso molecular:273.231TCS PIM-1 1
CAS:TCS PIM-1 1 (SC 204330) is a potent ATP-competitive inhibitor of Pim-1 kinase with an IC50 of 50 nM, selective over MEK1/2 and Pim-2.Fórmula:C18H11BrN2O2Pureza:97% - 97.98%Cor e Forma:SolidPeso molecular:367.2Hispidulin
CAS:Hispidulin, a natural flavone with a broad spectrum of biological activities, is a Pim-1 inhibitor (IC50: 2.71 μM).Fórmula:C16H12O6Pureza:98.53% - 99.87%Cor e Forma:SolidPeso molecular:300.26SMI-16a
CAS:SMI-16a (PIM1/2 Kinase Inhibitor VI) , a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (Fórmula:C13H13NO3SPureza:99.99%Cor e Forma:White SolidPeso molecular:263.312CX-6258 hydrochloride
CAS:CX-6258 hydrochloride (Pim-Kinase Inhibitor X) is an effective, orally efficacious Pim1/2/3 kinase inhibitor (IC50: 5/25/16 nM).Fórmula:C26H25Cl2N3O3Pureza:96.03% - 98.60%Cor e Forma:SolidPeso molecular:498.401
