STAT
As proteínas STAT são componentes críticos da via de sinalização JAK/STAT, que transmite sinais extracelulares de citocinas e fatores de crescimento para o núcleo da célula, influenciando a expressão gênica. As proteínas STAT estão envolvidas na regulação de respostas imunológicas, crescimento celular, diferenciação e sobrevivência. A desregulação da sinalização STAT está implicada em várias doenças, incluindo câncer, distúrbios autoimunes e inflamação crônica. Na CymitQuimica, oferecemos uma ampla gama de moduladores da via STAT para apoiar sua pesquisa em transdução de sinal, imunologia e desenvolvimento terapêutico.
Foram encontrados 102 produtos para "STAT".
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Garcinone C
CAS:Garcinone C, a xanthone from Garcinia oblongifolia, is anti-inflammatory, promotes healing, and may fight some cancers.Fórmula:C23H26O7Pureza:99.13% - 99.92%Cor e Forma:SolidPeso molecular:414.45Diosgenin
CAS:Diosgenin (Nitogenin) is a spirostan found in DIOSCOREA and other plants.Fórmula:C27H42O3Pureza:98% - 99.87%Cor e Forma:Flaky Or Needle CrystalPeso molecular:414.62Artesunate
CAS:Artesunate (WR-256283) is part of the artemisinin group of drugs that treat malaria.Fórmula:C19H28O8Pureza:97.67% - 99.9%Cor e Forma:White Crystalline PowderPeso molecular:384.42UC-514321
CAS:UC-514321 directly targets STAT3/5 and represses TET1 expression.Fórmula:C26H35NO5Pureza:98.50%Cor e Forma:SolidPeso molecular:441.56Ref: TM-T13950
1mg71,00€5mg152,00€1mL*10mM (DMSO)167,00€10mg236,00€25mg477,00€50mg713,00€100mg1.071,00€200mg1.468,00€L002
CAS:L002 is a potent inhibitor of acetyltransferase p300 with an IC50 of 1.98 μM, blocking histone and p53 acetylation, and may treat cardiac hypertrophy.Fórmula:C15H15NO5SPureza:98.59%Cor e Forma:SolidPeso molecular:321.35Niclosamide
CAS:Niclosamide (Niclocide)(BAY2353) is used to treat most tapeworm infections by inhibiting DNA replication.Fórmula:C13H8Cl2N2O4Pureza:98.47% - 99.1%Cor e Forma:Pale Yellow Crystals SolidPeso molecular:327.12STAT3-IN-1
CAS:STAT3-IN-1 selective and orally active inhibitor of STAT3(in HT29 and MDA-MB 231 cells, with IC50 values of 1.82 μM and 2.14 μM , respectively), induces tumorFórmula:C28H29NO6Pureza:95.89% - 98.13%Cor e Forma:SolidPeso molecular:475.53Ref: TM-T13009
1mg57,00€5mg124,00€1mL*10mM (DMSO)130,00€10mg170,00€25mg289,00€50mg423,00€100mg620,00€STX-0119
CAS:STX-0119 is a selective, orally active STAT3 dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC50 of 74 μM.
Fórmula:C22H14N4O3Pureza:99.61%Cor e Forma:SolidPeso molecular:382.37Nifuroxazide
CAS:Nifuroxazide (Diarlidan), an oral nitrofuran antidiarrheal, blocks STAT1/3/5 activation.Fórmula:C12H9N3O5Pureza:99.79% - 99.95%Cor e Forma:Yellow SolidPeso molecular:275.22Fludarabine
CAS:Fludarabine (Fludarabinum) is a fluorinated purine analog, an inhibitor of nucleic acid synthesis and an inhibitor of STAT1 activation.Fórmula:C10H12FN5O4Pureza:99.65% - 99.89%Cor e Forma:White SolidPeso molecular:285.23Niclosamide olamine
CAS:Niclosamide olamine (Niclosamide Ethanolamine salt) is an Repellent, Insect Attractant and Chemosterilant.Fórmula:C15H15Cl2N3O5Pureza:99.89%Cor e Forma:SolidPeso molecular:388.20STAT3-IN-41
STAT3-IN-41 (Compound 16) is a prodrug of compound 1. It gradually releases compound 1, which inhibits the STAT3 signaling pathway. STAT3-IN-41 exhibits antitumor activity against lung cancer, hepatocellular carcinoma, and pancreatic cancer.Fórmula:C22H30F3NO7Cor e Forma:SolidPeso molecular:477.471APTSTAT3-9R acetate
APTSTAT3-9R acetate is a selective peptide binding STAT3 with antiproliferative and antitumor activity.Fórmula:C225H334N80O53Pureza:98%Cor e Forma:SolidPeso molecular:5007.56MNK8
CAS:MNK8 is a potent STAT3 inhibitor, impairs DNA binding, and inhibits liver cancer cell growth.Fórmula:C15H12N2O2Pureza:99.74%Cor e Forma:SolidPeso molecular:252.27STAT4-IN-1
STAT4-IN-1 is a STAT4 inhibitor with a Ki of 0.35 μM. It holds promise for research into autoimmune diseases, including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and diabetes.Cor e Forma:Odour SolidSTAT3-IN-23
CAS:STAT3-IN-23 (PY*LKTK) acts as a potent inhibitor of STAT3 [1].Fórmula:C36H61N8O12PCor e Forma:SolidPeso molecular:828.89Eflepedocokin alfa
CAS:Eflepedocokin alfa is a recombinant IL-22/IgG2-Fc protein, potentially protecting cells and enhancing immune function and tissue repair.Cor e Forma:LiquidSTAT5-IN-3
STAT5-IN-3 (Compound 14a) is a STAT5 inhibitor with anticancer properties. It works by blocking the tyrosine phosphorylation of STAT5A/5B at the Y694/699 sites, significantly reducing the expression of the STAT5B protein. This leads to the inhibition of downstream gene transcription, thereby preventing the proliferation and survival of leukemia cells. Additionally, STAT5-IN-3 has significant potential in overcoming chemotherapy resistance.Fórmula:C25H27N5OCor e Forma:SolidPeso molecular:413.51STAT3-IN-34
STAT3-IN-34 (Compound 15E) acts as a STAT3 inhibitor, blocking both the nuclear translocation and the transcriptional regulator activity of STAT3. It effectively inhibits HaCaT cell proliferation with an IC50 value of 0.008 μM. Additionally, STAT3-IN-34 reduces IL-17A expression and mitigates Imiquimod-induced psoriasis in mouse models.Fórmula:C19H16N2O4SCor e Forma:SolidPeso molecular:368.41JAK-STAT Compound Library
A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;Cor e Forma:Odour SolidRef: TM-L3700
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultar
