Sinalização JAK/STAT
Os inibidores da sinalização JAK/STAT são compostos que interrompem a via da Janus quinase (JAK) e do transdutor e ativador da transcrição (STAT), que está envolvida na sinalização de citocinas, crescimento celular e resposta imunológica. Esses inibidores são ferramentas importantes para estudar a regulação dessa via e seu papel em diversas doenças, incluindo cânceres, distúrbios imunológicos e condições inflamatórias. Os inibidores de JAK/STAT também estão sendo desenvolvidos como terapias direcionadas para essas doenças. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de sinalização JAK/STAT de alta qualidade para apoiar sua pesquisa em biologia molecular, oncologia e imunologia.
Subcategorias de "Sinalização JAK/STAT"
Foram encontrados 362 produtos de "Sinalização JAK/STAT"
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Axltide
CAS:Axltide mimics mouse Insulin receptor substrate 1, amino acids 979-989 with sequence KKSRGDYMTMQIG.Fórmula:C63H107N19O20S2Pureza:98%Cor e Forma:SolidPeso molecular:1514.77SJ1008030 formic
SJ1008030 (compound 8) formic is a selective JAK2 degrader within the PROTAC class, demonstrating efficacy in inhibiting MHH-CALL-4 leukemia cell growth with anFórmula:C43H45N13O9SPureza:98%Cor e Forma:SolidPeso molecular:919.96Pim-1 kinase inhibitor 11
Pim-1 kinase inhibitor 11 (10f) is an inhibitor of PIM-1 with an IC50 value of 0.18 μM. It exhibits anticancer activity by inducing apoptosis and causing cell cycle arrest.Cor e Forma:Odour SolidLH168
LH168 is a potent and selective probe for WDR5, with a SPR Kd value of 13 nM.Fórmula:C29H31F3N6O2SCor e Forma:SolidPeso molecular:584.66TYD-68
TYD-68 is a potent and selective CRBN-recruiting TYK2 PROTAC degrader, with a DC50 value of 0.42 nM. This compound effectively inhibits IL-12 and IFN-α-induced phosphorylation of STAT4 and STAT1, thereby blocking TYK2-dependent signaling pathways. TYD-68 is applicable in psoriasis research.Cor e Forma:Odour SolidOSM-SMI-10B
OSM-SMI-10B, a variant of OSM-SMI-10, inhibits OSM-induced STAT3 activation in cancer cells.Fórmula:C21H14O7Cor e Forma:SolidPeso molecular:378.33WDR5 ligand 2
CAS:WDR5ligand 2 is a ligand for WDR5 and can be utilized in the synthesis of PROTAC WDR5degrader 1.Fórmula:C29H31F3N4O4Cor e Forma:SolidPeso molecular:556.576JAK-IN-15
CAS:JAK-IN-15 is a JAK inhibitor. WO2016119700A1 (Compound 15).Fórmula:C22H23FN4O3SCor e Forma:SolidPeso molecular:442.51Pim-1/2 kinase inhibitor 1
CAS:Orally active Pim-1/2 inhibitor blocks kinase phosphorylation; used in prostate cancer research.Fórmula:C11H9NO3SPureza:99.78%Cor e Forma:SolidPeso molecular:235.26DTP3
CAS:DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.Fórmula:C26H35N7O5Cor e Forma:SolidPeso molecular:525.6Atinvicitinib
CAS:Atinvicitinib, a selective JAK1 inhibitor, blocks cytokine signaling, modulating itch, allergy, and inflammatory responses, immune and therapeutic studies.Fórmula:C16H17FN6O3Pureza:99.36%Cor e Forma:SolidPeso molecular:360.35Ref: TM-T39646
1mg138,00€5mg334,00€10mg550,00€25mg1.063,00€50mg1.738,00€100mg2.547,00€1mL*10mM (DMSO)264,00€Itacitinib adipate
CAS:Itacitinib adipate: oral JAK1 inhibitor, tested in phase II myelofibrosis trial.Fórmula:C32H33F4N9O5Cor e Forma:SolidPeso molecular:699.66CHZ868
CAS:CHZ868 is a type II JAK inhibitor with potential antitumor activity that reverses the persistence of type I JAK inhibitors and can be used to study leukemia.Fórmula:C22H19F2N5O2Pureza:99.38%Cor e Forma:SolidPeso molecular:423.42Ilunocitinib
CAS:Ilunocitinib is a non-selective and orally active Janus kinase (JAK) inhibitor for pruritus and atopic dermatitis caused by atopic dermatitis in dogs.Fórmula:C17H17N7O2SPureza:99.88%Cor e Forma:SolidPeso molecular:383.43Ref: TM-T38571
1mg92,00€5mg230,00€10mg356,00€25mg713,00€50mg1.189,00€100mg1.791,00€200mg2.412,00€1mL*10mM (DMSO)251,00€Stafib-1
CAS:Stafib-1 is a selective inhibitor of STAT5β targeting SH2 domain with an IC50 of 154 nM and a Ki of 44 nM.Fórmula:C26H24N2O11P2Pureza:97.18%Cor e Forma:SolidPeso molecular:602.42SD-436
CAS:SD-436 is a selective and highly efficient STAT3 PROTAC degrader (DC50 = 0.5 μM), with an IC50 of 19 nM for STAT3, significantly higher than for STAT1/4/5/6. SD-436 depletes STAT3 and induces tumour regression in mouse leukaemia and lymphoma xenograft models.Fórmula:C58H62F4N9O14PSPureza:99.34%Cor e Forma:SolidPeso molecular:1248.2AK-1690
CAS:AK-1690 is a potent and selective STAT6 PROTAC degrader that induces degradation of STAT6 proteins in cells and depletes STAT6 proteins in mouse tissues.Fórmula:C51H56F2N5O11PSPureza:99.95% - 99.96%Cor e Forma:SolidPeso molecular:1016.05Ifidancitinib
CAS:Ifidancitinib (ATI-50002) is a JAK kinase 1/3 inhibitor used to study autoimmune diseases.Fórmula:C20H18FN5O3Pureza:98.05%Cor e Forma:SolidPeso molecular:395.395,15-DPP
CAS:5,15-Diphenylporphyrin (5,15-DPP) is a selective STAT3-SH2 antagonist with IC 50s of 0.28 μM and 10 μM for STAT3 and STAT1, respectively [1].Fórmula:C32H22N4Cor e Forma:SolidPeso molecular:462.54ZM39923 hydrochloride
CAS:ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.Fórmula:C23H25NO·HClPureza:98.05%Cor e Forma:SolidPeso molecular:367.91
