MAPK
As MAPKs são uma família de proteínas quinases envolvidas em uma variedade de processos celulares, incluindo crescimento, proliferação, diferenciação e respostas ao estresse. A via de sinalização MAPK consiste em várias camadas, incluindo ERK, JNK e p38 MAPKs, cada uma desempenhando papéis distintos na função celular. A desregulação da sinalização MAPK está ligada ao câncer, doenças inflamatórias e distúrbios metabólicos. Na CymitQuimica, oferecemos uma ampla gama de inibidores e ativadores de MAPK para apoiar sua pesquisa em biologia celular, transdução de sinais e mecanismos de doenças.
Foram encontrados 887 produtos de "MAPK"
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SCH54292
CAS:SCH-54292 is a GDP exchange inhibitor.Fórmula:C24H28N2O9SPureza:95.65%Cor e Forma:SolidPeso molecular:520.55CK1-IN-1
CAS:CK1-IN-1, a CK1 inhibitor with IC50: 15nM CK1δ, 16nM CK1ε, 73nM p38σ; patent WO2015119579A1.Fórmula:C24H15F2N3Pureza:98.79%Cor e Forma:SolidPeso molecular:383.39Ref: TM-T5393
1mg47,00€2mg62,00€5mg92,00€10mg152,00€25mg289,00€50mg447,00€100mg670,00€1mL*10mM (DMSO)101,00€Compound 3344 hydrochloride
Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions，with an affnity of 126nm.Fórmula:C24H27ClN2O3Pureza:99.23%Cor e Forma:SolidPeso molecular:426.94Ref: TM-T9184L
1mg136,00€5mg269,00€10mg404,00€25mg665,00€50mg888,00€100mg1.243,00€1mL*10mM (DMSO)318,00€p-Cresyl sulfate potassium
CAS:p-Cresyl sulfate potassium (p-Tolyl sulfate potassium salt) is a prototype protein-bound uremic toxin derived from the metabolites of tyrosine and phenylalanineFórmula:C7H7KO4SPureza:99.38% - 99.90%Cor e Forma:SolidPeso molecular:226.29BMS582949
CAS:BMS-582949 inhibits p38 MAPK with 13 nM IC50, blocking kinase activity and activation.Fórmula:C22H26N6O2Pureza:98.11%Cor e Forma:SolidPeso molecular:406.48Ref: TM-T6789
1mg82,00€2mg114,00€5mg200,00€10mg284,00€25mg477,00€50mg692,00€100mg973,00€1mL*10mM (DMSO)200,00€Pyridoxal 5'-phosphate hydrate
CAS:Pyridoxal 5'-phosphate hydrate (PLP)(1:x), the active form of vitamin B6, is a cofactor for many different enzymes involved in transamination reactions,Fórmula:C8H10NO6PPureza:97.52%Cor e Forma:SolidPeso molecular:247.14GSK-114
CAS:GSK-114, a TNNI3K inhibitor with a 25 nM IC50, is 40x more selective than B-Raf and good for in vivo studies.Fórmula:C19H23N5O4SPureza:99.51%Cor e Forma:SolidPeso molecular:417.48Rasarfin
CAS:Rasarfin inhibits Ras and ARF6.Fórmula:C23H24ClN3O3Pureza:97.98%Cor e Forma:SolidPeso molecular:425.91Ref: TM-T9407
1mg38,00€5mg75,00€10mg110,00€25mg193,00€50mg323,00€100mg460,00€200mg620,00€1mL*10mM (DMSO)84,00€ZT-12-037-01
CAS:Zt-12-037-01 is a ATP competitive STK19 inhibitor（IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).Fórmula:C21H31N5O2Pureza:99.56%Cor e Forma:SolidPeso molecular:385.5KRPEP-2D acetate
KRPEP-2D acetate: inhibitor targeting K-Ras(G12D) mutant, a crucial cancer-related protein.Fórmula:C110H186N44O27S2Pureza:98.94%Cor e Forma:SolidPeso molecular:2621.06SB 239063
CAS:SB 239063 (SB239063) is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.
Fórmula:C20H21FN4O2Pureza:99.42% - 99.81%Cor e Forma:SolidPeso molecular:368.4Pimasertib HCl
CAS:Pimasertib HCl, an oral MEK1/2 inhibitor, may thwart tumor growth by blocking RAS/RAF/MEK/ERK signaling.Fórmula:C15H16ClFIN3O3Cor e Forma:SolidPeso molecular:467.66ERK5-IN-2
CAS:ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively.Fórmula:C17H11BrFN3O2Pureza:99.01%Cor e Forma:SolidPeso molecular:388.19Ref: TM-T5535
1mg46,00€5mg90,00€10mg160,00€25mg268,00€50mg401,00€100mg580,00€200mg798,00€1mL*10mM (DMSO)101,00€SLV-2436
CAS:SLV-2436 (SEL201-88) is a novel effective and ATP-competitive inhibitor of MNK1 and MNK2 (IC50: 10.8/5.4 nM).Fórmula:C19H15ClN4OPureza:98.56%Cor e Forma:SolidPeso molecular:350.8Ref: TM-T4424
1mg77,00€2mg101,00€5mg166,00€10mg260,00€25mg462,00€50mg677,00€100mg888,00€200mg1.234,00€1mL*10mM (DMSO)178,00€Belvarafenib TFA
Belvarafenib TFA (HM95573 TFA) inhibits RAF: B-RAF (56 nM), B-RAFv600E (7 nM), C-RAF (5 nM) effectively.Fórmula:C25H17ClF4N6O3SCor e Forma:SolidPeso molecular:592.95JNK-IN-8
CAS:JNK-IN-8 (JNK Inhibitor XVI) is an irreversible JNK1/2/4 inhibitor (IC50: 4.7/18.7/1 nM).Fórmula:C29H29N7O2Pureza:99.24% - >99.99%Cor e Forma:SolidPeso molecular:507.59Ref: TM-T2668
2mg47,00€5mg77,00€10mg119,00€25mg207,00€50mg344,00€100mg510,00€200mg722,00€1mL*10mM (DMSO)87,00€N-tert-butyl-α-Phenylnitrone
CAS:N-tert-butyl-α-Phenylnitrone ((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) inhibits COX2 catalytic activity.Fórmula:C11H15NOPureza:99.46% - 99.84%Cor e Forma:SolidPeso molecular:177.24ARS-1620
CAS:ARS-1620 is a covalent inhibitor of K-RASG12C.Fórmula:C21H17ClF2N4O2Pureza:98.86%Cor e Forma:SolidPeso molecular:430.84K-Ras-IN-1
CAS:K-Ras-IN-1 is a K-Ras inhibitor.Fórmula:C11H13NOSPureza:98.72%Cor e Forma:SolidPeso molecular:207.29PF-06260933 HCl
CAS:PF-06260933 Dihydrochloride, a MAP4K4 inhibitor, hinders HGK, Mink, Tnik (IC50s: 140, 8, 13 nM) and lessens mouse fasting hyperglycemia.Fórmula:C16H15Cl3N4Cor e Forma:SolidPeso molecular:369.68
