MAPK
As MAPKs são uma família de proteínas quinases envolvidas em uma variedade de processos celulares, incluindo crescimento, proliferação, diferenciação e respostas ao estresse. A via de sinalização MAPK consiste em várias camadas, incluindo ERK, JNK e p38 MAPKs, cada uma desempenhando papéis distintos na função celular. A desregulação da sinalização MAPK está ligada ao câncer, doenças inflamatórias e distúrbios metabólicos. Na CymitQuimica, oferecemos uma ampla gama de inibidores e ativadores de MAPK para apoiar sua pesquisa em biologia celular, transdução de sinais e mecanismos de doenças.
Foram encontrados 887 produtos de "MAPK"
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Ulixertinib
CAS:Ulixertinib (VRT752271) (BVD-523, VRT752271) is an effective and reversible ERK1/ERK2 inhibitor. The IC50 of Ulixertinib is less than 0.3 nM for ERK2.Fórmula:C21H22Cl2N4O2Pureza:99.31% - 99.95%Cor e Forma:SolidPeso molecular:433.33Rasarfin
CAS:Rasarfin inhibits Ras and ARF6.Fórmula:C23H24ClN3O3Pureza:97.98%Cor e Forma:SolidPeso molecular:425.91Ref: TM-T9407
1mg38,00€5mg75,00€10mg110,00€25mg193,00€50mg323,00€100mg460,00€200mg620,00€1mL*10mM (DMSO)84,00€ZT-12-037-01
CAS:Zt-12-037-01 is a ATP competitive STK19 inhibitor（IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).Fórmula:C21H31N5O2Pureza:99.56%Cor e Forma:SolidPeso molecular:385.5SB 239063
CAS:SB 239063 (SB239063) is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.
Fórmula:C20H21FN4O2Pureza:99.42% - 99.81%Cor e Forma:SolidPeso molecular:368.4I-49 free base
I-49 free base (Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-6-(tetrahydro-2H-pyran-4-yl)-) is a novelFórmula:C23H26ClF3N4O2Pureza:99.64% - 99.88%Cor e Forma:SolidPeso molecular:482.92PD318088
CAS:PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binding simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-Fórmula:C16H13BrF3IN2O4Pureza:99.81%Cor e Forma:SolidPeso molecular:561.09Temuterkib
CAS:LY3214996 (Temuterkib) is a potent oral ERK1/2 inhibitor with potential cancer-fighting properties.
Fórmula:C22H27N7O2SPureza:99.57% - >99.99%Cor e Forma:SolidPeso molecular:453.56Belvarafenib TFA
Belvarafenib TFA (HM95573 TFA) inhibits RAF: B-RAF (56 nM), B-RAFv600E (7 nM), C-RAF (5 nM) effectively.Fórmula:C25H17ClF4N6O3SCor e Forma:SolidPeso molecular:592.95JNK-IN-8
CAS:JNK-IN-8 (JNK Inhibitor XVI) is an irreversible JNK1/2/4 inhibitor (IC50: 4.7/18.7/1 nM).Fórmula:C29H29N7O2Pureza:99.24% - >99.99%Cor e Forma:SolidPeso molecular:507.59Ref: TM-T2668
2mg47,00€5mg77,00€10mg119,00€25mg207,00€50mg344,00€100mg510,00€200mg722,00€1mL*10mM (DMSO)87,00€Dabrafenib Mesylate
CAS:Dabrafenib Mesylate (GSK2118436 Mesylate) is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively).Fórmula:C24H24F3N5O5S3Pureza:99.45% - 99.82%Cor e Forma:SolidPeso molecular:615.67DMX-5804
CAS:DMX-5804 is a potent, selective MAP4K4 inhibitor, with an IC50 of 3 nM.DMX-5804 enhances cardiomyocyte survival, and reduces ischemia-reperfusion injury in miceFórmula:C21H19N3O3Pureza:99.34%Cor e Forma:SolidPeso molecular:361.39Ref: TM-T5483
1mg106,00€2mg155,00€5mg235,00€10mg378,00€25mg630,00€50mg898,00€100mg1.216,00€1mL*10mM (DMSO)259,00€ARS-1620
CAS:ARS-1620 is a covalent inhibitor of K-RASG12C.Fórmula:C21H17ClF2N4O2Pureza:98.86%Cor e Forma:SolidPeso molecular:430.84K-Ras-IN-1
CAS:K-Ras-IN-1 is a K-Ras inhibitor.Fórmula:C11H13NOSPureza:98.72%Cor e Forma:SolidPeso molecular:207.29Deltarasin HCl
CAS:Deltarasin hinders KRAS-PDEδ, impairs cancer cell growth via a PDEδ pocket, disrupting RAS/RAF signaling and autophagy.Fórmula:C40H37N5O·xHClCor e Forma:SolidPeso molecular:713.144DB07268
CAS:DB07268 is a potent and selective JNK1 inhibitor.Fórmula:C17H15N5O2Pureza:98.2% - 98.91%Cor e Forma:SolidPeso molecular:321.336H05 (TFA)
CAS:6H05 TFA (6H05 trifluoroacetate) is a selective, and allosteric oncogenic mutant K-Ras(G12C) inhibitor.Fórmula:C22H31ClF3N3O4S3Pureza:98.83%Cor e Forma:SolidPeso molecular:590.14Ref: TM-T7326
1mg65,00€2mg90,00€5mg127,00€10mg217,00€25mg358,00€50mg538,00€100mg765,00€1mL*10mM (DMSO)166,00€CMPD1
CAS:CMPD1 is a non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor(apparent Ki (Kiapp): 330 nM).Fórmula:C22H20FNO2Pureza:99.8%Cor e Forma:SolidPeso molecular:349.4Ref: TM-T14988
1mg37,00€5mg104,00€10mg160,00€25mg281,00€50mg442,00€100mg685,00€500mg1.605,00€1mL*10mM (DMSO)114,00€Pyridoxal 5'-phosphate hydrate
CAS:Pyridoxal 5'-phosphate hydrate (PLP)(1:x), the active form of vitamin B6, is a cofactor for many different enzymes involved in transamination reactions,Fórmula:C8H10NO6PPureza:97.52%Cor e Forma:SolidPeso molecular:247.14GSK-114
CAS:GSK-114, a TNNI3K inhibitor with a 25 nM IC50, is 40x more selective than B-Raf and good for in vivo studies.Fórmula:C19H23N5O4SPureza:99.51%Cor e Forma:SolidPeso molecular:417.48SB-590885
CAS:SB590885 is an effective B-Raf inhibitor (Ki: 0.16 nM, in a cell-free assay).Fórmula:C27H27N5O2Pureza:95.42% - 99.06%Cor e Forma:SolidPeso molecular:453.54
