MAPK
As MAPKs são uma família de proteínas quinases envolvidas em uma variedade de processos celulares, incluindo crescimento, proliferação, diferenciação e respostas ao estresse. A via de sinalização MAPK consiste em várias camadas, incluindo ERK, JNK e p38 MAPKs, cada uma desempenhando papéis distintos na função celular. A desregulação da sinalização MAPK está ligada ao câncer, doenças inflamatórias e distúrbios metabólicos. Na CymitQuimica, oferecemos uma ampla gama de inibidores e ativadores de MAPK para apoiar sua pesquisa em biologia celular, transdução de sinais e mecanismos de doenças.
Foram encontrados 887 produtos de "MAPK"
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CMPD1
CAS:CMPD1 is a non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor(apparent Ki (Kiapp): 330 nM).Fórmula:C22H20FNO2Pureza:99.8%Cor e Forma:SolidPeso molecular:349.4Ref: TM-T14988
1mg37,00€5mg104,00€10mg160,00€25mg281,00€50mg442,00€100mg685,00€500mg1.605,00€1mL*10mM (DMSO)114,00€KO-947
CAS:KO-947 is a potent and specific inhibitor of ERK1/2 kinases.
Fórmula:C21H17N5OPureza:97.84%Cor e Forma:SolidPeso molecular:355.39I-49 free base
I-49 free base (Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-6-(tetrahydro-2H-pyran-4-yl)-) is a novelFórmula:C23H26ClF3N4O2Pureza:99.64% - 99.88%Cor e Forma:SolidPeso molecular:482.92Ulixertinib
CAS:Ulixertinib (VRT752271) (BVD-523, VRT752271) is an effective and reversible ERK1/ERK2 inhibitor. The IC50 of Ulixertinib is less than 0.3 nM for ERK2.Fórmula:C21H22Cl2N4O2Pureza:99.31% - 99.95%Cor e Forma:SolidPeso molecular:433.33JNK Inhibitor VIII
CAS:JNK Inhibitor VIII (TCS JNK 6o) is an ATP-competitive selective inhibitor of c-Jun N-terminal kinase (JNK)(IC50 values of 45 nM and 160 nM for JNK-1 and -2,Fórmula:C18H20N4O4Pureza:98.93%Cor e Forma:SolidPeso molecular:356.38Talmapimod
CAS:Talmapimod (SCIO-469): Oral ATP-competitive p38α inhibitor, IC50 = 9 nM (p38α), 90 nM (p38β), >2000-fold selectivity over 20 kinases.Fórmula:C27H30ClFN4O3Pureza:98% - 99.9%Cor e Forma:SolidPeso molecular:513Ref: TM-T12871
1mg50,00€2mg73,00€5mg109,00€10mg168,00€25mg358,00€50mg530,00€100mg758,00€1mL*10mM (DMSO)124,00€SB-590885
CAS:SB590885 is an effective B-Raf inhibitor (Ki: 0.16 nM, in a cell-free assay).Fórmula:C27H27N5O2Pureza:95.42% - 99.06%Cor e Forma:SolidPeso molecular:453.54JNK-IN-7
CAS:JNK-IN-7 (JNK inhibitor) is a selective JNK1/2/3 inhibitor (IC50: 1.54/1.99/0.75 nM).Fórmula:C28H27N7O2Pureza:98.02% - 99.53%Cor e Forma:SolidPeso molecular:493.56Ref: TM-T3598
1mg87,00€2mg158,00€5mg226,00€10mg290,00€25mg522,00€50mg752,00€100mg1.026,00€1mL*10mM (DMSO)245,00€AS601245
CAS:AS601245 is an inhibitor of the c-Jun NH2-terminal kinase (JNK), with neuroprotective properties.Fórmula:C20H16N6SPureza:98% - 99.02%Cor e Forma:SolidPeso molecular:372.45Pimasertib HCl
CAS:Pimasertib HCl, an oral MEK1/2 inhibitor, may thwart tumor growth by blocking RAS/RAF/MEK/ERK signaling.Fórmula:C15H16ClFIN3O3Cor e Forma:SolidPeso molecular:467.66IACS-13909
CAS:IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.Fórmula:C17H18Cl2N6Pureza:98.8%Cor e Forma:SolidPeso molecular:377.27TAK-715
CAS:TAK-715 is a p38 MAPK inhibitor for p38α.Fórmula:C24H21N3OSPureza:99.83%Cor e Forma:SolidPeso molecular:399.51Ref: TM-T6150
1mg38,00€2mg50,00€5mg82,00€10mg94,00€25mg166,00€50mg306,00€100mg480,00€1mL*10mM (DMSO)92,00€1-(4-methansulfinylphenyl)ethanone
CAS:The compound inhibits Ras function and therefore inhibits the abnormal growth of cells.Fórmula:C9H10O2SPureza:99.48%Cor e Forma:SolidPeso molecular:182.24Ref: TM-T8870
1mg49,00€5mg144,00€10mg195,00€25mg273,00€50mg383,00€100mg532,00€200mg718,00€1mL*10mM (DMSO)96,00€MK2-IN-3
CAS:MK2-IN-3 is a potent MK-2 inhibitor, cell-permeable, for rheumatoid arthritis treatment.Fórmula:C21H16N4OPureza:99.01%Cor e Forma:SolidPeso molecular:340.38Ref: TM-T9034
1mg34,00€5mg77,00€10mg111,00€25mg222,00€50mg350,00€100mg505,00€200mg690,00€1mL*10mM (DMSO)57,00€Refametinib
CAS:Refametinib (RDEA119) (RDEA119, Bay 86-9766) is an effective, ATP non-competitive and specific inhibitor of MEK1/2 (IC50: 19/47 nM).Fórmula:C19H20F3IN2O5SPureza:99.85% - >99.99%Cor e Forma:SolidPeso molecular:572.34Ref: TM-T6636
2mg46,00€5mg66,00€10mg87,00€25mg156,00€50mg235,00€100mg344,00€200mg512,00€1mL*10mM (DMSO)84,00€SM-7368
CAS:The NF-κB Activation Inhibitor III, controls the biological activity of NF-κB. It is primarily used for Inflammation/Immunology applications.Fórmula:C10H5ClN4O5SPureza:99.64%Cor e Forma:SolidPeso molecular:328.69Ref: TM-T22115
5mg44,00€10mg71,00€25mg128,00€50mg178,00€100mg268,00€200mg389,00€1mL*10mM (DMSO)52,00€Cefotetan
CAS:Cefotetan, a cephamycin antibiotic, fights various bacteria by disrupting cell wall synthesis.Fórmula:C17H17N7O8S4Pureza:95.72% - 99.38%Cor e Forma:SolidPeso molecular:575.62BIX02189
CAS:BIX 02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and 59 nM).Fórmula:C27H28N4O2Pureza:97.84%Cor e Forma:SolidPeso molecular:440.54Ref: TM-T21295
2mg34,00€5mg50,00€10mg74,00€25mg126,00€50mg210,00€100mg313,00€200mg452,00€1mL*10mM (DMSO)58,00€K-Ras(G12C) inhibitor 9
CAS:K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).Fórmula:C16H21ClIN3O4SPureza:97.33% - 97.45%Cor e Forma:SolidPeso molecular:513.78Ref: TM-T6556
1mg34,00€5mg78,00€10mg108,00€25mg215,00€50mg311,00€100mg425,00€200mg597,00€1mL*10mM (DMSO)108,00€Bentamapimod
CAS:Bentamapimod (AS 602801) is a novel, orally active inhibitor of JNK.
Fórmula:C25H23N5O2SPureza:97.04% - 99.92%Cor e Forma:SolidPeso molecular:457.55Ref: TM-T2675
1g2.080,00€2g2.802,00€2mg46,00€5mg66,00€10mg99,00€25mg162,00€50mg197,00€100mg350,00€500mg1.149,00€
