MAPK
As MAPKs são uma família de proteínas quinases envolvidas em uma variedade de processos celulares, incluindo crescimento, proliferação, diferenciação e respostas ao estresse. A via de sinalização MAPK consiste em várias camadas, incluindo ERK, JNK e p38 MAPKs, cada uma desempenhando papéis distintos na função celular. A desregulação da sinalização MAPK está ligada ao câncer, doenças inflamatórias e distúrbios metabólicos. Na CymitQuimica, oferecemos uma ampla gama de inibidores e ativadores de MAPK para apoiar sua pesquisa em biologia celular, transdução de sinais e mecanismos de doenças.
Foram encontrados 887 produtos de "MAPK"
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APS6-45
CAS:APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.Fórmula:C23H16F8N4O3Pureza:99.39%Cor e Forma:SolidPeso molecular:548.39Ref: TM-T8843
2mg37,00€5mg84,00€10mg120,00€25mg236,00€50mg380,00€100mg583,00€200mg785,00€1mL*10mM (DMSO)92,00€Deltarasin HCl
CAS:Deltarasin hinders KRAS-PDEδ, impairs cancer cell growth via a PDEδ pocket, disrupting RAS/RAF signaling and autophagy.Fórmula:C40H37N5O·xHClCor e Forma:SolidPeso molecular:713.144Ulixertinib
CAS:Ulixertinib (VRT752271) (BVD-523, VRT752271) is an effective and reversible ERK1/ERK2 inhibitor. The IC50 of Ulixertinib is less than 0.3 nM for ERK2.Fórmula:C21H22Cl2N4O2Pureza:99.31% - 99.95%Cor e Forma:SolidPeso molecular:433.331588-A4
CAS:1588-A4 (ARS-1620 Intermediate) is an intermediate of ARS-1620 which is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics.Fórmula:C17H19BrClFN4O2Pureza:98.59%Cor e Forma:SolidPeso molecular:445.71Varenicline Tartrate
CAS:Varenicline Tartrate (CP 526555-18) is a benzazepine derivative that functions as an ALPHA4/BETA2 NICOTINIC RECEPTOR partial agonist.
Fórmula:C13H13N3·C4H6O6Pureza:98.23% - 98.32%Cor e Forma:Tan SolidPeso molecular:361.35ML-098
CAS:ML-098 (CID-7345532) is an activator of the GTP-binding protein Rab7 (EC50: 77.6 nM).Fórmula:C19H19NO3Pureza:99.06% - 99.23%Cor e Forma:SolidPeso molecular:309.36Ref: TM-T4619
1mg39,00€2mg49,00€5mg70,00€10mg99,00€25mg200,00€50mg283,00€100mg394,00€500mg934,00€1mL*10mM (DMSO)88,00€Adagrasib
CAS:View and buy Adagrasib (MRTX849) from TargetMol.MRTX849 is a potent, selective and covalent KRASG12C inhibitor with potential antineoplastic activity. Cited in 2 publications.Fórmula:C32H35ClFN7O2Pureza:99.10% - 99.9%Cor e Forma:SolidPeso molecular:604.12TAK-733
CAS:TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.Fórmula:C17H15F2IN4O4Pureza:98.31% - 99.53%Cor e Forma:SolidPeso molecular:504.23AS601245
CAS:AS601245 is an inhibitor of the c-Jun NH2-terminal kinase (JNK), with neuroprotective properties.Fórmula:C20H16N6SPureza:98% - 99.02%Cor e Forma:SolidPeso molecular:372.45β-Glycerophosphate disodium salt pentahydrate
CAS:β-Glycerophosphate disodium salt pentahydrate is a protein phosphatase inhibitor.Fórmula:C3H7O6PH2ONaPureza:98.94% - ≥98%Cor e Forma:SolidPeso molecular:306.11Temuterkib
CAS:LY3214996 (Temuterkib) is a potent oral ERK1/2 inhibitor with potential cancer-fighting properties.
Fórmula:C22H27N7O2SPureza:99.57% - >99.99%Cor e Forma:SolidPeso molecular:453.56Encorafenib
CAS:Encorafenib (LGX818) is an orally available mutated BRaf V600E inhibitor(IC50=0.3 nM) with potential antineoplastic activity.Fórmula:C22H27ClFN7O4SPureza:99.51% - 99.83%Cor e Forma:SolidPeso molecular:540.01GSK-114
CAS:GSK-114, a TNNI3K inhibitor with a 25 nM IC50, is 40x more selective than B-Raf and good for in vivo studies.Fórmula:C19H23N5O4SPureza:99.51%Cor e Forma:SolidPeso molecular:417.48MRTX1133
CAS:View and buy MRTX1133 from TargetMol.MRTX1133 is a potent, selective, and noncovalent inhibitor of KRAS G12D.Fórmula:C33H31F3N6O2Pureza:97.39% - 99.6%Cor e Forma:SolidPeso molecular:600.63Ref: TM-T9303
1mg177,00€5mg379,00€10mg580,00€25mg893,00€50mg1.251,00€100mg1.639,00€200mg2.215,00€1mL*10mM (DMSO)502,00€APS-2-79
CAS:APS-2-79: KSR-dependent MEK inhibitor, blocks ATP biotin at KSR2, IC50 of 120 nM, disrupts Ras-MAPK signaling.Fórmula:C23H21N3O3Cor e Forma:SolidPeso molecular:387.43Talmapimod
CAS:Talmapimod (SCIO-469): Oral ATP-competitive p38α inhibitor, IC50 = 9 nM (p38α), 90 nM (p38β), >2000-fold selectivity over 20 kinases.Fórmula:C27H30ClFN4O3Pureza:98% - 99.9%Cor e Forma:SolidPeso molecular:513Ref: TM-T12871
1mg50,00€2mg73,00€5mg109,00€10mg168,00€25mg358,00€50mg530,00€100mg758,00€1mL*10mM (DMSO)124,00€ERK-IN-4
CAS:ERK-IN-4 is a cell-permeable ERK inhibitor with potential antiproliferative effects for the study of diseases caused by immune dysfunction.Fórmula:C14H17ClN2O3SPureza:98.92% - 99.84%Cor e Forma:SolidPeso molecular:328.814Ref: TM-T36675
1mg48,00€2mg60,00€5mg87,00€10mg144,00€25mg230,00€50mg341,00€100mg510,00€1mL*10mM (DMSO)104,00€Raf inhibitor 1
CAS:B-Raf inhibitor 1 (B-Raf inhibitor 1) is a potent and selective B-Raf inhibitor.Fórmula:C26H19ClN8Pureza:99.91%Cor e Forma:SolidPeso molecular:478.94GW284543
CAS:GW284543 (UNC10225170) is a selective inhibitor of MEK5 .Fórmula:C23H20N2O3Pureza:99.75%Cor e Forma:SolidPeso molecular:372.42Ulixertinib hydrochloride
CAS:Ulixertinib hydrochloride (Ulixertinib HCl) is an ERK1/2 inhibitor with anticancer and antitumor activity that inhibits the NB cell cycle and promotes apoptosisFórmula:C21H23Cl3N4O2Pureza:99.85%Cor e Forma:SolidPeso molecular:469.79
