MAPK
As MAPKs são uma família de proteínas quinases envolvidas em uma variedade de processos celulares, incluindo crescimento, proliferação, diferenciação e respostas ao estresse. A via de sinalização MAPK consiste em várias camadas, incluindo ERK, JNK e p38 MAPKs, cada uma desempenhando papéis distintos na função celular. A desregulação da sinalização MAPK está ligada ao câncer, doenças inflamatórias e distúrbios metabólicos. Na CymitQuimica, oferecemos uma ampla gama de inibidores e ativadores de MAPK para apoiar sua pesquisa em biologia celular, transdução de sinais e mecanismos de doenças.
Foram encontrados 887 produtos de "MAPK"
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TBAP-001
CAS:TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay and an IC50 of 18 nM in Cell-Based Phosho-ERK Assay.Fórmula:C27H23F2N7O3Pureza:99.58%Cor e Forma:SolidPeso molecular:531.51Ref: TM-T9693
1mg48,00€5mg97,00€10mg156,00€25mg271,00€50mg408,00€100mg567,00€200mg748,00€1mL*10mM (DMSO)113,00€NCB-0846
CAS:NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).Fórmula:C21H21N5O2Pureza:97.04% - 99.89%Cor e Forma:SolidPeso molecular:375.42AMG410
CAS:AMG410 is a non-covalent, dual-modality KRAS inhibitor effective against both GDP (OFF) and GTP (ON) binding independently of the cell cycle and other mutants,Fórmula:C31H32ClF2N7O5Pureza:98.01% - 99.84%Cor e Forma:SoildPeso molecular:656.08AZD0022
CAS:AZD0022 is a selective, reversible, and orally active KRAS G12D inhibitor, exhibits tumour marker inhibition in PDAC and NSCLC models.Fórmula:C34H30F4N6OPureza:98.73%Cor e Forma:SoildPeso molecular:614.64Trametiglue
CAS:Trametiglue, a potent Trametinib derivative, selectively targets KSR-MEK and RAF-MEK through unique binding.Fórmula:C25H24FIN6O5SCor e Forma:SolidPeso molecular:666.46ASK1-IN-6
CAS:ASK1-IN-6 (Compound 32), a selective apoptosis signal-regulating kinase 1 (ASK1) inhibitor, exhibits an IC50 of 25 nM. This compound readily crosses the blood-brain barrier, as evidenced by rat pharmacokinetics showing a clearance/unchanged clearance rate of 1.6/56 L/h/kg and an unbound partition coefficient (Kp,uu) of 0.46. Additionally, ASK1-IN-6 demonstrates anti-inflammatory activity and effectively improves symptoms in the Alzheimer's Disease Tg4510 mouse model.Fórmula:C17H14F4N6O2Peso molecular:410.33SC-68376
CAS:SC-68376 is a potent, reversible, cell-permeable, ATP-competitive, and selective inhibitor of p38 MAP kinase.Fórmula:C15H12N2OPureza:98%Cor e Forma:SolidPeso molecular:236.27ETC-168
CAS:ETC-168 is a selective, orally active MNK inhibitor with IC50 values of 23 nM for MNK1 and 43 nM for MNK2. It demonstrates antiproliferative efficacy both in vivo and in vitro [1].Fórmula:C24H19N5O2Cor e Forma:SolidPeso molecular:409.44Cephradine monohydrate
CAS:Cephradine monohydrate is a β-lactam cephalosporin antibiotic exhibiting broad-spectrum activity against Gram-positive and Gram-negative pathogens.Fórmula:C16H21N3O5SPureza:99.91%Cor e Forma:SolidPeso molecular:367.42Deltarasin
CAS:Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.Fórmula:C40H37N5OPureza:99.4%Cor e Forma:SolidPeso molecular:603.75FMK
CAS:FMK 是一种不可逆的 RSK2 抑制剂，能够共价修饰 RSK 的 C 末端区域。Fórmula:C18H19FN4O2Pureza:99.71%Cor e Forma:SolidPeso molecular:342.37Ref: TM-TQ0310
1mg74,00€2mg96,00€5mg168,00€10mg301,00€25mg512,00€50mg738,00€100mg1.035,00€500mg2.062,00€1mL*10mM (DMSO)187,00€6H05
CAS:6H05 (K-Ras inhibitor) is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).Fórmula:C20H30ClN3O2S3Pureza:98%Cor e Forma:SolidPeso molecular:476.12PLX7904
CAS:PLX7904 (PB04), a selective RAF inhibitor, blocks ERK1/2 in mutant BRAF melanoma without activating it in RAS mutants.Fórmula:C24H22F2N6O3SPureza:99.51% - 99.66%Cor e Forma:SolidPeso molecular:512.53Sulindac sulfide
CAS:Sulindac sulfide: NSAID targeting COX-1, inhibits Ras-Raf-1 and gamma-secretase (IC50: 20.2 μM), active sulinic acid metabolite.Fórmula:C20H17FO2SPureza:99.35%Cor e Forma:SolidPeso molecular:340.41Cot inhibitor-2
CAS:Cot inhibitor-2: Potent, selective Tpl2/MAP3K8 blocker. IC50: 1.6 nM; hampers LPS-induced TNF-α, IC50: 0.3 μM. Orally active.Fórmula:C26H25Cl2FN8Pureza:99.85%Cor e Forma:SolidPeso molecular:539.43Ref: TM-T10866
1mg72,00€5mg158,00€10mg243,00€25mg512,00€50mg753,00€100mg1.074,00€200mg1.444,00€1mL*10mM (DMSO)180,00€B-Raf IN 7
CAS:"B-Raf IN 7 inhibits B-Raf (IC50: 110.23 nM); fights colon, breast, liver, cervical, prostate cancers (IC50: 7.50-12.83 μM)."Fórmula:C15H16N6O3Cor e Forma:SolidPeso molecular:328.33TOPK-p38/JNK-IN-1
CAS:TOPK-p38/JNK-IN-1 (Compound B12) is an orally active inhibitor of the TOPK-p38/JNK signaling pathway, with an IC50 value of 2.14 μM for the inhibition of NOFórmula:C17H15F3N2O4Cor e Forma:SolidPeso molecular:368.31(2Z,3Z)-U0126
CAS:U0126 selectively inhibits MEK1/2, blocks MAPK/ERK signaling, and suppresses Ki-ras-induced cell growth, with IC50s of 72 nM and 58 nM for MEK1/2.Fórmula:C18H16N6S2Cor e Forma:SolidPeso molecular:380.49BRAF inhibitor
CAS:BRAF inhibitor is an inhibitor of B-Raf.Fórmula:C22H18F2N4O3SPureza:98.2% - 98.41%Cor e Forma:SolidPeso molecular:456.47Ref: TM-T10599
1mg47,00€5mg93,00€10mg144,00€25mg250,00€50mg393,00€100mg560,00€200mg812,00€1mL*10mM (DMSO)104,00€SR-3737
CAS:SR-3737 is potent both JNK3 and p38 inhibitor.Fórmula:C29H25FN4O4Pureza:98%Cor e Forma:SolidPeso molecular:512.53
