MAPK
As MAPKs são uma família de proteínas quinases envolvidas em uma variedade de processos celulares, incluindo crescimento, proliferação, diferenciação e respostas ao estresse. A via de sinalização MAPK consiste em várias camadas, incluindo ERK, JNK e p38 MAPKs, cada uma desempenhando papéis distintos na função celular. A desregulação da sinalização MAPK está ligada ao câncer, doenças inflamatórias e distúrbios metabólicos. Na CymitQuimica, oferecemos uma ampla gama de inibidores e ativadores de MAPK para apoiar sua pesquisa em biologia celular, transdução de sinais e mecanismos de doenças.
Foram encontrados 887 produtos de "MAPK"
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KRas G12C inhibitor 3
CAS:KRas G12C inhibitor 3 is a compound that inhibits KRas G12C.Fórmula:C32H36ClN7O2Pureza:98%Cor e Forma:SolidPeso molecular:586.13MW108
CAS:MW108 is an active site targeted, CNS-active, p38αMAPK inhibitor.Fórmula:C21H19ClN4Cor e Forma:SolidPeso molecular:362.86(S)-CCG-1423
(S)-CCG-1423, a stereoisomer, inhibits Rho to block myocardin-related transcription factor A & serum response signaling.Fórmula:C18H13ClF6N2O3Pureza:98%Cor e Forma:SolidPeso molecular:454.8Cuspin-1
CAS:Cuspin-1, a small molecule, increases SMN levels by 50% in SMA by boosting ERK phosphorylation and Ras-Raf-MEK signaling.Fórmula:C13H10BrNOCor e Forma:SolidPeso molecular:276.13K-Ras G12C-IN-3
CAS:K-Ras G12C-IN-3: novel, irreversible inhibitor of K-Ras G12C mutant protein for cancer treatment.Fórmula:C21H19Cl3N2O3Cor e Forma:SolidPeso molecular:453.75BRAF inhibitor
CAS:BRAF inhibitor is an inhibitor of B-Raf.Fórmula:C22H18F2N4O3SPureza:98.2% - 98.41%Cor e Forma:SolidPeso molecular:456.47Ref: TM-T10599
1mg47,00€5mg93,00€10mg144,00€25mg250,00€50mg393,00€100mg560,00€200mg812,00€1mL*10mM (DMSO)104,00€ML 3403
CAS:p38 MAPK inhibitor; IC50: 0.38μM. Reduces IL-1β & TNF-α release in PBMC assay; IC50: 0.039μM & 0.16μM.Fórmula:C23H21FN4SCor e Forma:SolidPeso molecular:404.5CCG-232601
CAS:CCG-232601 is a inhibitor of the Rho/MRTF/SRF transcriptional pathway.Fórmula:C24H20ClF2N3O2Pureza:98%Cor e Forma:SolidPeso molecular:455.88Tinlorafenib
CAS:Tinlorafenib (PF-07284890), a BRAFV600E/K inhibitor, is oral & CNS-permeable, used for BRAF-linked CNS tumors. IC50: 4.25/2.7 nM.Fórmula:C19H19ClF2N4O3SCor e Forma:SolidPeso molecular:456.89PHT-7.3
CAS:PHT-7.3 is a selective connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain inhibitorFórmula:C24H23N3O3SPureza:98%Cor e Forma:SolidPeso molecular:433.52MEK inhibitor
CAS:MEK inhibitor is a MEK receptor and cell cycle protein/CDK complex inhibitor with antitumor activity that can be used to study tumor cell proliferation.Fórmula:C26H26N4O2Pureza:97.48%Cor e Forma:SolidPeso molecular:426.51BRAF V600E/CRAF-IN-1
CAS:BRAF V600E/CRAF-IN-1: potent BRAF/CRAF inhibitor, induces cell cycle arrest and apoptosis in HCT-116 cells, promising for cancer research.Fórmula:C25H17F6N3O2Cor e Forma:SolidPeso molecular:505.41NSC-70220
CAS:SOS1-IN-1 is an inhibitor of SOS1.Fórmula:C22H15NO2Pureza:98%Cor e Forma:SolidPeso molecular:325.36KRAS inhibitor-6
CAS:KRAS inhibitor-6 is a potent KRAS G12C inhibitor.Fórmula:C27H30ClF2N5O3Pureza:98%Cor e Forma:SolidPeso molecular:546.01(R)-STU104
CAS:(R)-STU104 is a TAK1-MKK3 protein-protein interaction (PPI) inhibitor. (R)-STU104 is a candidate compound for the treatment of ulcerative colitis.Fórmula:C18H18O4Pureza:98.91% - 99.42%Cor e Forma:SolidPeso molecular:298.33REDX05358
CAS:REDX05358: Selective pan RAF inhibitor for BRAF/RAS mutant tumors with high affinity, safety, and low paradoxical activation.Fórmula:C26H21ClN4O3Cor e Forma:SolidPeso molecular:472.92KRAS inhibitor-3
CAS:KRAS inhibitor-3 targets WT/oncogenic KRAS; high affinity (KD: 0.28-0.74 μM); disrupts KRAS-Raf interaction.Fórmula:C25H27N5OCor e Forma:SolidPeso molecular:413.51CK1-IN-2
CAS:CK1-IN-2 (compound Nr.4) is a potent CK1 inhibitor p38a, and is used in DUX4 overexpression-associated diseases, such as muscular dystrophy.Fórmula:C17H12FN3O2Pureza:99.31%Cor e Forma:SolidPeso molecular:309.29Spiclomazine HCl
CAS:Spiclomazine HCl induced apoptosis in pancreatic cancer cells, which was generally related to cell viability, migration, and invasion.Fórmula:C22H25Cl2N3OS2Cor e Forma:SolidPeso molecular:482.49BAY-846
CAS:BAY-846: allosteric MEK inhibitor, long-lasting, highly bioavailable, low brain entry, effective in K-Ras A549 model.Fórmula:C19H13F4IN4O4SCor e Forma:SolidPeso molecular:596.29
