MAPK
As MAPKs são uma família de proteínas quinases envolvidas em uma variedade de processos celulares, incluindo crescimento, proliferação, diferenciação e respostas ao estresse. A via de sinalização MAPK consiste em várias camadas, incluindo ERK, JNK e p38 MAPKs, cada uma desempenhando papéis distintos na função celular. A desregulação da sinalização MAPK está ligada ao câncer, doenças inflamatórias e distúrbios metabólicos. Na CymitQuimica, oferecemos uma ampla gama de inibidores e ativadores de MAPK para apoiar sua pesquisa em biologia celular, transdução de sinais e mecanismos de doenças.
Foram encontrados 924 produtos para "MAPK".
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Cephradine
CAS:Cephradine (Anspor) is a beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity.Fórmula:C16H19N3O4SPureza:99.63%Cor e Forma:White Crystalline Powder; Polymorphic SolidPeso molecular:349.405CHIR 98024
CAS:CHIR 98024: strong GSK-3α/β blocker, IC50 0.65/0.58 nM, selective over Cdc2/ERK2.Fórmula:C20H17Cl2N9O2Pureza:99.45%Cor e Forma:SolidPeso molecular:486.314GW284543
CAS:GW284543 (UNC10225170) is a selective inhibitor of MEK5 .Fórmula:C23H20N2O3Pureza:99.75%Cor e Forma:SolidPeso molecular:372.4165SHP389
CAS:SHP389 is a highly effective allosteric inhibitor of SHP2, inhibiting SHP2 and p-ERK, used in cancer research.Fórmula:C23H29ClN8O2Pureza:98.24%Cor e Forma:SolidPeso molecular:484.982Ulixertinib hydrochloride
CAS:Ulixertinib hydrochloride (Ulixertinib HCl) is an ERK1/2 inhibitor with anticancer and antitumor activity that inhibits the NB cell cycle and promotes apoptosisFórmula:C21H23Cl3N4O2Pureza:99.85%Cor e Forma:SolidPeso molecular:469.792TBAP-001
CAS:TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay and an IC50 of 18 nM in Cell-Based Phosho-ERK Assay.Fórmula:C27H23F2N7O3Pureza:99.28% - 99.58%Cor e Forma:Yellow SolidPeso molecular:531.5134NCB-0846
CAS:NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).Fórmula:C21H21N5O2Pureza:97.04% - 99.89%Cor e Forma:SolidPeso molecular:375.4237AZD0022
CAS:AZD0022 is a selective, reversible, and orally active KRAS G12D inhibitor, exhibits tumour marker inhibition in PDAC and NSCLC models.Fórmula:C34H30F4N6OPureza:98.73%Cor e Forma:Yellow SolidPeso molecular:614.64BBO-11818
CAS:BBO-11818 is an oral pan-KRAS inhibitor suppressing MAPK/ERK signaling.Fórmula:C34H33F6N7O3SPureza:98.19%Peso molecular:733.73AMG410
CAS:AMG410 is a non-covalent, dual-modality KRAS inhibitor effective against both GDP (OFF) and GTP (ON) binding independently of the cell cycle and other mutants,Fórmula:C31H32ClF2N7O5Pureza:98.01% - 99.84%Cor e Forma:White SolidPeso molecular:656.08ASK1-IN-6
CAS:ASK1-IN-6 (Compound 32), a selective apoptosis signal-regulating kinase 1 (ASK1) inhibitor, exhibits an IC50 of 25 nM. This compound readily crosses the blood-brain barrier, as evidenced by rat pharmacokinetics showing a clearance/unchanged clearance rate of 1.6/56 L/h/kg and an unbound partition coefficient (Kp,uu) of 0.46. Additionally, ASK1-IN-6 demonstrates anti-inflammatory activity and effectively improves symptoms in the Alzheimer's Disease Tg4510 mouse model.Fórmula:C17H14F4N6O2Cor e Forma:SolidPeso molecular:410.336H05
CAS:6H05 (K-Ras inhibitor) is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).Fórmula:C20H30ClN3O2S3Pureza:98%Cor e Forma:SolidPeso molecular:476.12IQ-1S
CAS:IQ-1S is an inhibitor of NF-κB/activating protein 1 (AP-1) with an IC50 of 1.8 μM. It exhibits high binding affinity to all three JNKs, with Kd values for JNK3, JNK2, and JNK1 being 87 nM, 360 nM, and 390 nM, respectively.Fórmula:C15H8N3NaOCor e Forma:SolidPeso molecular:269.23Cephradine monohydrate
CAS:Cephradine monohydrate is a β-lactam cephalosporin antibiotic exhibiting broad-spectrum activity against Gram-positive and Gram-negative pathogens.Fórmula:C16H21N3O5SPureza:99.91%Cor e Forma:Yellow SolidPeso molecular:367.42Deltarasin
CAS:Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.Fórmula:C40H37N5OPureza:99.4%Cor e Forma:SolidPeso molecular:603.75ETC-168
CAS:ETC-168 is a selective, orally active MNK inhibitor with IC50 values of 23 nM for MNK1 and 43 nM for MNK2. It demonstrates antiproliferative efficacy both in vivo and in vitro [1].Fórmula:C24H19N5O2Cor e Forma:SolidPeso molecular:409.44SC-68376
CAS:SC-68376 is a potent, reversible, cell-permeable, ATP-competitive, and selective inhibitor of p38 MAP kinase.Fórmula:C15H12N2OPureza:98%Cor e Forma:SolidPeso molecular:236.27FMK
CAS:FMK 是一种不可逆的 RSK2 抑制剂，能够共价修饰 RSK 的 C 末端区域。Fórmula:C18H19FN4O2Pureza:99.71%Cor e Forma:SolidPeso molecular:342.3675PLX7904
CAS:PLX7904 (PB04), a selective RAF inhibitor, blocks ERK1/2 in mutant BRAF melanoma without activating it in RAS mutants.Fórmula:C24H22F2N6O3SPureza:99.51% - 99.66%Cor e Forma:SolidPeso molecular:512.532Sulindac sulfide
CAS:Sulindac sulfide: NSAID targeting COX-1, inhibits Ras-Raf-1 and gamma-secretase (IC50: 20.2 μM), active sulinic acid metabolite.Fórmula:C20H17FO2SPureza:99.35%Cor e Forma:SolidPeso molecular:340.41
