MAPK
As MAPKs são uma família de proteínas quinases envolvidas em uma variedade de processos celulares, incluindo crescimento, proliferação, diferenciação e respostas ao estresse. A via de sinalização MAPK consiste em várias camadas, incluindo ERK, JNK e p38 MAPKs, cada uma desempenhando papéis distintos na função celular. A desregulação da sinalização MAPK está ligada ao câncer, doenças inflamatórias e distúrbios metabólicos. Na CymitQuimica, oferecemos uma ampla gama de inibidores e ativadores de MAPK para apoiar sua pesquisa em biologia celular, transdução de sinais e mecanismos de doenças.
Foram encontrados 887 produtos de "MAPK"
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PF-04880594
CAS:PF-04880594 is a potent and selective RAF inhibitor which inhibits both wild-type and mutant BRAF and CRAF. PF-04880594 exhibits antitumor activity [1].Fórmula:C19H16F2N8Cor e Forma:SolidPeso molecular:394.38KRAS G12C inhibitor 48
KRAS G12C inhibitor 48: potent with IC50 639.91 nM; hampers H358, H23, A549 cell growth with IC50s of 0.796, 6.33, 16.14 µM, respectively.Fórmula:C36H39ClN8O2Cor e Forma:SolidPeso molecular:651.2KRAS G12C inhibitor 31
CAS:KRAS G12C inhibitor 31 is an inhibitor of KRAS G12C that can be used to study cancer.Fórmula:C25H22ClFN6O3Cor e Forma:SolidPeso molecular:508.93L-167307
CAS:L-167307 is a p38 kinase inhibitor.Fórmula:C22H17FN2OSPureza:98%Cor e Forma:SolidPeso molecular:376.45KRAS4b-IN-D14
CAS:KRAS4b-IN-D14 inhibits oncogenic KRAS4b, shrinks tumors, and induces cancer cell apoptosis.Fórmula:C24H24ClN5O4Cor e Forma:SolidPeso molecular:481.93HPK1-IN-15
CAS:HPK1-IN-15 selectively inhibits HPK1, a MAP4K family kinase, potentially aiding in cancer treatment.Fórmula:C24H21ClF3N5Cor e Forma:SolidPeso molecular:471.91KRAS G12D inhibitor 13
CAS:KRAS G12D inhibitor 13 targets KRAS G12D-mediated cancers with potency (WO2021108683A1, cmpd 142).Fórmula:C31H33F2N7O3Cor e Forma:SolidPeso molecular:589.64KRAS G12C inhibitor 42
CAS:KRAS G12C inhibitor 42 targets KRAS G12C for potential cancer therapy. (Patent WO2020146613A1, compound 10)Fórmula:C33H34FN7O2Cor e Forma:SolidPeso molecular:579.67p38-α MAPK-IN-4
CAS:p38-α MAPK-IN-4 (Compound 69) is a selective inhibitor of p38α MAPK, demonstrating potent inhibition with an IC50 of 1.5 μM.Fórmula:C17H13BrN2OCor e Forma:SolidPeso molecular:341.2LCRF-0004
CAS:LCRF-0004 inhibits RON kinase, key in KRAS-driven pancreatic cancer, reducing cell migration and enhancing chemo sensitivity.Fórmula:C28H18F4N6O2SCor e Forma:SolidPeso molecular:578.54KRAS G12C inhibitor 39
CAS:KRAS G12C inhibitor 39 effectively targets KRAS G12C, a key protein in cancer research.Fórmula:C37H43N9O2Cor e Forma:SolidPeso molecular:645.8MNK1/2-IN-5
CAS:MNK1/2-IN-5 is a potent and selective MNK1/2 inhibitor with anticancer activity and can be used to study solid tumors and hematological malignancies.Fórmula:C17H16N4O2Pureza:98.04%Cor e Forma:SolidPeso molecular:308.33Ref: TM-T60733
1mg60,00€2mg86,00€5mg130,00€10mg187,00€25mg338,00€50mg497,00€100mg708,00€200mg973,00€1mL*10mM (DMSO)138,00€CBS-3595
CAS:CBS-3595: potent p38α MAPK/PDE-4 dual inhibitor, strong anti-inflammatory, low toxicity.Fórmula:C18H17FN4O2SPureza:98%Cor e Forma:SolidPeso molecular:372.42GP17
CAS:GP17 is a type II kinase inhibitor of the IRE1α endoribonuclease that acts by targeting the ATP-binding pocket of IRE1α.Fórmula:C26H21F3N4OCor e Forma:SolidPeso molecular:462.47JNK-1-IN-1
CAS:JNK-1-IN-1 is an inhibitor specifically targeting JNK-1, also exhibiting inhibition of MKK7 with an IC50 value of 7.8μM.Fórmula:C24H22N6SCor e Forma:SolidPeso molecular:426.54SR-3306
CAS:SR-3306 is a brain-penetrant and selective pan-JNK (JNK1/2/3) inhibitor with IC50 values of 67 nM, 283 nM, 159 nM.Cost-effective and quality-assured.Fórmula:C28H26N8OPureza:99.38% - 99.71%Cor e Forma:SolidPeso molecular:490.56Ref: TM-T16927
1mg49,00€5mg98,00€10mg152,00€25mg288,00€50mg520,00€100mg835,00€500mg1.674,00€1mL*10mM (DMSO)108,00€ADTL-EI1712
CAS:ADTL-EI1712: ERK1/2/5 inhibitor (ERK1 IC50=40.43nM, ERK5=64.5nM), blocks HL-60/MKN74 cell growth, not HeLa; effective in MKN74 mouse model.Fórmula:C22H18Cl2N4O2S2Cor e Forma:SolidPeso molecular:505.44GNE-1858
CAS:GNE-1858 inhibits HPK1; IC50: 1.9 nM for wild-type, 1.9 nM (HPK1-TSEE), 4.5 nM (HPK1-SA).Fórmula:C21H26F2N8Pureza:99.36%Cor e Forma:SolidPeso molecular:428.48Ref: TM-T11438
1mg163,00€5mg334,00€10mg500,00€25mg807,00€50mg1.099,00€100mg1.485,00€500mg2.962,00€1mL*10mM (DMSO)358,00€JX 401
CAS:JX 401 is a p38α inhibitor.Fórmula:C21H25NO2SPureza:98%Cor e Forma:SolidPeso molecular:355.49
