MAPK
As MAPKs são uma família de proteínas quinases envolvidas em uma variedade de processos celulares, incluindo crescimento, proliferação, diferenciação e respostas ao estresse. A via de sinalização MAPK consiste em várias camadas, incluindo ERK, JNK e p38 MAPKs, cada uma desempenhando papéis distintos na função celular. A desregulação da sinalização MAPK está ligada ao câncer, doenças inflamatórias e distúrbios metabólicos. Na CymitQuimica, oferecemos uma ampla gama de inibidores e ativadores de MAPK para apoiar sua pesquisa em biologia celular, transdução de sinais e mecanismos de doenças.
Foram encontrados 887 produtos de "MAPK"
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Anti-inflammatory agent 33
CAS:Agent 33: potent p38α inhibitor, reduces NO, iNOS, COX-2, p-p38α, p-MK2; shows anti-inflammatory effects.Fórmula:C22H15N3O5SCor e Forma:SolidPeso molecular:433.44RSK2-IN-3
CAS:RSK2-IN-3 (Compound 26) is a covalent, reversible inhibitor of RPS6KA3 (RSK2) kinase.Fórmula:C24H26N4O5Cor e Forma:SolidPeso molecular:450.49MLKL-IN-5
CAS:MLKL-IN-5 is a potent MLKL inhibitor that mediates necroptosis .Fórmula:C18H20N6O4SCor e Forma:SolidPeso molecular:416.45ZG-10
CAS:ZG-10 (JNK-IN-2) is an inhibitor of JNK, blocking JNK1, JNK2, and JNK3, and is used in studies of SARS-CoV-2 virus infection.Fórmula:C28H27N7O2Pureza:99.41% - 99.91%Cor e Forma:SolidPeso molecular:493.56HPK1-IN-28
CAS:HPK1-IN-28 inhibits HPK1, boosts anti-tumor immunity, and shows promise in immune disease research per patent WO2021175270A1.Fórmula:C25H22F3N5O4Cor e Forma:SolidPeso molecular:513.47JTP-70902
CAS:JTP-70902 is a protein kinase inhibitor with antineoplastic activity.Fórmula:C24H21BrFN5O5SCor e Forma:SolidPeso molecular:590.42MEK-IN-4
CAS:MEK-IN-4 is a MEK inhibitor that can be used to study inflammatory diseases and cancer.Fórmula:C21H18N4OSPureza:98.35% - 99.16%Cor e Forma:SolidPeso molecular:374.46Antifungal agent 46
CAS:Compound 2f (Antifungal Agent 46) is a potent antifungal that inhibits Ras signaling by targeting protein farnesyltransferase [1].Fórmula:C26H28BrF3N4O2Pureza:98%Cor e Forma:SolidPeso molecular:565.43p38 MAP Kinase Inhibitor IV
CAS:p38 MAPK inhibitor IV blocks p38α/β/γ/δ with IC50s 0.13-8.63 μM and stops TNF-α/IL-1β at 22/44 nM in human cells.Fórmula:C12H4Cl6O4SCor e Forma:SolidPeso molecular:456.94TAK1/MAP4K2 inhibitor 1
CAS:TAK1/MAP4K2 inhibitor 1 (compound 5) is a dual kinase inhibitor of TAK1 and MAP4K2 with IC50 values of 41.1 nM and 18.2 nM, respectively.Fórmula:C29H31F3N6O2Pureza:98%Cor e Forma:SolidPeso molecular:552.59KRAS inhibitor-10
CAS:KRAS inhibitor-10: potent, selective KRAS protein blocker; effective in various cancers; oral; tetrahydroisoquinoline class.Fórmula:C30H37N3O5Cor e Forma:SolidPeso molecular:519.63KRAS G12C inhibitor 45
CAS:KRAS G12C inhibitor 45 is a potent KRAS G12C inhibitor .Fórmula:C32H33F2N5O5SCor e Forma:SolidPeso molecular:637.7JNK3 inhibitor-4
CAS:JNK3 inhibitor-4: potent, selective JNK3 blocker (IC50=1.0nM), neuroprotective, BBB-permeable.
Fórmula:C28H27N7OCor e Forma:SolidPeso molecular:477.56HPK1-IN-17
CAS:HPK1-IN-17 selectively inhibits HPK1, a MAP4Ks family kinase from blood progenitor cells; useful against HPK1-related diseases like cancer.Fórmula:C26H28N6OCor e Forma:SolidPeso molecular:440.54KRAS inhibitor-17
CAS:KRAS inhibitor-17 blocks G12C mutation (IC50: 3.37μM) and p-ERK in MIA PaCA-2 (IC50: 9.25μM). Could target pancreatic, colorectal, lung cancers.Fórmula:C21H18Cl2FN3O2SCor e Forma:SolidPeso molecular:466.36BRAF V600E/CRAF-IN-2
CAS:Potent BRAFV600E/CRAF inhibitor, IC50: 0.888/0.229 μM, induces G0/G1 arrest and apoptosis in HCT-116 cells, potential for cancer research.Fórmula:C30H30F3N5O2Cor e Forma:SolidPeso molecular:549.59KRAS4b-PDEδ stabilizer C19
CAS:KRAS4b-PDEδ stabilizer C19 is a stabilizer of the KRAS4b-PDEδ complex which decreases the proliferation of colorectal cancer cells, and increases apoptosis viaFórmula:C18H20Cl2N2O3Cor e Forma:SolidPeso molecular:383.27SCH 51344
CAS:SCH 51344 inhibits Ras induced malignant transformation. SCH 51344 prevents anchorage-independent growth of oncogene transformed fibroblasts [1].Fórmula:C16H20N4O3Cor e Forma:SolidPeso molecular:316.36LX-3
CAS:LX-3 activates p38 MAPK, enabling expression of genes normally silenced by DNA methylation.Fórmula:C20H13BrN4OSCor e Forma:SolidPeso molecular:437.31KRAS G12C inhibitor 47
CAS:KRAS G12C inhibitor 47 strongly blocks KRAS G12C (IC50: 0.172 μM) and p-ERK in cells; promising for pancreatic, colorectal, lung cancers.Fórmula:C30H28ClFN4O3Cor e Forma:SolidPeso molecular:547.02
