MAPK
As MAPKs são uma família de proteínas quinases envolvidas em uma variedade de processos celulares, incluindo crescimento, proliferação, diferenciação e respostas ao estresse. A via de sinalização MAPK consiste em várias camadas, incluindo ERK, JNK e p38 MAPKs, cada uma desempenhando papéis distintos na função celular. A desregulação da sinalização MAPK está ligada ao câncer, doenças inflamatórias e distúrbios metabólicos. Na CymitQuimica, oferecemos uma ampla gama de inibidores e ativadores de MAPK para apoiar sua pesquisa em biologia celular, transdução de sinais e mecanismos de doenças.
Foram encontrados 887 produtos de "MAPK"
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SOS1-IN-3
CAS:SOS1-IN-3 is an effective inhibitor of SOS1 (son of sevenless homolog 1) (IC50=5 nM). SOS1-IN-3 shows antitumor activity.Fórmula:C21H21F3N4OCor e Forma:SolidPeso molecular:402.41SOS1 activator 1
CAS:SOS1 activator 1 enhances SOS1's GDP-GTP exchange on Ras (Kd: 44 nM).Fórmula:C26H32ClFN6Cor e Forma:SolidPeso molecular:483.026-T-GDP
CAS:6-T-GDP (6-Thioguanosine 5'-diphosphate) is a metabolite of thiopurine. It inhibits the activity of Rac1, thereby reducing the transcription of inflammatory factors and the expression of cell adhesion molecules, which ultimately suppresses leukocyte migration and the occurrence of tissue inflammation.Fórmula:C10H15N5O10P2SCor e Forma:SolidPeso molecular:459.27RMM-46
CAS:RMM-46 is a reversible covalent inhibitor with high ligand efficiency and selectivity for MSK/RSK family kinases.Fórmula:C24H26N4O5Pureza:98.89%Cor e Forma:SolidPeso molecular:450.49GDC-0879
CAS:GDC-0879 (AR-00341677) is a novel, potent and selective B-Raf inhibitor with IC50 of 0.13 nM with activity against c-Raf as well.Fórmula:C19H18N4O2Pureza:99.62%Cor e Forma:SolidPeso molecular:334.37Ref: TM-T6320
1mg35,00€2mg50,00€5mg74,00€10mg105,00€25mg205,00€50mg334,00€100mg537,00€200mg765,00€1mL*10mM (DMSO)82,00€mSIRK
CAS:mSIRK (G-Protein βγ Binding Peptide) is an ERK1 and ERK2 dual activator that promotes alpha-subunit dissociation.Fórmula:C93H150N20O25Pureza:99.26%Cor e Forma:SolidPeso molecular:1948.31Tpl2-IN-I
CAS:Tpl2-IN-I is an inhibitor of tumour progression locus 2 (Tpl2) kinase.Fórmula:C21H14ClFN6Pureza:98%Cor e Forma:SolidPeso molecular:404.83NSC1011
CAS:NSC1011 is an inhibitor of ras converting enzyme 1 (Rce1).Fórmula:C23H18N2O3Pureza:98%Cor e Forma:SolidPeso molecular:370.4AZD6703 free base
CAS:AZD6703 is a potent, selective and reversible orally bioavailable inhibitor of p38 mitogen-activated protein kinase 14 (MAPK14).Fórmula:C24H27N5O2Cor e Forma:SolidPeso molecular:417.5Kobe2601
CAS:Kobe2601 is a Kobe0065 and Kobe02602 water-soluble analog. It displays inhibitory activity towards Ras-Raf binding.Fórmula:C13H10FN5O4SPureza:98%Cor e Forma:SolidPeso molecular:351.31GSK329
CAS:GSK329 selectively inhibits TNNI3K, showing cardioprotection in ischemic heart models.Fórmula:C19H14Cl2F3N5O2Pureza:98%Cor e Forma:SolidPeso molecular:472.25Ref: TM-T24109
1mg50,00€2mg72,00€5mg110,00€10mg173,00€25mg295,00€50mg424,00€100mg577,00€200mg778,00€1mL*10mM (DMSO)130,00€HCI-2184
CAS:HCI-2184 is an inhibitor of AXL kinase and Nek2 that acts by successfully mitigating drug resistance in bortezomib-resistant multiple myeloma.Fórmula:C23H28ClN7O2SPureza:98%Cor e Forma:SolidPeso molecular:502.03GSK649A
CAS:GSK649A is a novel activator of Satellite Cell Proliferation, it could enhance repair of Damaged Muscle.Fórmula:C15H12ClFN6OSPureza:98%Cor e Forma:SolidPeso molecular:378.81CP-281384
CAS:CP-281384 is a potent, p38alpha-selective inhibitor.Fórmula:C18H14F2N4OPureza:98%Cor e Forma:SolidPeso molecular:340.33RBC6
CAS:RBC6 is an inhibitor of the binding of Ral to its effector RALBP1.Fórmula:C16H14Cl2N4O2Pureza:98%Cor e Forma:SolidPeso molecular:365.21CP-944629
CAS:CP-944629 is a novel, potent, and selective inhibitor of p38alpha.Fórmula:C19H15F3N4OPureza:98%Cor e Forma:SolidPeso molecular:372.34ERK1/2 inhibitor 1
CAS:ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively.
Fórmula:C29H32ClN5O4Pureza:98.81%Cor e Forma:SolidPeso molecular:550.05PF-05381941
CAS:PF-05381941 is a selective and potent dual inhibitor of TAK1 and p38α that inhibits the kinase activity of TAK1 by binding to its active site.Fórmula:C27H26N6O2Pureza:98.04%Cor e Forma:SolidPeso molecular:466.53MEK-IN-1
CAS:MEK-IN-1 is a MEK inhibitor.Fórmula:C24H20N4O4Pureza:98%Cor e Forma:SolidPeso molecular:428.44BNC-1
CAS:BNC-1 reduces amyloid in mice, enhances synapses by activating Elk-1.Fórmula:C16H14N2O3Pureza:98%Cor e Forma:SolidPeso molecular:282.29
