MAPK
As MAPKs são uma família de proteínas quinases envolvidas em uma variedade de processos celulares, incluindo crescimento, proliferação, diferenciação e respostas ao estresse. A via de sinalização MAPK consiste em várias camadas, incluindo ERK, JNK e p38 MAPKs, cada uma desempenhando papéis distintos na função celular. A desregulação da sinalização MAPK está ligada ao câncer, doenças inflamatórias e distúrbios metabólicos. Na CymitQuimica, oferecemos uma ampla gama de inibidores e ativadores de MAPK para apoiar sua pesquisa em biologia celular, transdução de sinais e mecanismos de doenças.
Foram encontrados 888 produtos de "MAPK"
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REDX05358
CAS:REDX05358: Selective pan RAF inhibitor for BRAF/RAS mutant tumors with high affinity, safety, and low paradoxical activation.Fórmula:C26H21ClN4O3Cor e Forma:SolidPeso molecular:472.92Migoprotafib
CAS:Migoprotafib (GDC-1971) is a potent and highly selective SHP2 (Src Homology-2 Domain-Containing Phosphatase 2) inhibitor for advanced solid tumours.Fórmula:C25H26N8OPureza:98.31%Cor e Forma:SolidPeso molecular:454.53Ref: TM-T62798
1mg130,00€5mg313,00€10mg497,00€25mg982,00€50mg1.603,00€100mg2.592,00€1mL*10mM (DMSO)341,00€SW-034538
CAS:SW-034538 is a TAO2 inhibitor (IC 50= 300 nM).Fórmula:C18H20N4O3S2Cor e Forma:SolidPeso molecular:404.51KRAS inhibitor-3
CAS:KRAS inhibitor-3 targets WT/oncogenic KRAS; high affinity (KD: 0.28-0.74 μM); disrupts KRAS-Raf interaction.Fórmula:C25H27N5OCor e Forma:SolidPeso molecular:413.51HPK1-IN-24
CAS:HPK1-IN-24 (example 51) has potential to be used in the cancer research which is an inhibitor of hematopoietic progenitor kinase 1 (HPK1) (Ki = 100 nM) [1].Fórmula:C19H14FN5Cor e Forma:SolidPeso molecular:331.35(R)-CE3F4
CAS:(R)-CE3F4 is a selective inhibitor of exchange protein directly activated by cAMP isoform 1 (Epac1)(IC50 of 4.2 μM),Fórmula:C11H10Br2FNOCor e Forma:SolidPeso molecular:351.01Ras modulator-1
CAS:Ras modulator-1 is a modulator of Ras.Fórmula:C29H21N5O4SCor e Forma:SolidPeso molecular:535.57B-Raf IN 6
CAS:B-Raf IN 6: potent B-Raf kinase inhibitor, IC50 of 1.7 nM, doesn't target PXR, metabolically stable, potential in cancer research.Fórmula:C24H21F3N6O2S2Cor e Forma:SolidPeso molecular:546.59pan-KRAS-IN-16
CAS:3344 is an inhibitor of KRAS-effector interactions，with an affnity of 126nm.Fórmula:C24H26N2O3Pureza:98%Cor e Forma:SolidPeso molecular:390.47LX-3
CAS:LX-3 activates p38 MAPK, enabling expression of genes normally silenced by DNA methylation.Fórmula:C20H13BrN4OSCor e Forma:SolidPeso molecular:437.31CK1-IN-2
CAS:CK1-IN-2 (compound Nr.4) is a potent CK1 inhibitor p38a, and is used in DUX4 overexpression-associated diseases, such as muscular dystrophy.Fórmula:C17H12FN3O2Pureza:99.31%Cor e Forma:SolidPeso molecular:309.29KRAS G12C inhibitor 47
CAS:KRAS G12C inhibitor 47 strongly blocks KRAS G12C (IC50: 0.172 μM) and p-ERK in cells; promising for pancreatic, colorectal, lung cancers.Fórmula:C30H28ClFN4O3Cor e Forma:SolidPeso molecular:547.02LY-2584702 hydrochloride
CAS:Ly-2584702 hydrochloride is a p70S6K selective ATP competitive inhibitor with IC50 of 4 nM.In the S6K1 enzyme assay, the IC50 of LY-2584702 was 2 nM.Fórmula:C21H20ClF4N7Pureza:98%Cor e Forma:SolidPeso molecular:481.88SOS1-IN-3
CAS:SOS1-IN-3 is an effective inhibitor of SOS1 (son of sevenless homolog 1) (IC50=5 nM). SOS1-IN-3 shows antitumor activity.Fórmula:C21H21F3N4OCor e Forma:SolidPeso molecular:402.41(2Z,3Z)-U0126
CAS:U0126 selectively inhibits MEK1/2, blocks MAPK/ERK signaling, and suppresses Ki-ras-induced cell growth, with IC50s of 72 nM and 58 nM for MEK1/2.Fórmula:C18H16N6S2Cor e Forma:SolidPeso molecular:380.49Spiclomazine HCl
CAS:Spiclomazine HCl induced apoptosis in pancreatic cancer cells, which was generally related to cell viability, migration, and invasion.Fórmula:C22H25Cl2N3OS2Cor e Forma:SolidPeso molecular:482.49SOS1 activator 1
CAS:SOS1 activator 1 enhances SOS1's GDP-GTP exchange on Ras (Kd: 44 nM).Fórmula:C26H32ClFN6Cor e Forma:SolidPeso molecular:483.02KB-5246
CAS:KB-5246, displays antibacterial activities.is a tetracyclic quinolone.Fórmula:C18H17ClFN3O4SPureza:98%Cor e Forma:SolidPeso molecular:425.863,4-Dephostatin
CAS:3,4-Dephostatin is an inhibitor of the interactions of CFTR-associated ligand (CAL) and PSD-95/Dlg1/ZO-1 (PDZ) domain.Fórmula:C7H8N2O3Cor e Forma:SolidPeso molecular:168.15B-Raf IN 8
CAS:B-Raf IN 8: strong B-Raf inhibitor (70.65 nM IC50); combats liver, colon, breast & prostate cancer with IC50s from 9.78 to 29.85 μM.Fórmula:C18H17N3O2Cor e Forma:SolidPeso molecular:307.35
