MEK
MEK é uma quinase de dupla especificidade que desempenha um papel central na via de sinalização MAPK/ERK, ativando ERK por meio de fosforilação. A sinalização de MEK é crucial para a regulação do crescimento, sobrevivência e diferenciação celular. A atividade anômala de MEK tem sido implicada em vários tipos de câncer e distúrbios do desenvolvimento, tornando-a um importante alvo terapêutico. Na CymitQuimica, oferecemos uma variedade de inibidores e moduladores de MEK para apoiar sua pesquisa em oncologia, sinalização celular e desenvolvimento terapêutico.
Foram encontrados 74 produtos para "MEK".
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Trametiglue
CAS:Trametiglue, a potent Trametinib derivative, selectively targets KSR-MEK and RAF-MEK through unique binding.Fórmula:C25H24FIN6O5SCor e Forma:SolidPeso molecular:666.46BAY-846
CAS:BAY-846: allosteric MEK inhibitor, long-lasting, highly bioavailable, low brain entry, effective in K-Ras A549 model.Fórmula:C19H13F4IN4O4SCor e Forma:SolidPeso molecular:596.29Balamapimod
CAS:Balamapimod is a reversible inhibitor of Ras/Raf/MEK. It also has a potential anti-tumor activity.Fórmula:C30H32ClN7OSPureza:99.84%Cor e Forma:White SolidPeso molecular:574.14(2Z,3Z)-U0126
CAS:U0126 selectively inhibits MEK1/2, blocks MAPK/ERK signaling, and suppresses Ki-ras-induced cell growth, with IC50s of 72 nM and 58 nM for MEK1/2.Fórmula:C18H16N6S2Cor e Forma:SolidPeso molecular:380.49Avutometinib potassium
CAS:Avutometinib potassium, a MEKi, blocks Delta and Omicron infection in airway cells, potentially lessening disease severity.Fórmula:C21H17FKN5O5SCor e Forma:SolidPeso molecular:509.55(R)-PD 0325901CL
CAS:(R)-PD 0325901CL, a PD 0325901CL isomer, is a MEK inhibitor used in cancer research, effective against cancer cells in vitro and in vivo.Fórmula:C16H14ClF2IN2O4Cor e Forma:SolidPeso molecular:498.65JTP-70902
CAS:JTP-70902 is a protein kinase inhibitor with antineoplastic activity.Fórmula:C24H21BrFN5O5SCor e Forma:SolidPeso molecular:590.42MEK-IN-4
CAS:MEK-IN-4 is a MEK inhibitor that can be used to study inflammatory diseases and cancer.Fórmula:C21H18N4OSPureza:98.35% - 98.38%Cor e Forma:White SolidPeso molecular:374.46MEK-IN-1
CAS:MEK-IN-1 is a MEK inhibitor.Fórmula:C24H20N4O4Pureza:98%Cor e Forma:SolidPeso molecular:428.44MEK inhibitor
CAS:MEK inhibitor is a MEK receptor and cell cycle protein/CDK complex inhibitor with antitumor activity that can be used to study tumor cell proliferation.Fórmula:C26H26N4O2Pureza:97.48%Cor e Forma:SolidPeso molecular:426.51RO4927350
CAS:RO4927350 is a potent, selective MEK1/2 inhibitor, blocking MAPK pathway in vitro/vivo and showing notable antitumor effects.Fórmula:C27H28N4O6SCor e Forma:SolidPeso molecular:536.6Cobimetinib racemate
CAS:Cobimetinib racemate (Cobimetinib (racemate)) (GDC-0973 racemate) is a selective inhibitor of MEK.Cobimetinib racemate is also known as a mitogen-activatedFórmula:C21H21F3IN3O2Pureza:98.00% - 99.71%Cor e Forma:SolidPeso molecular:531.31MEK-IN-6 hydrate
CAS:MEK-IN-6 hydrate (compound 69), a MEK inhibitor, exhibits an IC50 value of 2 nM in A375 cells [1].Fórmula:C18H22FN3O5SPureza:98%Cor e Forma:SolidPeso molecular:411.45MS934
CAS:MS934, a novel VHL-recruiting MEK 1/2 degrader, exhibits potent anti-proliferative effects on HT-29 cell growth, achieving a GI50 of 0.023 μM.Fórmula:C52H69F3IN7O6SPureza:98%Cor e Forma:SolidPeso molecular:1104.11Nedometinib
CAS:Nedometinib (NFX-179) is a MEK1 inhibitor with anticancer and antitumor activities, which can be used to study malignant tumors.Fórmula:C17H16FIN4O3Pureza:99.18%Cor e Forma:SolidPeso molecular:470.24Ref: TM-T78209
1mg66,00€5mg145,00€1mL*10mM (DMSO)150,00€10mg215,00€25mg353,00€50mg537,00€100mg708,00€GSK1790627
CAS:GSK1790627, the N-deacetylated metabolite of Trametinib, represents an orally active MEK inhibitor that promotes autophagy and triggers apoptosis [1].Fórmula:C24H21FIN5O3Cor e Forma:SolidPeso molecular:573.36Atebimetinib
CAS:Atebimetinib, Oral MEK inhibitor, suppresses MAPK signaling, for combination therapy in metastatic pancreatic cancer and NSCLC.Fórmula:C23H27FN4O6SPureza:99.40%Cor e Forma:White SolidPeso molecular:506.55MEK4 inhibitor-2
CAS:MEK4 Inhibitor-2, a novel MEK4 inhibitor, demonstrates efficacy against pancreatic adenocarcinoma, exhibiting an IC50 value of 83 nM.Fórmula:C20H15FN4O3SCor e Forma:SolidPeso molecular:410.42Luvometinib
CAS:Luvometinib is an inhibitor of the mitogen-activated protein kinase (MEK) with antitumor activity.Fórmula:C26H22F2IN5O4SCor e Forma:SolidPeso molecular:665.45Refametinib R enantiomer
CAS:Refametinib R enantiomer (RDEA119 R enantiomer) is an MEK inhibitor with an EC50 of 2.0-15 nM.Refametinib (R enantiomer) has anticancer activity and can be usedFórmula:C19H20F3IN2O5SPureza:99.86%Cor e Forma:Yellow SolidPeso molecular:572.34MEK1/2-IN-2
MEK1/2-IN-2 is a potent, ATP-competitive MEK1/2 inhibitor that exhibits equal inhibitory effects on wild-type MEK1/2 and a group of MEK1/2 mutant cells.Fórmula:C28H22ClFN6OCor e Forma:SolidPeso molecular:512.97EBI-1051
CAS:EBI-1051 is a highly potent and orally efficacious inhibitor of MEK (IC50: 3.9 nM).Fórmula:C18H15F2IN2O5Pureza:98%Cor e Forma:SolidPeso molecular:504.22G-479
CAS:G-479, a potent MEK inhibitor and improved analogue of GDC-0623, has distributed polarity enhancing bioactivity.Fórmula:C16H15FIN5O4Cor e Forma:SolidPeso molecular:487.22
