Ras
As proteínas Ras são pequenas GTPases que atuam como interruptores moleculares na via de sinalização MAPK, controlando o crescimento, a diferenciação e a sobrevivência celular. Ras ativado inicia uma cascata de sinalização que inclui Raf, MEK e ERK, levando a várias respostas celulares. As mutações nos genes Ras são comuns em cânceres, tornando Ras um foco importante da pesquisa sobre o câncer. Na CymitQuimica, oferecemos uma variedade de moduladores de Ras para apoiar sua pesquisa em biologia do câncer, transdução de sinais e desenvolvimento terapêutico.
Foram encontrados 155 produtos de "Ras"
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MRTX-1257
CAS:<p>MRTX-1257: selective, irreversible KRAS G12C inhibitor; IC50 of 900 pM; 31% bioavailable in mice; 77% target engagement.</p>Fórmula:C33H39N7O2Pureza:97.3% - 99.07%Cor e Forma:SolidPeso molecular:565.71HJC0197
CAS:<p>HJC0197 is a selective Epac antagonist; blocks cAMP-induced activation with IC50=5.9 μM for Epac2.</p>Fórmula:C19H21N3OSPureza:98.05%Cor e Forma:SolidPeso molecular:339.45Ketoconazole
CAS:<p>Ketoconazole (R-41400), a CYP3A4 inhibitor, is an imidazole anti-fungal agent.</p>Fórmula:C26H28Cl2N4O4Pureza:99.53% - 99.62%Cor e Forma:Crystals From 4-Methylpentanone SolidPeso molecular:531.43ARS-1630
CAS:<p>ARS-1630 is a mutant K-ras G12C inhibitor. It is a less active enantiomer of ARS-1620.</p>Fórmula:C21H17ClF2N4O2Pureza:97.78%Cor e Forma:SolidPeso molecular:430.84BI-3406
CAS:<p>BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.</p>Fórmula:C23H25F3N4O3Pureza:99.2% - 99.66%Cor e Forma:SolidPeso molecular:462.46RMC-6236
CAS:<p>RMC-6236 is a potent RAS(ON)MULTI inhibitor with broad-spectrum inhibitory activity against RAS-GTP.Cost-effective and quality-assured.</p>Fórmula:C44H58N8O5SPureza:98.24% - 99.92%Cor e Forma:SolidPeso molecular:811.05K-Ras G12C-IN-4
CAS:<p>K-Ras G12C-IN-4 是一种 KRAS G12C 共价抑制剂。</p>Fórmula:C31H33ClN4O4Pureza:99.00%Cor e Forma:SolidPeso molecular:561.07MBQ-167
CAS:<p>MBQ-167 is a dual inhibitor of Rac/Cdc42 (IC50s: 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively).</p>Fórmula:C22H18N4Pureza:98.07% - 99.52%Cor e Forma:SolidPeso molecular:338.41KRAS inhibitor-38
CAS:<p>KRAS Inhibitor-38 (Example 18) is a potent inhibitor capable of effectively suppressing the activity of KRAS G12C, KRAS G12D, and KRAS G12V in vivo.</p>Fórmula:C53H68ClF2N9O8SCor e Forma:SolidPeso molecular:1064.68GGTI298 Trifluoroacetate
CAS:<p>GGTI298 trifluoroacetate (GGTI298TFA salt) is a geranylgeranyltransferase I inhibitor that causes cell cycle arrest and induces apoptosis.</p>Fórmula:C27H33N3O3S·C2HF3O2Pureza:98.07% - >99.99%Cor e Forma:SolidPeso molecular:593.66KRAS G12D inhibitor 20
KRAS G12D inhibitor 20 (Compound 14) is a selective G12D KRAS inhibitor with antitumor activity.Fórmula:C18H26N6OPeso molecular:342.21681Rapaprutug
CAS:<p>Rapaprutug is a monoclonal antibody that targets human KARS1 (lysyl-tRNA synthetase 1). It can block inflammation-related signaling pathways involving KARS1, thereby reducing the production and release of inflammatory factors. Rapaprutug shows potential for research into inflammatory diseases.</p>Cor e Forma:LiquidG12 TFA
<p>G12 (Ras5-17) TFA is a wild-type Ras peptide comprising amino acids 5-17 (KLVVVGAGGVGKS). It serves as a control in studies involving mutant Ras peptides, such as V12.</p>Fórmula:C54H96F3N15O17Peso molecular:1283.70607pan-KRAS-IN-10
<p>Pan-KRAS-IN-10 (Compound 58) acts as an inhibitor of the human tumor mutant gene KRAS. It suppresses the proliferation of KRAS mutant cells, specifically AsPC-1 (G12D mutant) and SW480 (G12V mutant), with IC50 values of 0.7 and 0.24 nM, respectively.</p>Fórmula:C45H57N7O5SPeso molecular:807.41419KRpep-2d TFA
<p>KRpep-2d (TFA) is a potent inhibitor of K-Ras, effectively hindering the proliferation of K-Ras-driven cancer cells, thereby serving as a valuable asset for</p>Fórmula:C110H183F3N44O27S2Cor e Forma:SolidPeso molecular:2675.03SOS1-IN-11
CAS:<p>SOS1-IN-11 is an effective inhibitor of SOS1 (IC50 = 30 nM).</p>Fórmula:C22H24F3N5OPureza:99.4%Cor e Forma:SolidPeso molecular:431.45KRpep-2d
CAS:<p>KRpep-2d, a potent inhibitor of K-Ras, effectively suppresses the proliferation of cancer cells driven by K-Ras.</p>Fórmula:C109H183N43O25S2Cor e Forma:SolidPeso molecular:2560.02Rac1 Inhibitor W56
CAS:<p>Peptide (45-60) blocks Rac1 binding with TrioN, GEF-H1, Tiam1 GEFs.</p>Fórmula:C74H117N19O23SPureza:98%Cor e Forma:SolidPeso molecular:1671.93KRAS inhibitor-42
<p>KRAS inhibitor-42 (compound 8) is an effective USP7 inhibitor that exhibits high affinity for GDP-bound KRASG12D, with a Ki value of 2.7 μM.</p>Fórmula:C34H47ClN8O4S2Cor e Forma:SolidPeso molecular:730.285026-Thio-GTP tetrasodium
<p>6-Thio-GTP (tetrasodium) is an inhibitor of Vav1-Rac. It can suppress TCR-induced T cell proliferation and CD28-mediated T cell survival. In a murine model of allogeneic heart transplantation, 6-Thio-GTP (tetrasodium) demonstrates immunosuppressive effects, which can prolong the survival time of heart transplants.</p>Fórmula:C10H12N5Na4O13P3SCor e Forma:SolidPeso molecular:626.89559SEPT9-IN-1
<p>SEPT9-IN-1 (compound 8b) is a SEPT9 inhibitor with an IC50 value of 94.83 μM. It exhibits cytotoxicity against human oral squamous carcinoma cells, with an IC50 of 21 µM.</p>Fórmula:C26H30ClN3O3Cor e Forma:SolidPeso molecular:467.988(E/Z)-ZINC09659342
CAS:<p>(E/Z)-ZINC09659342 is an inhibitor of Lbc-Rho A interaction.</p>Fórmula:C23H15F3N2O4Pureza:>99.99%Cor e Forma:SolidPeso molecular:440.37Ibetazol
<p>Ibetazol is an inhibitor of importin β1 (KPNB1), which functions by binding to Cys585 of importin β1, thus preventing importin β1-mediated nuclear import with an EC50 of 6.1 µM.</p>Fórmula:C13H11F3N2OSCor e Forma:SolidPeso molecular:300.3ADT-007
CAS:<p>ADT-007 is a pan-RAS inhibitor with potent anticancer activity.</p>Fórmula:C26H24FNO5Pureza:97.75%Cor e Forma:SoildPeso molecular:449.47MAPK Inhibitor Library
<p>A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;</p>Cor e Forma:Odour SolidMC 976
CAS:<p>MC 976 is a derivative of Vitamin D3.</p>Fórmula:C27H42O3Pureza:98%Cor e Forma:SolidPeso molecular:414.63KRAS G12C inhibitor 60
<p>KRAS G12C Inhibitor 60 (compound 23), a selective inhibitor targeting the Kras-G12C mutation, is utilized in the investigation of lung, colorectal, and</p>Fórmula:C31H30F5N7O2Pureza:98%Cor e Forma:SolidPeso molecular:627.61KS-58
CAS:<p>KS-58 is a derivative of KRpep-2d. It acts as an inhibitory peptide for K-Ras(G12D), selectively binding to K-Ras. KS-58 is capable of penetrating cells and interrupts the interaction between intracellular Ras and effector proteins. It inhibits the proliferation of tumor cells and exhibits antitumor activity.</p>Fórmula:C64H89FN12O14S2Cor e Forma:SolidPeso molecular:1333.59Ras Inhibitory Peptide acetate
<p>Ras Inhibitory Peptide acetate, involved in cancer-related Ras signaling.</p>Fórmula:C55H95N19O13Pureza:96.63%Cor e Forma:SolidPeso molecular:1230.46KRAS inhibitor-33
<p>KRAS inhibitor-33 (compound 115a) is a pyrido[2,3-d]pyrimidine derivative that serves as an effective inhibitor of KRAS, exhibiting an IC50 value of ≤ 100nM.</p>Fórmula:C33H39ClF2N6O3Cor e Forma:SolidPeso molecular:641.15MRTF-A-IN-2
<p>MRTF-A-IN-2 (compound 16) is an inhibitor of MRTF-A. It effectively suppresses cell proliferation and induces senescence in HCC cells.</p>Cor e Forma:Odour SolidMRTF-A-IN-1
<p>MRTF-A-IN-1 (compound 14) is an inhibitor of MRTF-A. It effectively suppresses cell proliferation and induces senescence in HCC cells.</p>Fórmula:C22H21N3Cor e Forma:SolidPeso molecular:327.42BI1701963
<p>BI1701963 is an orally effective inhibitor that targets the SOS1 and KRAS interaction, specifically inhibiting the activation of KRAS by blocking its GTP loading. This compound is utilized in cancer research to explore potential therapeutic effects against KRAS-driven malignancies.</p>Fórmula:C47H62N8O4SCor e Forma:SolidPeso molecular:835.11Pan-RAS-IN-7
CAS:<p>Pan-RAS-IN-7 (Compound D101) is a broad-spectrum RAS inhibitor used in the synthesis of antibody-drug conjugates (ADCs). It is also applicable in cancer research.</p>Fórmula:C59H76N8O8Cor e Forma:SolidPeso molecular:1025.28KRASG12C IN-14
<p>KRASG12C IN-14 (compound 15), a potent inhibitor specifically designed for the KRAS G12C mutation, exhibits impressive efficacy in impeding CYPA-dependent KRAS-BRAF interaction and ERK phosphorylation in NCI-H358 cells, both with an IC 50 of 0.002 μM.</p>Fórmula:C51H65F4N9O9S2Cor e Forma:SolidPeso molecular:1088.24FAM49B (190-198) mouse
CAS:<p>FAM49B (190-198) mouse represents a peptide fragment of the mitochondria-localized protein FAM49B, which is instrumental in regulating mitochondrial fission, function, and integrity, in addition to influencing tumor progression. Beyond its role in mitochondrial dynamics, FAM49B serves as a negative regulator of T cell activation by inhibiting GTPase Rac activity and affecting cytoskeleton reorganization.</p>Fórmula:C49H71N9O14SCor e Forma:SolidPeso molecular:1042.2Sevelamer Carbonate
CAS:<p>Sevelamer carbonate, a non-absorbed polymer, binds phosphate with carbonate instead of chloride.</p>Fórmula:(C3H7N·C3H5ClO)x·xCH2O3Pureza:98%Cor e Forma:SolidPeso molecular:211.64Y16
CAS:<p>Y16 is a G protein-coupled Rho GEFs inhibitor and also a specific inhibitor of LARG with a Kd of 76 nM.Cost-effective and quality-assured.</p>Fórmula:C24H20N2O3Pureza:98.26% - 99.32%Cor e Forma:SolidPeso molecular:384.43APS6-45
CAS:<p>APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.</p>Fórmula:C23H16F8N4O3Pureza:99.39%Cor e Forma:SolidPeso molecular:548.39CCG-100602
CAS:<p>CCG-100602 inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC-3 prostate cancer cells (IC50 :9.8 μM).</p>Fórmula:C21H17ClF6N2O2Pureza:99.58%Cor e Forma:SolidPeso molecular:478.82K-Ras(G12C) inhibitor 6
CAS:<p>Irreversible K-Ras(G12C) inhibitor 6 fully modifies the protein at 10 μM after 24h in vitro.</p>Fórmula:C17H22Cl2N2O3SPureza:89.07% - 97.09%Cor e Forma:SolidPeso molecular:405.34Rhosin hydrochloride
CAS:<p>Rhosin hydrochloride is a specific inhibitor of the RhoA subfamily Rho GTPases.Cost-effective and quality-assured.</p>Fórmula:C20H20Cl2N6OPureza:97.33% - 98.92%Cor e Forma:SolidPeso molecular:431.318CCG-203971
CAS:<p>CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50: 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM.</p>Fórmula:C23H21ClN2O3Pureza:98.82% - 99.50%Cor e Forma:SolidPeso molecular:408.88ML141
CAS:<p>ML141 (CID-2950007) is an effective, specific and reversible non-competitive inhibitor of Rho family GTPase cdc42 (IC50: 200 nM).</p>Fórmula:C22H21N3O3SPureza:99.36% - 99.56%Cor e Forma:SolidPeso molecular:407.49ARS-1620
CAS:<p>ARS-1620 is a covalent inhibitor of K-RASG12C.</p>Fórmula:C21H17ClF2N4O2Pureza:98.86%Cor e Forma:SolidPeso molecular:430.84Rasarfin
CAS:<p>Rasarfin inhibits Ras and ARF6.</p>Fórmula:C23H24ClN3O3Pureza:97.98%Cor e Forma:SolidPeso molecular:425.91Atranorin
CAS:<p>Atranorin has antinociceptive, anti-inflammatory, can be pro-oxidant or antioxidant, and protects cells from H(2)O(2)-induced oxidative stress.</p>Fórmula:C19H18O8Pureza:98.76% - 99.57%Cor e Forma:SolidPeso molecular:374.34CASIN
CAS:<p>CASIN (Pirl1-related Compound 2) is a specific inhibitor of GTPase Cdc42 (IC50: 2 uM).</p>Fórmula:C20H22N2OPureza:98.18% - >99.99%Cor e Forma:SolidPeso molecular:306.4EHT 1864 2HCl
CAS:<p>EHT 1864 (EHT 1864 2HCl) is a Rac family GTPase inhibitor that blocks activation by direct binding to Rac1, Rac1b, Rac2, and Rac3. Cost effective and quality assured.</p>Fórmula:C25H29Cl2F3N2O4SPureza:98.39% - 99.42%Cor e Forma:SolidPeso molecular:581.47Kobe0065
CAS:<p>Kobe0065: novel small-molecule, inhibits Ras–Raf, Ki=46±13 μM, blocks H-Ras·GTP/c-Raf-1 RBD binding.</p>Fórmula:C15H11ClF3N5O4SPureza:98% - >99.99%Cor e Forma:SolidPeso molecular:449.79FTI-277 hydrochloride
CAS:<p>FTI-277 HCl: potent FTase inhibitor, IC50 500 pM, 100x more selective than GGTase I.</p>Fórmula:C22H30ClN3O3S2Pureza:97.57% - 97.61%Cor e Forma:SolidPeso molecular:484.07(S)-AMG-510
CAS:<p>(S)-AMG-510 is the S-type compound of AMG-510 (Sotorasib), which effectively and selectively inhibits KRASG12C.Cost-effective and quality-assured.</p>Fórmula:C30H30F2N6O3Pureza:99.05% - 99.76%Cor e Forma:SolidPeso molecular:560.594K-Ras(G12C) inhibitor 12
CAS:<p>K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic K-Ras(G12C).</p>Fórmula:C15H17ClIN3O3Pureza:97.16%Cor e Forma:SolidPeso molecular:449.67ERK-IN-3
CAS:<p>ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK.</p>Fórmula:C22H25ClFN7O2Pureza:99.55% - 99.76%Cor e Forma:SolidPeso molecular:473.93ASP2453
CAS:<p>ASP2453 is a potent, selective and covalent inhibitor of KRAS G12C.</p>Fórmula:C40H48F3N7O4Pureza:99.71%Cor e Forma:SolidPeso molecular:747.85CCG-1423
CAS:<p>CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.</p>Fórmula:C18H13ClF6N2O3Pureza:99.80%Cor e Forma:SolidPeso molecular:454.756H05 (TFA)
CAS:<p>6H05 TFA (6H05 trifluoroacetate) is a selective, and allosteric oncogenic mutant K-Ras(G12C) inhibitor.</p>Fórmula:C22H31ClF3N3O4S3Pureza:98.83%Cor e Forma:SolidPeso molecular:590.14SCH54292
CAS:<p>SCH-54292 is a GDP exchange inhibitor.</p>Fórmula:C24H28N2O9SPureza:95.65%Cor e Forma:SolidPeso molecular:520.55ZT-12-037-01
CAS:<p>Zt-12-037-01 is a ATP competitive STK19 inhibitor（IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).</p>Fórmula:C21H31N5O2Pureza:99.56%Cor e Forma:SolidPeso molecular:385.5BAY-293
CAS:<p>BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).</p>Fórmula:C25H28N4O2SPureza:97.16%Cor e Forma:SolidPeso molecular:448.58(Rac)-Antineoplaston A10
CAS:<p>Antineoplaston A10 is the first identified human antineoplaston, naturally occurring with anti-proliferative properties.</p>Fórmula:C13H14N2O3Pureza:98.41%Cor e Forma:SolidPeso molecular:246.261A-116
CAS:<p>1A-116 is a specific Rac1 inhibitor.</p>Fórmula:C16H16F3N3Pureza:99.71%Cor e Forma:SolidPeso molecular:307.31K-Ras(G12C) inhibitor 9
CAS:<p>K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).</p>Fórmula:C16H21ClIN3O4SPureza:97.33% - 97.45%Cor e Forma:SolidPeso molecular:513.78RBC8
CAS:<p>RBC8 is a specific GTPases RalA/RalB inhibitor by inhibiting the binding of Ral to its effector RALBP1, no inhibition on the GTPases RhoA and Ras.</p>Fórmula:C25H20N4O3Pureza:98.44% - 99.81%Cor e Forma:SolidPeso molecular:424.45Adagrasib
CAS:<p>View and buy Adagrasib (MRTX849) from TargetMol.MRTX849 is a potent, selective and covalent KRASG12C inhibitor with potential antineoplastic activity. Cited in 2 publications.</p>Fórmula:C32H35ClFN7O2Pureza:99.10% - 99.9%Cor e Forma:SolidPeso molecular:604.12MLS000532223
CAS:<p>MLS000532223 is a selectiveRho family GTPases inhibitor(EC50 : 16 μM to 120 μM).</p>Fórmula:C15H9NO3Pureza:98.6%Cor e Forma:SolidPeso molecular:251.24ML-097
CAS:<p>ML-097 (CID-2160985) is a pan activator of Ras-related GTPases</p>Fórmula:C14H11BrO3Pureza:99.12%Cor e Forma:SolidPeso molecular:307.139ZCL278
CAS:<p>ZCL278 is a selective Cdc42 GTPase inhibitor.</p>Fórmula:C21H19BrClN5O4S2Pureza:96.29% - 99.72%Cor e Forma:SolidPeso molecular:584.89EHop-016
CAS:<p>EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 μM for Rac1 in MDA-MB-231 and MDA-MB-435 cells, equally effective inhibition for Rac3.</p>Fórmula:C25H30N6OPureza:98.99% - >99.99%Cor e Forma:SolidPeso molecular:430.551-(4-methansulfinylphenyl)ethanone
CAS:<p>The compound inhibits Ras function and therefore inhibits the abnormal growth of cells.</p>Fórmula:C9H10O2SPureza:99.48%Cor e Forma:SolidPeso molecular:182.24ARS-853
CAS:<p>ARS-853 is an inhibitor of K-RASG12C(IC50 : 2.5 μM), a mutant form of K-RAS that accumulates in the active GTP-bound state in certain cancer cells</p>Fórmula:C22H29ClN4O3Pureza:97.43% - 98.4%Cor e Forma:SolidPeso molecular:432.94Antineoplaston A10
CAS:<p>Antineoplaston A10 (NSC-648539) is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer.</p>Fórmula:C13H14N2O3Pureza:99.42%Cor e Forma:SolidPeso molecular:246.26Phellodendrine chloride
CAS:<p>Phellodendrine chloride combats kidney inflammation by blocking macrophage and T cell activity in glomeruli.</p>Fórmula:C20H24ClNO4Pureza:98.85% - 99.05%Cor e Forma:SolidPeso molecular:377.86NSC 23766 trihydrochloride
CAS:<p>NSC 23766 trihydrochloride (Rac1 Inhibitor) is an inhibitor of Rac GTPase targeting Rac activation by GEFs; no inhibitory for RhoA or Cdc42.</p>Fórmula:C24H35N7·3HClPureza:96.48% - 99.54%Cor e Forma:SolidPeso molecular:530.96CID-1067700
CAS:<p>CID-1067700 is one of the first identified competitive inhibitors of nucleotide binding by Ras-related GTPases（Rab7 with a Ki of 13 nM).</p>Fórmula:C18H18N2O4S2Pureza:99.46%Cor e Forma:SolidPeso molecular:390.48MLS-573151
CAS:<p>MLS-573151 is a selective inhibitor of GTPase Cdc42(EC50 of 2 μM).</p>Fórmula:C21H19N3O2SPureza:98.80%Cor e Forma:SolidPeso molecular:377.46CCG-222740
CAS:<p>CCG-222740 is an inhibitor of Rho/MRTF pathway</p>Fórmula:C23H19ClF2N2O3Pureza:98.76%Cor e Forma:SolidPeso molecular:444.86Salirasib
CAS:<p>Salirasib: Competitive PPMTase inhibitor, blocks Ras methylation, potential cancer treatment, Ki=2.6 μM.</p>Fórmula:C22H30O2SPureza:99.45%Cor e Forma:SolidPeso molecular:358.54Kobe2602
CAS:<p>Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities.</p>Fórmula:C14H9F4N5O4SPureza:98.36% - 99.39%Cor e Forma:SolidPeso molecular:419.31Arglabin
CAS:<p>Arglabin ((+)-Arglabin) is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects.</p>Fórmula:C15H18O3Pureza:98.97% - 99.62%Cor e Forma:SolidPeso molecular:246.3BQU57
CAS:<p>BQU57 shows selective inhibition for Ral relative to Ras or Rho and inhibit xenograft tumor growth.</p>Fórmula:C16H13F3N4OPureza:97.45% - 98.72%Cor e Forma:SolidPeso molecular:334.3Sotorasib
CAS:<p>Sotorasib (AMG-510) is an orally active and selective covalent inhibitor of KRAS G12C.</p>Fórmula:C30H30F2N6O3Pureza:98% - 99.95%Cor e Forma:SolidPeso molecular:560.594KRAS inhibitor-9
CAS:<p>KRAS inhibitor-9 (DUN09716) hinders GTP-KRAS formation, with a Kd of 92 μM, causes G2/M arrest, and induces apoptosis in mutated NSC-LC cells.</p>Fórmula:C13H9ClN2S2Pureza:99.66%Cor e Forma:SolidPeso molecular:292.81CID44216842
CAS:<p>CID44216842 is a potent Cdc42-selective inhibitor with EC50: 1.0μM (WT), 1.2μM (Q61L) in GTP assay; 0.3μM (WT), 0.5μM (Q61L) in GDP assay. Use as a probe.</p>Fórmula:C22H20BrN3O3SPureza:99.66%Cor e Forma:SolidPeso molecular:486.38Eicosapentaenoic Acid
CAS:<p>Eicosapentaenoic Acid is an ω-3 fatty acid and an inhibitor of fatty acid synthase (FASN). High-Quality, Low-Cost!</p>Fórmula:C20H30O2Pureza:97.03% - 99.83%Cor e Forma:LiquidPeso molecular:302.45K-Ras-IN-1
CAS:<p>K-Ras-IN-1 is a K-Ras inhibitor.</p>Fórmula:C11H13NOSPureza:98.72%Cor e Forma:SolidPeso molecular:207.29MRTX1133
CAS:<p>View and buy MRTX1133 from TargetMol.MRTX1133 is a potent, selective, and noncovalent inhibitor of KRAS G12D.</p>Fórmula:C33H31F3N6O2Pureza:97.39% - 99.6%Cor e Forma:SolidPeso molecular:600.63ML-098
CAS:<p>ML-098 (CID-7345532) is an activator of the GTP-binding protein Rab7 (EC50: 77.6 nM).</p>Fórmula:C19H19NO3Pureza:99.06% - 99.23%Cor e Forma:SolidPeso molecular:309.36Lonafarnib
CAS:<p>Lonafarnib (Sch66336) is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B, and N-ras (IC50: 1.9/5.2/2.8 nM).</p>Fórmula:C27H31Br2ClN4O2Pureza:98% - 99.94%Cor e Forma:SolidPeso molecular:638.82Oncrasin-1
CAS:<p>Oncrasin 1 is a potent inhibitor of anticancer that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations</p>Fórmula:C16H12ClNOPureza:99.75%Cor e Forma:SolidPeso molecular:269.73Z62954982
CAS:<p>Z62954982 (ZINC08010136) is a Rac1 inhibitor that inhibits Rac1 activation and reduces proliferation, p38 phosphorylation, and IL-6 levels in pulmonary arteries</p>Fórmula:C20H21N3O5SPureza:98.28%Cor e Forma:SolidPeso molecular:415.46AZD0022
CAS:<p>AZD0022 is a selective, reversible, and orally active KRAS G12D inhibitor, exhibits tumour marker inhibition in PDAC and NSCLC models.</p>Fórmula:C34H30F4N6OPureza:98.73%Cor e Forma:SoildPeso molecular:614.64Deltarasin
CAS:<p>Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.</p>Fórmula:C40H37N5OPureza:99.4%Cor e Forma:SolidPeso molecular:603.756H05
CAS:<p>6H05 (K-Ras inhibitor) is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).</p>Fórmula:C20H30ClN3O2S3Pureza:98%Cor e Forma:SolidPeso molecular:476.12KRas G12C inhibitor 3
CAS:<p>KRas G12C inhibitor 3 is a compound that inhibits KRas G12C.</p>Fórmula:C32H36ClN7O2Pureza:98%Cor e Forma:SolidPeso molecular:586.13KRas G12C inhibitor 4
CAS:KRas G12C inhibitor 4 is a compound that inhibits KRas G12C.Fórmula:C33H38ClN7O2Pureza:98%Cor e Forma:SolidPeso molecular:600.15CCG-257081
CAS:<p>CCG-257081 blocks Rho/MRTF/SRF pathway; prevents fibrosis in mice; useful in cancer and fibrosis research.</p>Fórmula:C24H19ClF3N3O2Pureza:99.76% - 99.94%Cor e Forma:SolidPeso molecular:473.87Digeranyl bisphosphonate
CAS:<p>Digeranyl bisphosphonate (DGBP) is a potent geranylgeranyl pyrophosphate (GGPP) synthase inhibitor that inhibits geranyl pyrophosphorylation of Rac1.Digeranyl</p>Fórmula:C21H34Na4O6P2Pureza:98.5%Cor e Forma:SolidPeso molecular:536.4Nexinhib20
CAS:<p>Nexinhib20 is an inhibitor of exosome synthesis and transport with anti-inflammatory activity, inhibits RAB27A and neutral sphingomyelinase 2 (nSMase2) nsMase2.</p>Fórmula:C15H16N4O3Pureza:99.89%Cor e Forma:SolidPeso molecular:300.31KRAS inhibitor-7
CAS:<p>KRAS inhibitor-7 is a potent KRAS G12C inhibitor.</p>Fórmula:C26H27ClF2N6O2Pureza:98%Cor e Forma:SolidPeso molecular:528.98ESI-08
CAS:<p>ESI-08 is an effective antagonist of EPAC2 with an IC50 of 8.4 μM. ESI-08 selectively blocks cAMP-induced EPAC activation but not cAMP-mediated PKA activation.</p>Fórmula:C20H23N3OSPureza:97.17%Cor e Forma:SolidPeso molecular:353.48KRAS inhibitor-6
CAS:<p>KRAS inhibitor-6 is a potent KRAS G12C inhibitor.</p>Fórmula:C27H30ClF2N5O3Pureza:98%Cor e Forma:SolidPeso molecular:546.01Methylophiopogonanone B
CAS:<p>1. Methylophiopogonanone B (MOPB) induces cell morphological change and Rho activation via melanocyte dendrite retraction and stress fiber formation.</p>Fórmula:C19H20O5Pureza:99.24% - 99.83%Cor e Forma:SolidPeso molecular:328.36MCP110
CAS:<p>MCP110 is an inhibitor of the interaction of Ras with Raf-1 and can be used in studies about the treatment of human tumors.</p>Fórmula:C33H36N2O3Pureza:97.23%Cor e Forma:OilPeso molecular:508.65BI-2852
CAS:<p>BI-2852: nanomolar affinity KRAS switch I/II pocket inhibitor; blocks signaling, halts KRAS mutant cell growth.</p>Fórmula:C31H28N6O2Pureza:98.98%Cor e Forma:SolidPeso molecular:516.59PROTAC KRAS G12C degrader-3
CAS:<p>PROTAC KRAS G12C Degrader-3 (Comp 283) serves as a potent degrader of KRAS G12C, utilized in cancer research [1].</p>Fórmula:C63H75ClN14O6Pureza:98%Cor e Forma:SolidPeso molecular:1159.81KRAS G12C inhibitor 58
CAS:<p>KRAS G12C inhibitor 58 is utilized in cancer research as an inhibitor of the KRAS G12C mutation [1].</p>Fórmula:C51H64ClF4N9O8SPureza:98%Cor e Forma:SolidPeso molecular:1074.62KRAS G12C inhibitor 5
CAS:<p>KRAS G12C inhibitor 5 is a KRas G12C inhibitor.</p>Fórmula:C32H37N7O2Pureza:98%Cor e Forma:SolidPeso molecular:551.68KRAS G12D modulator-1
CAS:<p>KRAS G12D modulator-1 (compound 6), a potent modulator of KRAS G12D, exhibits IC50 values ranging from 1-10 μM against NEA-G12D, PPI-G12D, and p ERK-AGS, and is</p>Fórmula:C30H36FN5O4Pureza:98%Cor e Forma:SolidPeso molecular:549.64Rac1-IN-3
CAS:<p>Rac1-IN-3 (Compound 2) is a Rac1 inhibitor exhibiting an inhibitory concentration 50 (IC50) of 46.1 μM [1].</p>Fórmula:C21H23N7O2Pureza:98%Cor e Forma:SolidPeso molecular:405.45TH-Z827
CAS:<p>TH-Z827 is a mutant-selective inhibitor targeting KRAS(G12D) with an IC50 of 2.4 μM, demonstrating specificity by not binding to KRAS(WT) or KRAS(G12C).</p>Fórmula:C30H38N6OPureza:98%Cor e Forma:SolidPeso molecular:498.66KRAS G12C inhibitor 32
CAS:<p>KRAS G12C Inhibitor 32, an eight-membered heterocyclic compound with nitrogen, acts as a potent inhibitor of KRAS G12C [1].</p>Fórmula:C29H30Cl3FN6O3Pureza:98%Cor e Forma:SolidPeso molecular:635.94SOS1/KRAS-IN-1
CAS:<p>SOS1/KRAS-IN-1 (Compound 2) serves as an inhibitor of SOS1/KRAS, with potential application in the study of diseases mediated by SOS1/KRAS [1].</p>Fórmula:C24H26F3N5OPureza:98%Cor e Forma:SolidPeso molecular:457.49pan-KRAS-IN-2
CAS:<p>Pan-KRAS-IN-2 (compound 6) is a broad-spectrum KRAS inhibitor exhibiting potent activity with IC50 values of ≤10 nM against KRAS wild type and its mutants (G12D</p>Fórmula:C34H34F2N4O3Pureza:98%Cor e Forma:SolidPeso molecular:584.66pan-KRAS-IN-3
CAS:<p>Pan-KRAS-IN-3 (Example 84) is a pan-KRAS inhibitor suitable for cancer research [1].</p>Fórmula:C33H32F3N5O2Pureza:98%Cor e Forma:SolidPeso molecular:587.63KRas G12C inhibitor 1
CAS:<p>KRas G12C inhibitor 1 is a compound that inhibits KRas G12C.</p>Fórmula:C31H38N6O3Pureza:98%Cor e Forma:SolidPeso molecular:542.67XRP44X
CAS:<p>XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway.</p>Fórmula:C21H21ClN4OPureza:99.67%Cor e Forma:SolidPeso molecular:380.87KRAS G12C inhibitor 59
CAS:<p>KRAS G12C Inhibitor 59 is a compound with anticancer properties.</p>Fórmula:C32H39F6N7O5Pureza:98%Cor e Forma:SolidPeso molecular:715.69RBC10
CAS:<p>RBC10 inhibits the binding of Ral to its effector RALBP1, as well as inhibiting Ral-mediated cell spreading of murine embryonic fibroblasts and anchorage-</p>Fórmula:C24H25ClN2O2Pureza:99.71%Cor e Forma:SolidPeso molecular:408.92KRAS G12C inhibitor 14
CAS:<p>KRAS G12C inhibitor 14 is a potent KRAS G12C inhibitor with an IC 50 of 18 nM [1].</p>Fórmula:C24H19ClF2N4O3Pureza:98%Cor e Forma:SolidPeso molecular:484.88KRAS G12C inhibitor 17
CAS:<p>KRAS G12C inhibitor 17 is a potent KRAS G12C inhibitor.</p>Fórmula:C24H20ClF2N3O3Pureza:98%Cor e Forma:SolidPeso molecular:471.88CCG-232964
CAS:<p>CCG-232964 is an orally active Rho/MRTF/SRF inhibitor that suppresses LPA-induced CTGF gene expression [1].</p>Fórmula:C15H15ClN2O3SPureza:98%Cor e Forma:SolidPeso molecular:338.81ML-099
CAS:ML-099 is a pan Ras-related GTPases activator that activates Rac1, Ras, GTP-binding protein (Rab7), Rab2A and cell division cycle 42.Fórmula:C14H13NO2SPureza:99.73%Cor e Forma:SolidPeso molecular:259.32KRAS G12C inhibitor 13
CAS:<p>KRAS G12C inhibitor 13 is a KRAS G12C inhibitor .</p>Fórmula:C40H46F3N7O4Pureza:98%Cor e Forma:SolidPeso molecular:745.83ARS-1323
CAS:<p>ARS-1323 is the racemate of ARS-1620 and a mutant K-ras G12C inhibitor.</p>Fórmula:C21H17ClF2N4O2Pureza:99.53%Cor e Forma:SolidPeso molecular:430.84pan-KRAS-IN-4
CAS:<p>Pan-KRAS-IN-4 (compound 5) is a potent KRAS inhibitor, demonstrating IC50 values of 0.37 nM for Kras G12C and 0.19 nM for Kras G12V [1].</p>Fórmula:C36H34F2N6O3Pureza:98%Cor e Forma:SolidPeso molecular:636.69BDP9066
CAS:<p>BDP9066 is a potent and selective MRCK inhibitor, inhibits MRCKβ and MRCKα/β, and can be used for the prevention and treatment of skin cancer.</p>Fórmula:C20H24N6Pureza:98.18%Cor e Forma:SolidPeso molecular:348.44Pan-RAS-IN-1
CAS:<p>Pan-RAS-IN-1 is an inhibitor of pan-Ras. It disrupts the interaction of Ras proteins and their effectors.</p>Fórmula:C36H41Cl2F3N6O2Pureza:99.77%Cor e Forma:SolidPeso molecular:717.65Rho GTPase inhibitor 1
CAS:<p>Rho GTPase inhibitor 1 (compound 7) is a potent inhibitor of Rho GTPase. It exhibits high affinity for Cdc42, Rac1, and RhoA, with dissociation constants (KDs) of 151 μM, 352 μM, and 232 μM, respectively. Additionally, Rho GTPase inhibitor 1 reduces cell migration in glioblastoma cell lines.</p>Fórmula:C18H16N2OCor e Forma:SolidPeso molecular:276.33SOS2 ligand 1
CAS:<p>SOS2 ligand 1 (compound 2) is a selective ligand for son of sevenless 2 (SOS2), exhibiting a KD value of 4.6 µM.</p>Fórmula:C19H21N5OCor e Forma:SolidPeso molecular:335.403(+)-Perillyl alcohol
CAS:<p>(+)-Perillyl alcohol (0.25-1 mM) inhibits cell growth in SW480 cells. At a concentration of 1 mM and a duration of 24 hours, (+)-Perillyl alcohol increases the number of cells in the G0/G1 phase and reduces the number in the S phase in SW480 cells.</p>Fórmula:C10H16OCor e Forma:SolidPeso molecular:152.23PAT-IN-1
CAS:<p>PAT-IN-1, a protein acyl transferases (PAT) inhibitor, competitively inhibits Erf2 autopalmitoylation (WO2017011518A1; compound 13) [1].</p>Fórmula:C45H68N4OCor e Forma:SolidPeso molecular:681.05KRAS G12C inhibitor 15
CAS:<p>KRAS G12C inhibitor 15 is a potent KRAS G12C inhibitor .</p>Fórmula:C25H21ClF2N4O3Pureza:98%Cor e Forma:SolidPeso molecular:498.91KRAS inhibitor-8
CAS:<p>KRAS inhibitor-8 is a potent KRAS G12C inhibitor.</p>Fórmula:C26H24ClF4N5O3Pureza:98%Cor e Forma:SolidPeso molecular:565.95KRAS G12D inhibitor 26
CAS:<p>KRAS G12D inhibitor 26 (Compound 64B) is an inhibitor of KRAS G12D with an IC50 ≤ 100 nM.</p>Fórmula:C35H44ClFN8O2Pureza:99.93%Cor e Forma:SolidPeso molecular:663.23INCB159020
CAS:<p>INCB159020 is an orally active inhibitor of KRAS G12D, exhibiting a KRAS G12D SPR value of 2.2 nM. It demonstrates anti-tumor activity.</p>Fórmula:C37H35ClFN7O2Cor e Forma:SolidPeso molecular:664.171pan-KRAS-IN-17
CAS:<p>pan-KRAS-IN-17 (Example 34) is an inhibitor that targets multiple forms of the KRAS protein.</p>Fórmula:C34H33F3N5O8PCor e Forma:SolidPeso molecular:727.623KRAS inhibitor-34
CAS:<p>KRAS inhibitor-34 (compound 27) is a KRAS inhibitor with an IC50 of 6.4 nM and is utilized in oncological research.</p>Fórmula:C43H41F3N6O3Cor e Forma:SolidPeso molecular:746.82SOF-436
CAS:<p>SOF-436 is a KRAS inhibitor that can suppress SOS1-mediated KRAS nucleotide exchange (IC50 = 60 μM) and inhibit the interaction between KRAS and the effector protein RAF. SOF-436 is applicable to cancer research.</p>Fórmula:C15H13F2NO4S2Cor e Forma:SolidPeso molecular:373.395J-104871
CAS:<p>J-104871 (UNII-6137X5QNJF) is an FTase inhibitor that inhibits tumor growth in nude mice transplanted with activated H-ras-transformed NIH3T3 cells.</p>Fórmula:C38H32N2O12Pureza:98%Cor e Forma:SolidPeso molecular:708.67RGT-018
CAS:<p>RGT-018 is a potent oral SOS1 inhibitor with antitumor properties. It exerts its anticancer activity by inhibiting KRAS activation, thereby hindering cancer cell proliferation.</p>Fórmula:C27H24F3N7O2Cor e Forma:SolidPeso molecular:535.52KRAS inhibitor-32
CAS:<p>KRAS inhibitor-32 (compound 139A) is a KRAS inhibitor utilized in cancer research.</p>Fórmula:C29H35FN10OS2Cor e Forma:SolidPeso molecular:622.78BMS-214662
CAS:<p>BMS-214662 is a selective farnesyl transferase inhibitor with anti-tumor activity, used in research on pancreatic cancer, head and neck cancer, and lung cancer.</p>Fórmula:C25H23N5O2S2Pureza:99.58% - 99.58%Cor e Forma:SolidPeso molecular:489.61pan-KRAS degrader 1
CAS:<p>Pan-KRAS degrader 1 (Compound 1) is a broad-spectrum KRAS degrader, exhibiting an inhibitory constant Ki value of 25 nM against KRASG12V as determined by surface plasmon resonance (SPR). Additionally, this compound demonstrates antitumor activity.</p>Fórmula:C22H26N8OSCor e Forma:SolidPeso molecular:450.56KRAS inhibitor-37
CAS:<p>KRAS inhibitor-37 (compound 2) is a potent inhibitor of KRAS, exhibiting low dissociation constants (KD) with various KRAS mutations: wild type (0.004 nM), G12D (0.041 nM), G12C (0.019 nM), and G12V (0.144 nM). This compound effectively inhibits cell proliferation, demonstrating half-maximal inhibitory concentrations (IC50) ranging from <2 nM to 14 nM in H358, SW620, and PANC08.13 cell lines. KRAS inhibitor-37 holds potential for cancer research applications.</p>Fórmula:C32H33ClFN7O3Cor e Forma:SolidPeso molecular:618.10KRas G12C inhibitor 2
CAS:<p>KRas G12C inhibitor 2 is a compound that inhibits KRas G12C.</p>Fórmula:C32H37N7O3Pureza:98%Cor e Forma:SolidPeso molecular:567.68Dorrigocin A
CAS:<p>Dorrigocin A, an analog of Migrastatin, inhibits the carboxymethyltransferase involved in Ras processing, reversing the morphology of Ras-transformed NIH/3T3 cells. Dorrigocin A holds potential for research as an anticancer and anti-arthritis agent.</p>Fórmula:C27H41NO8Cor e Forma:SolidPeso molecular:507.616ZCL279
CAS:<p>ZCL279 is a small molecule modulator (SMM) that inhibits the interaction between CDC42 and intersectin (ITSN). At lower concentrations (<10 μM), ZCL279 activates Cdc42, a cytoplasmic small GTPase in the Ras superfamily, while at higher concentrations (<10 μM) it significantly inhibits it.</p>Fórmula:C24H18N2O7S2Cor e Forma:SolidPeso molecular:510.539KRAS inhibitor-31
CAS:<p>KRAS inhibitor-31 (compound 33), a potent agent targeting KRAS, exhibits K D (SPR) values of 0.019 nM for KRas G12D, 0.019 nM for KRas G12C, and 0.096 nM for KRas G12V, illustrating its efficacy across these variants.</p>Fórmula:C33H30F3N5O4Cor e Forma:SolidPeso molecular:617.62XMU-MP-9
CAS:<p>XMU-MP-9, a bifunctional compound, targets the C2 domain of Nedd4-1 and the allosteric site of K-Ras. It enhances the interaction and induces conformational changes within the Nedd4-1/K-Ras complex. Furthermore, XMU-MP-9 facilitates the ubiquitination and degradation of various K-Ras mutants and inhibits the proliferation of cells with these mutants. This compound is useful in cancer research.</p>Fórmula:C19H13ClFN3OSCor e Forma:SolidPeso molecular:385.84AM-001
CAS:AM-001 is a non-competitive inhibitor of Epac1, preventing the activation of its downstream effector Rap1 in cultured cells. This compound is utilized in research related to cardiac diseases.Fórmula:C24H16FN3OS2Cor e Forma:SolidPeso molecular:445.53KRAS inhibitor-35
CAS:<p>KRAS inhibitor-35 (compound 72) is a KRAS inhibitor with an IC50 of 2 nM, utilized in tumor research.</p>Fórmula:C38H32F4N6O3SCor e Forma:SolidPeso molecular:728.76KRAS inhibitor-41
CAS:<p>KRAS inhibitor-41 is a KRAS inhibitor with an IC50 value of less than 0.01 μM for both KRAS G12D and KRAS G12V mutations. It effectively inhibits RAS mutant cell lines GP2D (KRAS-G12D) and SW620 (KRAS-G12V). KRAS inhibitor-41 is applicable for cancer research.</p>Fórmula:C30H37FN10OSCor e Forma:SolidPeso molecular:604.745Sosimerasib
CAS:<p>Sosimerasib is an inhibitor of the kirsten rat sarcoma viral oncogene homolog (KRAS) and exhibits antitumor activity.</p>Fórmula:C36H39ClFN7O4Cor e Forma:SolidPeso molecular:688.191KRAS G12D inhibitor 28
CAS:<p>KRAS G12D inhibitor 28 (Compound 1) is an inhibitor of KRAS G12D and can be utilized in cancer research.</p>Fórmula:C35H32Cl2FN5OCor e Forma:SolidPeso molecular:628.57
