Ras
As proteínas Ras são pequenas GTPases que atuam como interruptores moleculares na via de sinalização MAPK, controlando o crescimento, a diferenciação e a sobrevivência celular. Ras ativado inicia uma cascata de sinalização que inclui Raf, MEK e ERK, levando a várias respostas celulares. As mutações nos genes Ras são comuns em cânceres, tornando Ras um foco importante da pesquisa sobre o câncer. Na CymitQuimica, oferecemos uma variedade de moduladores de Ras para apoiar sua pesquisa em biologia do câncer, transdução de sinais e desenvolvimento terapêutico.
Foram encontrados 155 produtos de "Ras"
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KRAS G12C inhibitor 17
CAS:<p>KRAS G12C inhibitor 17 is a potent KRAS G12C inhibitor.</p>Fórmula:C24H20ClF2N3O3Pureza:98%Cor e Forma:SolidPeso molecular:471.88CCG-232964
CAS:<p>CCG-232964 is an orally active Rho/MRTF/SRF inhibitor that suppresses LPA-induced CTGF gene expression [1].</p>Fórmula:C15H15ClN2O3SPureza:98%Cor e Forma:SolidPeso molecular:338.81ML-099
CAS:ML-099 is a pan Ras-related GTPases activator that activates Rac1, Ras, GTP-binding protein (Rab7), Rab2A and cell division cycle 42.Fórmula:C14H13NO2SPureza:99.73%Cor e Forma:SolidPeso molecular:259.32KRAS G12C inhibitor 13
CAS:<p>KRAS G12C inhibitor 13 is a KRAS G12C inhibitor .</p>Fórmula:C40H46F3N7O4Pureza:98%Cor e Forma:SolidPeso molecular:745.83ARS-1323
CAS:<p>ARS-1323 is the racemate of ARS-1620 and a mutant K-ras G12C inhibitor.</p>Fórmula:C21H17ClF2N4O2Pureza:99.53%Cor e Forma:SolidPeso molecular:430.84pan-KRAS-IN-4
CAS:<p>Pan-KRAS-IN-4 (compound 5) is a potent KRAS inhibitor, demonstrating IC50 values of 0.37 nM for Kras G12C and 0.19 nM for Kras G12V [1].</p>Fórmula:C36H34F2N6O3Pureza:98%Cor e Forma:SolidPeso molecular:636.69BDP9066
CAS:<p>BDP9066 is a potent and selective MRCK inhibitor, inhibits MRCKβ and MRCKα/β, and can be used for the prevention and treatment of skin cancer.</p>Fórmula:C20H24N6Pureza:98.18%Cor e Forma:SolidPeso molecular:348.44Pan-RAS-IN-1
CAS:<p>Pan-RAS-IN-1 is an inhibitor of pan-Ras. It disrupts the interaction of Ras proteins and their effectors.</p>Fórmula:C36H41Cl2F3N6O2Pureza:99.77%Cor e Forma:SolidPeso molecular:717.65Rho GTPase inhibitor 1
CAS:<p>Rho GTPase inhibitor 1 (compound 7) is a potent inhibitor of Rho GTPase. It exhibits high affinity for Cdc42, Rac1, and RhoA, with dissociation constants (KDs) of 151 μM, 352 μM, and 232 μM, respectively. Additionally, Rho GTPase inhibitor 1 reduces cell migration in glioblastoma cell lines.</p>Fórmula:C18H16N2OCor e Forma:SolidPeso molecular:276.33SOS2 ligand 1
CAS:<p>SOS2 ligand 1 (compound 2) is a selective ligand for son of sevenless 2 (SOS2), exhibiting a KD value of 4.6 µM.</p>Fórmula:C19H21N5OCor e Forma:SolidPeso molecular:335.403(+)-Perillyl alcohol
CAS:<p>(+)-Perillyl alcohol (0.25-1 mM) inhibits cell growth in SW480 cells. At a concentration of 1 mM and a duration of 24 hours, (+)-Perillyl alcohol increases the number of cells in the G0/G1 phase and reduces the number in the S phase in SW480 cells.</p>Fórmula:C10H16OCor e Forma:SolidPeso molecular:152.23PAT-IN-1
CAS:<p>PAT-IN-1, a protein acyl transferases (PAT) inhibitor, competitively inhibits Erf2 autopalmitoylation (WO2017011518A1; compound 13) [1].</p>Fórmula:C45H68N4OCor e Forma:SolidPeso molecular:681.05KRAS G12C inhibitor 15
CAS:<p>KRAS G12C inhibitor 15 is a potent KRAS G12C inhibitor .</p>Fórmula:C25H21ClF2N4O3Pureza:98%Cor e Forma:SolidPeso molecular:498.91KRAS inhibitor-8
CAS:<p>KRAS inhibitor-8 is a potent KRAS G12C inhibitor.</p>Fórmula:C26H24ClF4N5O3Pureza:98%Cor e Forma:SolidPeso molecular:565.95KRAS G12D inhibitor 26
CAS:<p>KRAS G12D inhibitor 26 (Compound 64B) is an inhibitor of KRAS G12D with an IC50 ≤ 100 nM.</p>Fórmula:C35H44ClFN8O2Pureza:99.93%Cor e Forma:SolidPeso molecular:663.23INCB159020
CAS:<p>INCB159020 is an orally active inhibitor of KRAS G12D, exhibiting a KRAS G12D SPR value of 2.2 nM. It demonstrates anti-tumor activity.</p>Fórmula:C37H35ClFN7O2Cor e Forma:SolidPeso molecular:664.171pan-KRAS-IN-17
CAS:<p>pan-KRAS-IN-17 (Example 34) is an inhibitor that targets multiple forms of the KRAS protein.</p>Fórmula:C34H33F3N5O8PCor e Forma:SolidPeso molecular:727.623KRAS inhibitor-34
CAS:<p>KRAS inhibitor-34 (compound 27) is a KRAS inhibitor with an IC50 of 6.4 nM and is utilized in oncological research.</p>Fórmula:C43H41F3N6O3Cor e Forma:SolidPeso molecular:746.82SOF-436
CAS:<p>SOF-436 is a KRAS inhibitor that can suppress SOS1-mediated KRAS nucleotide exchange (IC50 = 60 μM) and inhibit the interaction between KRAS and the effector protein RAF. SOF-436 is applicable to cancer research.</p>Fórmula:C15H13F2NO4S2Cor e Forma:SolidPeso molecular:373.395J-104871
CAS:<p>J-104871 (UNII-6137X5QNJF) is an FTase inhibitor that inhibits tumor growth in nude mice transplanted with activated H-ras-transformed NIH3T3 cells.</p>Fórmula:C38H32N2O12Pureza:98%Cor e Forma:SolidPeso molecular:708.67
