ERK
ERK é uma proteína chave na via de sinalização MAPK (Mitogen-Activated Protein Kinase), que está envolvida na transmissão de sinais dos receptores de superfície celular para o DNA no núcleo da célula. ERK desempenha um papel crucial na regulação de vários processos celulares, incluindo proliferação, diferenciação e sobrevivência. A desregulação da sinalização ERK está associada ao desenvolvimento de câncer e outras doenças, tornando-a um alvo importante para intervenções terapêuticas. Na CymitQuimica, oferecemos uma seleção de inibidores e moduladores de ERK de alta qualidade para apoiar sua pesquisa em sinalização celular, oncologia e desenvolvimento terapêutico.
Foram encontrados 238 produtos para "ERK".
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Lidocaine
CAS:Lidocaine, an amide local anesthetic, reduces pain and inflammation by dampening ICAM-1, cytokines, and neutrophil influx.Fórmula:C14H22N2OPureza:99.88% - >99.99%Cor e Forma:White SolidPeso molecular:234.3373Mefloquine
CAS:Mefloquine (Ro 215998), a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor.Fórmula:C17H16F6N2OPureza:99.89%Cor e Forma:SolidPeso molecular:378.3122MK2-IN-3 hydrate
CAS:MK2-IN-3 hydrate (MK-2 Inhibitor III) is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM)Fórmula:C21H18N4O2Pureza:99.58%Cor e Forma:SolidPeso molecular:358.3932Mefloquine hydrochloride
CAS:Mefloquine hydrochloride (Mefloquin hydrochloride) is a quinoline derivative used for the prevention and therapy of P. falciparum malaria.Fórmula:C17H17ClF6N2OPureza:99% - 99.99%Cor e Forma:SolidPeso molecular:414.77MRTX-1257
CAS:MRTX-1257: selective, irreversible KRAS G12C inhibitor; IC50 of 900 pM; 31% bioavailable in mice; 77% target engagement.Fórmula:C33H39N7O2Pureza:96.76% - 97.3%Cor e Forma:Yellow SolidPeso molecular:565.7085PD 198306
CAS:PD 198306: a MEK inhibitor with antihyperalgesic properties, reduces Streptozocin-boosted active ERK1.Fórmula:C18H16F3IN2O2Pureza:99.66%Cor e Forma:SolidPeso molecular:476.23AX-15836
CAS:AX-15836 is an inhibitor of ERK5 (IC50 : 8 nM).Fórmula:C32H40N8O5SPureza:98.96%Cor e Forma:SolidPeso molecular:648.776LUT014
CAS:LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.Fórmula:C27H19F3N8OPureza:99.03%Cor e Forma:Yellow SolidPeso molecular:528.488CC-90003
CAS:CC-90003 is a selective inhibitor of ERK 1/2. It has antitumor activity.Fórmula:C22H21F3N6O2Pureza:99.42%Cor e Forma:SolidPeso molecular:458.4363Methylthiouracil
CAS:Methylthiouracil (NSC-193526) is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.Fórmula:C5H6N2OSPureza:98.82% - 99.89%Cor e Forma:SolidPeso molecular:142.179BAY 2965501
CAS:BAY 2965501 is a potent and selective diacylglycerol kinase zeta (DGKζ) inhibitor that induces pERK activation.BAY 2965501 can be used in the study of cancer.Fórmula:C20H19FN4O3SPureza:99.89%Cor e Forma:SolidPeso molecular:414.453ERK5-IN-5
CAS:ERK5-IN-5 is extracellular signal-regulated kinase 5 (ERK5) inhibitor with anticancer activity anticonvulsant activity inhibits A549 cell proliferation.Fórmula:C19H16ClN3OPureza:99.89%Cor e Forma:SolidPeso molecular:337.8(E/Z)-BCI
CAS:(E/Z)-BCI (NSC-150117), a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory properties, reduces LPS-induced inflammatory mediators and ROSFórmula:C22H23NOPureza:99.94%Cor e Forma:White SolidPeso molecular:317.4241ERK5-IN-6
CAS:ERK5-IN-6 is an ERK5 kinase inhibitor with antiproliferative, anticonvulsant, and antitumor activity for the study of central nervous system related diseases.Fórmula:C23H21N3Pureza:99.87%Cor e Forma:SolidPeso molecular:339.43Honokiol
CAS:Honokiol (NSC-293100) is the active principle of magnolia extract. It inhibits the activation of Akt and enhances the phosphorylation of ERK1/ERK2.Fórmula:C18H18O2Pureza:99.65% - 99.94%Cor e Forma:Dark Brown To White Fine Powder With Pleasant Odor Spicy And Slightly Bitter TastePeso molecular:266.3343Lidocaine Hydrochloride hydrate
CAS:Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.Fórmula:C14H22N2O·HCl·H2OPureza:99.95%Cor e Forma:SolidPeso molecular:288.82Urolithin B
CAS:Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in diverse plant foods, including pomegranates, berries, walnuts, tropicalFórmula:C13H8O3Pureza:99.45%Cor e Forma:SolidPeso molecular:212.2008Anti-inflammatory agent 35
CAS:Anti-inflammatory agent 35 is a potent anti-inflammatory agent.Fórmula:C27H29NO8Pureza:99.98%Cor e Forma:White SolidPeso molecular:495.5211Endothelin-1 (1-31) (Human)
CAS:Endothelin-1 (1-31) is a human-derived vasoconstrictor and hypertensive formed by chymase hydrolysis of big ET-1.Fórmula:C162H236N38O47S5Peso molecular:3628.16SOS1-IN-18
SOS1-IN-18 (Compound 8) is an inhibitor of the Son of Sevenless 1 protein (SOS1) with a dissociation constant (KD) of 2.6 nM. It disrupts the SOS1-KRAS G12C interaction with an IC50 of 3.4 nM, inhibits ERK phosphorylation in H358 cells with an IC50 of 31 nM, and curtails the proliferation of H358 cells with an IC50 of 5 nM.Fórmula:C26H29F3N4O2Cor e Forma:SolidPeso molecular:486.53
