p38 MAPK
As p38 MAPKs são um subgrupo de MAPKs que respondem a sinais de estresse e estão envolvidas na regulação da inflamação, diferenciação celular, apoptose e autofagia. A sinalização de p38 MAPK é crucial nas respostas imunes e está implicada em várias doenças, incluindo condições inflamatórias crônicas, câncer e distúrbios neurodegenerativos. Na CymitQuimica, oferecemos uma gama abrangente de inibidores e moduladores de p38 MAPK para apoiar sua pesquisa em inflamação, resposta ao estresse e desenvolvimento terapêutico.
Foram encontrados 125 produtos para "p38 MAPK".
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AZD7624
CAS:AZD7624 is an p38 inhibitor. It has potent anti-inflammatory activity.Fórmula:C27H30FN5O3Pureza:98.82%Cor e Forma:White SolidPeso molecular:491.56Ref: TM-T14381
1mg70,00€5mg152,00€1mL*10mM (DMSO)166,00€10mg236,00€25mg432,00€50mg647,00€100mg964,00€Aspirin
CAS:Aspirin (Acetylsalicylic Acid) is a COX inhibitor. Aspirin has anti-inflammatory, antipyretic and analgesic activities. Cost-effective and quality-assured.Fórmula:C9H8O4Pureza:99.78% - 99.91%Cor e Forma:SolidPeso molecular:180.1574Oxidopamine hydrobromide
CAS:Oxidopamine hydrobromide (6-OHDA hydrobromide) is a neurotransmitter dopamine antagonist.Fórmula:C8H12BrNO3Pureza:98.59% - 99.88%Cor e Forma:Brown SolidPeso molecular:250.09LXH254
CAS:LXH254 is a B/C RAF inhibitor with IC50 values of 0.2 nM and 0.07 nM for inhibiting BRAF and CRAF.Cost-effective and quality-assured.Fórmula:C25H25F3N4O4Pureza:98.30% - 99.92%Cor e Forma:White SolidPeso molecular:502.49Ref: TM-T11898
1mg50,00€5mg115,00€1mL*10mM (DMSO)128,00€10mg175,00€25mg344,00€50mg537,00€100mg653,00€200mg898,00€500mg1.369,00€Dehydrocorydaline chloride
CAS:Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid with anti-inflammatory and anti-cancer activity. Can improve the activation of p38 MAPK.Fórmula:C22H24ClNO4Pureza:99.53%Cor e Forma:SolidPeso molecular:401.88Ref: TM-T10990
1mg55,00€5mg105,00€1mL*10mM (DMSO)117,00€10mg152,00€25mg250,00€50mg375,00€100mg533,00€Carbimazole
CAS:Carbimazole, an imidazolium-based thyroid blocker, turns to MMI in the body. Used in Graves' disease research.Fórmula:C7H10N2O2SPureza:99.98%Cor e Forma:White SolidPeso molecular:186.23Ro-3201195
CAS:Ro-3201195 is a novel orally available p38 MAPK inhibitor with high selectivity.Fórmula:C19H18FN3O4Pureza:99.84%Cor e Forma:SolidPeso molecular:371.36Ref: TM-T68134
1mg81,00€5mg172,00€1mL*10mM (DMSO)187,00€10mg259,00€25mg424,00€50mg583,00€100mg800,00€BI-3406
CAS:BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.Fórmula:C23H25F3N4O3Pureza:99.2% - 99.66%Cor e Forma:SolidPeso molecular:462.46Ref: TM-T12979
1mg70,00€5mg152,00€1mL*10mM (DMSO)155,00€10mg236,00€25mg439,00€50mg628,00€100mg872,00€500mg1.738,00€PF-3644022
CAS:PF-3644022 is a selective MK2 inhibitor, effective against TNFα (IC50: 5.2 nM, Ki: 3 nM), with anti-inflammatory properties. Also blocks MK3 and PRAK.Fórmula:C21H18N4OSPureza:98.13%Cor e Forma:SolidPeso molecular:374.46Ref: TM-T16501
1mg34,00€5mg105,00€1mL*10mM (DMSO)117,00€10mg192,00€25mg394,00€50mg587,00€100mg788,00€500mg1.575,00€Dilmapimod
CAS:Dilmapimod (SB-681323) is a potent inhibitor of p38 MAPK ,it potentially suppresses inflammation in chronic obstructive pulmonary disease.Fórmula:C23H19F3N4O3Pureza:97.53%Cor e Forma:White SolidPeso molecular:456.42SB220025
CAS:SB220025 is a P38 mitogen-activated protein kinase inhibitor that inhibits p56Lck and PKC, and inhibits angiogenesis.Fórmula:C18H19FN6Pureza:99.97%Cor e Forma:White SolidPeso molecular:338.38Oxidopamine hydrochloride
CAS:Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is an neurotransmitter dopamine antagonist.Fórmula:C8H12ClNO3Pureza:98.34% - 99.85%Cor e Forma:White SolidPeso molecular:205.64Hesperetin
CAS:Hesperetin belongs to the flavanone class of flavonoids.Fórmula:C16H14O6Pureza:98.45% - 99.27%Cor e Forma:SolidPeso molecular:302.28Klotho-derived peptide 1 hydrochloride
Klotho-derived peptide 1 (KP1 human) hydrochloride inhibits the interaction between TGF-β and TGF-β receptor 2, suppressing the activation of TGF-β-induced Smad2/3 and mitogen-activated protein kinase (MAPK). Additionally, it exhibits antifibrotic and renal protective effects in mouse models.Cor e Forma:Odour SolidNR-11c
NR-11c is a selective and potent p38α PROTAC degrader. It effectively degrades p38α in various tumor cells. When administered to mice via intraperitoneal or tail vein injection, NR-11c primarily acts in the liver. It is used for cancer research.Fórmula:C59H71BrF2N10O8SCor e Forma:SolidPeso molecular:1198.22OVA-E1 peptide TFA
CAS:OVA-E1 peptide TFA activates the p38 and JNK cascades similarly in mutant and wild-type thymocytes.Fórmula:C49H77F3N10O16Pureza:98%Cor e Forma:SolidPeso molecular:1119.19p38 MAP Kinase Inhibitor Ⅵ
CAS:p38 MAP Kinase Inhibitor Ⅵ is a potent p38 MAP Kinase inhibitor with anti-inflammatory activity.Fórmula:C16H13FN2OS2Pureza:98.53%Cor e Forma:Yellow SolidPeso molecular:332.42DB-10
DB-10 serves as a precursor to 3-nbutylphthalide (NBP). It is absorbed by cells in a temperature and energy-dependent manner through the pyrilamine cation transporter. DB-10 enhances cell survival and rapidly converts into an active form in vivo, increasing accumulation within the brain. This compound is applicable in ischemic stroke research.Cor e Forma:Odour SolidPDE4-IN-26
PDE4-IN-26 (Compound A5) is an orally active, highly selective inhibitor of PDE4. It exhibits anti-inflammatory properties by inhibiting p38 MAPK phosphorylation. In mouse models of acute lung injury and chronic obstructive pulmonary disease, PDE4-IN-26 reduces lung inflammation, damage, and fibrosis, while promoting sputum secretion and alleviating cough. It is useful for researching lung injury-related diseases.Fórmula:C22H18F2N4O3SCor e Forma:SolidPeso molecular:456.47MAP3K5-IN-1
CAS:Compound 7, also known as 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine, serves as an inhibitor of protein kinases, displaying IC50 values of 0.092 μM for PKC-α, 0.26 μM for ROCK, and 0.77 μM for ASK1. Additionally, this compound exhibits significant cytotoxicity towards PC-3 cancer cells, with an IC50 of 0.16 μM [1].Fórmula:C28H24N4O4Cor e Forma:SolidPeso molecular:480.51
