CFTR
CFTR é uma proteína de canal de cloreto que regula o transporte de íons cloreto e bicarbonato através das membranas das células epiteliais, desempenhando um papel crucial na manutenção do equilíbrio de fluidos nos tecidos. As mutações no gene CFTR levam à fibrose cística, uma desordem genética caracterizada pela produção de muco espesso que pode obstruir as vias aéreas e levar a graves problemas respiratórios e digestivos. Na CymitQuimica, oferecemos uma seleção de moduladores de CFTR para apoiar sua pesquisa em fibrose cística, transporte de íons e distúrbios genéticos.
Foram encontrados 67 produtos para "CFTR".
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GLPG-3221
CAS:GLPG-3221, a potent oral CFTR corrector for cystic fibrosis treatment, has an EC50 of 105 nM.Fórmula:C30H37F3N2O6Pureza:98%Cor e Forma:SolidPeso molecular:578.62(R)-Olacaftor
CAS:(R)-Olacaftor (VX-440) is a CFTR modulator with promise for researching cystic fibrosis.Fórmula:C29H34FN3O4SCor e Forma:SolidPeso molecular:539.661Ivacaftor-D9
CAS:Ivacaftor-D9 is a deuterated compound of ivacaftor used for isotope tracing. Ivacaftor is an effective, orally administered CFTR modulator, cystic fibrosis.Fórmula:C24H19D9N2O3Pureza:99.13%Cor e Forma:White SolidPeso molecular:401.55GLPG2451
CAS:GLPG2451 is an effective CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) enhancer, potentiates cold-rescued F508del CFTR (EC50=11.1 nM).Fórmula:C16H16F3N3O5SPureza:99.13%Cor e Forma:White SolidPeso molecular:419.376SRI-37240
CAS:SRI-37240 suppresses CFTR nonsense mutations, aids in fixing premature termination codons, works with G418.Fórmula:C24H23N3O2Pureza:98.73%Cor e Forma:SolidPeso molecular:385.4583Crinecerfont
CAS:Crinecerfont (SSR-125543) is a CRF1 antagonist, useful in congenital adrenal hyperplasia research.Fórmula:C27H28ClFN2OSPureza:97.79% - 98.55%Cor e Forma:SolidPeso molecular:483.04VRT-325
CAS:VRT-325 aids in dimerizing NBDs and folding TMDs, speeding up CF cell monolayer repair.Fórmula:C27H34N4O4SPureza:99.15% - 99.58%Cor e Forma:White SolidPeso molecular:510.648Bamocaftor
CAS:Bamocaftor corrects CFTR in CF, restoring F508del-CFTR function, used with tezacaftor and VX-561 for F508del/MF patients.Fórmula:C28H32F3N5O4SPureza:99.71%Cor e Forma:SolidPeso molecular:591.645UCCF-853
CAS:UCCF-853 是一种小分子 CFTR 调节剂，可用于研究囊性纤维化。Fórmula:C14H8ClF3N2OPureza:99.82%Cor e Forma:SolidPeso molecular:312.67VRT-532
CAS:VRT-532 (CFpot-532) is an effective modulator of CFTR and is commonly used in studies of cystic fibrosis (CF) caused by CFTR defects.Fórmula:C16H14N2OPureza:99.88% - 99.93%Cor e Forma:SolidPeso molecular:250.2952PG01
CAS:PG01 is a potent CFTR Cl-channel potentiator, effective against ΔF508 (Ka 0.3 μM), and also against E193K, G970R and G551D (CFTR mutants), with Kd values of 0.Fórmula:C28H29N3O2Pureza:99.79%Cor e Forma:SolidPeso molecular:439.55CFTR corrector 8
CAS:CFTR corrector 8: potent for cystic fibrosis research, modulates CFTR protein.Fórmula:C29H27F2NO7Pureza:99.57%Cor e Forma:White SolidPeso molecular:539.524CFTR corrector 6
CAS:CFTR corrector 6, a potent CFTR potentiator, aids cystic fibrosis research and related disorders.Fórmula:C22H13F4N9Cor e Forma:SolidPeso molecular:479.3925CFTR corrector 12
CAS:CFTR corrector 12 is a CFTR corrector that rescues all mutant proteins except M760R ABCA3 and can be used to study cystic fibrosis.Fórmula:C19H21ClN4O2S2Pureza:99.97%Cor e Forma:SolidPeso molecular:436.98(R)-Vanzacaftor
CAS:(R)-Vanzacaftor ((R)-VX-121) is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator [1].Fórmula:C32H39N7O4SCor e Forma:SolidPeso molecular:617.76DNDS
CAS:DNDS is a channel blocker of voltage-dependent cystic fibrosis transmembrane conductance regulator (CFTR).Fórmula:C14H8N2Na2O10S2Pureza:99.92%Cor e Forma:Yellow SolidPeso molecular:474.33Chromanol 293B
CAS:Chromanol 293B, Cardiac IK and CFTR chloride current inhibitor (IC50=1-19 μM), weak KATP channel blocker, for arrhythmia research.Fórmula:C15H20N2O4SPureza:99.78%Cor e Forma:White SolidPeso molecular:324.4BPO-27 racemate
CAS:BPO-27 racemate (BPO-27 (racemate)) is an effective CFTR inhibitor with IC50 of 8 nM.Fórmula:C26H18BrN3O6Pureza:97.67% - 98.86%Cor e Forma:SolidPeso molecular:548.342CRF1 receptor antagonist-1
CAS:CRF1 Receptor Antagonist-1 (Compound 2), a CRF1 receptor antagonist, is utilized in research pertaining to congenital adrenal hyperplasia (CAH) [1].Fórmula:C27H28ClFN2O2SPureza:98%Cor e Forma:SolidPeso molecular:499.04(R)-Elexacaftor
CAS:(R)-Elexacaftor (compound 37) is the enantiomer of Elexacaftor (compound 1). (R)-Elexacaftor is a CFTR modulator with an EC50 of 0.29 μM for CFTR dF508.Fórmula:C26H34F3N7O4SPureza:98.99%Cor e Forma:White SolidPeso molecular:597.65
