CFTR
CFTR é uma proteína de canal de cloreto que regula o transporte de íons cloreto e bicarbonato através das membranas das células epiteliais, desempenhando um papel crucial na manutenção do equilíbrio de fluidos nos tecidos. As mutações no gene CFTR levam à fibrose cística, uma desordem genética caracterizada pela produção de muco espesso que pode obstruir as vias aéreas e levar a graves problemas respiratórios e digestivos. Na CymitQuimica, oferecemos uma seleção de moduladores de CFTR para apoiar sua pesquisa em fibrose cística, transporte de íons e distúrbios genéticos.
Foram encontrados 66 produtos de "CFTR"
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GLPG2451
CAS:GLPG2451 is an effective CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) enhancer, potentiates cold-rescued F508del CFTR (EC50=11.1 nM).Fórmula:C16H16F3N3O5SPureza:99.13%Cor e Forma:SolidPeso molecular:419.38Ref: TM-T13705
1mg106,00€5mg253,00€1mL*10mM (DMSO)279,00€10mg387,00€25mg785,00€50mg1.170,00€100mg1.564,00€(R)-Posenacaftor sodium
CAS:(R)-Posenacaftor sodium is a modulator for correcting cystic fibrosis protein folding.Fórmula:C27H27NNaO5Cor e Forma:SolidPeso molecular:468.505Posenacaftor
CAS:Posenacaftor (PTI-801) regulates CFTR protein for cystic fibrosis research.Fórmula:C27H27NO5Cor e Forma:SolidPeso molecular:445.51GLPG-3221
CAS:GLPG-3221, a potent oral CFTR corrector for cystic fibrosis treatment, has an EC50 of 105 nM.Fórmula:C30H37F3N2O6Pureza:98%Cor e Forma:SolidPeso molecular:578.62Bamocaftor
CAS:Bamocaftor corrects CFTR in CF, restoring F508del-CFTR function, used with tezacaftor and VX-561 for F508del/MF patients.Fórmula:C28H32F3N5O4SPureza:99.71%Cor e Forma:SolidPeso molecular:591.65Ref: TM-T30293
1mg354,00€5mg847,00€10mg1.159,00€1mL*10mM (DMSO)1.225,00€25mg1.700,00€50mg2.308,00€100mg3.117,00€PG01
CAS:PG01 is a potent CFTR Cl-channel potentiator, effective against ΔF508 (Ka 0.3 μM), and also against E193K, G970R and G551D (CFTR mutants), with Kd values of 0.Fórmula:C28H29N3O2Pureza:99.79%Cor e Forma:SolidPeso molecular:439.55Ref: TM-T16516
1mg55,00€1mL*10mM (DMSO)144,00€5mg148,00€10mg215,00€25mg344,00€50mg465,00€100mg630,00€200mg850,00€Crinecerfont
CAS:Crinecerfont (SSR-125543) is a CRF1 antagonist, useful in congenital adrenal hyperplasia research.Fórmula:C27H28ClFN2OSPureza:97.79% - 98.55%Cor e Forma:SolidPeso molecular:483.04VRT-325
CAS:VRT-325 aids in dimerizing NBDs and folding TMDs, speeding up CF cell monolayer repair.Fórmula:C27H34N4O4SPureza:99.15% - 99.58%Cor e Forma:SolidPeso molecular:510.65UCCF-853
CAS:UCCF-853 是一种小分子 CFTR 调节剂，可用于研究囊性纤维化。Fórmula:C14H8ClF3N2OPureza:99.82%Cor e Forma:SolidPeso molecular:312.67VRT-532
CAS:VRT-532 (CFpot-532) is an effective modulator of CFTR and is commonly used in studies of cystic fibrosis (CF) caused by CFTR defects.
Fórmula:C16H14N2OPureza:99.88% - 99.93%Cor e Forma:SolidPeso molecular:250.3CFTR corrector 8
CAS:CFTR corrector 8: potent for cystic fibrosis research, modulates CFTR protein.
Fórmula:C29H27F2NO7Pureza:99.57%Cor e Forma:SolidPeso molecular:539.52Chromanol 293B
CAS:Chromanol 293B, Cardiac IK and CFTR chloride current inhibitor (IC50=1-19 μM), weak KATP channel blocker, for arrhythmia research.Fórmula:C15H20N2O4SPureza:98%Cor e Forma:SolidPeso molecular:324.4(R)-Elexacaftor
CAS:(R)-Elexacaftor (compound 37) is the enantiomer of Elexacaftor (compound 1). (R)-Elexacaftor is a CFTR modulator with an EC50 of 0.29 μM for CFTR dF508.Fórmula:C26H34F3N7O4SPureza:98.991%Cor e Forma:SolidPeso molecular:597.65Ref: TM-T78240
1mg99,00€5mg249,00€1mL*10mM (DMSO)329,00€10mg402,00€25mg782,00€50mg1.180,00€100mg1.848,00€200mg2.489,00€CRF1 receptor antagonist-1
CAS:CRF1 Receptor Antagonist-1 (Compound 2), a CRF1 receptor antagonist, is utilized in research pertaining to congenital adrenal hyperplasia (CAH) [1].Fórmula:C27H28ClFN2O2SPureza:98%Cor e Forma:SolidPeso molecular:499.04CFTR corrector 6
CAS:CFTR corrector 6, a potent CFTR potentiator, aids cystic fibrosis research and related disorders.Fórmula:C22H13F4N9Cor e Forma:SolidPeso molecular:479.39CFTR corrector 12
CAS:CFTR corrector 12 is a CFTR corrector that rescues all mutant proteins except M760R ABCA3 and can be used to study cystic fibrosis.Fórmula:C19H21ClN4O2S2Pureza:99.47%Cor e Forma:SolidPeso molecular:436.98DNDS
CAS:DNDS is a channel blocker of voltage-dependent cystic fibrosis transmembrane conductance regulator (CFTR).Fórmula:C14H8N2Na2O10S2Pureza:99.92%Cor e Forma:Physical Description White Powder (Ntp 1992)Peso molecular:474.33BPO-27 racemate
CAS:BPO-27 racemate (BPO-27 (racemate)) is an effective CFTR inhibitor with IC50 of 8 nM.Fórmula:C26H18BrN3O6Pureza:97.67% - 98.86%Cor e Forma:SolidPeso molecular:548.34Ref: TM-T10591
1mg44,00€5mg111,00€1mL*10mM (DMSO)128,00€10mg166,00€25mg265,00€50mg388,00€100mg535,00€200mg718,00€(R)-Vanzacaftor
CAS:(R)-Vanzacaftor ((R)-VX-121) is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator [1].Fórmula:C32H39N7O4SCor e Forma:SolidPeso molecular:617.76CFTR corrector 4
CAS:Potent, oral CFTR corrector 4 targets cystic fibrosis, increasing cell surface CFTR levels.Fórmula:C29H27F2NO7Pureza:99.32%Cor e Forma:SolidPeso molecular:539.52Ref: TM-T10776
1mg71,00€5mg166,00€1mL*10mM (DMSO)192,00€10mg250,00€25mg507,00€50mg713,00€100mg1.018,00€500mg2.035,00€
