Canal TRP/TRPV
Os canais TRP (Potencial do Receptor Transitório), incluindo a subfamília TRPV, são um grupo de canais iônicos envolvidos em vários processos sensoriais, como sensação de temperatura, percepção da dor e osmorregulação. Os canais TRP são amplamente expressos em diferentes tecidos e desempenham um papel nas respostas fisiológicas aos estímulos ambientais. Os canais TRPV, em particular, estão envolvidos na detecção de mudanças de temperatura e estão implicados em condições como dor crônica, inflamação e câncer. Na CymitQuimica, oferecemos uma gama abrangente de moduladores de canais TRP/TRPV para apoiar sua pesquisa em biologia sensorial, manejo da dor e transdução de sinais.
Foram encontrados 97 produtos de "Canal TRP/TRPV"
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BTD
CAS:BTD is a TRPC5 activator that activates heteromeric channel complexes composed of TRPC5 and its closest relatives TRPC1 or TRPC4.Fórmula:C24H33N3O4SCor e Forma:SolidPeso molecular:459.6Phenazopyridine
CAS:Phenazopyridine is an orally administered azo dye with local analgesic effects on urinary tract infections,. against SARM1 and TRPM8.Fórmula:C11H11N5Pureza:99.98%Cor e Forma:SolidPeso molecular:213.24JNJ-17203212
CAS:JNJ-17203212 is a potent and selective antagonist of TRPV1 (human TRPV1 and rat TRPV1, IC50 of 65 nM and 102 nM).Fórmula:C17H15F6N5OPureza:99.18%Cor e Forma:SolidPeso molecular:419.32HC067047 Hydrochloride(883031-03-6 free base)
CAS:HC-067047 hydrochloride, a TRPV4 antagonist, selectively inhibits human, rat, and mouse currents with IC50s: 486 nM, 133 nM, and 17 nM.Fórmula:C26H29ClF3N3O2Pureza:99.95%Cor e Forma:SolidPeso molecular:507.98Ref: TM-T4680L
1mg84,00€5mg168,00€1mL*10mM (DMSO)207,00€10mg245,00€25mg404,00€50mg567,00€100mg767,00€200mg1.018,00€ML204 hydrochloride
CAS:ML204 hydrochloride (ML204 HCl) is a TRPC4/TRPC5 channel antagonist.Fórmula:C15H19ClN2Cor e Forma:SolidPeso molecular:262.78MK6-83
CAS:MK6-83 is the transient receptor potential channel ML3 agonist.Fórmula:C16H20N2O2S2Pureza:99.5%Cor e Forma:SolidPeso molecular:336.47RQ-00203078
CAS:RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist.Fórmula:C21H13ClF6N2O5SPureza:98% - 99.6%Cor e Forma:SolidPeso molecular:554.85A-967079
CAS:A 967079 is a potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC50 values of 67 and 289 nM for the human and rat isoforms, respectively
Fórmula:C12H14FNOPureza:98.34% - 99.75%Cor e Forma:SolidPeso molecular:207.24HC-030031
CAS:HC-030031 (TOSLAB 829227) is a potent TRPA1 inhibitor, which antagonizes AITC- and formalin-evoked calcium influx with IC50s of 6.2 and 5.3 μM, respectively.Fórmula:C18H21N5O3Pureza:99.69% - ≥95%Cor e Forma:SolidPeso molecular:355.39Evifacotrep
CAS:Evifacotrep: TRPC5 antagonist for neurological disease research (WO2020061162, compound 100).Fórmula:C18H12ClF4N5O2Pureza:98.6%Cor e Forma:SolidPeso molecular:441.77Ref: TM-T40042
1mg92,00€1mL*10mM (DMSO)152,00€5mg178,00€10mg286,00€25mg440,00€50mg655,00€100mg973,00€200mg1.468,00€WS-12
CAS:WS-12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 : 193 nM)Fórmula:C18H27NO2Pureza:99.99%Cor e Forma:Whitish To White Solid CrystallinePeso molecular:289.41Chembridge-5861528
CAS:Chembridge-5861528 (TCS 5861528) is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx with IC50 values of 14.3 and 18.7 μM.Fórmula:C19H23N5O3Pureza:99.97%Cor e Forma:SolidPeso molecular:369.42GSK2193874
CAS:GSK2193874 was identified as a selective, orally active TRPV4 blocker.Fórmula:C37H38BrF3N4OPureza:99.99% - ≥95%Cor e Forma:SolidPeso molecular:691.62Ref: TM-T5640
1mg40,00€2mg54,00€5mg77,00€1mL*10mM (DMSO)105,00€10mg120,00€25mg234,00€50mg384,00€100mg570,00€Pyr10
CAS:Pyr10, a pyrazole derivative, selectively inhibits TRPC3, not STIM1/Orai1, with IC50 of 0.72 μM in TRPC3-HEK293, and 13.08 μM in BRL-2H3 cells.Fórmula:C18H13F6N3O2SPureza:99.69% - 99.7%Cor e Forma:SolidPeso molecular:449.37Pico145
CAS:Pico145 (HC-608) is a remarkable inhibitor of TRPC1/4/5 channels.Fórmula:C23H20ClF3N4O5Pureza:99.06%Cor e Forma:SolidPeso molecular:524.88Ref: TM-T16532
1mg70,00€5mg150,00€1mL*10mM (DMSO)167,00€10mg215,00€25mg358,00€50mg517,00€100mg707,00€200mg1.009,00€Ononetin
CAS:Ononetin (2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone) is a TRPM3 channel blocker(IC50: 0.3 μM).Fórmula:C15H14O4Pureza:98.06%Cor e Forma:SolidPeso molecular:258.27TRPM4-IN-1
CAS:TRPM4-IN-1 (4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid) is a potent and selective inhibitor of TRPM4 with an IC50 of 1.5 μM.Fórmula:C15H11Cl2NO4Pureza:97.22%Cor e Forma:SolidPeso molecular:340.16AMG 333
CAS:AMG 333 is TRPM8 antagonist with an IC50 of 13 nM,a Clinical Candidate for the Treatment of Migraine.Fórmula:C20H12F5N3O4Pureza:99.95%Cor e Forma:SolidPeso molecular:453.32PF-4840154
CAS:PF-4840154: potent TrpA1 agonist; EC50 of 97 nM (rat) & 23 nM (human); triggers nociception in mice.
Fórmula:C26H38N6O2Pureza:>99.99%Cor e Forma:SolidPeso molecular:466.629-Phenanthrol
CAS:9-Phenanthrol is inhibitor of the transient receptor potential melastatin 4 (TRPM) channel, a Ca2+ -activated non-selective cation channel.Fórmula:C14H10OPureza:98.48%Cor e Forma:SolidPeso molecular:194.23
