Canal TRP/TRPV
Os canais TRP (Potencial do Receptor Transitório), incluindo a subfamília TRPV, são um grupo de canais iônicos envolvidos em vários processos sensoriais, como sensação de temperatura, percepção da dor e osmorregulação. Os canais TRP são amplamente expressos em diferentes tecidos e desempenham um papel nas respostas fisiológicas aos estímulos ambientais. Os canais TRPV, em particular, estão envolvidos na detecção de mudanças de temperatura e estão implicados em condições como dor crônica, inflamação e câncer. Na CymitQuimica, oferecemos uma gama abrangente de moduladores de canais TRP/TRPV para apoiar sua pesquisa em biologia sensorial, manejo da dor e transdução de sinais.
Foram encontrados 96 produtos de "Canal TRP/TRPV"
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Mavatrep
CAS:Mavatrep (JNJ-39439335) is a selective antagonist of TRPV1 with Ki of 6.5 nM and can be used for studies about inflammatory pain.Fórmula:C25H21F3N2OPureza:98.51% - 99.31%Cor e Forma:SolidPeso molecular:422.44Ref: TM-T16014
1mg63,00€2mg90,00€5mg137,00€1mL*10mM (DMSO)150,00€10mg215,00€25mg385,00€50mg618,00€100mg888,00€200mg1.243,00€SET 2
CAS:SET 2 is an antagonist of transient receptor potential vanilloid type 2(TRPV2) with an IC50 of 0.46 μM. SET 2 shows selectivity over TRPV1, TRPV3 and TRPV4.Fórmula:C17H21F3N4O2SPureza:99.77%Cor e Forma:SolidPeso molecular:402.43Ref: TM-T37097
500mgA consultar5mg55,00€1mL*10mM (DMSO)67,00€10mg92,00€25mg168,00€50mg284,00€100mg414,00€FEMA-4809
CAS:FEMA-4809 activates TRPM8, the ion channel for cold sensation, and is used as a cooling agent.Fórmula:C17H17N3O2SPureza:99.9%Cor e Forma:SolidPeso molecular:327.4Ref: TM-T27308
1mg34,00€5mg73,00€1mL*10mM (DMSO)84,00€10mg110,00€25mg180,00€50mg255,00€100mg363,00€200mg497,00€MSP3
CAS:MSP3 is an agonist of TRPV1 (EC50 = 0.87 μM) and shows antinociceptive and neuroprotective effects.Fórmula:C16H19NO3SPureza:99.89%Cor e Forma:SolidPeso molecular:305.39Ref: TM-T28118
2mg33,00€5mg50,00€1mL*10mM (DMSO)71,00€10mg80,00€25mg161,00€50mg243,00€100mg358,00€200mg505,00€MK-2295
CAS:MK-2295 is a potent TRPV1 antagonist. MK-2295 can be used in studies about the treatment of chronic pain.Fórmula:C27H31FN6O2Pureza:98.83% - 99.44%Cor e Forma:SolidPeso molecular:490.57Mesendogen
CAS:Mesendogen is an inhibitor of transient receptor potential cation channel, subfamily M, member 6 (TRPM6) and 7 (TRPM7) and acts by inhibiting TRPM6/TRPM7Fórmula:C18H16ClF3N2OSPureza:99.66%Cor e Forma:SolidPeso molecular:400.85GSK3395879
CAS:GSK3395879 is a selective and orally bioavailable antagonist of transient receptor potential vanilloid-4 (TRPV4) (IC50: 1 nM for hTRPV4).Fórmula:C20H15F4N3O5SPureza:98%Cor e Forma:SolidPeso molecular:485.41PF-05105679
CAS:PF-05105679 is a selective TRPM8 antagonist (IC50 = 103 nM). PF-05105679 can be used in research on cold-related pain.Fórmula:C26H21FN2O3Pureza:99.84%Cor e Forma:SolidPeso molecular:428.45Ref: TM-T16483
1mg44,00€2mg57,00€1mL*10mM (DMSO)90,00€5mg93,00€10mg138,00€25mg264,00€50mg404,00€100mg610,00€200mg848,00€JT010
CAS:JT010 is an effective agonist of TRPA1 (EC50 = 0.65 nM).Fórmula:C16H19ClN2O3SPureza:99.75%Cor e Forma:SolidPeso molecular:354.85A-1165442
CAS:A-1165442 is a competitive TRPV1 antagonist. For human TRPV, the IC50 values is 9 nM.Fórmula:C22H20ClF2N3O2Cor e Forma:SolidPeso molecular:431.86AMG-0347
CAS:AMG-0347 inhibits TRPA1 ion channels in sensory neurons, blocking pain perception.Fórmula:C24H26F3N3O2Pureza:99.93%Cor e Forma:SolidPeso molecular:445.48Ref: TM-T29968
1mg215,00€5mg523,00€1mL*10mM (DMSO)537,00€10mg695,00€25mg1.054,00€50mg1.414,00€100mg1.900,00€200mg2.565,00€AMG2850
CAS:AMG2850 is a potent, orally bioavailable, and selective antagonist of transient receptor potential melastatin 8 (TRPM8).Fórmula:C19H17F6N3OPureza:99.84%Cor e Forma:SolidPeso molecular:417.35Ref: TM-T10300
1mg71,00€5mg161,00€1mL*10mM (DMSO)172,00€10mg235,00€25mg423,00€50mg627,00€100mg803,00€ELP-004
CAS:ELP-004 is a TRPC channel inhibitor that blocks Ca2+ entry mediated by TRPC channels. It serves as an osteoclast inhibitor by preventing osteoclast differentiation. ELP-004 also hinders basal Ca2+ levels and the associated translocation of NFATc1 in inflammatory osteoclastogenesis. Additionally, it reduces bone erosion in mouse models of rheumatoid arthritis.Fórmula:C10H11Cl2NOCor e Forma:SolidPeso molecular:232.106TRPA1 Antagonist 1
CAS:TRPA1 Antagonist 1 is an antagonist of TRPA1(IC50: 8 nM) and is a methylene phosphate prodrug which converts to its active parent drug.Fórmula:C24H20F6N5Na2O7PSPureza:98%Cor e Forma:SolidPeso molecular:713.45Apcin A HCL
CAS:Apcin A HCL is an Apcin derivative. Apcin A HCL is an anaphase-promoting complex (APC) inhibitor. Apcin-A HCL interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A HCL can be used to synthesize the PROTAC CP5V [1].
Fórmula:C10H15Cl4N5O2Pureza:99.30%Cor e Forma:SolidPeso molecular:379.07Motugivatrep
CAS:Motugivatrep is a potent and selective TRPV1 antagonist that can be used to study TRPV1-related respiratory diseases.
Fórmula:C22H20F3NO3Pureza:99.22%Cor e Forma:SolidPeso molecular:403.39
