Canal TRP/TRPV
Os canais TRP (Potencial do Receptor Transitório), incluindo a subfamília TRPV, são um grupo de canais iônicos envolvidos em vários processos sensoriais, como sensação de temperatura, percepção da dor e osmorregulação. Os canais TRP são amplamente expressos em diferentes tecidos e desempenham um papel nas respostas fisiológicas aos estímulos ambientais. Os canais TRPV, em particular, estão envolvidos na detecção de mudanças de temperatura e estão implicados em condições como dor crônica, inflamação e câncer. Na CymitQuimica, oferecemos uma gama abrangente de moduladores de canais TRP/TRPV para apoiar sua pesquisa em biologia sensorial, manejo da dor e transdução de sinais.
Foram encontrados 98 produtos para "Canal TRP/TRPV".
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Olvanil
CAS:Olvanil (N-Vannilyloleoylamide) is a vanilloid receptor agonist with EC50 of 0.7nM.Fórmula:C26H43NO3Pureza:99.58%Cor e Forma:SolidPeso molecular:417.62Ref: TM-T23106
2mg34,00€5mg49,00€1mL*10mM (DMSO)50,00€10mg75,00€25mg145,00€50mg236,00€100mg385,00€200mg560,00€Pyr3
CAS:Pyr3 selectively blocks TRPC3 channels, reducing Ca2+ influx; it's effective at 700 nM.Fórmula:C16H11Cl3F3N3O3Pureza:98.04%Cor e Forma:White SolidPeso molecular:456.63Ref: TM-T16687
1mg34,00€2mg49,00€5mg73,00€1mL*10mM (DMSO)81,00€10mg92,00€25mg203,00€50mg344,00€100mg485,00€200mg700,00€500mg1.063,00€MSP3
CAS:MSP3 is an agonist of TRPV1 (EC50 = 0.87 μM) and shows antinociceptive and neuroprotective effects.Fórmula:C16H19NO3SPureza:99.89%Cor e Forma:SolidPeso molecular:305.39HC-070
CAS:HC-070 is a TRPC5 and TRPC4 antagonist (IC50 = 9.3 nM and 46 nM).Fórmula:C22H20Cl2N4O4Pureza:98.48%Cor e Forma:SolidPeso molecular:475.32Ref: TM-T15465
1mg84,00€5mg160,00€1mL*10mM (DMSO)165,00€10mg236,00€25mg406,00€50mg572,00€100mg772,00€200mg1.035,00€ABT 102
CAS:ABT 102 (CHEMBL398338) is a selective antagonist of transient receptor potential vanilloid 1 (TRPV1) receptor.Fórmula:C21H24N4OPureza:98.38% - 99.86%Cor e Forma:White SolidPeso molecular:348.44Ref: TM-T29522
1mg109,00€5mg235,00€1mL*10mM (DMSO)245,00€10mg349,00€25mg532,00€50mg745,00€100mg999,00€200mg1.333,00€TC-I 2014
CAS:TC-I 2014 shows antiallodynic properties in pain models.Fórmula:C23H19F6N3OPureza:99.07%Cor e Forma:White SolidPeso molecular:467.41Ref: TM-T17006
1mg57,00€5mg120,00€1mL*10mM (DMSO)126,00€10mg192,00€25mg385,00€50mg620,00€100mg1.018,00€200mg1.378,00€MK-2295
CAS:MK-2295 is a potent TRPV1 antagonist. MK-2295 can be used in studies about the treatment of chronic pain.Fórmula:C27H31FN6O2Pureza:98.83% - 99.44%Cor e Forma:SolidPeso molecular:490.57A-1165442
CAS:A-1165442 is a competitive TRPV1 antagonist. For human TRPV, the IC50 values is 9 nM.Fórmula:C22H20ClF2N3O2Cor e Forma:SolidPeso molecular:431.86GSK3395879
CAS:GSK3395879 is a selective and orally bioavailable antagonist of transient receptor potential vanilloid-4 (TRPV4) (IC50: 1 nM for hTRPV4).Fórmula:C20H15F4N3O5SPureza:98%Cor e Forma:SolidPeso molecular:485.41JT010
CAS:JT010 is an effective agonist of TRPA1 (EC50 = 0.65 nM).Fórmula:C16H19ClN2O3SPureza:99.75%Cor e Forma:Orange SolidPeso molecular:354.85PF-05105679
CAS:PF-05105679 is a selective TRPM8 antagonist (IC50 = 103 nM). PF-05105679 can be used in research on cold-related pain.Fórmula:C26H21FN2O3Pureza:99.84%Cor e Forma:SolidPeso molecular:428.45Ref: TM-T16483
1mg44,00€2mg57,00€1mL*10mM (DMSO)90,00€5mg93,00€10mg138,00€25mg264,00€50mg404,00€100mg610,00€200mg848,00€Mesendogen
CAS:Mesendogen is an inhibitor of transient receptor potential cation channel, subfamily M, member 6 (TRPM6) and 7 (TRPM7) and acts by inhibiting TRPM6/TRPM7Fórmula:C18H16ClF3N2OSPureza:99.66%Cor e Forma:SolidPeso molecular:400.85TRPV2-selective blocker 1
CAS:TRPV2-selective blocker 1 specifically inhibits TRPV2 channel activity in macrophages.Fórmula:C15H18OS2Pureza:99.96%Cor e Forma:Transparent LiquidPeso molecular:278.43Ref: TM-T80930
1mg105,00€1mL*10mM (DMSO)240,00€5mg250,00€10mg432,00€25mg858,00€50mg1.369,00€100mg1.783,00€AMG-0347
CAS:AMG-0347 inhibits TRPA1 ion channels in sensory neurons, blocking pain perception.Fórmula:C24H26F3N3O2Pureza:99.93%Cor e Forma:Yellow SolidPeso molecular:445.48Ref: TM-T29968
1mg215,00€5mg523,00€1mL*10mM (DMSO)537,00€10mg695,00€25mg1.054,00€50mg1.414,00€100mg1.900,00€200mg2.565,00€AMG2850
CAS:AMG2850 is a potent, orally bioavailable, and selective antagonist of transient receptor potential melastatin 8 (TRPM8).Fórmula:C19H17F6N3OPureza:99.84%Cor e Forma:SolidPeso molecular:417.35Ref: TM-T10300
1mg71,00€5mg161,00€1mL*10mM (DMSO)172,00€10mg235,00€25mg423,00€50mg627,00€100mg803,00€ELP-004
CAS:ELP-004 is a TRPC channel inhibitor that blocks Ca2+ entry mediated by TRPC channels. It serves as an osteoclast inhibitor by preventing osteoclast differentiation. ELP-004 also hinders basal Ca2+ levels and the associated translocation of NFATc1 in inflammatory osteoclastogenesis. Additionally, it reduces bone erosion in mouse models of rheumatoid arthritis.Fórmula:C10H11Cl2NOCor e Forma:SolidPeso molecular:232.106IAA65
CAS:IAA65 is a potent selective TRPA1 inhibitor; IC50 4.3 nM; blocks calcium influx; analgesic; used for inflammatory and neuropathic pain research.Fórmula:C16H13F6NO2Pureza:97.46%Cor e Forma:SolidPeso molecular:365.27TRPA1 Antagonist 1
CAS:TRPA1 Antagonist 1 is an antagonist of TRPA1(IC50: 8 nM) and is a methylene phosphate prodrug which converts to its active parent drug.Fórmula:C24H20F6N5Na2O7PSPureza:98%Cor e Forma:SolidPeso molecular:713.45
