Canal de Sódio
Os canais de sódio são proteínas de membrana essenciais que permitem a passagem de íons de sódio (Na+) através da membrana celular, gerando e propagando sinais elétricos em neurônios, células musculares e outros tecidos excitáveis. Esses canais são vitais para a iniciação e condução de potenciais de ação, sendo cruciais em processos como a transmissão de impulsos nervosos, contração muscular e função cardíaca. A desregulação dos canais de sódio pode levar a distúrbios neurológicos, arritmias e condições de dor crônica. Na CymitQuimica, oferecemos uma variedade de moduladores de canais de sódio para apoiar sua pesquisa em neurobiologia, cardiologia e manejo da dor.
Foram encontrados 273 produtos para "Canal de Sódio".
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NaV1.2/1.6 channel blocker-1
CAS:NaV1.2/1.6 channel blocker-1 is a NaV1.2/1.6 channel blocker that inhibits rNaV1.6 and can be used to study generalised epilepsy and movement disorders.Fórmula:C14H14N2OSPureza:99.54%Cor e Forma:SolidPeso molecular:258.34Silperisone HCl
CAS:Silperisone HCl is a muscle relaxant and vasodilator, treating myoclonus, hypertonia, dystonia, and myospasm by blocking Na+ and Ca2+ channels.Fórmula:C15H25ClFNSiPureza:99.97%Cor e Forma:White SolidPeso molecular:301.9Elpetrigine
CAS:Elpetrigine (GW273293) is a potential sodium channel blocker with antiepileptic activity that can be used to study epilepsy.Fórmula:C10H7Cl3N4Pureza:99.04% - 99.96%Cor e Forma:SolidPeso molecular:289.55TC-N 1752
CAS:TC-N 1752 is an orally active inhibitor of Nav1.7 channel with IC50 of 0.17 μM. TC-N 1752 shows analgesic activities.Fórmula:C25H27F3N6O3Pureza:99.71%Cor e Forma:SolidPeso molecular:516.52Ref: TM-T23439
1mg34,00€5mg75,00€1mL*10mM (DMSO)84,00€10mg111,00€25mg245,00€50mg363,00€100mg515,00€200mg702,00€GDC-0310
CAS:GDC-0310 is a selective, orally available Nav1.7 inhibitor with an IC50 of 0.6 nM for human Nav1.7, suitable for pain research.Fórmula:C25H29Cl2FN2O4SPureza:99.87%Cor e Forma:White SolidPeso molecular:543.48Dimethylamiloride
CAS:Dimethylamiloride is a specific inhibitor of antiporters [1].Fórmula:C8H12ClN7OPureza:98.90%Cor e Forma:Yellow SolidPeso molecular:257.68SLC13A5-IN-1
CAS:SLC13A5-IN-1 is a selective inhibitor of sodium-citrate co-transporter (SLC13A5),completely blocks the uptake of 14C-citrate(IC50 : 0.022 μM in HepG2 cells).Fórmula:C19H19Cl3N2O3SPureza:99.67%Cor e Forma:White SolidPeso molecular:461.79Ref: TM-T12931
1mg48,00€5mg92,00€1mL*10mM (DMSO)92,00€10mg152,00€25mg268,00€50mg447,00€100mg623,00€200mg883,00€500mg1.305,00€PF 04531083
CAS:PF 04531083 is a selective blocker of the NaV1.8 channel. PF 04531083 can be used for neuropathic and inflammatory pain studies.Fórmula:C17H16ClN5O2Pureza:99.85%Cor e Forma:White SolidPeso molecular:357.79Aneratrigine
CAS:Aneratrigine is a blocker of the sodium channel protein type 9 subunit alpha, utilized in research on neuropathic pain diseases [1].Fórmula:C19H20ClF2N5O2S2Pureza:98%Cor e Forma:SolidPeso molecular:487.97(Rac)-AMG8379
CAS:(Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379 which is an orally active and selective sulfonamide NaV1.7 antagonist.Fórmula:C25H16ClF2N3O5SPureza:99.6%Cor e Forma:White SolidPeso molecular:543.93Co 102862
CAS:Co 102862 is a voltage-gated sodium channel blocker. Co 102862 can be used for anticonvulsant studies.Fórmula:C14H12FN3O2Pureza:99.82%Cor e Forma:SolidPeso molecular:273.266-Iodoamiloride
CAS:6-Iodoamiloride is a potent inhibitor of acid-sensing ion channel 1 (ASIC1), exhibiting an IC50 value of 88 nM.Fórmula:C6H8IN7OPureza:98%Cor e Forma:SolidPeso molecular:321.08PF-05150122
CAS:PF-05150122 is a potent and selective human Nav1.7 channel blocker with oral activity for treating acute or chronic pain.Fórmula:C24H21ClN6O3S2Pureza:99.95%Cor e Forma:White SolidPeso molecular:541.04Sodium Channel inhibitor 4
CAS:Sodium Channel inhibitor 4 is a NaV1.7 inhibitor; IC50=33 nM; analgesic activity; neuropathic pain research.Fórmula:C19H18ClN3O4S2Pureza:99.89%Cor e Forma:White SolidPeso molecular:451.95VGSCs-IN-1
CAS:VGSCs-IN-1, a VGSC inhibitor and Riluzole analog, exhibits good blocking activity on Nav1.4 and can be used to study cellular excitability disorders.Fórmula:C12H12F3N3OSPureza:99.92%Cor e Forma:SolidPeso molecular:303.3Funapide
CAS:Funapide (TV 45070) is a potent Nav1.7 inhibitor, potentially treating inflammation and various pains.Fórmula:C22H14F3NO5Pureza:99.91%Cor e Forma:SolidPeso molecular:429.35Ref: TM-T15358
1mg120,00€5mg289,00€1mL*10mM (DMSO)318,00€10mg439,00€25mg708,00€50mg954,00€100mg1.288,00€Aneratrigine hydrochloride
CAS:Aneratrigine hydrochloride is a Nav 1.9 blocker that may be used to prevent or treat sodium channel blocker-related disorders.Fórmula:C19H21Cl2F2N5O2S2Pureza:98.90% - 99.11%Cor e Forma:SolidPeso molecular:524.43ASIC1a antagonist-1
CAS:ASIC1a antagonist-1 (Compound 5b) is an orthosteric non-competitive antagonist of the acid-sensing ion channel 1a (ASIC1a) with an IC50 of 27 nM at pH 6.7. It alters the pH dependency of ASIC1a activation and suppresses its maximum response. Additionally, ASIC1a antagonist-1 completely inhibits the induction of long-term potentiation (LTP) in the CA3-CA1 pathway. This compound is useful for research into brain diseases and pathologies.Fórmula:C23H29Cl3N4O2Peso molecular:499.86Nav1.7 blocker 1
CAS:Nav1.7 blocker 1 (example 41), an effective Na+ channel (Na v) blocker, exhibits a potent IC50 value of 0.037 μM. This compound is utilized in pain research, encompassing neuropathic, postoperative, and inflammatory pain among others [1].Fórmula:C22H21FN4O4Cor e Forma:SolidPeso molecular:424.42PF-05661014
CAS:PF-05661014, a demethylated analogue of PF-06526290, selectively inhibits Nav1.3 and Nav1.7 currents by stabilizing the inactivated state through interaction with the D4 VSD. This compound is utilized in research focused on sodium channel modulation.Fórmula:C17H16N4O3S2Cor e Forma:SolidPeso molecular:388.46
