Canal de Sódio
Os canais de sódio são proteínas de membrana essenciais que permitem a passagem de íons de sódio (Na+) através da membrana celular, gerando e propagando sinais elétricos em neurônios, células musculares e outros tecidos excitáveis. Esses canais são vitais para a iniciação e condução de potenciais de ação, sendo cruciais em processos como a transmissão de impulsos nervosos, contração muscular e função cardíaca. A desregulação dos canais de sódio pode levar a distúrbios neurológicos, arritmias e condições de dor crônica. Na CymitQuimica, oferecemos uma variedade de moduladores de canais de sódio para apoiar sua pesquisa em neurobiologia, cardiologia e manejo da dor.
Foram encontrados 273 produtos para "Canal de Sódio".
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Lubeluzole dihydrochloride
CAS:Lubeluzole (dihydrochloride) acts as a neuroprotective agent by blocking neuronal voltage-gated sodium channels and also affects cardiac sodium channels, exhibiting both tonic and blocking effects. This compound is considered promising in the research of antiarrhythmic agents.Fórmula:C22H27Cl2F2N3O2SCor e Forma:SolidPeso molecular:506.44Quinacainol dihydrochloride
CAS:Quinacainol dihydrochloride (PK 10139 dihydrochloride) is the bis(2 hydrochloride) salt form of Quinacainol. It acts as an inhibitor of the sodium current, with an EC50 of 95 µM. This compound displays antiarrhythmic activity by modulating the electrophysiological properties of the heart.Fórmula:C21H32Cl2N2OCor e Forma:SolidPeso molecular:399.398Nav1.8-IN-20
CAS:Nav1.8-IN-20 (Compound I) is an orally active inhibitor of the voltage-gated sodium channel Nav1.8, with an IC50 value of 14 nM. It effectively blocks the generation and propagation of action potentials in peripheral nociceptive neurons, providing analgesic effects. Nav1.8-IN-20 shows potential for research in several pain types, including acute, chronic, inflammatory, and neuropathic pain.Fórmula:C18H10Cl2F3N3O4Peso molecular:460.19Nav1.8-IN-19
CAS:Nav1.8-IN-19 (Compound 122) is a potent inhibitor of Nav1.8.Fórmula:C21H20F3N5O3SPeso molecular:479.48Nav1.8-IN-15
CAS:Nav1.8-IN-15 (compound 6) is a potent inhibitor of Nav1.8. It exhibits analgesic properties and holds potential for research in chronic pain management.Fórmula:C23H26ClNO4S2Cor e Forma:SolidPeso molecular:480.04LBA-3
CAS:LBA-3, a selective and orally active inhibitor of the sodium-coupled citrate transporter SLC13A5, exhibits an IC50 of 67 nM. This compound effectively reduces triglyceride and total cholesterol levels in both oleic and palmitic acid (OPA)-stimulated AML12 cells and PCN-stimulated primary mouse hepatocytes, as well as in mouse models, without showing detectable toxicity. Additionally, LBA-3 is permeable to the blood-brain barrier [1].Fórmula:C18H18O5Cor e Forma:SolidPeso molecular:314.33Vormatrigine
CAS:Vormatrigine effectively inhibits sodium channels (sodium channel).Fórmula:C16H12F6N4O2Cor e Forma:SolidPeso molecular:406.28Nav1.8-IN-5
CAS:Nav1.8-IN-5 (Example 1), a voltage-gated sodium channel Nav1.8 inhibitor, is applicable in the research of Nav1.8-mediated diseases including pain, pain-related disorders, and cardiovascular diseases (such as atrial fibrillation) [1].Fórmula:C23H15F4N3O2Cor e Forma:SolidPeso molecular:441.38Olisutrigine bromide
CAS:Olisutrigine bromide is a sodium channel blocker used as an analgesic.Fórmula:C25H35BrN2Cor e Forma:SolidPeso molecular:443.463ErSO-TFPy
CAS:ErSO-TFPy activates the sodium ion channel TRPM4, resulting in an imbalance of intracellular calcium and sodium ions. It exhibits low nanomolar-level cytotoxicity (IC50 = 5-25 nM) by inducing necrosis in ERα+ breast cancer cell lines. Additionally, ErSO-TFPy shows antitumor activity in mouse models.Fórmula:C19H13F7N2O2Cor e Forma:SolidPeso molecular:434.307Olorigliflozin
CAS:Olorigliflozin is a sodium glucose co-transporter (SGLT) inhibitor with antihyperglycemic properties.Fórmula:C23H27ClO7Cor e Forma:SolidPeso molecular:450.909Zilvetrigine
CAS:Zilvetrigine is a sodium channel (sodium channel) blocker. It can be used as an analgesic.Fórmula:C20H20ClN3O2Cor e Forma:SolidPeso molecular:369.845Suzetrigine
CAS:Suzetrigine (VX-548) is an oral NaV1.8 inhibitor with analgesic properties for acute pain research.Fórmula:C21H20F5N3O4Pureza:98.08% - 99.95%Cor e Forma:White SolidPeso molecular:473.39Ref: TM-T69552
300gA consultar1mg55,00€5mg108,00€1mL*10mM (DMSO)112,00€10mg161,00€25mg253,00€50mg434,00€100mg707,00€200mg973,00€
