OAT
Os transportadores de aniões orgânicos são uma família de proteínas de membrana que mediam a captação e excreção de vários aniões orgânicos endógenos e exógenos, incluindo medicamentos, toxinas e subprodutos metabólicos. Os OATs são principalmente expressos nos rins e no fígado, onde desempenham um papel crucial na desintoxicação e na depuração de medicamentos. A desregulação da função dos OAT pode levar à toxicidade de medicamentos e a distúrbios renais. Na CymitQuimica, oferecemos uma variedade de moduladores de OAT para apoiar sua pesquisa em farmacologia, toxicologia e função renal.
Foram encontrados 32 produtos de "OAT"
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URAT1 inhibitor 7
CAS:URAT1 inhibitor 7, a uric acid transporter protein URAT1 inhibitor.URAT1 inhibitor 7 inhibits CYP2C9 and can be used in the study of hyperuricemia and gout.Fórmula:C19H10ClFN4O3SPureza:97.14%Cor e Forma:SoildPeso molecular:428.824'-hydroxy Trazodone
CAS:<p>4’-hydroxy Trazodone is a metabolite of the antidepressant and sedative trazodone.1It is an inhibitor of organic anion transporter 3 (OAT3; Ki= 16.9 μM) and is</p>Fórmula:C19H22ClN5O2Cor e Forma:SolidPeso molecular:387.87Epaminurad HCl
CAS:Epaminurad HCl is a URAT1 inhibitor with partial inhibition of OAT1 and OAT3 (organic anion transporters).Epaminurad HCl is a pro-uric acid excretory agent used for the prevention and treatment of gout and hyperuricemia.Fórmula:C14H11Br2ClN2O3Pureza:99.01% - 99.42%Cor e Forma:SoildPeso molecular:450.51hURAT1 inhibitor 1
Compound 27b, also known as hURAT1 inhibitor 1, is an isomarine-derived, orally active inhibitor that targets both hURAT1 and GLUT9 with IC50 values of 0.16 μM and 4.47 μM, respectively. This compound exhibits significant anti-hyperuricemia effects and has demonstrated potent uric acid-lowering activity in a hyperuricemia mouse model at a dose of 10 mg/kg. Importantly, Compound 27b displays no notable in vitro cytotoxicity or in vivo hepatotoxicity, and possesses favorable pharmacokinetic (PK) characteristics.Fórmula:C24H19BrO4Peso molecular:451.31URAT1 inhibitor 10
URAT1 inhibitor10 (Compound 23a) is a URAT1 inhibitor with an IC50 of 0.052 μM. It exhibits oral efficacy and low cytotoxicity. The compound demonstrates high selectivity for OAT1, with an IC50 of 9.17 μM.URAT1 inhibitor 11
CAS:URAT1 inhibitor11 (Compound 7) is a potent URAT1 inhibitor, exhibiting an IC50 of 0.18 μM. It effectively reduces uric acid levels in zebrafish with hyperuricemia induced by Potassium oxonate and Xanthinesodium salt.Fórmula:C20H16F4N2O2Cor e Forma:SolidPeso molecular:392.35Euphol acetate
CAS:Euphol acetate, a triterpene from Euphorbia broteri, inhibits liver transport proteins OATP1B1/3.Fórmula:C32H52O2Cor e Forma:SolidPeso molecular:468.75URAT1/GLUT9-IN-1
URAT1/GLUT9-IN-1 (compound 29) effectively inhibits urate transporter 1 (URAT1) with an IC50 value of 2.01 μM and glucose transporter 9 (GLUT9) with an IC50 of 18.21 μM. This compound exhibits favorable pharmacokinetic properties and oral bioavailability, making it useful for research in gout and hyperuricemia.Ruzinurad
CAS:Ruzinurad (WO2020088641, compound I) is a potent URAT1 inhibitor, exhibiting high selectivity.Fórmula:C14H12BrNO2SCor e Forma:SolidPeso molecular:338.22Lesinurad sodium
CAS:Lesinurad sodium (RDEA594 sodium) is a selective inhibitor of uric acid reabsorption and is used in the study of cardiovascular diseases.Fórmula:C17H13BrN3NaO2SPureza:99.97%Cor e Forma:SolidPeso molecular:426.26Verinurad
CAS:Verinurad (RDEA3170) (RDEA3170) is an organic anion transporter URAT1 (SLC22A12) inhibitor for the treatment of gout and hyperuricemia.Fórmula:C20H16N2O2SPureza:97.36% - 99.22%Cor e Forma:SolidPeso molecular:348.42Cabotegravir
CAS:Cabotegravir (S/GSK1265744) (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor and inhibits the HIV-1 integrase catalyzed strand transfer reaction (Fórmula:C19H17F2N3O5Pureza:98.55% - 99.92%Cor e Forma:SolidPeso molecular:405.35Lesinurad
CAS:Lesinurad (RDEA594), a selective uric acid reabsorption inhibitor, is used to treat gout without causing liver damage.Fórmula:C17H14BrN3O2SPureza:99.83% - 99.86%Cor e Forma:SolidPeso molecular:404.28Epaminurad
CAS:Epaminurad (UR-1102) is an oral URAT1 inhibitor for gout research with a Ki of 0.057 μM, modestly affects OAT1/3.Fórmula:C14H10Br2N2O3Cor e Forma:SolidPeso molecular:414.05Dotinurad
CAS:Dotinurad ((3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone) is a potent agent of uricosuric (IC50: 3.6 μM for uric acid).Fórmula:C14H9Cl2NO4SPureza:97.43% - 98.04%Cor e Forma:SolidPeso molecular:358.2XOR/URAT1-IN-1
CAS:Compound II15, known as XOR/URAT1-IN-1, serves as a dual inhibitor targeting xanthine oxidoreductase (XOR) and uric acid transporter 1 (URAT1), exhibiting IC50 values of 6 nM and 12.9 μM, respectively. This compound effectively reduces uric acid levels in a mouse model of acute hyperuricemia induced by potassium oxonate and hypoxanthine.Fórmula:C18H13ClN2O3Peso molecular:340.76JTT-552
CAS:JTT-552, a uric acid transporter 1 (URAT1) inhibitor, is used potentially for the treatment of hyperuricemia.Fórmula:C15H12ClNO3Pureza:98%Cor e Forma:SolidPeso molecular:289.71URAT1 inhibitor 4
CAS:URAT1 inhibitor 4 is a potent, orally active Lesinurad derivative with a 7.56 μM IC50, showing greater in vivo efficacy.Fórmula:C27H20BrN3O4S3Cor e Forma:SolidPeso molecular:626.56Xininurad
CAS:Xininurad (XNW3009) is a urate transporter (URAT) inhibitor.Fórmula:C15H10Br2FN3O2Cor e Forma:SolidPeso molecular:443.07Puliginurad
CAS:Puliginurad (YL-90148) is a urate transporter protein inhibitor that inhibits the reabsorption of uric acid.Puliginurad is used in the treatment of gout.Fórmula:C19H16N2O2SPureza:99.50% - 99.96%Cor e Forma:SolidPeso molecular:336.41URAT1&XO inhibitor 2
CAS:Compound BDEO (URAT1&XO inhibitor 2) serves as a dual-action inhibitor targeting both xanthine oxidase (XO) and URAT1, demonstrating an IC50 value of 3.3 μM forFórmula:C14H12BrNO3Pureza:98%Cor e Forma:SolidPeso molecular:322.15Lingdolinurad
CAS:Lingdolinurad is a uric acid transporter protein inhibitor targeting hURAT1 for the study of hyperuricemia or gout.Fórmula:C17H12BrN3O2Pureza:96.26%Cor e Forma:SolidPeso molecular:370.2URAT1 inhibitor 6
CAS:URAT1 inhibitor 6 (Compound 1h), with an IC50 of 35 nM for hURAT1, demonstrates 200-fold and 8-fold greater potency compared to Lesinurad and Benzbromarone,Fórmula:C9H7BrN3NaO2S2Cor e Forma:SolidPeso molecular:356.2URAT1 inhibitor 8
CAS:URAT1 Inhibitor 8 (example 247) serves as a highly potent inhibitor of URAT1, demonstrating an IC50 value of 0.001 μM.Fórmula:C19H13ClFN3O4SCor e Forma:SolidPeso molecular:433.84URAT1 inhibitor 1
CAS:URAT1 inhibitor 1 (1g) is an inhibitor of uric acid transporter 1 (URAT1) (IC50: 32 nM), has the potential to treat hyperuricemia associated with gout.Fórmula:C19H15Br2N5O2S2Pureza:98%Cor e Forma:SolidPeso molecular:569.29TRPV1 antagonist 10
CAS:TRPV1 antagonist 10 is a potent, orally active TRPV1 antagonist with an IC50 of 33.06 nM and serves as a moderate to weak inhibitor of URAT1 (IC50 = 22.51 μM) and GLUT9 (inhibition of 60.25% at 50 μM). It exhibits analgesic and urate-lowering properties and is applicable for research in hyperuricemia and inflammatory pain.Fórmula:C16H14N2O5Cor e Forma:SolidPeso molecular:314.293URAT1 inhibitor 13
CAS:URAT1 inhibitor13 (compound 22k) is a potent inhibitor of URAT1, useful for research related to gout.Fórmula:C18H14Cl2N2O2Peso molecular:361.22KPH2f
CAS:KPH2f: dual URAT1/GLUT9 inhibitor, orally active, IC50: 0.24μM (URAT1), 9.37μM (GLUT9), minimal OAT1/ABCG2 impact.Fórmula:C24H16N3NaO2SCor e Forma:SolidPeso molecular:433.46hURAT1 inhibitor 2
CAS:hURAT1 inhibitor 2 (Compound 5) is an inhibitor of hURAT1 (uric acid transporter 1, SLC22A12) with an IC50 of 18 nM. It also exhibits some inhibitory activity against OATP1B1, with an IC50 of 0.73 μM. hURAT1 inhibitor 2 can be used in research related to hyperuricemia, gout, and other diseases associated with abnormal uric acid metabolism.Fórmula:C17H11Br2FO3Cor e Forma:SolidPeso molecular:442.074URAT1 inhibitor 3
URAT1 inhibitor 3: potent oral URAT1 blocker, IC50=0.8 nM, for gout/hyperuricemia study.Fórmula:C14H8Cl2N2O2Cor e Forma:SolidPeso molecular:307.13URAT1 inhibitor 2
URAT1 inhibitor 2: oral URAT1/CYP blocker, IC50 of 1.36μM (URAT1), 16.97μM (CYP1A2), 5.22μM (CYP2C9); potential gout treatment.Fórmula:C21H18BrN3O2SCor e Forma:SolidPeso molecular:456.36URAT1-IN-14
CAS:URAT1-IN-14 is a potent and orally active inhibitor of uric acid transporter 1 (URAT1). It demonstrates an IC50 value of 0.72 μM for inhibiting human URAT1 in HEK293 cells and exhibits low cytotoxicity in Hep-G2 cells. URAT1-IN-14 reduces uric acid levels in a hyperuricemia mouse model and is applicable in research on hyperuricemia and gout.Fórmula:C19H19NO3SCor e Forma:SolidPeso molecular:341.42
