PDE
As fosfodiesterases (PDEs) são enzimas que hidrolisam nucleotídeos cíclicos, como AMPc e GMPc, em suas formas inativas, desempenhando um papel crucial na regulação das vias de sinalização intracelular. Inibidores de PDE são utilizados no tratamento de diversas condições, incluindo doenças cardiovasculares, disfunção erétil e distúrbios respiratórios, devido à sua capacidade de modular os níveis de nucleotídeos cíclicos. Na CymitQuimica, oferecemos uma variedade de inibidores de PDE para apoiar sua pesquisa em sinalização celular, farmacologia e desenvolvimento terapêutico.
Foram encontrados 170 produtos de "PDE"
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EMD57439
CAS:EMD57439 is a selective PDE-III inhibitor, showing no significant increase in c-AMP concentration and producing little change in Ca(50).Fórmula:C22H23N3O4SPureza:99.35% - 99.57%Cor e Forma:SolidPeso molecular:425.5NSP-805
CAS:NSP-805 is a potent and selective guinea pig cardiac phosphodiesterase 3 (PDE3) inhibitor.Fórmula:C17H19N3O2Pureza:99.85%Cor e Forma:SolidPeso molecular:297.35Ref: TM-T12267
1mg38,00€5mg86,00€10mg129,00€25mg216,00€50mg309,00€100mg427,00€200mg577,00€1mL*10mM (DMSO)94,00€Carbodenafil
CAS:Carbodenafil is a Sildenafil related compound found in healthy foods. Sildenafil is a PDE5 inhibitor (IC50: 5.22 nM).Fórmula:C24H32N6O3Pureza:98.96% - 99.89%Cor e Forma:SolidPeso molecular:452.55ITI-214
CAS:ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members, exhibits potent PDE1 inhibitory activity.Fórmula:C29H29FN7O5PPureza:98.21%Cor e Forma:SolidPeso molecular:605.56Ref: TM-T11689
1mg71,00€2mg92,00€5mg158,00€10mg286,00€25mg505,00€50mg712,00€100mg1.009,00€1mL*10mM (DMSO)207,00€ATX inhibitor 1
CAS:ATX inhibitor 1 is a potent ATX inhibitor (IC50: 1.23 nM, FS-3 and 2.18 nM, bis-pNPP).Fórmula:C21H23Cl2N2O6PPureza:99.52%Cor e Forma:SolidPeso molecular:501.3Cilostazol
CAS:Cilostazol (OPC 21) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of cilostazol is as a Phosphodiesterase 3 Inhibitor.Fórmula:C20H27N5O2Pureza:99.58% - 99.90%Cor e Forma:Off-White SolidPeso molecular:369.46Zatolmilast
CAS:Zatolmilast (BPN14770) is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3).Fórmula:C21H15ClF3NO2Pureza:98.20%Cor e Forma:SolidPeso molecular:405.8Ref: TM-T10590
1mg66,00€5mg128,00€10mg231,00€25mg388,00€50mg532,00€100mg740,00€200mg973,00€1mL*10mM (DMSO)141,00€Roflumilast
CAS:Roflumilast (APTA 2217) is an orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potentialFórmula:C17H14Cl2F2N2O3Pureza:99.76% - 99.86%Cor e Forma:SolidPeso molecular:403.21N-Methylbenzamide
CAS:N-Methylbenzamide is a potent phosphodiesterase 10A (PDE10A) inhibitor,with anti-cancer activity.Fórmula:C8H9NOPureza:99.83%Cor e Forma:Physical Description Off-White Crystalline Solid (Ntp 1992)Peso molecular:135.16Amrinone
CAS:Amrinone (Inocor) is a positive inotropic cardiotonic (cardiotonic agent) with vasodilator properties, phosphodiesterase 3 inhibitory activity.Fórmula:C10H9N3OPureza:98.88% - 99.45%Cor e Forma:SolidPeso molecular:187.2MR-L2
CAS:MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).Fórmula:C19H16Cl3FN4OPureza:98.09% - 98.94%Cor e Forma:SolidPeso molecular:441.71Ref: TM-T12103
1mg145,00€2mg207,00€5mg354,00€10mg528,00€25mg852,00€50mg1.159,00€100mg1.568,00€500mg3.125,00€1mL*10mM (DMSO)378,00€Pumafentrine
CAS:Pumafentrine（BY 343） is a dual PDE3/PDE4 inhibitor that reduces clinical scores and TNF expression in experimental colitis in mice.Fórmula:C29H39N3O3Pureza:99.85%Cor e Forma:SolidPeso molecular:477.64Trapidil
CAS:Trapidil (Avantrin) is a coronary vasodilator agent.Fórmula:C10H15N5Pureza:99.42%Cor e Forma:SolidPeso molecular:205.26Milrinone
CAS:Milrinone (Win 47203) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of milrinone is as a Phosphodiesterase 3 Inhibitor.Fórmula:C12H9N3OPureza:99.22% - 99.92%Cor e Forma:SolidPeso molecular:211.22Pimobendan
CAS:Pimobendan (UD-CG 115 BS) is a selective inhibitor of PDE3 (IC50: 0.32 μM).Fórmula:C19H18N4O2Pureza:99.91%Cor e Forma:SolidPeso molecular:334.37ONO-8430506
CAS:ONO-8430506 is an orally available, potent autotaxin (ATX)/ENPP2 inhibitor (IC90: 100 nM) that inhibits ATX activity in mouse plasma.Fórmula:C27H28FN3O3Pureza:98.34%Cor e Forma:SolidPeso molecular:461.53Ref: TM-T38759
1mg103,00€5mg244,00€10mg338,00€25mg510,00€50mg687,00€100mg919,00€1mL*10mM (DMSO)271,00€PDE10A-IN-5
PDE10A-IN-5 (Compound A30) is an orally active inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 value of 3.5 nM. By inhibiting PDE10A, it activates the cyclic adenosine monophosphate (cAMP)-related signaling pathway, exhibiting activity against pulmonary vascular remodeling. This compound is applicable to research in the field of pulmonary arterial hypertension.Cor e Forma:Odour SolidAcetildenafil
CAS:Acetildenafil is an analog of the phosphodiesterase inhibitor sildenafil.Fórmula:C25H34N6O3Cor e Forma:Off-White To Pale Yelow SolidPeso molecular:466.58PDE4B-IN-4
PDE4B-IN-4 is an inhibitor of PDE4B (IC50: 2.82 nM) and TNF-α (IC50: 7.20 nM). It demonstrates anti-inflammatory properties by reducing neutrophilia in a mouse model of lipopolysaccharide (LPS)-induced sepsis.Fórmula:C26H27N5O5Cor e Forma:SolidPeso molecular:489.52Enpp-1-IN-27
Enpp-1-IN-27 is a selective ENPP1 inhibitor with an IC50 of 14.68 nM, exhibiting approximately 410-fold selectivity over ENPP2 and roughly 10-fold selectivity over ENPP3. This compound stabilizes cGAMP levels and activates the STING pathway, leading to cytokine release and an enhanced innate immune response. In addition, Enpp-1-IN-27 activates ISRE and boosts cGAMP-mediated immune responses, demonstrating significant antitumor effects in 4T1 and CT26 syngeneic mouse models. It is applicable to breast cancer and colon cancer research.Cor e Forma:Odour Solid
