PDE
As fosfodiesterases (PDEs) são enzimas que hidrolisam nucleotídeos cíclicos, como AMPc e GMPc, em suas formas inativas, desempenhando um papel crucial na regulação das vias de sinalização intracelular. Inibidores de PDE são utilizados no tratamento de diversas condições, incluindo doenças cardiovasculares, disfunção erétil e distúrbios respiratórios, devido à sua capacidade de modular os níveis de nucleotídeos cíclicos. Na CymitQuimica, oferecemos uma variedade de inibidores de PDE para apoiar sua pesquisa em sinalização celular, farmacologia e desenvolvimento terapêutico.
Foram encontrados 166 produtos de "PDE"
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Pumafentrine
CAS:<p>Pumafentrine（BY 343） is a dual PDE3/PDE4 inhibitor that reduces clinical scores and TNF expression in experimental colitis in mice.</p>Fórmula:C29H39N3O3Pureza:>99.99%Cor e Forma:SolidPeso molecular:477.64Roflumilast
CAS:<p>Roflumilast (APTA 2217) is an orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potential</p>Fórmula:C17H14Cl2F2N2O3Pureza:99.76% - 99.86%Cor e Forma:SolidPeso molecular:403.21EMD57439
CAS:<p>EMD57439 is a selective PDE-III inhibitor, showing no significant increase in c-AMP concentration and producing little change in Ca(50).</p>Fórmula:C22H23N3O4SPureza:99.38% - 99.57%Cor e Forma:SolidPeso molecular:425.5T-0156
CAS:<p>T-0156 is a PEG5 inhibitor that inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP) with low affinity for PDE6, PDE1, PDE2, PDE3 and PDE4.</p>Fórmula:C31H29N5O7Pureza:98.53% - 98.76%Cor e Forma:SoildPeso molecular:583.59ATX inhibitor 1
CAS:<p>ATX inhibitor 1 is a potent ATX inhibitor (IC50: 1.23 nM, FS-3 and 2.18 nM, bis-pNPP).</p>Fórmula:C21H23Cl2N2O6PPureza:99.52%Cor e Forma:SolidPeso molecular:501.3Carbodenafil
CAS:<p>Carbodenafil is a Sildenafil related compound found in healthy foods. Sildenafil is a PDE5 inhibitor (IC50: 5.22 nM).</p>Fórmula:C24H32N6O3Pureza:98.96% - 99.89%Cor e Forma:SolidPeso molecular:452.55Amrinone
CAS:<p>Amrinone (Inocor) is a positive inotropic cardiotonic (cardiotonic agent) with vasodilator properties, phosphodiesterase 3 inhibitory activity.</p>Fórmula:C10H9N3OPureza:98.88% - 99.45%Cor e Forma:SolidPeso molecular:187.2ITI-214
CAS:<p>ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members, exhibits potent PDE1 inhibitory activity.</p>Fórmula:C29H29FN7O5PPureza:98.21%Cor e Forma:SolidPeso molecular:605.56Zatolmilast
CAS:<p>Zatolmilast (BPN14770) is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3).</p>Fórmula:C21H15ClF3NO2Pureza:98.20%Cor e Forma:SolidPeso molecular:405.8N-Methylbenzamide
CAS:<p>N-Methylbenzamide is a potent phosphodiesterase 10A (PDE10A) inhibitor,with anti-cancer activity.</p>Fórmula:C8H9NOPureza:99.83%Cor e Forma:Physical Description Off-White Crystalline Solid (Ntp 1992)Peso molecular:135.16MR-L2
CAS:<p>MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).</p>Fórmula:C19H16Cl3FN4OPureza:98.09% - 98.94%Cor e Forma:SolidPeso molecular:441.71Trapidil
CAS:<p>Trapidil (Avantrin) is a coronary vasodilator agent.</p>Fórmula:C10H15N5Pureza:99.42%Cor e Forma:SolidPeso molecular:205.26NSP-805
CAS:<p>NSP-805 is a potent and selective guinea pig cardiac phosphodiesterase 3 (PDE3) inhibitor.</p>Fórmula:C17H19N3O2Pureza:99.85%Cor e Forma:SolidPeso molecular:297.35Milrinone
CAS:<p>Milrinone (Win 47203) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of milrinone is as a Phosphodiesterase 3 Inhibitor.</p>Fórmula:C12H9N3OPureza:99.22% - 99.92%Cor e Forma:SolidPeso molecular:211.22Pimobendan
CAS:<p>Pimobendan (UD-CG 115 BS) is a selective inhibitor of PDE3 (IC50: 0.32 μM).</p>Fórmula:C19H18N4O2Pureza:99.91%Cor e Forma:SolidPeso molecular:334.37Cilostazol
CAS:<p>Cilostazol (OPC 21) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of cilostazol is as a Phosphodiesterase 3 Inhibitor.</p>Fórmula:C20H27N5O2Pureza:99.58% - 99.90%Cor e Forma:Off-White SolidPeso molecular:369.46Acetildenafil
CAS:<p>Acetildenafil is an analog of the phosphodiesterase inhibitor sildenafil.</p>Fórmula:C25H34N6O3Cor e Forma:Off-White To Pale Yelow SolidPeso molecular:466.58ONO-8430506
CAS:<p>ONO-8430506 is an orally available, potent autotaxin (ATX)/ENPP2 inhibitor (IC90: 100 nM) that inhibits ATX activity in mouse plasma.</p>Fórmula:C27H28FN3O3Pureza:98.34%Cor e Forma:SolidPeso molecular:461.53PDE10A-IN-5
<p>PDE10A-IN-5 (Compound A30) is an orally active inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 value of 3.5 nM. By inhibiting PDE10A, it activates the cyclic adenosine monophosphate (cAMP)-related signaling pathway, exhibiting activity against pulmonary vascular remodeling. This compound is applicable to research in the field of pulmonary arterial hypertension.</p>Cor e Forma:Odour SolidArofylline
CAS:<p>Arofylline (LAS 31025) is a PDE4 inhibitor and can be used for asthma studies.</p>Fórmula:C14H13ClN4O2Pureza:98.19%Cor e Forma:SolidPeso molecular:304.73
