PDE
As fosfodiesterases (PDEs) são enzimas que hidrolisam nucleotídeos cíclicos, como AMPc e GMPc, em suas formas inativas, desempenhando um papel crucial na regulação das vias de sinalização intracelular. Inibidores de PDE são utilizados no tratamento de diversas condições, incluindo doenças cardiovasculares, disfunção erétil e distúrbios respiratórios, devido à sua capacidade de modular os níveis de nucleotídeos cíclicos. Na CymitQuimica, oferecemos uma variedade de inibidores de PDE para apoiar sua pesquisa em sinalização celular, farmacologia e desenvolvimento terapêutico.
Foram encontrados 166 produtos de "PDE"
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PDE4B-IN-4
<p>PDE4B-IN-4 is an inhibitor of PDE4B (IC50: 2.82 nM) and TNF-α (IC50: 7.20 nM). It demonstrates anti-inflammatory properties by reducing neutrophilia in a mouse model of lipopolysaccharide (LPS)-induced sepsis.</p>Fórmula:C26H27N5O5Cor e Forma:SolidPeso molecular:489.52UK 227786
CAS:<p>UK 227786 is an inhibitor of phosphodiesterase 5 (PDE5), used for treatment of prostatic diseases.</p>Fórmula:C22H22Cl2N4O4Pureza:99.9%Cor e Forma:SoildPeso molecular:477.34BC 11-38
CAS:<p>BC 11-38 is a potent, selective PDE biodepressant which is mainly effective against PDE11 (IC50 : 0.28 μM).</p>Fórmula:C15H16N2OS2Pureza:98.95% - 99.28%Cor e Forma:SolidPeso molecular:304.43Arofylline
CAS:<p>Arofylline (LAS 31025) is a PDE4 inhibitor and can be used for asthma studies.</p>Fórmula:C14H13ClN4O2Pureza:98.19%Cor e Forma:SolidPeso molecular:304.73cis-Tadalafil
CAS:<p>Tadalafil: a carboline-based PDE5 inhibitor, treats erectile dysfunction, prostatic hyperplasia, and pulmonary hypertension.</p>Fórmula:C22H19N3O4Pureza:99.89%Cor e Forma:SolidPeso molecular:389.4FCPR03
CAS:<p>FCPR03 is a selective inhibitor of phosphodiesterase 4 (PDE4) with IC50s of 31 nM, 47 nM, and 60 nM for PDE4B1, PDE4D7, and PDE4 catalytic domain, respectively.</p>Fórmula:C15H19F2NO3Pureza:99.94%Cor e Forma:SolidPeso molecular:299.31Dazonone
CAS:<p>Dazonone (Imidazo[2,1-b]quinazolin-2(3H)-one, 6-chloro-1,5-dihydro-3-methyl-) is a specific PDE III inhibitors.</p>Fórmula:C11H10ClN3OPureza:99.54% - 99.73%Cor e Forma:SolidPeso molecular:235.67PDE10A-IN-5
<p>PDE10A-IN-5 (Compound A30) is an orally active inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 value of 3.5 nM. By inhibiting PDE10A, it activates the cyclic adenosine monophosphate (cAMP)-related signaling pathway, exhibiting activity against pulmonary vascular remodeling. This compound is applicable to research in the field of pulmonary arterial hypertension.</p>Cor e Forma:Odour SolidOPC18750 HCl
CAS:<p>OPC18750 HCl is a phosphodiesterase inhibitor with positive inotropic effects that can be used to study asthma, cancer, diabetes, and psychiatric disorders.</p>Fórmula:C20H23ClN2O4Pureza:98.92%Cor e Forma:SoildPeso molecular:390.86BAY 2666605
CAS:<p>BAY 2666605 is an orally active inhibitor of PDE3A and PDE3B with IC50s of 87 nM and 50 nM, respectively. BAY 2666605 has anticancer effects.</p>Fórmula:C17H12F4N2O2Pureza:99.81%Cor e Forma:SolidPeso molecular:352.28Acetildenafil
CAS:<p>Acetildenafil is an analog of the phosphodiesterase inhibitor sildenafil.</p>Fórmula:C25H34N6O3Cor e Forma:Off-White To Pale Yelow SolidPeso molecular:466.58WAY-313170
CAS:<p>WAY-313170 Inhibits hedgehog signaling and phosphodiesterase.</p>Fórmula:C19H17ClN2O2S2Pureza:99.3%Cor e Forma:SolidPeso molecular:404.93Oglemilast
CAS:<p>Oglemilast (GRC 3886) suppresses pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro and in vivo.</p>Fórmula:C20H13Cl2F2N3O5SPureza:99.82%Cor e Forma:SolidPeso molecular:516.3(1R,2R)-MK-8189
CAS:<p>(1R,2R)-MK-8189 is an isomer of MK-8189, a potent and selective pyrimidine PDE10A inhibitor.</p>Fórmula:C19H22N6OSPureza:>99.99% - >99.99%Cor e Forma:SoildPeso molecular:382.48PDE5-IN-9
CAS:<p>WAY-639921 treats cardiovascular and respiratory conditions by inhibiting PDE1c.</p>Fórmula:C18H14N4SPureza:99.98%Cor e Forma:SolidPeso molecular:318.4ENPP1 Inhibitor C
CAS:<p>ML-354 (VU0099704) is an antagonist with and PAR4 for the study of cardiovascular diseases.</p>Fórmula:C15H18N6Pureza:99.28%Cor e Forma:SolidPeso molecular:282.34N-Ethyl tadalafil
CAS:<p>N-Ethyl tadalafil (NEthyl tadalafil) is a PDE inhibitor used in the study of cardiovascular disease.</p>Fórmula:C23H21N3O4Pureza:99.58%Cor e Forma:SolidPeso molecular:403.43BAY 73-6691 racemate
CAS:<p>BAY 73-6691 racemate (Rac-BAY 73-6691) is a phosphodiesterase 9A (PDE9A) inhibitor, useful for studying Parkinson’s disease.</p>Fórmula:C15H12ClF3N4OCor e Forma:SolidPeso molecular:356.73Anti-ALDH7A1 Antibody (6G475)
<p>Anti-ALDH7A1 Antibody (6G475) is a Mouse antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (6G475) can be used in IHC-P.</p>Cor e Forma:Odour LiquidAnti-ALDH7A1 Antibody-FITC (5P692)
<p>Anti-ALDH7A1 Antibody-FITC (5P692) is a FITC-conjugated Rabbit antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody-FITC (5P692) can be used in FCM.</p>Cor e Forma:Odour Liquid
