PDE
As fosfodiesterases (PDEs) são enzimas que hidrolisam nucleotídeos cíclicos, como AMPc e GMPc, em suas formas inativas, desempenhando um papel crucial na regulação das vias de sinalização intracelular. Inibidores de PDE são utilizados no tratamento de diversas condições, incluindo doenças cardiovasculares, disfunção erétil e distúrbios respiratórios, devido à sua capacidade de modular os níveis de nucleotídeos cíclicos. Na CymitQuimica, oferecemos uma variedade de inibidores de PDE para apoiar sua pesquisa em sinalização celular, farmacologia e desenvolvimento terapêutico.
Foram encontrados 166 produtos de "PDE"
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Z-HA155
CAS:<p>Z-HA155 (CS-963) selectively and potently inhibits autotaxin with an IC50 of 5.7 nM.</p>Fórmula:C24H19BFNO5SPureza:99.18%Cor e Forma:SolidPeso molecular:463.29ML-030
CAS:<p>ML-030 is a potent PDE4 inhibitor, selective for subtypes (A1, B1, B2, C1, D2) with IC50 ranging from 6.7 to 452 nM.</p>Fórmula:C20H20N4O4SPureza:97.93%Cor e Forma:SolidPeso molecular:412.46Udenafil
CAS:<p>Udenafil is an inhibitor of PDE5 .</p>Fórmula:C25H36N6O4SPureza:99.90%Cor e Forma:Off-White SolidPeso molecular:516.66MBCQ
CAS:<p>MBCQ is an inhibitor of cGMP-specific phosphodiesterase PDE5.</p>Fórmula:C16H12ClN3O2Pureza:99.45%Cor e Forma:SolidPeso molecular:313.74ICI 63197
CAS:<p>ICI 63197 (2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one) is a PDE4 inhibitor.</p>Fórmula:C9H13N5OPureza:99.70%Cor e Forma:White SolidPeso molecular:207.23MY-5445
CAS:<p>MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) is a specific inhibitor of phosphodiesterase type 5 (PDE5).</p>Fórmula:C20H14ClN3Pureza:99.77%Cor e Forma:SolidPeso molecular:331.8Cilomilast
CAS:<p>Cilomilast (SB-207499) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. Phase 3.</p>Fórmula:C20H25NO4Pureza:97.37% - 99.52%Cor e Forma:White SolidPeso molecular:343.42K-Ras-PDEδ-IN-1
CAS:<p>K-Ras-PDEδ-IN-1 is a potent inhibitor of competitive K-Ras-PDEδ.It binds to the farnesyl binding pocket of PDEδ(Kd of 8 nM).</p>Fórmula:C25H26FN5O2Pureza:99.48%Cor e Forma:SolidPeso molecular:447.5THPP-1
CAS:<p>THPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1 nM and 1.3 nM for human and rat PDE10A, respectively).</p>Fórmula:C23H21ClN6O3Pureza:99.46%Cor e Forma:SolidPeso molecular:464.9Piclamilast
CAS:<p>Piclamilast (RP 73401) is a PDE4 inhibitor.</p>Fórmula:C18H18Cl2N2O3Pureza:98.28% - 99.57%Cor e Forma:SolidPeso molecular:381.25Irsogladine
CAS:<p>Irsogladine (Dicloguamine) is an anti-ulcer agent that promotes gap junction intercellular communication via M1 muscarinic acetylcholine receptor binding.</p>Fórmula:C9H7Cl2N5Pureza:99.74% - 99.91%Cor e Forma:White Or Colorless Crystal Or Crystalline Powder Odorless Slightly BitterPeso molecular:256.09Nortadalafil
CAS:<p>Nortadalafil, a demethylated form of Tadalafil, is a PDE5 inhibitor used to treat ED and pulmonary arterial hypertension as Adcirca.</p>Fórmula:C21H17N3O4Pureza:99.42%Cor e Forma:SolidPeso molecular:375.38BRL-50481
CAS:<p>BRL-50481 is a novel and selective inhibitor of PDE7 with IC50s of 0.15, 12.1, 62 and 490 μM for PDE7A, PDE7B, PDE4 and PDE3, respectively.</p>Fórmula:C9H12N2O4SPureza:99.66%Cor e Forma:SolidPeso molecular:244.27Sildenafil Mesylate
CAS:<p>Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5.</p>Fórmula:C22H30N6O4S·xCH4O3SPureza:99.84%Cor e Forma:SolidPeso molecular:570.68BW-A 78U
CAS:<p>BW-A 78U is a PDE4 inhibitor (IC50: 3 μM). It is not inhibition on the lipopolysaccharide (LPS)-induced TNF-α release.</p>Fórmula:C13H12FN5Pureza:99.45%Cor e Forma:SolidPeso molecular:257.27RS-25344 hydrochloride
CAS:<p>RS 25344 hydrochloride is a phosphodiesterase (PDE) 4 inhibitor</p>Fórmula:C19H14ClN5O4Pureza:99.25%Cor e Forma:SolidPeso molecular:411.8Lodenafil
CAS:<p>Lodenafil (Hydroxyhomosildenafil) is a potent PDE5 inhibitor, with treatment of erectile dysfunction (ED)</p>Fórmula:C23H32N6O5SPureza:99.92%Cor e Forma:SolidPeso molecular:504.6Balipodect
CAS:<p>Balipodect (TAK063) is a highly effective and selective PDE10A inhibitor (IC50: 0.30 nM); Its selectivity is >15000-fold over other PDEs.</p>Fórmula:C23H17FN6O2Pureza:98% - 99.79%Cor e Forma:SolidPeso molecular:428.42Roflumilast N-oxide
CAS:<p>Roflumilast N-oxide is an inhibitor of PDE type 4.</p>Fórmula:C17H14Cl2F2N2O4Pureza:98.19% - 99.69%Cor e Forma:SolidPeso molecular:419.21Mardepodect
CAS:<p>Mardepodect (PF-2545920) is a phosphodiesterase inhibitor selective for the PDE10A subtype with an IC50 of 0.37 nM, >1000-fold selectivity over PDE.</p>Fórmula:C25H20N4OPureza:99.81% - 99.94%Cor e Forma:SolidPeso molecular:392.45
