PDE
As fosfodiesterases (PDEs) são enzimas que hidrolisam nucleotídeos cíclicos, como AMPc e GMPc, em suas formas inativas, desempenhando um papel crucial na regulação das vias de sinalização intracelular. Inibidores de PDE são utilizados no tratamento de diversas condições, incluindo doenças cardiovasculares, disfunção erétil e distúrbios respiratórios, devido à sua capacidade de modular os níveis de nucleotídeos cíclicos. Na CymitQuimica, oferecemos uma variedade de inibidores de PDE para apoiar sua pesquisa em sinalização celular, farmacologia e desenvolvimento terapêutico.
Foram encontrados 189 produtos para "PDE".
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RS-25344 hydrochloride
CAS:RS 25344 hydrochloride is a phosphodiesterase (PDE) 4 inhibitorFórmula:C19H14ClN5O4Pureza:99.25%Cor e Forma:SolidPeso molecular:411.8BRL-50481
CAS:BRL-50481 is a novel and selective inhibitor of PDE7 with IC50s of 0.15, 12.1, 62 and 490 μM for PDE7A, PDE7B, PDE4 and PDE3, respectively.Fórmula:C9H12N2O4SPureza:99.66%Cor e Forma:SolidPeso molecular:244.27Piclamilast
CAS:Piclamilast (RP 73401) is a PDE4 inhibitor.Fórmula:C18H18Cl2N2O3Pureza:98.28% - 99.57%Cor e Forma:White SolidPeso molecular:381.25Ensifentrine
CAS:Ensifentrine (Ensifentrinum) is a PDE3/4 inhibitor, although its affinity for PDE3(IC50: 0.4 nM) is 3,440 times higher than that for PDE4(IC50: 1479 nM), thatFórmula:C26H31N5O4Pureza:99.76% - 99.94%Cor e Forma:Green SolidPeso molecular:477.56Ref: TM-T25376
1mg34,00€1mL*10mM (DMSO)92,00€5mg93,00€10mg136,00€25mg268,00€50mg429,00€100mg685,00€200mg888,00€Z-HA155
CAS:Z-HA155 (CS-963) selectively and potently inhibits autotaxin with an IC50 of 5.7 nM.Fórmula:C24H19BFNO5SPureza:99.18%Cor e Forma:SolidPeso molecular:463.29Ref: TM-T11533
1mg34,00€5mg71,00€1mL*10mM (DMSO)73,00€10mg101,00€25mg200,00€50mg321,00€100mg475,00€200mg680,00€Crisaborole
CAS:Crisaborole (AN-2728) is a Phosphodiesterase 4 Inhibitor.Fórmula:C14H10BNO3Pureza:99.70%Cor e Forma:SolidPeso molecular:251.045Udenafil
CAS:Udenafil is an inhibitor of PDE5 .Fórmula:C25H36N6O4SPureza:99.90%Cor e Forma:SolidPeso molecular:516.66Ref: TM-T17199
5mg48,00€1mL*10mM (DMSO)50,00€10mg75,00€25mg133,00€50mg207,00€100mg301,00€200mg434,00€GSK256066
CAS:GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380, 000-fold selectivity versus PDE1/2/3/5/6 and >2500-foldFórmula:C27H26N4O5SPureza:99.60% - 99.91%Cor e Forma:Yellow SolidPeso molecular:518.58Nortadalafil
CAS:Nortadalafil, a demethylated form of Tadalafil, is a PDE5 inhibitor used to treat ED and pulmonary arterial hypertension as Adcirca.Fórmula:C21H17N3O4Pureza:99.42%Cor e Forma:White SolidPeso molecular:375.38Ref: TM-T6147
1mg34,00€2mg49,00€5mg74,00€1mL*10mM (DMSO)82,00€10mg105,00€25mg192,00€50mg334,00€100mg537,00€200mg762,00€500mg1.134,00€Homo Sildenafil
CAS:Homo Sildenafil is an analog of Sildenafil, It acts as a phosphodiesterase inhibitor.Fórmula:C23H32N6O4SPureza:99.88%Cor e Forma:SolidPeso molecular:488.6Ref: TM-T8919
2mg39,00€5mg60,00€1mL*10mM (DMSO)73,00€10mg96,00€25mg177,00€50mg266,00€100mg371,00€200mg523,00€GEBR-7b
CAS:GEBR-7b (3-(Cyclopentyloxy)-4-methoxybenzaldehyde) is a phosphodiesterase-4 (PDE4) inhibitor.Fórmula:C13H16O3Pureza:99.53%Cor e Forma:SolidPeso molecular:220.26Enoximone
CAS:Enoximone is a selective inhibitor of phosphodiesterase III (PDE3), with treatment of congestive heart failure.Fórmula:C12H12N2O2SPureza:98.53%Cor e Forma:SolidPeso molecular:248.3MY-5445
CAS:MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) is a specific inhibitor of phosphodiesterase type 5 (PDE5).Fórmula:C20H14ClN3Pureza:99.77%Cor e Forma:White SolidPeso molecular:331.8Amino Tadalafil
CAS:Amino tadalafil is a potent phosphodiesterase 5 (PDE5) inhibitor.Fórmula:C21H18N4O4Pureza:99.85%Cor e Forma:White PowderPeso molecular:390.39Sildenafil Mesylate
CAS:Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5.Fórmula:C22H30N6O4S·xCH4O3SPureza:99.84%Cor e Forma:SolidPeso molecular:570.68Lodenafil
CAS:Lodenafil (Hydroxyhomosildenafil) is a potent PDE5 inhibitor, with treatment of erectile dysfunction (ED)Fórmula:C23H32N6O5SPureza:99.92%Cor e Forma:SolidPeso molecular:504.6Ref: TM-T7346
2mg34,00€5mg52,00€1mL*10mM (DMSO)52,00€10mg77,00€25mg122,00€50mg177,00€100mg245,00€200mg353,00€[11C]MP 10
CAS:[11C]MP 10 (PF-2545920), a specific and effective PDE10A inhibitor (IC50=0.37 nM), is with more than1000-fold specificity activity over the PDE.Fórmula:C25H20N4OPureza:99.5%Cor e Forma:SolidPeso molecular:391.45Osoresnontrine
CAS:Osoresnontrine is a potent and selective inhibitor of PDE9A (IC50 of 52 nM),and can be used in the research of memory.Fórmula:C16H17N5O2Pureza:99.93%Cor e Forma:SolidPeso molecular:311.34Ref: TM-T8515
1mg35,00€2mg52,00€5mg77,00€1mL*10mM (DMSO)85,00€10mg113,00€25mg178,00€50mg333,00€100mg495,00€200mg710,00€CP671305
CAS:CP671305 is an orally active, potent and selective inhibitor of phosphodiesterase-4-D.Fórmula:C23H19FN2O7Pureza:99.39%Cor e Forma:SolidPeso molecular:454.4Ziritaxestat
CAS:Ziritaxestat (GLPG1690), an autotaxin inhibitor, currently being evaluated in an exploratory phase 2 study in idiopathic pulmonary fibrosis patients.Fórmula:C30H33FN8O2SPureza:97% - 99.85%Cor e Forma:White SolidPeso molecular:588.7
![[11C]MP 10](https://static.cymitquimica.com/products/TM/thumb-webp/T6042.webp)
