Glucoquinase
A glucocinase (GK) é uma enzima que catalisa a fosforilação da glicose em glicose-6-fosfato, um passo crítico na glicólise. A GK é predominantemente expressa no fígado e no pâncreas, onde desempenha um papel fundamental na regulação dos níveis de glicose no sangue. Inibidores de GK são de grande interesse no estudo de distúrbios metabólicos como o diabetes, pois podem modular o metabolismo da glicose e a secreção de insulina. Na CymitQuimica, oferecemos inibidores de glucocinase para apoiar sua pesquisa em diabetes, metabolismo e desenvolvimento terapêutico.
Foram encontrados 53 produtos de "Glucoquinase"
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MitoPQ
CAS:<p>MitoPQ (MitoParaquat) inhibits insulin-stimulated glucose uptake and plasma membrane translocation in myotubes and can be used to study oxidative stress.</p>Fórmula:C39H46I3N2PPureza:99.91% - ≥98%Cor e Forma:SolidPeso molecular:954.48WAY-640509
CAS:<p>WAY-640509 is a glucocerebrosidase inhibitor.</p>Fórmula:C25H23N5O4SPureza:99.36%Cor e Forma:SolidPeso molecular:489.55Dorzagliatin
CAS:<p>Dorzagliatin (HMS5552) is a dual-acting glucokinase (GK) activator. It also improves glycaemic control and pancreatic β-cell function in type 2 diabetes.</p>Fórmula:C22H27ClN4O5Pureza:98.67% - 99.45%Cor e Forma:SolidPeso molecular:462.93KAN0438757
CAS:<p>KAN0438757 is a selective and potent inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM.</p>Fórmula:C21H18FNO7SPureza:99.34%Cor e Forma:SolidPeso molecular:447.43MK-0941 free base
CAS:<p>MK-0941: an oral glucokinase activator for type 2 diabetes with potent glucose-lowering effects.</p>Fórmula:C21H24N4O6SPureza:98.75%Cor e Forma:SolidPeso molecular:460.5Oxfendazole
CAS:<p>Oxfendazole (RS-8858), a broad spectrum benzimidazole anthelmintic, protects livestock against roundworm, strongyles and pinworms.</p>Fórmula:C15H13N3O3SPureza:98.99% - 99.17%Cor e Forma:White To Yellowish PowderPeso molecular:315.35ADP-specific glucokinase
CAS:<p>ADP-specific glucokinase, expressed in thermophilic archaea, is an ADP-specific enzyme that catalyzes the conversion of glucose to glucose-6-phosphate, thereby facilitating glycolysis. This enzyme can activate T cells and enhance the phagocytic activity of macrophages. It is used in research related to metabolic disorders, neurological diseases, and tumors.</p>Cor e Forma:SolidML266
CAS:<p>ML266: GCase chaperone, non-inhibiting, IC50=2.5 µM, aids mutant protein transport, may help in Gaucher disease study.</p>Fórmula:C24H22BrN3O4Pureza:99.58%Cor e Forma:SolidPeso molecular:496.35(1S,2R)-Globalagliatin
CAS:<p>(1S,2R)-Globalagliatin is a highly potent glucokinase (GK) activator for the study of type 2 diabetes.</p>Fórmula:C28H37N3O3S3Pureza:99.09% - >99.99%Cor e Forma:SoildPeso molecular:559.81ML251
CAS:<p>ML251, potent inhibitor, targets T. brucei PFK (IC50=0.37μM) & T. cruzi PFK (IC50=0.13μM), aids parasite research.</p>Fórmula:C17H13Cl2N3O4SPureza:99.87%Cor e Forma:SolidPeso molecular:426.27AP-III-a4 hydrochloride
CAS:<p>AP-III-a4 hydrochloride (ENOblock hydrochloride) is a direct enolase (enolase) inhibitor that inhibit metastasis and affect glucose homeostasis.</p>Fórmula:C31H44ClFN8O3Pureza:98%Cor e Forma:SolidPeso molecular:631.18Anti-Glucokinase Antibody (5Q209)
<p>Anti-Glucokinase Antibody (5Q209) is a Mouse antibody targeting Glucokinase. Anti-Glucokinase Antibody (5Q209) can be used in ELISA.</p>Cor e Forma:Odour Liquid5MPN
CAS:<p>5MPN is a PFKFB4 inhibitor that inhibits the F6P binding site and suppresses the proliferation of myeloma cells.</p>Fórmula:C15H19N3O4Pureza:98.92% - 99.69%Cor e Forma:SolidPeso molecular:305.33Glucokinase Protein, Human, Recombinant
<p>Glucokinase belongs to the bacterial glucokinase family.</p>Cor e Forma:Lyophilized PowderPeso molecular:52.2 kDa (predicted); 52.2 kDa (reducing conditions)PF-04991532
CAS:<p>PF-04991532 is a hepatoselective glucokinase activator that reduces plasma glucose and AMP concentrations in the Goto-Kakizaki rat model.</p>Fórmula:C18H19F3N4O3Pureza:99.99%Cor e Forma:SolidPeso molecular:396.36Cadisegliatin
CAS:<p>Cadisegliatin (TTP-399) may activate liver GK to lower blood sugar in type 2 diabetes studies.</p>Fórmula:C21H33N3O4S2Cor e Forma:SolidPeso molecular:455.63Anti-Glucokinase Antibody (3U461)
<p>Anti-Glucokinase Antibody (3U461) is a Rabbit antibody targeting Glucokinase. Anti-Glucokinase Antibody (3U461) can be used in ELISA.</p>Cor e Forma:Odour LiquidML198
CAS:<p>ML198: Activates & chaperones glucocerebrosidase; a potential Gaucher disease treatment lead.</p>Fórmula:C17H14N4OPureza:98.31%Cor e Forma:SolidPeso molecular:290.32Globalagliatin
CAS:<p>Globalagliatin (LY2608204) has been used in trials studying the treatment of Diabetes Mellitus, Type 2.</p>Fórmula:C28H37N3O3S3Pureza:98% - 99.49%Cor e Forma:SolidPeso molecular:559.81AM-2394
CAS:<p>AM-2394 is an effective and specific Glucokinase agonist (GKA, EC50: 60 nM), which catalyzes the phosphorylation of glucose to glucose-6-phosphate.</p>Fórmula:C22H25N5O4Pureza:99.01% - 99.62%Cor e Forma:SolidPeso molecular:423.463PO
CAS:<p>3PO inhibits PFKFB3 (IC50: 22.9 µM) and cancer cell growth (IC50: 1.4-24 µM), reducing glucose uptake and key cellular metabolites.</p>Fórmula:C13H10N2OPureza:99.56% - 99.67%Cor e Forma:SolidPeso molecular:210.23Palmitelaidic Acid
CAS:<p>Palmitelaidic Acid (trans-Palmitoleic acid) is one of the most abundant fatty acids in serum and tissue.</p>Fórmula:C16H30O2Pureza:99.76%Cor e Forma:SolidPeso molecular:254.41(E)-3PO
CAS:<p>(E)-3PO is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase) inhibitor.</p>Fórmula:C13H10N2OPureza:98.8% - 98.92%Cor e Forma:SolidPeso molecular:210.23PFK-015
CAS:<p>PFK-015 (PFK15) is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in Y cells (IC50: 20 nM).</p>Fórmula:C17H12N2OPureza:99.7% - 99.85%Cor e Forma:SolidPeso molecular:260.29Genz-123346 free base
CAS:<p>Genz 123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1.</p>Fórmula:C24H38N2O4Pureza:99.41%Cor e Forma:SolidPeso molecular:418.57AMG-3969
CAS:<p>AMG-3969 is an effective glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor (IC50: 4 nM).</p>Fórmula:C21H20F6N4O3SPureza:99.65%Cor e Forma:SolidPeso molecular:522.46Glucokinase activator 3
CAS:<p>Glucokinase activator 3: potent GK activator, AC50=38 nM, potential for type 2 diabetes research.</p>Fórmula:C26H33N2O9PS2Cor e Forma:SolidPeso molecular:612.65RO-28-1675
CAS:<p>RO-28-1675 is a direct and selective glucokinase activator, the GK/GKRP complex,insulin secretion and type 2 diabetes.</p>Fórmula:C18H22N2O3S2Pureza:98.13%Cor e Forma:SolidPeso molecular:378.51PSN-GK1
CAS:<p>PSN-GK1 is a potent activator of glucokinase (EC50: 0.13 μM).</p>Fórmula:C20H23FN2O4S2Pureza:98%Cor e Forma:SolidPeso molecular:438.54GKA-22
CAS:<p>GKA-22 is a human glucokinase allosteric activator in the absence of glucose.</p>Fórmula:C22H22N2O5SPureza:98%Cor e Forma:SolidPeso molecular:426.49Piragliatin
CAS:<p>Piragliatin (RO4389620) activates glucokinase, boosts insulin, and lowers glucose in type 2 diabetes.</p>Fórmula:C19H20ClN3O4SCor e Forma:SolidPeso molecular:421.9Glucokinase activator 1
CAS:<p>Glucokinase activator 1 is a liver-directed glucokinase activator (EC50: 34 nM).</p>Fórmula:C27H20F2N2O7S2Pureza:98%Cor e Forma:SolidPeso molecular:586.58IHVR-11029
CAS:<p>IHVR-11029 inhibits ER α-glucosidase, combats hemorrhagic fever viruses, and hinders enveloped virus morphogenesis.</p>Fórmula:C18H27F2NO5Cor e Forma:SolidPeso molecular:375.41GKA-71
CAS:<p>GKA-71 is an effective glucokinase activator (GKA).</p>Fórmula:C21H23N3O6S2Cor e Forma:SolidPeso molecular:477.55PF-04279405
CAS:<p>PF-04279405 is a potent and selective glucokinase activator.</p>Fórmula:C25H25FN4O4Cor e Forma:SolidPeso molecular:464.49Cefetrizole
CAS:<p>Ceftezole is an α-Glucosidase inhibitor (IC50: 2.1 μM; Ki: 0.578 μM).</p>Fórmula:C16H15N5O4S3Pureza:98%Cor e Forma:SolidPeso molecular:437.52YZ9
CAS:<p>Y29 is a potent PFKFB3 inhibitor with an IC50 of 0.183 µM, and acts as a competitive inhibitor against Fru-6-P with a Ki of 0.094 µM[1].</p>Fórmula:C12H10O5Pureza:99.59%Cor e Forma:SolidPeso molecular:234.2AMG-1694
CAS:<p>AMG-1694 disrupts GK-GKRP complex, enhancing GK activity with 7 nM IC50; normalizes glucose in diabetic rodents without affecting normoglycemic animals.</p>Fórmula:C23H30F3N3O4S2Pureza:98.37%Cor e Forma:SolidPeso molecular:533.63AR453588
CAS:<p>AR453588 is an orally bioavailable anti-diabetic glucokinase activator (EC50: 42 nM) with anti-hyperglycemic activity.</p>Fórmula:C25H25N7O2S2Cor e Forma:SolidPeso molecular:519.64KDM4-IN-2
CAS:<p>KDM4-IN-2 is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively.</p>Fórmula:C25H26N6OPureza:98%Cor e Forma:SolidPeso molecular:426.51AR453588 hydrochloride
CAS:<p>AR453588 hydrochloride is an orally bioavailable anti-diabetic glucokinase activator (EC50: 42 nM) with anti-hyperglycemic activity.</p>Fórmula:C25H26ClN7O2S2Pureza:98%Cor e Forma:SolidPeso molecular:556.1CM-10-18
CAS:<p>CM-10-18: potent ER α-glucosidase inhibitor, strong antiviral against hemorrhagic fever viruses, protects mice from dengue fatality.</p>Fórmula:C17H35NO5Cor e Forma:SolidPeso molecular:333.46PF-04937319
CAS:<p>PF-04937319 activates glucokinase (EC50=154.4μM) with low hypoglycemia risk, researched for type 2 diabetes treatment.</p>Fórmula:C22H20N6O4Pureza:99.89%Cor e Forma:SolidPeso molecular:432.43AZD-1656
CAS:<p>AZD-1656 is a glucokinase activator (GKA) that can cause dose-limiting hypoglycemia in normal animals used in embryofetal development studies and type 2</p>Fórmula:C24H26N6O5Pureza:97.07% - 99.37%Cor e Forma:SolidPeso molecular:478.5AZD1092
CAS:<p>AZD1092 is the glucokinase enzyme activator.</p>Fórmula:C24H26N4O5Pureza:98%Cor e Forma:SolidPeso molecular:450.49WAY-297848
CAS:<p>WAY-297848 is a novel glucokinase activator for the prevention or treatment of hyperglycemia, diabetes mellitus, obesity, dyslipidemia, and metabolic syndrome.</p>Fórmula:C13H13ClN2O2SPureza:98.19%Cor e Forma:SolidPeso molecular:296.77Glucokinase activator 7
CAS:<p>Glucokinase activator7 is an activator of glucose kinase (Glucokinase) and can be utilized in research on diabetes and hyperglycemia [refer to compound on page 176].</p>Fórmula:C14H13N3O2SCor e Forma:SolidPeso molecular:287.337GKA50 quarterhydrate
<p>GKA50 quarterhydrate: glucokinase activator, EC50 of 33 nM, boosts insulin, cuts glucose in rats.</p>Fórmula:C26H30N2O7Cor e Forma:SolidPeso molecular:469.01Gcase activator 2
CAS:<p>Gcase activator 2 is a β-glucocerebrosidase activator that induces dimerization of GCase, increases lysosomal substrate metabolism.</p>Fórmula:C21H24N4O2Pureza:99.51% - 99.76%Cor e Forma:SolidPeso molecular:364.44Glucokinase activator 8
CAS:<p>Glucokinase activator8 is an activator of glucose kinase (glucokinase).</p>Fórmula:C14H13N3O2SCor e Forma:SolidPeso molecular:287.337MK-0941
CAS:<p>MK-0941 is an orally active and allosteric glucokinase activator, has potential in the treatment of type 2 diabetes.</p>Fórmula:C22H28N4O9S2Cor e Forma:SolidPeso molecular:556.61Hex
CAS:<p>Hex is a potent inhibitor of enolase, exhibiting inhibitory activity with Ki values of 74.4 nM and 269.4 nM against ENO2 and ENO1, respectively.</p>Fórmula:C5H10NO5PCor e Forma:SolidPeso molecular:195.11GKA50
CAS:<p>GKA50 stimulates insulin release from mouse islets of Langerhans and MIN6 cells. GKA50 shows significant glucose lowering in high fat fed female rats. GKA50 is a potent glucokinase activator (EC50=33 nM at 5 mM glucose).</p>Fórmula:C26H28N2O6Pureza:98%Cor e Forma:SolidPeso molecular:464.51
