Glucoquinase
A glucocinase (GK) é uma enzima que catalisa a fosforilação da glicose em glicose-6-fosfato, um passo crítico na glicólise. A GK é predominantemente expressa no fígado e no pâncreas, onde desempenha um papel fundamental na regulação dos níveis de glicose no sangue. Inibidores de GK são de grande interesse no estudo de distúrbios metabólicos como o diabetes, pois podem modular o metabolismo da glicose e a secreção de insulina. Na CymitQuimica, oferecemos inibidores de glucocinase para apoiar sua pesquisa em diabetes, metabolismo e desenvolvimento terapêutico.
Foram encontrados 56 produtos de "Glucoquinase"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
MitoPQ
CAS:MitoPQ (MitoParaquat) inhibits insulin-stimulated glucose uptake and plasma membrane translocation in myotubes and can be used to study oxidative stress.Fórmula:C39H46I3N2PPureza:99.87% - 99.91%Cor e Forma:SolidPeso molecular:954.48Dorzagliatin
CAS:Dorzagliatin (HMS5552) is a dual-acting glucokinase (GK) activator. It also improves glycaemic control and pancreatic β-cell function in type 2 diabetes.Fórmula:C22H27ClN4O5Pureza:98.67% - 99.45%Cor e Forma:SolidPeso molecular:462.93Ref: TM-T15159
1mg38,00€2mg50,00€5mg82,00€1mL*10mM (DMSO)90,00€10mg116,00€25mg227,00€50mg358,00€100mg537,00€KAN0438757
CAS:KAN0438757 is a selective and potent inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM.
Fórmula:C21H18FNO7SPureza:99.34%Cor e Forma:SolidPeso molecular:447.43MK-0941 free base
CAS:MK-0941: an oral glucokinase activator for type 2 diabetes with potent glucose-lowering effects.Fórmula:C21H24N4O6SPureza:98.75%Cor e Forma:SolidPeso molecular:460.5Ref: TM-T12056
1mg82,00€5mg168,00€1mL*10mM (DMSO)197,00€10mg244,00€25mg404,00€50mg567,00€100mg767,00€Oxfendazole
CAS:Oxfendazole (RS-8858), a broad spectrum benzimidazole anthelmintic, protects livestock against roundworm, strongyles and pinworms.Fórmula:C15H13N3O3SPureza:98.99% - 99.17%Cor e Forma:White To Yellowish PowderPeso molecular:315.35WAY-640509
CAS:WAY-640509 is a glucocerebrosidase inhibitor.Fórmula:C25H23N5O4SPureza:99.36%Cor e Forma:SolidPeso molecular:489.55Ref: TM-T60048
1mg109,00€2mg163,00€5mg241,00€10mg355,00€25mg532,00€50mg745,00€100mg1.018,00€500mg2.043,00€Neuron-specific enolase, Human
Neuron-specific enolase, Human (EC 4.2.1.11), is an enolase enzyme that serves as a biomarker for traumatic brain injury (TBI), stroke following cardiac arrest, hypoxic encephalopathy, and acute spinal cord injury (SCI).Cor e Forma:Odour SolidWAY-615145
CAS:WAY-615145 is a compound that activates glucokinase.Fórmula:C16H18N2OSCor e Forma:SolidPeso molecular:286.39AP-III-a4 hydrochloride
CAS:AP-III-a4 hydrochloride (ENOblock hydrochloride) is a direct enolase (enolase) inhibitor that inhibit metastasis and affect glucose homeostasis.Fórmula:C31H44ClFN8O3Pureza:98%Cor e Forma:SolidPeso molecular:631.18Ref: TM-T6759L
100mgA consultar200mgA consultar2mg92,00€5mg170,00€1mL*10mM (DMSO)235,00€10mg271,00€25mg557,00€50mg785,00€ML266
CAS:ML266: GCase chaperone, non-inhibiting, IC50=2.5 µM, aids mutant protein transport, may help in Gaucher disease study.Fórmula:C24H22BrN3O4Pureza:99.58%Cor e Forma:SolidPeso molecular:496.35ML251
CAS:ML251, potent inhibitor, targets T. brucei PFK (IC50=0.37μM) & T. cruzi PFK (IC50=0.13μM), aids parasite research.Fórmula:C17H13Cl2N3O4SPureza:99.87%Cor e Forma:SolidPeso molecular:426.27Ref: TM-T64320
1mg109,00€5mg260,00€1mL*10mM (DMSO)285,00€10mg409,00€25mg677,00€50mg954,00€100mg1.288,00€200mg1.728,00€ADP-specific glucokinase
CAS:ADP-specific glucokinase, expressed in thermophilic archaea, is an ADP-specific enzyme that catalyzes the conversion of glucose to glucose-6-phosphate, thereby facilitating glycolysis. This enzyme can activate T cells and enhance the phagocytic activity of macrophages. It is used in research related to metabolic disorders, neurological diseases, and tumors.Cor e Forma:Solid(1S,2R)-Globalagliatin
CAS:(1S,2R)-Globalagliatin is a highly potent glucokinase (GK) activator for the study of type 2 diabetes.Fórmula:C28H37N3O3S3Pureza:99.09% - 99.17%Cor e Forma:SoildPeso molecular:559.81Anti-Glucokinase Antibody (5Q209)
Anti-Glucokinase Antibody (5Q209) is a Mouse antibody targeting Glucokinase. Anti-Glucokinase Antibody (5Q209) can be used in ELISA.Cor e Forma:Odour Liquid5MPN
CAS:5MPN is a PFKFB4 inhibitor that inhibits the F6P binding site and suppresses the proliferation of myeloma cells.Fórmula:C15H19N3O4Pureza:98.92% - 99.69%Cor e Forma:SolidPeso molecular:305.33Ref: TM-T40565
2mg92,00€5mg160,00€1mL*10mM (DMSO)170,00€10mg260,00€25mg522,00€50mg835,00€100mg1.341,00€200mg1.773,00€Anti-Glucokinase Antibody (3U461)
Anti-Glucokinase Antibody (3U461) is a Rabbit antibody targeting Glucokinase. Anti-Glucokinase Antibody (3U461) can be used in ELISA.Cor e Forma:Odour LiquidHex
CAS:Hex is a potent inhibitor of enolase, exhibiting inhibitory activity with Ki values of 74.4 nM and 269.4 nM against ENO2 and ENO1, respectively.Fórmula:C5H10NO5PCor e Forma:SolidPeso molecular:195.11Cadisegliatin
CAS:Cadisegliatin (TTP-399) may activate liver GK to lower blood sugar in type 2 diabetes studies.Fórmula:C21H33N3O4S2Cor e Forma:SolidPeso molecular:455.63PF-04991532
CAS:PF-04991532 is a hepatoselective glucokinase activator that reduces plasma glucose and AMP concentrations in the Goto-Kakizaki rat model.Fórmula:C18H19F3N4O3Pureza:99.99%Cor e Forma:SolidPeso molecular:396.36Glucokinase Protein, Human, Recombinant
Glucokinase belongs to the bacterial glucokinase family.Cor e Forma:Lyophilized PowderPeso molecular:52.2 kDa (predicted); 52.2 kDa (reducing conditions)(E)-3PO
CAS:(E)-3PO is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase) inhibitor.Fórmula:C13H10N2OPureza:98.8% - 98.92%Cor e Forma:SolidPeso molecular:210.23AMG-3969
CAS:AMG-3969 is an effective glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor (IC50: 4 nM).Fórmula:C21H20F6N4O3SPureza:99.65%Cor e Forma:SolidPeso molecular:522.46Ref: TM-TQ0055
1mg52,00€5mg111,00€1mL*10mM (DMSO)131,00€10mg172,00€25mg289,00€50mg399,00€100mg532,00€200mg740,00€Globalagliatin
CAS:Globalagliatin (LY2608204) has been used in trials studying the treatment of Diabetes Mellitus, Type 2.Fórmula:C28H37N3O3S3Pureza:98% - 99.56%Cor e Forma:SolidPeso molecular:559.81Genz-123346 free base
CAS:Genz 123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1.Fórmula:C24H38N2O4Pureza:99.41%Cor e Forma:SolidPeso molecular:418.57AM-2394
CAS:AM-2394 is an effective and specific Glucokinase agonist (GKA, EC50: 60 nM), which catalyzes the phosphorylation of glucose to glucose-6-phosphate.Fórmula:C22H25N5O4Pureza:99.01% - 99.62%Cor e Forma:SolidPeso molecular:423.46Ref: TM-T3312
2mg34,00€5mg49,00€1mL*10mM (DMSO)50,00€10mg66,00€25mg105,00€50mg172,00€100mg264,00€200mg394,00€3PO
CAS:3PO inhibits PFKFB3 (IC50: 22.9 µM) and cancer cell growth (IC50: 1.4-24 µM), reducing glucose uptake and key cellular metabolites.
Fórmula:C13H10N2OPureza:99.56% - 99.67%Cor e Forma:SolidPeso molecular:210.23Palmitelaidic Acid
CAS:Palmitelaidic Acid (trans-Palmitoleic acid) is one of the most abundant fatty acids in serum and tissue.Fórmula:C16H30O2Pureza:99.76%Cor e Forma:SolidPeso molecular:254.41ML198
CAS:ML198: Activates & chaperones glucocerebrosidase; a potential Gaucher disease treatment lead.Fórmula:C17H14N4OPureza:98.31%Cor e Forma:SolidPeso molecular:290.32Ref: TM-T8986
2mg46,00€1mL*10mM (DMSO)80,00€5mg92,00€10mg124,00€25mg241,00€50mg360,00€100mg537,00€200mg710,00€YZ9
CAS:Y29 is a potent PFKFB3 inhibitor with an IC50 of 0.183 µM, and acts as a competitive inhibitor against Fru-6-P with a Ki of 0.094 µM[1].Fórmula:C12H10O5Pureza:99.59%Cor e Forma:SolidPeso molecular:234.2Piragliatin
CAS:Piragliatin (RO4389620) activates glucokinase, boosts insulin, and lowers glucose in type 2 diabetes.Fórmula:C19H20ClN3O4SCor e Forma:SolidPeso molecular:421.9Glucokinase activator 1
CAS:Glucokinase activator 1 is a liver-directed glucokinase activator (EC50: 34 nM).Fórmula:C27H20F2N2O7S2Pureza:98%Cor e Forma:SolidPeso molecular:586.58IHVR-11029
CAS:IHVR-11029 inhibits ER α-glucosidase, combats hemorrhagic fever viruses, and hinders enveloped virus morphogenesis.Fórmula:C18H27F2NO5Cor e Forma:SolidPeso molecular:375.41GKA-71
CAS:GKA-71 is an effective glucokinase activator (GKA).Fórmula:C21H23N3O6S2Cor e Forma:SolidPeso molecular:477.55Glucokinase activator 3
CAS:Glucokinase activator 3: potent GK activator, AC50=38 nM, potential for type 2 diabetes research.Fórmula:C26H33N2O9PS2Cor e Forma:SolidPeso molecular:612.65PF-04279405
CAS:PF-04279405 is a potent and selective glucokinase activator.Fórmula:C25H25FN4O4Cor e Forma:SolidPeso molecular:464.49PSN-GK1
CAS:PSN-GK1 is a potent activator of glucokinase (EC50: 0.13 μM).Fórmula:C20H23FN2O4S2Pureza:98%Cor e Forma:SolidPeso molecular:438.54Sinogliatin
CAS:Sinogliatin, a glucokinase activator, is used potentially for the treatment of type 2 diabetes.Fórmula:C22H27ClN4O5Cor e Forma:SolidPeso molecular:462.93(R)-PF-04991532
(R)-PF-04991532 is the R-enantiomer of PF-04991532 . PF-04991532 is a potent, hepatoselective glucokinase activator .Fórmula:C18H19F3N4O3Cor e Forma:SolidPeso molecular:396.36Cefetrizole
CAS:Ceftezole is an α-Glucosidase inhibitor (IC50: 2.1 μM; Ki: 0.578 μM).Fórmula:C16H15N5O4S3Pureza:98%Cor e Forma:SolidPeso molecular:437.52RO-28-1675
CAS:RO-28-1675 is a direct and selective glucokinase activator, the GK/GKRP complex,insulin secretion and type 2 diabetes.Fórmula:C18H22N2O3S2Pureza:98.13%Cor e Forma:SolidPeso molecular:378.51Ref: TM-T16793
1mg59,00€5mg126,00€1mL*10mM (DMSO)138,00€10mg191,00€25mg386,00€50mg623,00€100mg947,00€200mg1.324,00€GKA-22
CAS:GKA-22 is a human glucokinase allosteric activator in the absence of glucose.Fórmula:C22H22N2O5SPureza:98%Cor e Forma:SolidPeso molecular:426.49AMG-1694
CAS:AMG-1694 disrupts GK-GKRP complex, enhancing GK activity with 7 nM IC50; normalizes glucose in diabetic rodents without affecting normoglycemic animals.Fórmula:C23H30F3N3O4S2Pureza:98.37%Cor e Forma:SolidPeso molecular:533.63CM-10-18
CAS:CM-10-18: potent ER α-glucosidase inhibitor, strong antiviral against hemorrhagic fever viruses, protects mice from dengue fatality.Fórmula:C17H35NO5Cor e Forma:SolidPeso molecular:333.46AZD-1656
CAS:AZD-1656 is a glucokinase activator (GKA) that can cause dose-limiting hypoglycemia in normal animals used in embryofetal development studies and type 2Fórmula:C24H26N6O5Pureza:97.07% - 99.37%Cor e Forma:SolidPeso molecular:478.5AZD1092
CAS:AZD1092 is the glucokinase enzyme activator.Fórmula:C24H26N4O5Pureza:98%Cor e Forma:SolidPeso molecular:450.49AR453588
CAS:AR453588 is an orally bioavailable anti-diabetic glucokinase activator (EC50: 42 nM) with anti-hyperglycemic activity.Fórmula:C25H25N7O2S2Cor e Forma:SolidPeso molecular:519.64PF-04937319
CAS:PF-04937319 activates glucokinase (EC50=154.4μM) with low hypoglycemia risk, researched for type 2 diabetes treatment.Fórmula:C22H20N6O4Pureza:99.89%Cor e Forma:SolidPeso molecular:432.43KDM4-IN-2
CAS:KDM4-IN-2 is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively.Fórmula:C25H26N6OPureza:98%Cor e Forma:SolidPeso molecular:426.51AR453588 hydrochloride
CAS:AR453588 hydrochloride is an orally bioavailable anti-diabetic glucokinase activator (EC50: 42 nM) with anti-hyperglycemic activity.Fórmula:C25H26ClN7O2S2Pureza:98%Cor e Forma:SolidPeso molecular:556.1WAY-297848
CAS:WAY-297848 is a novel glucokinase activator for the prevention or treatment of hyperglycemia, diabetes mellitus, obesity, dyslipidemia, and metabolic syndrome.Fórmula:C13H13ClN2O2SPureza:98.19%Cor e Forma:SolidPeso molecular:296.77
