Aminopeptidase
As aminopeptidases são um grupo de enzimas que catalisam a clivagem de aminoácidos a partir do N-terminal de peptídeos e proteínas, desempenhando um papel crucial na maturação e degradação de proteínas. Essas enzimas estão envolvidas em vários processos fisiológicos, incluindo o processamento de antígenos, a regulação de hormônios peptídicos e a homeostase celular. Inibidores de aminopeptidases são de interesse no tratamento de doenças como câncer, inflamação e doenças infecciosas. Na CymitQuimica, oferecemos uma variedade de inibidores de aminopeptidases para apoiar sua pesquisa em proteômica, desenvolvimento de medicamentos e tratamento de doenças.
Foram encontrados 76 produtos de "Aminopeptidase"
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Bufexamac
CAS:Bufexamac (Bufexamic acid) is a COX inhibitor for IFN-α release with anti-inflammatory, analgesic, and antipyretic action.Fórmula:C12H17NO3Pureza:99.73%Cor e Forma:Acicular CrystalPeso molecular:223.27ERAP1-IN-1
CAS:ERAP1-IN-1 inhibits and allosterically activates ERAP1, affecting fluorogenic, chromogenic, and nonamer peptide substrates.Fórmula:C20H21F3N2O5SPureza:98.95%Cor e Forma:SolidPeso molecular:458.45Ref: TM-T11221
1mg82,00€5mg161,00€1mL*10mM (DMSO)161,00€10mg259,00€25mg425,00€50mg583,00€100mg800,00€200mg1.071,00€BDM_92499
BDM_92499 is a nanomolar, selective IRAP inhibitor with an IC50 of 3.4 nM. It also inhibits ERAP1 and ERAP2, with IC50 values of 0.46 μM and 4.2 μM, respectively.Cor e Forma:Odour SolidAmastatin hydrochloride
CAS:Amastatin HCl is an inhibitor of aminopeptidase. It also induces vasoconstriction.Fórmula:C21H39ClN4O8Cor e Forma:White To Off-White PowderPeso molecular:511.01Aclimostat
CAS:Aclimostat (ZGN-1061) is a MetAP2 inhibitor with strong preclinical results, improving obesity-related metrics and gene expression.Fórmula:C26H42N2O6Cor e Forma:SolidPeso molecular:478.63Relzomostat
CAS:Relzomostat inhibits MetAP2, with research potential for obesity and type 2 diabetes.Fórmula:C24H36F2N2O5Cor e Forma:SolidPeso molecular:470.558CD13-IN-1
CD13-IN-1 (Compound 5f) is a CD13 inhibitor with an IC50 value of 1.71 μM. It effectively suppresses the proliferation of various tumor cells, demonstrating antitumor activity.Cor e Forma:Odour SolidERAP1 modulator-1
CAS:ERAP1 modulator-1 (Compound 1) is a regulator of endoplasmic reticulum aminopeptidase 1 (ERAP1) with an IC50 of less than 250 nM.Fórmula:C23H23F3N2O5SCor e Forma:SolidPeso molecular:496.5BAY-277
BAY-277 is a degrader of METAP2, with IC50 values of 5.8 nM for human METAP2 (hMETAP2) and 5.9 nM for mouse METAP2 (mMETAP2).Fórmula:C44H52N8O5Cor e Forma:SolidPeso molecular:772.93JNJ-40929837 succinate
CAS:JNJ-40929837 succinate is a selective, orally active inhibitor of LTA 4 H (leukotriene A 4 hydrolase). This compound effectively inhibits aminopeptidase activity, leading to the accumulation of Pro-Gly-Pro in serum, and can be utilized in asthma research [1].Fórmula:C22H24N4O2S·xC4H6O4Cor e Forma:SolidLYS006 hydrochloride
CAS:LYS006 hydrochloride is a potent inhibitor of leukotriene A4 hydrolase (LTA4H) with an IC50 value of 2 nM. It is applicable in the study of inflammatory and autoimmune diseases. For further details, please refer to compound 29 in patent document WO2015092740A1.Fórmula:C16H15Cl2FN6O3Cor e Forma:SolidPeso molecular:429.23NGR peptide Trifluoroacetate
NGR peptide Trifluoroacetate contains an NGR motif recognized by CD13/APN in tumor neovasculature, used for targeted drug delivery in cancer research.Fórmula:C22H37F3N10O10S2Pureza:99.69%Cor e Forma:SolidPeso molecular:722.72α-Cyclopentyl-4-(2-quinolinylmethoxy)benzeneacetic acid
CAS:α-Cyclopentyl-4-(2-quinolinylmethoxy)benzeneacetic acid was identified as possible dual inhibitors for hLTA4H and hLTC4S enzymes by the computer-aidedFórmula:C23H23NO3Pureza:97.19% - 99.36%Cor e Forma:SoildPeso molecular:361.43Ref: TM-T60040
1mg73,00€5mg146,00€1mL*10mM (DMSO)155,00€10mg208,00€25mg319,00€50mg447,00€100mg600,00€200mg808,00€ecMetAP-IN-1
CAS:ecMetAP-IN-1 可用作 QSAR 模型，以使用多元线性回归研究蛋氨酸氨基肽酶抑制剂作为抗癌剂。Fórmula:C13H11N3Pureza:99.34%Cor e Forma:SolidPeso molecular:209.25NGR peptide
CAS:Cell-penetrating peptideFórmula:C20H36N10O8S2Pureza:98%Cor e Forma:SolidPeso molecular:608.69H-Val-βNA
CAS:H-Val-βNA, also known as L-Valine β-naphthylamide, serves as a substrate for aminopeptidase and Valine arylamidase activities.Fórmula:C15H18N2OCor e Forma:SolidPeso molecular:242.322Lys-psi(CH2NH)-trp(nps)-ome
CAS:Lys-psi(CH2NH)-trp(nps)-ome peptide bond replaced by CH2NH group.Fórmula:C24H31N5O4SCor e Forma:SolidPeso molecular:485.60Matlystatin A
CAS:Matlystatin A is an inhibitor of aminopeptidase. It shows multiple inhibitory activities against both aminopeptidase N and matrix metalloproteinases.Fórmula:C27H47N5O8SCor e Forma:SolidPeso molecular:601.76DG013A formate
DG013A (formate) is a tripeptide-mimicking inhibitor of hypophosphorous acid. It exhibits IC50 values of 33 nM for ERAP1 and 11 nM for ERAP2. This compound can be utilized in research related to autoimmune diseases and cancer.Fórmula:C27H37N4O4PCH2O2Cor e Forma:SolidPeso molecular:530.99Antho-rwamide I
CAS:Antho-rwamide I is an anthozoan neuropeptide.Fórmula:C31H46N10O7Cor e Forma:SolidPeso molecular:670.76SDUY817
SDUY817 is a dual APN/NEP inhibitor with IC50 values of 0.29 μM for APN and 7.4 μM for NEP. It exhibits analgesic effects in a concentration- and time-dependent manner, making it a potential candidate for research in the field of neuropathic pain disorders.Fórmula:C18H16IN3O3Cor e Forma:SolidPeso molecular:449.24SDUY816
SDUY816 is an orally active dual APN/NEP inhibitor, with IC50 values of 0.68 μM for APN and 6.9 μM for NEP. It exhibits analgesic properties and demonstrates good safety and pharmacokinetic profiles, having an oral bioavailability of 27% and a half-life of 4.02 hours in rats (oral, 10 mg/kg). SDUY816 is applicable for research in the field of neuropathic pain disorders.Fórmula:C18H16IN3O3Cor e Forma:SolidPeso molecular:449.24Leuhistin
CAS:Leuhistin is an aminopeptidases N inhibitor isolated from Bacillus laterosporus BMI156-14F1.Fórmula:C11H19N3O3Pureza:98%Cor e Forma:White To Off-White SolidPeso molecular:241.29Probestin
CAS:Probestin is an aminopeptidase M inhibitor, isolated from Streptomyces azureus MH663-2F6.Fórmula:C26H38N4O6Pureza:98%Cor e Forma:SolidPeso molecular:502.60ERAP1-IN-3
ERAP1-IN-3 (compound 13) is a potent inhibitor of endoplasmic reticulum aminopeptidase 1 (ERAP1), with a pIC50 value of 8.6. ERAP1-IN-3 shows potential for research in cancer immunotherapy and autoimmune disease studies.Fórmula:C22H22N2O4SCor e Forma:SolidPeso molecular:410.49Aminopeptidase N inhibitor 2
AminopeptidaseN inhibitor 2 is an APN inhibitor (IC50: 4.3 μM) with antitumor properties.Fórmula:C12H16F2N2O4SCor e Forma:SolidPeso molecular:322.07988LTA4H-IN-4
LTA4H-IN-4 (compound 3) is an orally active inhibitor of LTA4H. It exhibits an IC50 value of 156 μM against hERG and is applicable for inflammation-related research.HFI-142
CAS:HFI-142 is a inhibitor to aminopeptidase N; inhibit leukotriene A4 biosynthesis in red blood cells; inhibit dditional aminopeptidases.Fórmula:C17H16N2O4Cor e Forma:SolidPeso molecular:312.32Apstatin TFA
Apstatin TFA is a potent inhibitor of aminopeptidase P (APP), with Ki values of 2.6 µM for rat APP and 0.64 µM for human APP. This compound also exhibits cardioprotective properties.Fórmula:C25H34F3N5O7Cor e Forma:SolidPeso molecular:573.56N-Acetyl-β-Asp-Glu
CAS:N-Acetyl-β-Asp-Glu is a peptide neurotransmitter, the third most common neurotransmitter in the mammalian nervous system.Fórmula:C11H16N2O8Pureza:99.94%Cor e Forma:SolidPeso molecular:304.25Tosedostat
CAS:Tosedostat (CHR-2797), an oral M1 aminopeptidase inhibitor, turns into CHR-79888, blocks tumor cell proteins, causing cell death.Fórmula:C21H30N2O6Pureza:98.14% - 99.84%Cor e Forma:SolidPeso molecular:406.47DG051
CAS:DG051 is a potent leukotriene A4 hydrolase (LTA4H) inhibitor (IC50: 47 nM).Fórmula:C21H25Cl2NO4Pureza:98.26%Cor e Forma:SolidPeso molecular:426.33Ref: TM-TQ0047
2mg34,00€5mg71,00€1mL*10mM (DMSO)79,00€10mg110,00€25mg225,00€50mg360,00€100mg577,00€200mg772,00€Acebilustat
CAS:Acebilustat (CTX-4430) (ZK322) is an effective and specific leukotriene B4 hydrolase inhibitor.Fórmula:C29H27N3O4Pureza:99.59% - 99.88%Cor e Forma:SolidPeso molecular:481.54Ref: TM-T3715
2mg35,00€5mg55,00€1mL*10mM (DMSO)62,00€10mg75,00€25mg138,00€50mg212,00€100mg315,00€200mg442,00€L(+)-Leucinol
CAS:L(+)-Leucinol is a potent inhibitor of leucine aminopeptidase.Fórmula:C6H15NOPureza:98%Cor e Forma:Clear Colorless To Slightly Yellow LiquidPeso molecular:117.19Bestatin trifluoroacetate
CAS:Bestatin trifluoroacetate inhibits CD13/APN and leukotriene A4 hydrolase, used in cancer research.Fórmula:C18H25F3N2O6Cor e Forma:SolidPeso molecular:422.401ARM1
CAS:ARM1 is a potent inhibitor of aminopeptidase and epoxide hydrolase. The IC50 values are 7.61 µM for aminopeptidase and 12.4 µM for epoxide hydrolase.Fórmula:C16H14N2SPureza:99.36%Cor e Forma:SolidPeso molecular:266.36Adamantanine
CAS:Adamantanine (NSC-145160) is an amino acid transport inhibitor.Fórmula:C11H17NO2Pureza:99.79%Cor e Forma:SolidPeso molecular:195.26DG-051
CAS:DG-051 is a novel leukotriene A4 (LTA4H) hydrolase inhibitor of leukotriene B4 biosynthesis.Fórmula:C21H24ClNO4Cor e Forma:SolidPeso molecular:389.87Firibastat
CAS:Firibastat (RB150) is a glutamyl aminopeptidase antagonist and an orally active brain penetrating prodrug of EC33.Fórmula:C8H20N2O6S4Pureza:99.5%Cor e Forma:SolidPeso molecular:368.51Methyl arachidate
CAS:Methyl arachidate (Methyl Icosanoate) is an esterified form of arachidic acidFórmula:C21H42O2Pureza:≥95%Cor e Forma:White PowderPeso molecular:326.56Puromycin aminonucleoside
CAS:Puromycin aminonucleoside (NSC-3056) increases podocyte permeability by modulating ZO-1 in an oxidative stress-dependent manner.Fórmula:C12H18N6O3Pureza:99.85% - 99.9%Cor e Forma:SolidPeso molecular:294.31SC-57461A
CAS:SC 57461A is a potent and specific leukotriene A4 hydrolase (LTA4H) inhibitor.Fórmula:C20H26ClNO3Pureza:99.91%Cor e Forma:SolidPeso molecular:363.9Bestatin hydrochloride
CAS:Bestatin hydrochloride (Ubenimex hydrochloride) is an inhibitor of aminopeptidase N (APN)/CD13 and aminopeptidase B.Fórmula:C16H25ClN2O4Pureza:98% - 99.93%Cor e Forma:SolidPeso molecular:344.84Ref: TM-T3529
5mg49,00€1mL*10mM (DMSO)54,00€10mg71,00€25mg101,00€50mg165,00€100mg264,00€200mg404,00€500mg655,00€Bestatin
CAS:Bestatin (Ubenimex) competitively inhibits many aminopeptidases. Bestatin is a microbial metabolite and dipeptide with immunomodulatory and antitumor effects.Fórmula:C16H24N2O4Pureza:98% - 99.63%Cor e Forma:White Crystalline PowderPeso molecular:308.37Ref: TM-T1257
2mg34,00€5mg52,00€1mL*10mM (DMSO)58,00€10mg64,00€25mg99,00€50mg157,00€100mg222,00€200mg330,00€ERAP2-IN-1
CAS:ERAP2-IN-1 is a specific non-competitive ERAP2 inhibitor with IC50s of 27 μM for Arg-AMC and 44 μM for peptides.Fórmula:C20H21F3N2O5SCor e Forma:SolidPeso molecular:458.45M8891
CAS:M8891: Oral, reversible MetAP-2 inhibitor, brain-penetrant (IC50: 54nM; Ki: 4.33nM), hinders endothelial & tumor cell growth, antiangiogenic & antitumor.Fórmula:C20H17F2N3O3Cor e Forma:SolidPeso molecular:385.36Aminopeptidase-IN-1
CAS:Aminopeptidase-IN-1: potent IRAP blocker, Ki 7.7 μM, useful for cognitive/memory disorder research.Fórmula:C18H16N2O6Pureza:98.34%Cor e Forma:SolidPeso molecular:356.33TP-004
CAS:TP-004 is a potent and reversible methionine aminopeptidase 2 (MetAP2) inhibitor (IC50: 6 nM).Fórmula:C17H16F3N5OPureza:98%Cor e Forma:SolidPeso molecular:363.34HFI-437
CAS:HFI-437 is a potent, non-peptidic, insulin-regulated aminopeptidase (IRAP) inhibitor with a K i of 20 nM and functions as a cognitive enhancer [1].Fórmula:C23H20N2O5Cor e Forma:SolidPeso molecular:404.42Aminopeptidase N Inhibitor
CAS:AP-N inhibitor: reversible, selective for AP-N/CD13 (IC50=25 μM), non-toxic to U937 cells at 100 μM.Fórmula:C17H10N2O8Cor e Forma:SolidPeso molecular:370.27
