IDO
A indoleamina 2,3-dioxigenase (IDO) é uma enzima envolvida no catabolismo do triptofano, levando à produção de quinurenina e outros metabólitos. A IDO desempenha um papel na tolerância imunológica e é frequentemente regulada em alta em condições como câncer e inflamações crônicas. Inibidores de IDO estão sendo explorados como potenciais agentes imunoterapêuticos no câncer e em doenças autoimunes. Na CymitQuimica, oferecemos inibidores de IDO para apoiar sua pesquisa em imunologia, oncologia e regulação metabólica.
Foram encontrados 88 produtos para "IDO".
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GNF-PF-3777
CAS:GNF-PF-3777 (8-Nitrotryptanthrin) (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2; Ki: 0.97 μM).Fórmula:C15H7N3O4Pureza:97.88%Cor e Forma:SolidPeso molecular:293.2338LY3381916
CAS:IDO1-IN-5 is a selective, potent and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.Fórmula:C23H25FN2O3Pureza:99.3%Cor e Forma:SolidPeso molecular:396.4546NLG802
CAS:NLG802 is a prodrug of indoximod, an orally active indoleamine 2,3-dioxygenase (IDO) inhibitor.Fórmula:C20H30ClN3O3Pureza:99.61%Cor e Forma:SolidPeso molecular:395.924IDO-IN-13
CAS:IDO-IN-13 (GS-4361) is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor (EC50: 17 nM).Fórmula:C26H17F3N4OPureza:99.29%Cor e Forma:SolidPeso molecular:458.4346Imsamotide
CAS:Imsamotide (IDO194-214), an IDO peptide DTLLKALLEIASCLEKALQVF, is used for immunization and cancer treatment.Fórmula:C106H180N24O31SCor e Forma:SolidPeso molecular:2318.76NU227326
CAS:NU227326 is a PROTAC degrader of indoleamine 2,3-dioxygenase 1 (IDO1) with a DC50 value of 4.5 nM. It effectively degrades IDO1 in U87 and GBM43 cells, with DC50 values of 7.1 nM and 11.8 nM, respectively. NU227326 exhibits favorable pharmacokinetic properties, with a plasma half-life of 5.7 hours and a brain tissue half-life of 11.8 hours. (Pink: ligand for target protein IDO1 ligand-1; Black: linker; Blue: ligand for E3 ligase Cereblon).Fórmula:C53H61FN8O7Cor e Forma:SolidPeso molecular:941.099CAY10581
CAS:CAY10581, a derivative of pyranonaphthoquinone, serves as a highly specific and reversible uncompetitive inhibitor of IDO, demonstrating potency with an IC50Fórmula:C22H21NO4Cor e Forma:SolidPeso molecular:363.41PROTAC IDO1 Degrader-1
CAS:First potent PROTAC IDO1 degrader; links IDO1 to CRBN E3 ligase for UPS-induced degradation (DC50=2.84 μM), boosts H ER2 CAR-T cell efficacy.Fórmula:C40H53BrFN9O13Cor e Forma:SolidPeso molecular:966.816human TDO2-IN-1
Human TDO2-IN-1 (Cpd-2) is a potent inhibitor of human TDO2, with an IC50 of 14.8 nM. It plays a significant role in studies related to metabolism, inflammation, and tumor immune surveillance.Fórmula:C30H36N4O5Cor e Forma:SolidPeso molecular:532.631IDO1-IN-12
CAS:IDO1-IN-12 is a potent and orally available IDO1 inhibitor.Fórmula:C21H19F3N2O2Cor e Forma:SolidPeso molecular:388.39IDO1-IN-7
CAS:IDO1-IN-7 is a potent IDO1 inhibitor with a 6.1 nM IC50 and immunomodulatory effects for cancer research.Fórmula:C22H19ClFN3O3Cor e Forma:SolidPeso molecular:427.86IDO1-IN-11
CAS:IDO1-IN-11 is an IDO1 inhibitor with an IC 50 value of 0.6 nM.Fórmula:C22H17ClFN3O3Cor e Forma:SolidPeso molecular:425.84NU223612
CAS:"NU223612 is a potent IDO1-degrading PROTAC with Kd 640 nM, binds CRBN at 290 nM, and crosses the BBB."Fórmula:C49H55FN6O9Cor e Forma:SolidPeso molecular:890.99TDO-IN-2
TDO-IN-2 is an orally active TDO inhibitor with an IC50 of 1.25 μM. It exhibits antitumor activity in a Hepa1-6 liver cancer allograft mouse model. Additionally, TDO-IN-2 works synergistically with PD-1/PD-L1 inhibitor BMS-202, making it useful for studying tumor immune tolerance.Fórmula:C20H15N3O3Cor e Forma:SolidPeso molecular:345.11134AT-0174
AT-0174 is an orally active dual inhibitor targeting IDO1 and TDO2 (tryptophan 2,3-dioxygenase-2), with IC50 values of 0.17 and 0.25 μM, respectively. It exhibits antitumor activity.Fórmula:C6H5ClFN3OCor e Forma:SolidPeso molecular:189.01052IDO-IN-15
CAS:IDO-IN-15 is an IDO1 inhibitor ( IC 50 < 0.51 nM).Fórmula:C29H39N5O4Cor e Forma:SolidPeso molecular:521.662BMT-297376
CAS:BMT-297376, the optimized Linrodostat, is a potent IDO1 inhibitor.Fórmula:C23H29F2N3O3Cor e Forma:SolidPeso molecular:433.5IDO1-IN-23
IDO1-IN-23 (compound 41) is a potent inhibitor of human indoleamine 2,3-dioxygenase 1 (IDO1), exhibiting an IC50 of 13 μM [1].Pureza:98%Cor e Forma:Odour SolidIDO1-IN-28
CAS:IDO1-IN-28 (Compound MQ-1) is a selective Apo-IDO1 inhibitor with an IC50 value of 1.29 μM that disrupts heme binding to the apo form of indoleamine 2,3-dioxygenase 1, IDO1-IN-28 is extensively applied in cancer research to investigate immune evasion mechanisms, tryptophan metabolism, and immuno-oncology therapeutic targeting.Fórmula:C24H22ClN3O2Pureza:98.17%Cor e Forma:White SolidPeso molecular:419.9XW-032
XW-032 is an apo-IDO1 inhibitor with an IC50 of 21 nM. In the CT26 syngeneic mouse model, XW-032 demonstrates significant in vivo antitumor efficacy with a TGI of 63%, showing potential for cancer research applications.Cor e Forma:Odour Solid
