Microbiologia/Virologia

<p>Antibacterial agent 61 (example 27) is a antibacterial agent.</p>

<p>Zegruvirimat is an antiviral agent. Zegruvirimat has antiviral activity [1] .</p>

<p>Salvinolone is a natural product that can be used as a reference standard.</p>

<p>Compound 3b is a potent broad-spectrum fungicide with strong respiratory and ATP synthesis inhibition.</p>

<p>Antibacterial agent 51 fights E. coli (NCTC 13351, M 50, 7 MP) with MICs: 4, 8, 8 mcg/mL (WO2013030733A1).</p>

<p>Felvizumab (SB 209763), a humanized IgG1κ monoclonal antibody, targets specific neutralizing epitopes on the F glycoprotein of Respiratory Syncytial Virus (RSV</p>

<p>Maniwamycin E, from Streptomyces sp. JA74, inhibits SARS-CoV-2 and H1N1 viruses.</p>

<p>Streptochlorin from Streptomyces sp. SF2583 has antiangiogenic, antiproliferative, anti-allergic effects, and hinders cancer cell growth.</p>

<p>Antibacterial agent 12 targets antibiotic-susceptible/resistant Gram-positive bacteria.</p>

<p>Cycloaspeptide A, obtained from the endophytic fungus Penicillium janczewskii, exhibits antiparasitic properties [1].</p>

<p>Thio-ITP (6-Thioinosine 5'-triphosphate) inhibits RNA polymerases I &amp; II with Ki of 40.9 &amp; 38.0 μM.</p>

<p>SDZ 283-910 is used as a statine-derived inhibitor.</p>

<p>Compound A07, effective against Fluconazole-resistant fungi, outperforms Miconazole, inhibits Candida at 0.25-1 μg/mL MIC.</p>

<p>FtsZ-IN-7: strong FtsZ inhibitor, blocks bacterial cell division, low resistance risk, minimal toxicity to mammals.</p>

<p>Virustomycin A is an antibiotic.</p>

<p>Ceratotoxins B, an antibacterial peptide, is produced by sexually mature females of Ceratitis capitata (medfly).</p>

<p>Compound B01, an antifungal, inhibits Candida albicans in vitro/vivo for invasive fungal infection research.</p>

<p>Penicillin G Benzathine Tetrahydrate (Benzathine Benzylpenicillin Tetrahydrate) serves as an antibiotic effective against numerous bacterial infections [1].</p>

<p>Cefalexin lysine is a derivative of Cefalexin which is an antibiotic.</p>

<p>Compound 6c, a tetrazole derivative, inhibits ergosterol synthesis and disrupts C. albicans cell membranes with potent antifungal effects.</p>

<p>Bromochloroacetonitrile, a water disinfection by-product, is mutagenic and can break DNA strands.</p>

<p>Spergualin trihydrochloride is a natural product that first identified as an antibiotic from culture filtrates of Bacillus laterosporus BMG162-aF2[1].</p>

Malachite Green Carbinol Base (MGOH, MGCB), non-fluorescent MG derivative, changes color under UV, releasing OH- for pH shift.

<p>Moniliformin sodium salt is water-soluble mycotoxin isolate from Fusarium moniliforme.</p>

<p>dTTP sodium hydrate, a DNA synthesis component, is a nucleoside triphosphate.</p>

<p>IPMCL-28b is an antimicrobial agent targeting bacterial cell membranes, with a minimum inhibitory concentration (MIC) of 1.56 μg/mL for Staphylococcus aureus ATCC 25923 and an MIC of 6.25 μg/mL for methicillin-resistant Staphylococcus aureus (MRSA). IPMCL-28b shows potential for research in the field of infection control.</p>

<p>AVX 13616: potent antibacterial vs. drug-resistant Staph, similar to mupirocin with single-use efficiency. MIC: 2-4 ug/ml. Targets various staph, MRSA.</p>

<p>Antimicrobial Agent-10 demonstrates exceptional antibacterial activity and inhibits SARS-CoV-2, positioning it as a potent antimicrobial compound [1].</p>

<p>Ganoderic acid GS-1, an extensively oxygenated lanostane-type triterpenoid, exhibits anti-HIV-1 protease activities, displaying an IC50 value of 58 μM [1].</p>

<p>Thiomarinol A: potent antibiotic, dithiolopyrrolone-marinolic acid hybrid with MRSA-targeting antimicrobial activity; inhibits IleRS, Ki app 19 nM.</p>

<p>Antimicrobial agent-11 is a SARS-CoV-2 inhibitor with antibacterial activity [1] .</p>

<p>BCX-1898: Oral cyclopentane-based neuraminidase inhibitor for flu A/B; EC50 &lt;0.01-21µM; effective in mouse models.</p>

<p>Alvircept sudotox, a recombinant CD4 fused with exotoxin A from Pneumonas aeruginosa, is utilized in HIV infection research [1].</p>

<p>NS2B/NS3-IN-7 is a highly potent inhibitor of the Zika virus NS2B-NS3 protease, possessing a Ki value of 2.33 nM.</p>

<p>Benalaxyl, (+)- is a fungicide agent.</p>

<p>Antimalarial 23: a benzimidazole with IC50s 0.08 μM (PfNF54), 0.10 μM (PfK1), inhibits β-hematin but not hemozoin formation.</p>

<p>Monascorubrin, from Monascus purpureus mycelium, is an antibiotic against Bacillus subtilis and Candida pseudotropicalis.</p>

Fortimicin C is a bioactive chemical.

<p>"Ribostamycin (Vistamycin) is a broad-spectrum antibiotic, effective against many bacteria and inhibits PDI."</p>

<p>Nannochelin B is a siderophore isolated from Nannocystis exedens.</p>

<p>Razupenem (SMP-601, PTZ601), a broad-spectrum injectable carbapenem, counters antibiotic-resistant bacteria.</p>

<p>Cepeginterferon alfa-2b: pegylated interferon with 20 kDa PEG for HCV, PV, ET research.</p>

<p>Harzianopyridone is an atpenin-like compound that functions as an inhibitor of mammalian and nematode mitochondrial complex II, also known as succinate:ubiquinone oxidoreductase (SQR), demonstrating IC50 values of 0.017, 0.2, and 2 μM against bovine, rat, and nematode complex II, respectively. Additionally, it inhibits nematode quinol-fumarate reductase (QFR) with an IC50 value of 0.36 μM. Significantly selective for complex II over complexes I and III in rats and cattle, as well as complex I in nematodes, with IC50 values exceeding 100 μM, it exhibits notable antibacterial and antifungal properties, with EC50 values of 35.9, 42.2, 60.4, and 50.2 μg/ml against R. solani, S. rolfsii, M. phaseolina, and F. oxysporum, respectively.</p>

<p>HCVP-IN-1 (compound 1) is a hepatitis C viral polymerase (HCVP) inhibitor.</p>

<p>Agent 37 from patent WO2015063714A1 is a potent antimicrobial for bacterial infection research.</p>

<p>PEX5-PEX14 PPI-IN-1 (Compound 8) is a PEX14-PEX5 protein-protein interaction (PPI) inhibitor that disrupts the interaction between PEX5 and TbPEX14 with an</p>

<p>Maximin 28, an antimicrobial peptide isolated from toad brain tissue, exhibits activity against various bacterial strains, including Staphylococcus aureus,</p>

<p>Compound 24f, an antifungal agent also known as 'Antifungal agent 85,' demonstrates potent antibacterial properties, exhibiting minimum inhibitory concentration</p>

<p>Collinin, a coumarin in Z. schinifolium, combats M. tuberculosis and inhibits NO production, platelet aggregation, and tumor growth in mice.</p>

<p>S-6123: Oxazolidinone antimicrobial that blocks ribosomal protein synthesis, sparing DNA/RNA.</p>