Microbiologia/Virologia

L 694746 is an inhibitor of HIV-1 protease.

5'-Ethynyl-2'-deoxycytidine (EdC) functions as a nucleoside analog effectively inhibiting the replication of herpes simplex virus-1 (HSV-1) KOS strain with an ID50 of 0.2 μg/mL. Additionally, it decreases virus-induced cytopathogenic effects in PRK cells for HSV-1, HSV-2, and vaccinia virus strains, demonstrating MIC values between 0.2 to 5 μg/mL. EdC acts as a thymidylate synthetase inhibitor, selectively impacting the DNA incorporation rates of [1',2'-3H]deoxyuridine compared to [CH3-3H]deoxythymidine in PRK cells with ID50s of 3 and 120 μg/mL, respectively. It further inhibits thymidine synthetase and curtails L1210 cell proliferation, a process reversible by deoxythymidine (ID50s are 4.4 and 1,000 μg/mL, respectively). Also, EdC is utilized in monitoring DNA synthesis and cellular replication through click chemistry conjugation, linking its ethynyl group with the azido group of various fluorochromes.

GS-6620 is a HCV nonstructural protein 5B (NS5B) inhibitor.

Thymidine-5’-O-(α,β-methylene)diphosphate (TMP-CP), a hydrolytically stable derivative of TDP, functions as an inhibitor of thymidine kinase (Ki = 23 µM).

Debrisoquin (Isocaramidine) is a TMPRSS2 inhibitor that prevents SARS-CoV-2 from entering human lung cells through TMPRSS2-dependent pathways, exhibiting an

PD 121373, a Benzothiopyrano-indazole, inhibits nucleic acid synthesis, equally affecting DNA/RNA.

Fenpropidin (Ro-12-3049), a fungicide, is a specific inhibitor of sterol 14-reductase and biosynthesis.

Methyl 3,4-dimethoxycinnamate impedes uredospore germination and concurrently inhibits global DNA methylation in Hep3B cells [1] [2].

<p>Bavtavirine is a non-nucleoside reverse HIV-1 transcriptase inhibitor (NNRTIs),inhibits HIV replication by preventing the transcription of viral RNA into DNA.</p>

CcpA-IN-1 is a Staphylococcus aureus antibiotic exhibiting significant bactericidal activity (MICs=460 nM) [1].

CGP 57813 is a lipophilic compound, which can be used as an inhibitor of HIV-1 protease.

SARS-CoV-2-IN-63 (Compound R3e) serves as an inhibitor of SARS-CoV-2 replication, demonstrating low cytotoxicity.

Sulfisoxazole acetyl (Gantrisin) is an agent with antibacterial activity.

AZD-7295 (A-689) is an NS5A inhibitor that may be used to treat HCV infection.

4'-Acetyl-chrysomycin B, a 4'-acetylated analog of chrysomycin B, exhibits anti-Gram-positive bacterial and antimicrobial activities [1].

SCH-538415: Microbial acyl carrier protein synthase inhibitor, IC50 4.19µM; anti-Staphylococcus aureus.

Kynostatin-272 is a HIV protease inhibitor. KNI-272 blocked the maturation of viral particles.

HBV-IN-6 is a potent inhibitor of HBV (EC50: 287.9 nM).

Tuberculosis inhibitor 8 (compound 3b), a 3-methoxy-2-phenylimidazo[1,2-b]pyridazine derivative, exhibits potent activity against both Mycobacterium

RSV L-protein-IN-5 (Compound E) serves as a potent inhibitor of the Respiratory Syncytial Virus (RSV), with an EC50 value of 0.1 μM.