Beta Amilóide
Os inibidores de beta-amiloide são compostos que visam especificamente inibir a formação ou agregação de peptídeos beta-amiloides, que desempenham um papel crítico na patogênese da doença de Alzheimer. O acúmulo de placas de beta-amiloide no cérebro é uma característica marcante da doença, levando à disfunção neuronal e ao declínio cognitivo. Ao impedir a agregação de beta-amiloide, esses inibidores estão sendo explorados como potenciais agentes terapêuticos para retardar ou prevenir a progressão da doença de Alzheimer. Na CymitQuimica, oferecemos uma variedade de inibidores de beta-amiloide de alta qualidade para apoiar sua pesquisa em neurodegeneração, agregação de proteínas e terapia para Alzheimer.
Foram encontrados 205 produtos de "Beta Amilóide"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
MK-0752
CAS:<p>MK-0752, a γ-secretase inhibitor, reduces Aβ40 production(IC50=5 nM).</p>Fórmula:C21H21ClF2O4SPureza:98% - 99.55%Cor e Forma:SolidPeso molecular:442.9PE859
CAS:<p>PE859 is a potent inhibitor of both tau and Aβ aggregation.</p>Fórmula:C28H24N4O2Pureza:98.8% - 99.09%Cor e Forma:SolidPeso molecular:448.52Solanezumab
CAS:<p>Solanezumab (LY 2062430) is a monoclonal antibody that binds preferentially to soluble amyloid and promotes its clearance from the brain.</p>Pureza:96.3% (SDS-PAGE); 97.5% (SEC-HPLC) - 96.3% (SDS-PAGE); 97.5% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:144.1 (kDa)γ-Secretase modulator 13
CAS:<p>γ-Secretase modulator 13 is a γ-secretase modulator (GSMs) that can be used to study Alzheimer's disease and tumors.</p>Fórmula:C22H23FN6SPureza:99.79%Cor e Forma:SolidPeso molecular:422.52Remternetug
CAS:<p>Remternetug is a humanized IgG1-kappa monoclonal antibody that targets the N3pGlu peptide of the amyloid beta A4 precursor protein (APP) Aβ42.</p>Pureza:95% - 95%Cor e Forma:LiquidBapineuzumab
CAS:<p>Bapineuzumab (AAB-001) is a humanised monoclonal antibody targeting amyloid-beta (Aβ), soluble and oligomeric forms of amyloid β, Alzheimer's disease (AD).</p>Pureza:95%Cor e Forma:LiquidDezamizumab
CAS:<p>Dezamizumab is a humanized antibody targeting the serum amyloid P component (SAP) to clear amyloid fibrils via macrophage phagocytosis, for research in systemic amyloid diseases.</p>Pureza:95% - 95%Cor e Forma:LiquidHomotaurine-d6
CAS:<p>Homotaurine-d6 is a deuterated compound of Homotaurine. Homotaurine has a CAS number of 3687-18-1. Because of its similarity in structure to the neurotransmitter gamma-aminobutyric acid (GABA), it has GABAergic effects and may be useful as an anticonvulsant. Homotaurine has also been investigated as a potential treatment for Alzheimer's disease. It binds to soluble amyloid beta and inhibits the formation of neurotoxic aggregates that lead to amyloid plaque deposition in the brain. However, clinical trials failed to show improvement compared to placebo.</p>Fórmula:C3D6H3NO3SCor e Forma:SolidPeso molecular:145.214-(6-Bromo-2-benzothiazolyl)benzenamine
CAS:<p>4-(6-Bromo-2-benzothiazolyl)benzenamine is a β-amyloid PET tracer and can be used in the diagnosis of neurological diseases.</p>Fórmula:C13H9BrN2SPureza:98%Cor e Forma:SolidPeso molecular:305.19Aftin-5
CAS:<p>Aftin-5 is an inducer of amyloid beta protein 42 (Aβ42). It functions by modifying the ultrastructure of mitochondria, leading to an upregulation of Aβ42 and a downregulation of Aβ38 through a β-secretase and γ-secretase-dependent mechanism. Aftin-5 exhibits mild cytotoxicity in SH-SY5Y, HT22, N2a, and N2a-AβPP695 cells, with IC50 values of 180, 194, 178, and 150 μM, respectively.</p>Fórmula:C19H26N6OCor e Forma:SolidPeso molecular:354.454-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine
CAS:<p>4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent amyloid imaging agent that binds to Amyloid-β (1-40) (KD: 1.7 nM).</p>Fórmula:C14H11BrN2SPureza:98%Cor e Forma:SolidPeso molecular:319.22Nicardipine pyridine metabolite II
CAS:<p>Nicardipine pyridine metabolite II is a biaoctive chemical.</p>Fórmula:C26H27N3O6Cor e Forma:SolidPeso molecular:477.51SEN-1269
CAS:<p>SEN-1269 prevents amyloid-β aggregation, shields neurons, and improves memory by hindering Aβ(1-42)-induced issues.</p>Fórmula:C18H18N4O2Pureza:98%Cor e Forma:SolidPeso molecular:322.36RU-505
CAS:<p>RU-505 is an interaction inhibitor of Aβ-fibrinogen that acts by rescuing altered thrombosis and cognitive decline in Alzheimer's disease mice.</p>Fórmula:C28H32FN5OPureza:98%Cor e Forma:SolidPeso molecular:473.58Astrophloxine
CAS:<p>Astrophloxine is a fluorescent imaging probe that targets antiparallel dimers.Astrophloxine can be used to detect aggregated Aβ in brain tissue and</p>Fórmula:C27H33IN2Pureza:99.89%Cor e Forma:SolidPeso molecular:512.47Aβ Fibrillization modulator 1
CAS:<p>Aβ Fibrillization Modulator 1 stabilizes amyloid-beta (Aβ) monomers, preventing their aggregation into fibrils.</p>Fórmula:C17H12N4O3SSeCor e Forma:SolidPeso molecular:431.33Neuroinflammatory-IN-2
CAS:<p>Neuroinflammatory-IN-2: anti-neuroinflammatory, inhibits MAO-B (IC50: 10.30µM), 96.33% Aβ1-42 aggregation reduction, neuroprotective in PC-12 cells.</p>Fórmula:C25H27FN2O3Cor e Forma:SolidPeso molecular:422.49ELND006
CAS:<p>ELND006, an oral Alzheimer's drug, has improved bioavailability as a nanosuspension, and food doesn't affect it.</p>Fórmula:C20H14F5N3O2SCor e Forma:SolidPeso molecular:455.4THK-523
CAS:<p>THK-523 selectively binds to tau in Alzheimer's, potent in vitro/vivo. 18F-THK523 excels in tau imaging.</p>Fórmula:C17H15FN2OCor e Forma:SolidPeso molecular:282.31TC-E 5006
CAS:<p>γ-secretase modulator</p>Fórmula:C29H29F4NO2Pureza:98%Cor e Forma:SolidPeso molecular:499.54
